Tag: 200-300

Nanofiltration membrane with high flux and oil rejection using graphene oxide/β-cyclodextrin for produced water reuse was written by Al-Gamal, Anwar Q.;Saleh, Tawfik A.;Alghunaimi, Fahd I.. And the article was included in Materials Today Communications in 2022.COA of Formula: C9H3Cl3O3 This article mentions the following:

A nanofiltration membrane with a high affinity to water and high rejection of salts and hydrocarbons was developed by intercalating a supramol. compound, graphene oxide with β-cyclodextrin (GO-beta-CD), into its layer of separation The GO-beta-CD membranes were synthesized by interfacial polymerization of an aqueous solution of (GO-beta-CD)/piperazine with an organic solution of 1, 3, 5-benzenetricarbonyl trichloride on porous substrates of polysulfone (PSf). Fourier transform IR spectroscopy (FTIR), field-emission scanning electron microscope (SEM), energy dispersive x-ray(EDX), and at. force microscope (AFM) analyses were applied to confirm the successful incorporation of GO-beta-CD into the rejection layer of the synthesized membrane and analyze the morphol., surface characteristics, and structure of the membrane surface. The hydrophilicity and porosity of the GO-beta-CD-embedded membranes were greatly enhanced and were confirmed by the contact angle decline and permeability enhancement. The collective results and analyses showed that the permeability, salt rejection and oil separation were significantly enhanced by the addition of GO-beta-CD. The prepared membranes were featured with hydrocarbons separation efficiency of about 100%, divalent salt rejection of about 89% and monovalent salt rejection of about 74%. The fluxes of the produced membranes were 80% greater than NF bare membranes. Addnl., the GO-beta-CD membranes were stable under a long-trail filtration of 15 h and exhibited excellent mech. and performance stability. The proposed membranes with excellent stability, high flux, salt rejection and oil rejection are highly promising for practical applications such as water desalination. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1COA of Formula: C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment was written by Huang, Ke;Jiang, Lulu;Liang, Ronghui;Li, Huiti;Ruan, Xiaoxue;Shan, Changliang;Ye, Deyong;Zhou, Lu. And the article was included in European Journal of Medicinal Chemistry in 2019.Related Products of 63624-28-2 This article mentions the following:

Phosphoglycerate mutase 1 (PGAM1) coordinates glycolysis, pentose phosphate pathway, and serine synthesis to promote tumor growth through the regulation of its substrate 3-phosphoglycerate (3 PG) and product 2-phosphoglycerate (2 PG). Herein, based on our previously reported PGAM1 inhibitor PGMI-004A, we have developed anthraquinone derivatives as novel allosteric PGAM1 inhibitors and the structure-activity relationship (SAR) was investigated. In addition, we determined the co-crystal structure of PGAM1 and the inhibitor 8g, demonstrating that the inhibitor was located at a novel allosteric site. Among the derivatives, compound 8t was selected for further study, with IC₅₀ values of 0.25 and approx. 5 μM in enzymic and cell-based assays, resp. Mechanistically, compound 8t reduced the glycolysis and oxygen consumption rate in cancer cells, which led to decreased ATP (ATP) production and subsequent 5′ adenosine monophosphate-activated protein kinase (AMPK) activation. The inhibitor 8t also exhibited good efficacy in delaying tumor growth in H1299 xenograft model without obvious toxicity. Taken together, this proof-of-principle work further validates PGAM1 as a potential target for cancer therapy and provides useful information on anti-tumor drug discovery targeting PGAM1. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Related Products of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules was written by You, Weijie;Rotili, Dante;Li, Tie-Mei;Kambach, Christian;Meleshin, Marat;Schutkowski, Mike;Chua, Katrin F.;Mai, Antonello;Steegborn, Clemens. And the article was included in Angewandte Chemie, International Edition in 2017.Formula: C7H4ClF3O2S This article mentions the following:

Sirtuins are protein deacylases regulating metabolism and stress responses, and are implicated in aging-related diseases. Small mol. activators for the human sirtuins Sirt1-7 are sought as chem. tools and potential therapeutics, such as for cancer. Activators are available for Sirt1 and exploit its unique N-terminus, whereas drug-like activators for Sirt2-7 are lacking. The authors synthesized and screened pyrrolo[1,2-a]quinoxaline derivatives, yielding the first synthetic Sirt6 activators. Biochem. assays show direct, substrate-independent compound binding to the Sirt6 catalytic core and potent activation of Sirt6-dependent deacetylation of peptide substrates and complete nucleosomes. Crystal structures of Sirt6/activator complexes reveal that the compounds bind to a Sirt6-specific acyl channel pocket and identify key interactions. The authors’ results establish potent Sirt6 activation with small mols. and provide a structural basis for further development of Sirt6 activators as tools and therapeutics. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Formula: C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Potential synergy between spores of Metarhizium anisopliae and plant secondary metabolite, 1-chlorooctadecane for effective natural acaricide development was written by Hussain, Abid;Aljabr, Ahmed Mohammed. And the article was included in Molecules in 2020.Reference of 3386-33-2 This article mentions the following:

Date palm dust mites are important pests severely infesting valuable nutritious fruits (dates) of date palm. In this regard, in vitro tests were performed to evaluate the interaction of M. anisopliae spores with multiple doses of 1-Chlorooctadecane (0.8, 1.6, 2.4, 3.2, and 4.0 mg/mL). Compatibility bioassay results evidenced from vegetative growth (77.7-84.40 mm), sporulation (5.50-7.30 x 106 spores/mL), and germination (96.70-98.20%), revealed that all the tested doses are compatible (biol. index > 82) with the spores of M. anisopliae. The impact of combined treatment of spores with 1-Chlorooctadecane in different proportions (Scheme I, II, III, and IV) compared to their sole application against O. afrasiaticus was evaluated by concentration-mortality response bioassays. Results showed that all the combined treatments revealed high mortality compared to the sole application, which showed relatively slow mortality response over time. Toxicity recorded from Scheme IV combinations (80% 1-Chlorooctadecane: 20% Spores), exhibited strong synergistic interaction (joint toxicity = 713). Furthermore, potent interactions have overcome the host antioxidant defense at the final stage of infection by tremendously reducing catalase, and superoxide dismutase activities. These experiments demonstrated fungal-toxin joint synergistic interaction as a promising date palm dust mite management option. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Reference of 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies was written by Chawla, Reena;Van Puyenbroeck, Victor;Pflug, Nicholas C.;Sama, Alekhya;Ali, Rameez;Schols, Dominique;Vermeire, Kurt;Bell, Thomas W.. And the article was included in Journal of Medicinal Chemistry in 2016.Reference of 63624-28-2 This article mentions the following:

Cyclotriazadisulfonamide prevents HIV entry into cells by down-modulating surface CD4 receptor expression through binding to the CD4 signal peptide. According to a two-site binding model, 28 new unsym. analogs bearing a benzyl tail group and nine bearing a cyclohexylmethyl tail have been designed and synthesized. The most potent new CD4 down-modulator (40 (CK147); IC₅₀ 63 nM) has a 4-dimethylaminobenzenesulfonyl side arm. One of the two side arms was varied with substituents in different positions. This gave a range of CD4 down-modulation potencies that correlated well with anti-HIV-1 activities. The side arms of 21 of the new benzyl-tailed analogs were modeled by means of quantum mech. calculations For CADA analogs with arenesulfonamide side arms, the pIC₅₀ values for CD4 down-modulation correlated with the component of the elec. dipole moment in the aromatic ring, suggesting that an attractive electronic interaction is a major factor determining the stability of the complex between the mol. and its target. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Reference of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Reference of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Library of Oligosaccharides Derived from the Capsular Polysaccharide of Streptococcus pneumoniae Serotypes 6A and 6B and Their Immunological Studies was written by Mettu, Ravinder;Lih, Yu-Hsuan;Vulupala, Hanmanth Reddy;Chen, Chiang-Yun;Hsu, Mei-Hua;Lo, Hong-Jay;Liao, Kuo-Shiang;Cheng, Yang-Yu;Chiu, Cheng-Hsun;Wu, Chung-Yi. And the article was included in ACS Infectious Diseases in 2022.Quality Control of (Chloromethanetriyl)tribenzene This article mentions the following:

Streptococcus pneumoniae serotypes 6A and 6B are two of the common causes of invasive pneumococcal diseases. Although capsular polysaccharide conjugates of these two serotypes are included in the leading 13-valent pneumococcal conjugate vaccine, its low immunogenicity and high threshold for manufacturing technol. indicated the need for vaccine improvement. Structurally defined synthetic immunogens have potential in dealing with these problems. To this end, we built a library of capsular polysaccharide fragments through convergent chem. synthesis in [2 + 2], [4 + 4], [4 + 3], [4 + 2], and [4 + 1] coupling manners. The library is comprised of 18 glycan antigens from trisaccharides to pseudo-octasaccharides, derived from the capsular repeating phosphorylated pseudo-tetrasaccharide with or without phosphate. Eight of them were selected for mouse immunization and further immunol. studies. Four pseudo-tetrasaccharides with terminal or bridging phosphate elicited opsonic antibodies, which exhibited bactericidal activities and moderate cross-reactivities. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Quality Control of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antifungal activity of novel 2-(1H-benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole derivatives was written by Ji, Zengchen;Liu, Feng;Zhang, Zeyuan;Li, Fubo;Jiang, Lin. And the article was included in Youji Huaxue in 2012.Synthetic Route of C7H3Cl2NS This article mentions the following:

Sixteen novel 2-(1H-benzimidazol-2-yl)-5-substituted phenyl-1,3,4-oxadiazoles I(R = H, 4-F, 4-Cl, 4-Br, 2,4-Cl₂, 3,4-Cl₂, 4-Me, 4-MeO) and 2-(1H-benzimidazol-2-yl)-5-substituted phenylamino-1,3,4-oxadiazoles II(R = H, 4-F, 4-Cl, 4-Br, 2,4-Cl₂, 3,4-Cl₂, 4-Me, 4-MeO) were synthesized from benzimidazole-2-carboxylic acid, hydrazine hydrate, substituted Ph isothiocyanate and substituted benzoic acid by multi-step reactions. The target compounds were evaluated for their antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum, and the results indicated that three target compounds displayed excellent antifungal activities against Botrytis cinerea, with EC₅₀ values of 2.55, 6.34 and 5.12 μg/mL, resp., even higher than that of carbendazim. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Synthetic Route of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

α_vβ₃ antagonists based on a central benzoic acid scaffold was written by Will, D. W.;Breipohl, G.;Gourvest, J.-F.;Ruxer, J.-M.;Doucet, B.;Auberval, M.;Baron, R.;Gaillard, M.;Gadek, T. R.;Knolle, J.;Stilz, H. U.;Peyman, A.. And the article was included in Polish Journal of Chemistry in 2005.Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride This article mentions the following:

A series of highly potent α_vβ₃ antagonists, e.g., I, based on a benzoic acid scaffold and containing an acylguanidine as an Arg-mimetic and sulfonamide side chains is described. The compounds were selective against the fibrinogen receptor α_IIbβ₃ and they were capable of inhibiting bone resorption in vivo in a TPTX model of osteoporosis. Therefore the compounds were promising drug substances for the treatment of osteoporosis. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, characterization and in vitro, in vivo and in silico antimicrobial and antiinflammatory activities of a new series of sulfonamide and carbamate derivatives of a nebivolol intermediate was written by Uma priya, K.;Venkataramaiah, Ch.;Sreedhar, N. Y.;Raju, C. Naga. And the article was included in RSC Advances in 2021.SDS of cas: 777-44-6 This article mentions the following:

A series of new sulfonamide and carbamate derivatives of Nebivolol drug intermediate (5) were designed and synthesized by reacting various biopotent sulfonylchlorides and chloroformates. The synthesized compounds are structurally characterized by spectral (IR, ¹H & ¹³C NMR and mass) and screened for their in vitro antimicrobial activity against four bacterial and three fungal strains, in vitro and in vivo antiinflammatory activity against LPS-induced inflammation in RAW 264.7, in vitro COX-1 and COX-2 inhibition potentiality, antagonistic profiles of carrageenan induced paw edema and cotton pellet induced granuloma in rat. Further, the compounds were screened for their antimicrobial and antiinflammatory activity against DNA gyrase A, COX-1 and COX-2 by using mol. docking approach. The bioactivity and toxicity risks were analyzed through Mol. Operating Environment. The results revealed that the compounds 8b, 8c, 8d, 8e, 8f, 8g and 9a exhibited the most promising antimicrobial activity against all the bacterial and fungal strains tested when compared with the standard drugs streptomycin and fluconazole. In view of in antiinflammatory activity, the compounds, 8b, 8c, 8d, 8e, 8f, 8g and 9a have shown potent antiinflammatory activity by inhibiting the LPS-induced inflammation in RAW 264.7 cell line, concentration dependent inhibition of COX-1 and COX-2, dose response dependent antagonism of carrageenan induced paw edema and granuloma tissue in rat. Mol. docking, ADMET and QSAR studies predicted that the recorded in silico profiles are in strong correlation with in vitro and in vivo antimicrobial and antiinflammatory results. In addition, the elevated toxicol. risks of the title compounds are identified with in the potential limits of drug candidates. Hence, it is suggested that the synthesized derivatives will stand as the promising antimicrobial and anti-inflammatory drug candidates in future. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6SDS of cas: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Conventional and non-conventional synthesis of some novel benzofuran incorporated thiadiazoles and triazoles was written by Kundlikar, S. G.;Randhavane, P. V.;Akolkar, H. N.;Karale, B. K.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2016.Safety of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

7-Bromo-5-chlorobenzofuran-2-carbohydrazide on reaction with substituted arylisothiocyanates gave corresponding thiosemicarbazides, further reaction in the presence of acidic and basic medium gave corresponding thiadiazoles and triazoles resp. The structures of all the synthesized compounds were characterized with the help of spectral techniques. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Safety of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics