Tag: 200-300

Unprecedented Access to β-Arylated Selenophenes through Palladium-Catalyzed Direct Arylation was written by Skhiri, Aymen;Ben Salem, Ridha;Soule, Jean-Francois;Doucet, Henri. And the article was included in Chemistry – A European Journal in 2017.Category: chlorides-buliding-blocks This article mentions the following:

The Pd-catalyzed coupling of benzenesulfonyl chlorides RS(O)₂Cl (R = 4-H₃CC₆H₄, 3,5-Cl₂C₆H₃, naphthalen-1-yl, etc.) with selenophenes I (R¹ = H, 4-H₃COC₆H₄, 3-F₃CC₆H₄; R² = H, Br, 4-H₃CC₆H₄, etc.; R³ = H) affording regiospecific β-arylated selenophenes II is reported. The reaction proceeds with easily accessible catalyst, base and substrates, and tolerates a variety of substituents both on the benzene and selenophene moieties. This transformation allows the programmed synthesis of polyarylated selenophenes II (R = 4-F₃CC₆H₄, 4-H₃COC₆H₄; R¹ = H, 4-O₂NC₆H₄; R² = 4-H₃CC(O)C₆H₄, 4-NCC₆H₄; R³ = 4-ClC₆H₄, 4-NCC₆H₄) with potential applications in pharmaceutical and materials chem., as the installation of aryl groups at the desired positions can be achieved. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Highly heat-resistant NF membrane modified by quinoxaline diamines for Li⁺ extraction from the brine was written by Xie, Huan-Yin;Tang, Run-Hua;Chen, Gui-E.;Xu, Zhen-Liang;Mao, Hai-Fang. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2022.SDS of cas: 4422-95-1 This article mentions the following:

The functional layers with excellent heat-resistance nanofiltration (HRN) property were designed by fixing thermal stabilized quinoxaline diamines (QHDA) on poly (m-phenyleneisophthalamide) (PMIA) substrate through interfacial polymerization QHDA was used as aqueous monomer while cinnamoyl chloride (CNC), isophthaloyl chloride (IPC) and trimesoyl chloride (TMC) were served as organic monomers to realize the immobilization of thermally stable N heterocycles. The exptl. results stated clearly that the compact package reaction of QHDA with TMC lead a raise of thermal stability and salts rejection at high temperature stream. With the optimal TMC and 0.5 weight% QHDA, the as-developed membrane achieved the excellent NF performance and thermal stability. The rejection of MgSO₄ reached to 94.6% at 30°C and hardly decrease at 90°C. The reduction in rejection was satisfactory at high temperatures The functional layer still showed highly stability after 10 h long-term operation at 90°C with only 2.8% reduction in MgSO₄ rejection. Besides, the excellent Mg²⁺ and poor Li⁺ rejection made this membrane have huge potential in the application of extracting Li⁺ from brine. The separation factor of Mg²⁺-Li⁺ at high temperature was satisfactory. Over all, this study offered a prospect technol. to exploit heat-resistant membranes for extraction lithium at high temperature In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1SDS of cas: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, antimicrobial, SAR, PASS, molecular docking, molecular dynamics and pharmacokinetics studies of 5′-O-uridine derivatives bearing acyl moieties: POM study and identification of the pharmacophore sites was written by Munia, Nasrin S.;Hosen, Mohammed A.;Azzam, Khaldun M. A.;Al-Ghorbani, Mohammed;Baashen, Mohammed;Hossain, Mohammed K.;Ali, Ferdausi;Mahmud, Shafi;Shimu, Mst. S. S.;Almalki, Faisal A.;Hadda, Taibi B.;Laaroussi, Hamid;Naimi, Souad;Kawsar, Sarkar M. A.. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2022.Recommanded Product: 76-83-5 This article mentions the following:

Novel uridine derivatives were designed and synthesized. The chem. structures and purity of these new uridine derivatives were confirmed by usual spectroscopic techniques. In vitro antimicrobial activity and SAR study was investigated. The incorporation of various aliphatic and aromatic groups in uridine structure significantly increased their biol. activity. PASS prediction anal. indicated that the compounds were less potent as anti-carcinogenic agents (0.31 < Pa < 0.52) than as antimicrobial agents. Mol. docking anal. showed that the novel uridine derivatives may possess excellent effectiveness for lanosterol 14a-demethylase CYP51A1 (3JUV) and Aspergillus flavus (1R⁴U). The stability of the docked complex was confirmed by performing mol. dynamics along with an estimation of MMPB/GBSA binding free energy which ensured that complex of some 5′-O-uridine derivatives were reported in improved dynamics stability as revealed by their uniform RMSD and RMSF profiles. In silico ADMET calculations predicted improved pharmacokinetic properties of all uridine derivatives The POM anal. showed the presence of an antifungal (O ^δ- — O′ ^δ-) pharmacophore site. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

(1-Adamantyl){4-[(2-chloro-9-isopropyl-9H-purin-6-yl)aminomethyl]phenyl}methanone trichloromethane solvate was written by Rouchal, Michal;Necas, Marek;Vicha, Robert. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2009.SDS of cas: 203436-45-7 This article mentions the following:

In the title compound, C₂₆H₃₀ClN₅O·CHCl₃, the purine mol. consists of essentially planar benzene and purine ring systems [maximum deviation 0.010 (4) Å for both ring systems] forming a dihedral angle of 85.52 (9)°. Intermol. N-H…N hydrogen bonds link adjacent mols. into centrosym. dimers. The structure also contains intermol. C-H…O and C-H…N interactions. The benzene rings form offset face-to-face π-π stacking interactions with an interplanar distance of 3.541 (4) Å and a centroid-to-centroid distance of 4.022 (4) Å. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7SDS of cas: 203436-45-7).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 203436-45-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nanofiltration membranes with enhanced performance by constructing an interlayer integrated with dextran nanoparticles and polyethyleneimine coating was written by Chen, Yuhao;Sun, Haixiang;Tang, Sihui;Feng, Huimei;Zhang, Hongbin;Chen, Kuo;Li, Peng;Niu, Q. Jason. And the article was included in Journal of Membrane Science in 2022.Recommanded Product: 4422-95-1 This article mentions the following:

The thin-film composite (TFC) nanofiltration (NF) membrane is a novel kind of membrane that has been extensively studied in recent years and broadly applied in desalination and wastewater treatment. The improvement of separation performance by optimizing the structure and morphol. of NF membranes can significantly reduce energy consumption and bring more economic benefits. In this work, glutaraldehyde (GA) was used to crosslink polyethyleneimine (PEI) and dextran nanoparticles (DNPs) to construct an interfacial coating interlayer on polysulfone (PSF) ultrafiltration (UF) substrate. Subsequently, the polyamide (PA) NF membranes were fabricated by interfacial polymerization (IP) between piperazine (PIP) and trimesoyl chloride (TMC). DNPs were semi-encapsulated in the PEI coating and the exposed nanoparticles would be embedded in the PA layer for forming interfacial channels after IP. The interlayer not only affected the adsorption and diffusion of aqueous phase monomers to form a thin membrane, but also improved the membrane d. to prevent selective defects associated with the incorporation of nanoparticles. The pure water permeance of the interlayered-TFC NF membrane was determined as 313.3 Lm^-2h^-1MPa^-1, which was approx. four-fold that of the pristine membrane. The retention rate of various divalent salts of the NF membrane also significantly improved, and the retention rate of Na₂SO₄ exceeded 99%. This innovative method of interlayer modification has exhibited great potential in rapid desalination and wastewater recovery, providing new possibilities for the preparation of industrial high-performance NF membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Recommanded Product: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of functionalized 5-(4-arylpiperazin-1-yl)-N-arylpentanamides and their evaluation as D₃ receptor ligands was written by Blass, Benjamin E.;Chen, Peng-Jen;Gordon, John C.. And the article was included in Medicinal Chemistry Research in 2022.COA of Formula: C19H15Cl This article mentions the following:

Cocaine use disorder (CUD) is a major, unmet medical need. This tropane alkaloid is one of the most commonly abused recreational drugs. In 2018, there were over 5.5 million cocaine users. Therapeutic options capable of addressing this issue are limited, as there are no approved pharmacotherapies. The D₃ dopamine receptor is a potential CUD therapeutic target that remains under active investigation. We have recently disclosed a series of functionalized 5-(4-arylpiperazin-1-yl)-N-arylpentanamides typified by I that are potent D₃ ligands that have moderate to high selectivity for D₃ over D₂. We have continued our exploration of this series of compounds in an effort to identify compounds with improved microsomal stability such as II. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5COA of Formula: C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

5-HT_2C receptor selectivity and structure-activity relationship of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogs was written by Jang, Jae Wan;Baek, Je-sook;Choi, Gil Don;Park, Woo-Kyu;Cho, Yong Seo;Baek, Du-Jong;Pae, Ae Nim. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Category: chlorides-buliding-blocks This article mentions the following:

Agonists of the 5-HT_2C receptor have attracted much attention as therapeutic agents for the treatment of obesity. Subtype selectivity against other 5-HT₂ receptors is one of the most important prerequisites for reducing side effects. We present the synthesis of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogs and their structure-activity relationship studies on 5-HT_2A and 5-HT_2C receptors. Although the compounds showed nanomolar activity to the 5-HT_2C receptor, their selectivity against the 5-HT_2A receptor was modest to low. Mol. modeling studies using homol. modeling and docking simulation revealed that selectivity originated from subtype specific residues. The observed binding modes and receptor-ligand interactions provided us a clue for optimizing the selectivity against the 5-HT_2A receptor. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Category: chlorides-buliding-blocks).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Substituent effects in substrates on activation parameters in the bimolecular nucleophilic reactions in solution was written by Vlasov, Vladislav M.. And the article was included in New Journal of Chemistry in 2010.Recommanded Product: Ethyl 4-chloro-3-nitrobenzoate This article mentions the following:

Changes of the activation parameters, ΔH^≠ and ΔS^≠, in the S_N2, S_NAr and acyl-transfer reactions with charged and neutral nucleophiles in various solvents were correlated with σ constants of the substituents in the aromatic ring of the substrates. The resultant δΔH^≠ and δΔS^≠ reaction constants are linearly related for variations of substituents at the substrate. Correlation of δΔH^≠ vs. δΔS^≠ allows one to estimate the contribution of changes of the internal enthalpy, δΔH^≠_int, to the enthalpy reaction constant, δΔH^≠, which gives a single linear dependence on the Hammett ρ reaction constants for all bimol. nucleophilic reactions. The deviations from dependence of δΔH^≠_int vs. ρ can be interpreted in terms of changes of the transition state structure or reaction mechanism. The results obtained show that the substituent effects in the substrates and nucleophiles on the charge development in the transition state are governed by the magnitude of δΔH^≠_int. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Recommanded Product: Ethyl 4-chloro-3-nitrobenzoate).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: Ethyl 4-chloro-3-nitrobenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents was written by El Abbouchi, Abdelmoula;El Brahmi, Nabil;Hiebel, Marie-Aude;Bignon, Jerome;Guillaumet, Gerald;Suzenet, Franck;El Kazzouli, Said. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.COA of Formula: C8H9ClO4S This article mentions the following:

A series of ethacrynic acid (2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid) (EA, Edecrin) containing sulfonamides linked via three types of linkers namely 1,2-ethylenediamine, piperazine and 4-aminopiperidine was synthesized and subsequently evaluated in vitro against HL60 and HCT116 cancer cell lines. All the EA analogs, excluding two derivs, showed anti-proliferative activity with IC_50s in the micromolar range (less than 4 uM). Three derivatives I–III were selected for their interesting dual activity on HL60 cell line in order to be further evaluated against a panel of cancer cell lines (HCT116, A549, MCF7, PC3, U87-MG and SKOV3) as well as on MRC5 as a normal cell line. These compounds displayed IC₅₀ values in nanomolar range against A549, MCF7, PC3 and HCT116 cell lines, deducing the discovery that piperazine or 4-aminopiperidine is the linker’s best choice to develop EA analogs with highly potent anti-proliferative activities own up to 24 nM. Besides, in terms of selectivity, those linkers are more suitable offering safety ratios of up to 63.8. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2COA of Formula: C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed Cross-Coupling of Aryl Chlorides and Triflates with Sodium Cyanate: A Practical Synthesis of Unsymmetrical Ureas was written by Vinogradova, Ekaterina V.;Fors, Brett P.;Buchwald, Stephen L.. And the article was included in Journal of the American Chemical Society in 2012.SDS of cas: 18437-66-6 This article mentions the following:

An efficient method for palladium-catalyzed cross-coupling of aryl chlorides and triflates with sodium cyanate is reported. The protocol allows for the synthesis of unsym. N,N’-di- and N,N,N’-trisubstituted ureas in one pot and is tolerant of a wide range of functional groups. Insight into the mechanism of aryl isocyanate formation was gleaned through studies of the transmetalation and reductive elimination steps of the reaction, including the first demonstration of reductive elimination from an arylpalladium isocyanate complex to produce an aryl isocyanate. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6SDS of cas: 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics