Tag: 200-300

Synthesis, structure-activity relationships and molecular docking studies of phenyldiazenyl sulfonamides as aromatase inhibitors was written by Giampietro, Letizia;Gallorini, Marialucia;Gambacorta, Nicola;Ammazzalorso, Alessandra;De Filippis, Barbara;Della Valle, Alice;Fantacuzzi, Marialuigia;Maccallini, Cristina;Mollica, Adriano;Cataldi, Amelia;Nicolotti, Orazio;Amoroso, Rosa. And the article was included in European Journal of Medicinal Chemistry in 2021.Reference of 63624-28-2 This article mentions the following:

In this respect, a series of phenyldiazenyl sulfonamides (E)-RS(O)₂NHC₆H₄N=NC₆H₅ (R = Me, Ph, 5-chlorothiophen-2-yl, etc.) and (E)-I was designed, synthesized and tested. Compounds (E)-RS(O)₂NHC₆H₄N=NC₆H₅ (R = 4-cyanophenyl, 2,4-dimethoxyphenyl (II)), and (E)-I (R = 2,4-dimethoxyphenyl) showed an aromatase inhibition in the micromolar range and were evaluated in vitro on the human breast cancer cell line MCF7 by MTT assay, cytotoxicity assay (LDH release), cell cycle anal. and apoptosis, revealing a dose-dependent inhibition profile. In particular, (II) displayed the best reduction in terms of metabolic activity and an anti-proliferative effect on MCF7 cells, being blocked in the G1/S phase checkpoint. Moreover, computational studies were carried out to better understand at a mol. level of detail the rationale behind the effective binding to the active site of aromatase of the more active inhibitor (II). The obtained results allow to consider this compound as an interesting lead for the development of a new class of non-steroidal aromatase inhibitors. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Reference of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Reference of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A General Synthesis of N-Hydroxyindoles was written by Wong, Audrey;Kuethe, Jeffrey T.;Davies, Ian W.. And the article was included in Journal of Organic Chemistry in 2003.Recommanded Product: 16588-16-2 This article mentions the following:

A general method for the formation of N-hydroxyindoles is demonstrated through a Pb-promoted intramol. reductive cyclization of o-nitrobenzyl ketones and aldehydes under transfer hydrogenation conditions. The N-hydroxyindoles are isolated in high purity and excellent yield (>90%) in an operationally simple procedure. This new method is exemplified by a two-step synthesis of the naturally occurring 1-methoxyindole-3-carboxaldehyde, which is pivotal in many alkaloid total syntheses. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Recommanded Product: 16588-16-2).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 16588-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-activity relationship of aloperine derivatives as new anti-liver fibrogenic agents was written by Wang, Kun;Guo, Zhihao;Bao, Yunyang;Pang, Yudong;Li, Yinghong;He, Hongwei;Song, Danqing. And the article was included in Molecules in 2020.Recommanded Product: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Novel 12N-substituted aloperine derivatives I [R = Et, 3,4,5-trimethylphenyl, oxan-4-yl, etc.; R¹ = H, Me, naphthalen-2-yl; RR¹ = -(CH₂)₄-] and 12N-N’-phenoxazinylcarbamoylmethyl aloperine, II [R² = naphthalen-1-yl, 3-(trifluoromethyl)phenyl, Ph, 4-bromo-3-(trifluoromethyl)phenyl], III [R² = Bu, 3-(trifluoromethoxy)phenyl, 3-bromophenyl, etc.]were synthesized and investigated for their inhibitory effects on collagen α1 (I) (COL1A1) promotor in human hepatic stellate LX-2 cells, taking aloperine (1) as the hit. A structure-activity relationship (SAR) study disclosed that the introduction of suitable substituents on the 12N atom might enhance the activity. Compound 12N-N’-phenoxazinylcarbamoylmethyl aloperine exhibited a good promise on down-regulating COL1A1 expression with the IC₅₀ value of 16.5μM. Its inhibitory activity against COL1A1 was further confirmed on both mRNA and protein levels. Meanwhile, it effectively inhibited the expression of other fibrogenic proteins, such as transforming growth factor β1 (TGF-α1) and smooth muscle actin (α-SMA). It also exhibited good in vivo safety profile with the oral LD₅₀ value of 400 mg kg^-1 in mice. The results initiated the anti-liver fibrogenic study of aloperine derivatives, and the key compound 12N-N’-phenoxazinylcarbamoylmethyl aloperine was selected as a novel lead for further investigation against liver fibrogenesis. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Recommanded Product: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of quinolines via ortho-lithiated N-acylanilines. A modified Friedlaender synthesis was written by Cho, In Seop;Gong, Leyi;Muchowski, Joseph M.. And the article was included in Journal of Organic Chemistry in 1991.Quality Control of tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:

A new variation of the Friedlaender quinoline synthesis was devised based on the sequential reaction of ortho-lithiated N–tert-Boc-anilines or N-pivaloylanilines with masked malondialdehyde derivatives, e.g., vinamidinium salts I (R = H, Ph), 3-(dimethylamino)acrolein, and 3-ethoxymethacrolein, and subsequent acid-induced cyclization. Thus, anilines II (R¹ = H, F, Cl, Me, OMe, R² = OCMe₃) were lithiated and cyclized with I (R = H) to give quinolines III. Lithiation of II (R¹ = F, R² = CMe₃) and cyclization with EtOCH:CMeCHO gave III (R¹ = F, R = Me). In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Quality Control of tert-Butyl (4-chlorophenyl)carbamate).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of tert-Butyl (4-chlorophenyl)carbamate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Late 3d-Transition Metal Complexes Bearing a Bis-Phosphine Borane Ligand, PhB(CH₂P^tBu₂)₂ was written by Handford, Rex C.;Zhong, Lingfei;Tilley, T. Don. And the article was included in Organometallics in 2022.Name: (Chloromethanetriyl)tribenzene This article mentions the following:

The coordination chem. of a bidentate ambiphilic ligand, PhB(CH₂P^tBu₂)₂ ([BP₂^tBu]), is established for a series of Co, Ni, and Cu compounds The chloride starting materials [BP₂^tBu]MCl₂ [M = Co (1_Co), Ni (1_Ni)] and [BP₂^tBu]CuCl (2_Cu) are readily accessed in high yields by the treatment of the corresponding metal chloride salts with [BP₂^tBu] in THF solution The reduction of 1_Ni to [BP₂^tBu]NiCl (2_Ni) was affected by treatment with KC₈. In contrast, the corresponding Co^I species was not isolable under similar reaction conditions. However, monovalent mesityl complexes of the form [BP₂^tBu]M(Mes) [M = Co (3_Co), Ni (3_Ni), Cu (3_Cu)] were prepared by the treatment of 1_Co with one equiv of Mes₂Mg(THF)₂ or by the reaction of 2_M (M = Ni, Cu) with 0.5 equiv of Mes₂Mg(THF)₂. Modification of the borane moiety in 2_Ni was explored by the treatment of this complex with 4-dimethylaminopyridine (DMAP) to produce [PhB(DMAP)(CH₂P^tBu₂)₂]NiCl (4), which displays distinct features in its UV-visible spectrum compared to 2_Ni. The solid-state mol. structures of most complexes have been determined by single-crystal X-ray diffraction anal. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Name: (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and antibacterial activity of fluoroquinolones containing bulky arenesulfonyl fragment: 2D-QSAR and docking study was written by Abdel-Aziz, Alaa A.-M.;Asiri, Yousif A.;Al-Agamy, Mohamed H. M.. And the article was included in European Journal of Medicinal Chemistry in 2011.Related Products of 63624-28-2 This article mentions the following:

Here in, we report the design, synthesis, and antibacterial activity of series of bulky arenesulfonamido derivatives using ciprofloxacin and norfloxacin as scaffolds. All the synthesized compounds were investigated in vitro for their antibacterial activities against two Gram-pos. and two Gram-neg. organisms using dilution broth method. Some of the synthetic compounds showed significance difference from the standard drug ciprofloxacin. 2D-QSAR study provides details on the fine relationship linking structure and activity and offers clues for structural modifications that can improve the activity. Docking study of the compound I into the active site of the topoisomerase II DNA-gyrase enzymes revealed a similar binding mode to ciprofloxacin with addnl. classical and nonclassical hydrogen bonds. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Related Products of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 1-aryl- and 1-alkyl-2,3-dimethylquinoxalinium perchlorates. 2. Synthesis and proton NMR spectra of 2,3-dimethyl-1-phenyl-6-X-quinoxalinium perchlorates was written by Schelz, Dieter. And the article was included in Helvetica Chimica Acta in 1978.Quality Control of Ethyl 4-chloro-3-nitrobenzoate This article mentions the following:

A general method for the preparation of the title compounds I (X = CH, R = Ph, R¹ = NO₂, SO₂Me, CN, CF₃, CO₂Et, Cl, Br, Me, OMe; R = Me, 4-ClC₆H₄, R¹ = NO₂, H, X = CH; R = Ph, R¹ = H, X = N) involved the condensation of 4,2-R(H₂N)C₆H₃NHR with MeCOCOMe and HClO₄ in a mixed solvent containing excess Et₂O. I were converted into II by heating with Et₃N and Me₂CO. The NMR shifts of I were correlated with Hammet’s constant σ_p. I are useful as dye precursors. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Quality Control of Ethyl 4-chloro-3-nitrobenzoate).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of Ethyl 4-chloro-3-nitrobenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Syntheses of new pyridonecarboxylic acid derivatives containing 3-, 5- or 6-quinolyl substituents at N-1 and their anti-HIV-RT activities was written by Oh, Yoon-Seok;Lee, Chi-Woo;Chung, Yong-Ho;Yoon, Sung-June;Cho, Sung-Hye. And the article was included in Journal of Heterocyclic Chemistry in 1998.Application of 96568-04-6 This article mentions the following:

A series of new pyridonecarboxylic acid derivatives containing 3-, 5-, or 6-quinolyl substituents at N-1 were synthesized and their in vitro anti-HIV-RT activities were evaluated. Several compounds in this series showed better activity than Atevirdine. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Application of 96568-04-6).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 96568-04-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of new 1,3,4-oxadiazoles as antibacterial and antifungal agents was written by Revanasiddappa, B. C.;Varghese, Saira Susan;Kalsi, Jasmine;Jisha, M. S.;Jose, Neethu. And the article was included in Indian Journal of Heterocyclic Chemistry in 2014.HPLC of Formula: 34662-36-7 This article mentions the following:

A new series of 1,3,4 oxadiazoles I (R = H, 4-Cl, 4-OH, etc.) were prepared by reacting 2-hydroxybenzohydrazide with substituted aromatic acids in presence of phosphorous oxychloride. All the newly synthesized compounds were evaluated for their in-vitro antibacterial and antifungal activities. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7HPLC of Formula: 34662-36-7).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 34662-36-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics of oxidation of benzyl alcohol and substituted benzyl alcohols by N-chlorosaccharin was written by Vijaya Mohan, K.;Rao, P. Raghunatha;Sundaram, E. V.. And the article was included in Proceedings of the National Academy of Sciences, India, Section A: Physical Sciences in 1988.Computed Properties of C7H4ClNO3S This article mentions the following:

The acid catalyzed oxidation of benzyl alcs. by N-chlorosaccharin was studied in aqueous AcOH medium in the presence of saccharin. The reaction is first-order with respect to [substrate] and [oxidant]. A plot of log k_obs vs. ρ is linear with σ = -3.07. The rate is not affected by added Cl^–. Bunnett’s plot shows that water mols. act as proton transfer agents in the rate determining step. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Computed Properties of C7H4ClNO3S).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C7H4ClNO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics