Tag: 200-300

{[K.18-Crown-6]Br₃}_n: A tribromide catalyst for the catalytic protection of amines and alcohols was written by Chehardoli, Gholamabbas;Zolfigol, Mohammad Ali;Derakhshanpanah, Fateme. And the article was included in Cuihua Xuebao in 2013.Category: chlorides-buliding-blocks This article mentions the following:

{[K.18-Crown-6]Br₃}_n, a unique tribromide-type catalyst, was utilized for the N-boc protection of amines and trimethylsilylation (TMS) and tetrahydropyranylation (THP) of alcs. The method is general for the preparation of N-boc derivatives of aliphatic (acyclic and cyclic) and aromatic, and primary and secondary amines and also various TMS-ethers and THP-ethers. The simple separation of the catalyst from the product is one of the many advantages of this method. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Category: chlorides-buliding-blocks).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Octanol/water partition coefficient of ortho-substituted aromatic solutes was written by Sotomatsu, Tomoko;Shigemura, Masao;Murata, Yoshiyuki;Fujita, Toshio. And the article was included in Journal of Pharmaceutical Sciences in 1993.Synthetic Route of C7H4ClNO4 This article mentions the following:

The partition coefficient (P) of some mono- and di-ortho-substituted aromatic compounds was measured in a 1-octanol/water system. For each series of compounds with the same functional group, the π value (the difference in the log P value between the substituted and unsubstituted compound) was analyzed on the same basis as the values of m- and p-substituted isomers by an extended Hammett-Taft procedure. In the procedure, the authors considered the intramol. electronic and steric effects, operating between substituents and governing the relative hydrogen-bonding solvation with partitioning solvents for solutes in which internal hydrogen-bond formation can be ignored. The π value for mono- and di-ortho-substituted derivatives was adequately included in the correlation equation for the values of the m- and p-substituted derivatives in each series. The effect of di-ortho substituents on partition behaviors could be roughly expressed by the sum of the effects of the 2- and 6-position substituents. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Synthetic Route of C7H4ClNO4).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enantioselective One-pot Synthesis of 3-Azabicyclo[3.1.0]hexanes via Allylic Substitution and Oxidative Cyclization was written by Chaki, Bijan Mohon;Takenaka, Kazuhiro;Zhu, Linpeng;Tsujihara, Tetsuya;Takizawa, Shinobu;Sasai, Hiroaki. And the article was included in Advanced Synthesis & Catalysis in 2020.Application In Synthesis of 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:

An enantioselective one-pot synthesis of 3-azabicyclo[3.1.0]hexanes I (R = (2,4-dimethoxyphenyl)sulfonyl, mesyl, tosyl, etc.; R¹ = Me, Ph, thiophen-2-yl, etc.; R² = Me, cyano, benzoyl, etc.) from allyl carbonates R²C(=CH₂)CH₂OBoc and propargyl amines RNHCH₂CCR¹ was reported. An amine catalyst promoted the allylic substitution to form intermediary N-allyl propargylamines RN(CH₂C(=CH₂)R²)CH₂CCR¹, which underwent enantioselective Pd(II)/Pd(IV)-mediated oxidative cyclization in situ. The chiral ligand (P,R,R)-i-Pr-SPRIX is crucial to the cyclization, producing the desired bicyclic compounds in up to 92% yield and 90% ee. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Application In Synthesis of 2,4-Dimethoxybenzene-1-sulfonyl chloride).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of 2,4-Dimethoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sulfonylguanidine Derivatives as Potential Antimelanoma Agents was written by Baladi, Tom;Hamouda-Tekaya, Nedra;Goncalves, Leticia Christina Pires;Rocchi, Stephane;Ronco, Cyril;Benhida, Rachid. And the article was included in ChemMedChem in 2020.COA of Formula: C7H4ClF3O2S This article mentions the following:

Sulfonylguanidines are interesting bioactive compounds with a broad range of applications in the treatment of different pathologies. 2-Aminobenzazole-based structures are well employed in the development of new anticancer drugs. Two series of novel N-benzazol-2-yl-N’-sulfonyl guanidine derivatives were synthesized with the sulfonylguanidine in either an extra- or intracyclic frame. They were evaluated for their antiproliferative activity against malignant melanoma tumor cells, thus allowing structure-activity relationships to be defined. Addnl., NCI-60 screening was performed for the best analog to study its efficiency against a panel of other cancer cell lines. The stability profile of this promising compound was then validated. During the synthetic process, an unexpected new deamidination of the sulfonylguanidine towards sulfonamide function was also identified. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6COA of Formula: C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Practical and efficient applications of novel dioxaborolanes and dioxaborinanes in the synthesis of corresponding boronates and their use in the palladium-catalyzed cross coupling reactions was written by Myslinska, Malgorzata;Heise, Glenn L.;Walsh, Dana J.. And the article was included in Tetrahedron Letters in 2012.Application of 18437-66-6 This article mentions the following:

The syntheses of boronates derived from the reaction of dioxaborolanes and dioxaborinanes with either organolithium or organomagnesium reagents are investigated along with their subsequent use in the palladium cross coupling reaction. The intrinsic stability of these cyclic esters contributes to their facile reaction with both lithium and magnesium nucleophiles at mild and safe conditions. We have found that many of the reactions proceed at room temperature which is a significant improvement over the traditional routes which require cryogenic temperatures The scope of these reactions and their practical application to large scale process synthesis is described. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Application of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fabrication of dialyzer membrane-based forward osmosis modules via vacuum-assisted interfacial polymerization for the preparation of dialysate was written by Zhao, Shuwei;Dou, Pengjia;Sun, Nan;Shon, Ho Kyong;He, Tao. And the article was included in Journal of Membrane Science in 2022.Related Products of 4422-95-1 This article mentions the following:

Direct preparation of dialyzate from tap water based on osmotic dilution is beneficial for home hemodialysis which requires a defect-free forward osmosis (FO) membrane module. This report introduced a new vacuum-assisted interfacial polymerization (VAIP) process for optimal distribution of the aqueous phase and a well-controlled IP using dialyzer membranes. We demonstrated statistically that the vacuum-assisted process is beneficial for the preparation of integral FO modules with multiple fine fibers due to the good distribution of the aqueous phase. The as-prepared FO module displayed a low structural parameter (262μm), an acceptable water flux (17.6 L m^-2 h^-1), and a low specific reverse salt flux (0.16 g/L) using deionized (DI) water as the feed and 1 M NaCl as the draw in AL-FS mode. Direct dialyzate preparation from tap water using the FO module was presented and modeled with a good fit. The work showcases a new FO module based on dialyzer and its potential applications in the medical field. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Related Products of 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemoselective Amide-Forming Ligation Between Acylsilanes and Hydroxylamines Under Aqueous Conditions was written by Deng, Xingwang;Zhou, Guan;Tian, Jing;Srinivasan, Rajavel. And the article was included in Angewandte Chemie, International Edition in 2021.Recommanded Product: 76-83-5 This article mentions the following:

We report the facile amide-forming ligation of acylsilanes R¹COSiMe₃ with hydroxylamines R²NHOCONEt₂ (ASHA ligation) under aqueous conditions, yielding amides R¹CONHR² in a chemoselective way in MeCN/H₂O mixtures catalyzed by citric acid. The ligation is fast, chemoselective, mild, high-yielding and displays excellent functional-group tolerance. Late-stage modifications of an array of marketed drugs, peptides, natural products, and biol. active compounds showcase the robustness and functional-group tolerance of the reaction. The key to the success of the reaction could be the possible formation of the strong Si-O bond via a Brook-type rearrangement. Given its simplicity and efficiency, this ligation has the potential to unfold new applications in the areas of medicinal chem. and chem. biol. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting was written by Hassan, Muhammad Murtaza;Israelian, Johan;Nawar, Nabanita;Ganda, Giovanni;Manaswiyoungkul, Pimyupa;Raouf, Yasir S.;Armstrong, David;Sedighi, Abootaleb;Olaoye, Olasunkanmi O.;Erdogan, Fettah;Cabral, Aaron D.;Angeles, Fabrizio;Altintas, Rabia;de Araujo, Elvin D.;Gunning, Patrick T.. And the article was included in Journal of Medicinal Chemistry in 2020.Category: chlorides-buliding-blocks This article mentions the following:

Histone deacetylases (HDACs) are an attractive therapeutic target for a variety of human diseases. Currently, all four FDA-approved HDAC-targeting drugs are nonselective, pan-HDAC inhibitors, exhibiting adverse side effects at therapeutic doses. Although selective HDAC inhibition has been proposed to mitigate toxicity, the targeted catalytic domains are highly conserved. Herein, a series of rationally designed, conformationally constrained, benzanilide foldamers which selectively bind the catalytic tunnel of HDAC8 is described. The series includes benzanilides, MMH371, MMH409, and MMH410, which exhibit potent in vitro HDAC8 activity (IC₅₀ = 66, 23, and 66 nM, resp.) and up to 410-fold selectivity for HDAC8 over the next targeted HDAC. Exptl. and computational analyses of the benzanilide structure docked with human HDAC8 enzyme showed the adoption of a low-energy L-shaped conformer that favors HDAC8 selectivity. The conformationally constrained HDAC8 inhibitors present an alternative biol. probe for further determining the clin. utility and safety of pharmacol. knockdown of HDAC8 in diseased cells. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gold-iron oxide dimers for magnetic hyperthermia: the key role of chloride ions in the synthesis to boost the heating efficiency was written by Guardia, P.;Nitti, S.;Materia, M. E.;Pugliese, G.;Yaacoub, N.;Greneche, J.-M.;Lefevre, C.;Manna, L.;Pellegrino, T.. And the article was included in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2017.Application In Synthesis of 1-Chlorooctadecane This article mentions the following:

With the aim of producing Au-Fe_xO_y dimers with outstanding heating performances under magnetic hyperthermia conditions applicable to human patients, here we report two synthesis routes, a two-pot and a one-pot method. The addition of chloride ions and the absence of 1,2-hexadecanediol (HDDOL), a commonly used chem. in this synthesis, are the key factors that enable us to produce dimers at low temperature with crystalline iron oxide domains in the size range between 18-39 nm that is ideal for magnetic hyperthermia. In the case of two-pot synthesis, in which no chloride ions are initially present in the reaction pot, dimers are obtained only at 300 °C. In order to lower the reaction temperature to 200 °C and to tune the size of the iron oxide domain, the addition of chloride ions becomes the crucial parameter. In the one-pot method, the presence of chloride ions from the start of the synthesis (as counter ions of the gold salt precursor) enables a prompt formation of dimers directly at 200 °C. In this case, the reaction time is the main parameter used to tune the iron oxide size. A record value of specific absorption rates (SARs) up to 1300 W g_Fe^-1 at 330 kHz and 24 kA m^-1 was measured for dimers with an iron oxide domain of 24 nm in size. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Application In Synthesis of 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A mild and green method for the N-BOC protection of amines without assistant of catalyst under solvent-free conditions was written by Mojtahedi, Mohammad Majid;Niknejad, Nina;Veisi, Hojat. And the article was included in Letters in Organic Chemistry in 2013.Reference of 18437-66-6 This article mentions the following:

A facile, green and versatile method for the Boc protection of amines has been developed by a treatment with (Boc)₂O without any additive at room temperature The method is general for the preparation of N-Boc derivatives of aliphatic (acyclic and cyclic), aromatic, and heteroaromatic amines; primary and secondary amines. The advantages of this method are green, simplicity, short reaction times and excellent yields. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics