Tag: 200-300

Synthetic and pharmacological evaluation of some pyridine containing thiazolidinones was written by Firke, S. D.;Firake, B. M.;Chaudhari, R. Y.;Patil, V. R.. And the article was included in Asian Journal of Research in Chemistry in 2009.Computed Properties of C7H3Cl2NS This article mentions the following:

Several of 2-(2-pyridinyloxy)acetic acid 2-(4-oxo-2-thiazolidinylidene)hydrazide derivatives were obtained by a cyclization reaction of isothiocyanates with 2-(2-pyridinyloxy)acetic acid 2-[(amino)thioxomethyl]hydrazide (thiosemicarbazide) derivatives with chloroacetic acid. The product structures were confirmed by their anal. and spectral data. All the above-mentioned target compounds were evaluated for their activity as antidiabetic agents using a GOD-POD method on Wistar strain rats. The acute toxicity (LD₅₀) values of these compounds were also reported. here. The test compounds showed significant antidiabetic activity. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Computed Properties of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalyst-free sulfenylation of indoles with sulfinic esters in ethanol was written by Yang, Xiuqin;Bao, Yishu;Dai, Zonghao;Zhou, Qingfa;Yang, Fulai. And the article was included in Green Chemistry in 2018.Electric Literature of C7H4ClF3O2S This article mentions the following:

A novel catalyst-free method for the synthesis of structurally diverse indole thioethers in moderate to excellent yields was developed. In this reaction, sulfinic esters serve as new sulfur electrophiles. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Electric Literature of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Electric Literature of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC) was written by Wang, Wentian;Zhang, Lu;Morlock, Lorraine;Williams, Noelle S.;Shay, Jerry W.;De Brabander, Jef K.. And the article was included in Journal of Medicinal Chemistry in 2019.Reference of 1138-56-3 This article mentions the following:

Despite advances in targeted anticancer therapies, there are still no small-mol.-based therapies available that specifically target colorectal cancer (CRC) development and progression, the second leading cause of cancer deaths. We previously disclosed the discovery of truncating adenomatous polyposis coli (APC)-selective inhibitor 1 (TASIN-1), a small mol. that specifically targets colorectal cancer cells lines with truncating mutations in the adenomatous polyposis coli (APC) tumor suppressor gene through inhibition of cholesterol biosynthesis. Here, we report a medicinal chem. evaluation of a collection of TASIN analogs and activity against colon cancer cell lines and an isogenic cell line pair reporting on the status of APC-dependent selectivity. A number of potent and selective analogs were identified, including compounds with good metabolic stability and pharmacokinetic properties. The compounds reported herein represent a first-in-class genotype-selective series that specifically target apc mutations present in the majority of CRC patients and serve as a translational platform toward a targeted therapy for colon cancer. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Reference of 1138-56-3).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 1138-56-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carborane Stabilized “19-Electron” Molybdenum Metalloradical was written by Jaiswal, Kuldeep;Malik, Naveen;Tumanskii, Boris;Menard, Gabriel;Dobrovetsky, Roman. And the article was included in Journal of the American Chemical Society in 2021.Formula: C19H15Cl This article mentions the following:

Molybdenum 19-e paramagnetic complexes stabilized by carboranylphosphine 1,2-C₂B₁₀H₁₁PPh₂ (CbPPh₂) were prepared by photolysis of half-sandwich Mo-Mo dimer [Cp₂Mo₂(CO)₆] in the presence of CbPPh₂. Paramagnetic metal complexes gained a lot of attention due to their participation in a number of important chem. reactions. In most cases, these complexes are dominated by 17-e metalloradicals that are associatively activated with highly reactive paramagnetic 19-e species. Molybdenum paramagnetic complexes are among the most investigated ones. While some examples of persistent 17-e Mo-centered radicals have been reported, in contrast, 19-e Mo-centered radicals are illusive species and as such could rarely be detected. In this work, the photodissociation of the [Cp(CO)₃Mo]₂ dimer (1) in the presence of phosphines was revisited. As a result, the first persistent, formally 19-e Mo radical with significant electron d. on the Mo center (22%), Cp(CO)₃Mo^•PPh₂(o-C₂B₁₀H₁₁) (5b), was generated and characterized by EPR spectroscopy and MS as well as studied by DFT calculations The stabilization of 5b was likely achieved due to a unique electron-withdrawing effect of the o-carboranyl substituent at the phosphorus center. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Formula: C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pigeon egg white protein-based transparent durable hydrogel via monodisperse ionic surfactant-mediated protein condensation was written by Zhou, Xinlian;Chen, Zaozao;Nojima, Tatsuya. And the article was included in Scientific Reports in 2022.Electric Literature of C19H15Cl This article mentions the following:

The thermal gelation property of proteins is useful in creating protein-based materials. The gelation of protein solution often proceeds by the random aggregation of denatured proteins, and the protein-based gels are typically brittle or opaque, or both. Improvement in the mech. and optical properties of protein-based materials are required for them to be practical and functional. This study investigated pigeon egg white, which is semitransparent in its thermally gelled state, as a protein source for creating hydrogel materials. The protein thermal gelation process was initiated from the orderly condensed state of proteins complexed with monodisperse ionic surfactants to suppress random aggregation. The resultant gel showed transparency in the visible light region and was not destroyed at 99% compression under 17.8 MPa compressive stress, 350-fold higher than the compressive fracture strength of typical boiled pigeon egg white. These results showed that durable transparent hydrogels could be fabricated by the rational combination of natural proteins and surfactants. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Electric Literature of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cavitating substrates to boost water permeance of reverse osmosis membranes was written by Yang, Hao;Zhang, Zhe;Wang, Yong. And the article was included in Separation and Purification Technology in 2022.Name: Trimesoylchloride This article mentions the following:

Reverse osmosis membranes have been shown to achieve reliable freshwater supply by means of water desalination. Nevertheless, breaking the long-standing trade-off is a major challenge for realizing high-efficient desalination. Herein, we show that selective swelling of substrates made by a block copolymer, polysulfone-block-poly(ethylene glycol) (PSF-b-PEG), is very promising in the fabrication of high-flux reverse osmosis membranes. Polyamide layers are first formed on relatively dense PSF-b-PEG substrates by interfacial polymerization Then, the substrates are cavitated into highly porous substrates by selective swelling, which follows the mechanism of selective swelling-induced pore generation. The substrate porosity can be well tuned over a wide range via adjusting swelling duration. Selective swelling does not compromise the structural integrity and surface properties of polyamide layers atop the substrates. Importantly, the boosted porosity reduces the water transport resistance in substrates markedly, which in turn enables fast water permeation in reverse osmosis membranes. Thus, the optimal membrane shows exceptional water permeance of 50.4 L m-2 h^-1 MPa^-1 and a high NaCl rejection of 99.2%. Our work not only offers a novel strategy to enhance the water permeance of reverse osmosis membranes, but also demonstrates that the transport resistance of substrates also significantly influences water permeance of reverse osmosis membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Name: Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

U-87947E, a potent quinolone antibacterial agent incorporating a bicyclo[1.1.1]pent-1-yl (BCP) subunit was written by Barbachyn, Michael R.;Hutchinson, Douglas K.;Toops, Dana S.;Reid, Raymond J.;Zurenko, Gary E.;Yagi, Betty H.;Schaadt, Ronda D.;Allison, John W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1993.Application of 96568-04-6 This article mentions the following:

Incorporation of a bicyclo[1.1.1]pent-1-yl group at the N-1 position of quinolone antibacterial agents affords compounds with potent activity. One of these analogs, I.MeSO₃H (U-87947E), exhibits enhanced activity relative to that of ciprofloxacin against gram-pos. aerobic bacteria and anaerobic organisms. Time-kill kinetic studies reveal that U-87947E is exquisitely bactericidal against ciprofloxacin-resistant Staphylococcus aureus. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Application of 96568-04-6).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 96568-04-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Isolation and identification of chemical constituents from various polar solvent crude leaf, stem and root extracts of endemic – Pogostemon Speciosus Benth of the Nilgiri was written by Jeyaraman, S.;Rajeshkumar, S.;Nisha, M. C.;Kalimuthu, K.;Vajjiram, Chinnadurai. And the article was included in World Journal of Pharmaceutical Research in 2018.Computed Properties of C18H37Cl This article mentions the following:

Pogostemon speciosus Benth is endemic ethno medicinal plant, belongs to the family Lamiaceae found in Anamalai and Nilgiri hills of South Western Ghats, India. The present study was to anal. the secondary metabolites by preliminary phytochem. screening of the leaf (PSLPE, PSLEA, and PSLE), stem (PSSPE, PSSEA, PSSE) and root (PSRPE, PSREA, PSRE) petroleum ether, Et acetate and ethanol extracts by different test. Identification of the phytocompound through FTIR and GCMS from leaf, stem and root ethanol extracts (PSLE, PSSE, PSRE). Among these extracts, the ethanol extracts of leaf, stem and root showed the presence of majority of the metabolites when compared to other extracts FTIR anal. of PSLE, PSSE and PSRE revealed the presence of 6, 5, 7 major bonds resp. The important bioactive compounds present in PSLE are Caryophyllene, 1-Naphthalenol, Alpha.-bisabolol, N-Hexadecanoic acid, Phytol, Hexatriacontane, 2-Tetracosahexaene, Dotriacontane, and Butyl-4(adamantyl-1) benzene, in PSSE extract Caryophyllene, Alpha.-bisabolol, 2H Pyran, Flopropione, Phytol isomer and Dotriacontane. The bioactive compounds present in PSRE extract are Caryophyllene, Heneicosane, 2H Pyran, Dotriacontane with anti-inflammatory, antifungal, antioxidant, antitumor, antibacterial, anti-asthmatics, drugs for skeletal disorders, bronchodilators, antispasmodic, hypocholesterolemic, nematicide, pesticide, anti-inflammatory, cytotoxic bioactivity. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Computed Properties of C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Analytical studies of synthesized silver nanoparticles and their applications in degradation of different pollutants was written by Ibraheem, Sujood Q.;Al-Abdullah, Zainab Ty. And the article was included in Journal of Chemical, Biological and Physical Sciences in 2019.Related Products of 3386-33-2 This article mentions the following:

Silver nanoparticles have been synthesized by the wet method using silver nitrate as the source of silver, glucose as the reducing agent, and trisodium citrate as a capping agent. The progress of the reaction was examined by observing change in color from colorless to yellow and finally to light brown. The synthesized silver nanoparticles were confirmed using UV-visible spectra the plasmon of silver nanoparticles at 400 nm, SEM images show the silver nanoparticles in the range (10-78 nm), and EDS-SEM zeta sizer and zeta potential anal. showed the distribution of nanoparticles in nano range, and zeta potential distribution of silver nanoparticles was a neg. value (-46.3 Mv), proof of the presence of silver ions. Silver nanoparticles were applied for degradation of methylene blue from water and also for degradation of crude oil (Iraqi aliphatic crude oil in Basra). Gas chromatograph-mass spectrometry (GC-MS) was used to examine the organic compounds before and after addition of silver nanoparticles to the crude oil. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Related Products of 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enhancement of micro-filtration performance for biologically-treated leachate from municipal solid waste by ozonation in a micro bubble reactor was written by Cheng, Wen;Quan, Xuejun;Huang, Xiaoxue;Cheng, Chen;Yang, Lu;Cheng, Zhiliang. And the article was included in Separation and Purification Technology in 2018.Formula: C18H37Cl This article mentions the following:

The degradation of recalcitrant organic compounds in biol.-treated municipal solid waste leachate (MSW) was investigated using pre-ozonation in a micro bubble reactor. The effects of operating parameters such as reactor pressure, liquid phase temperature, inlet ozone concentration and ozone flow rate on micro filtration (MF) performance were studied systematically. It is demonstrated that the MF was obviously enhanced with ozonation time before 45 min and increasing inlet ozone concentration, as well as increasing ozone flow rate. Addnl., the reactor pressure and liquid phase temperature have no obvious effects on improving MF performance. And the mechanism for the enhancement of MF performance was explored through anal. of the colloids present in the leachate by SEM and organic compounds by GC/MS. The micro flocculation effect and the reduction of hydrocarbon and heterocycle compounds in the leachate by ozonation treatment were responsible for improving the MF performance. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Formula: C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics