Tag: 200-300

Synthesis and properties of a mitochondrial peripheral benzodiazepine receptor conjugate was written by El Alaoui, Abdessamad;Schmidt, Frederic;Sarr, Marianne;Decaudin, Didier;Florent, Jean-Claude;Johannes, Ludger. And the article was included in ChemMedChem in 2008.Name: tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:

Peripheral benzodiazepine receptors are potential targets for cancer therapeutics through the use of specific ligands such as the pro-apoptotic benzodiazepine RO5-4864. However, the poor water solubility of this compound has been a limitation to its application in vivo. Herein we describe an efficient synthesis for the conjugation, via a cleavable linker arm, of RO5-4864 to a novel tumor-delivery tool, the B-subunit of Shiga toxin (STxB). The conjugate is water soluble and specifically targets cancer cells that overexpress the glycolipid Gb3, the cellular Shiga toxin receptor that is found on several human tumors. After internalization via retrograde transport, the prodrug is cleaved inside cells to release the active principle. Delivery by STxB therefore increases in cytotoxic activity of RO5-4864 and its tumor specificity. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Name: tert-Butyl (4-chlorophenyl)carbamate).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: tert-Butyl (4-chlorophenyl)carbamate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of substituted N-F benzenesulfonimides and comparison of their fluorination reactivity via their reactions with silylenol ethers was written by Li, Qingwei;Chen, Fuli;Yang, Xianjin. And the article was included in Youji Huaxue in 2015.Recommanded Product: 63624-28-2 This article mentions the following:

The fluorination reactivity of N-F benzenesulfonimides depended on the strength of N-F bond and was easily affected by substituents on the Ph of substituted N-F benzenesulfonimides via electronic or steric effect. In this work, N-F benzenesulfonimides with different substituents were synthesized and reacted with silylenol ethers, and the results indicated that utilizing N-fluoro-4-fluoro-4′-nitrobenzenesulfonimide and N-fluoro-4-tert-butyl-4′-fluorobenzenesulfonimide could improve the reactivity or selectivity of fluorination than using N-F benzenesulfonimide in lots of selected experiments In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Recommanded Product: 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Titrimetric determination of iodine-bromine numbers of some edible oils using three N-chloroimides was written by Jayasree, Narayanan;Indrasenan, Parameswaran. And the article was included in Journal – Association of Official Analytical Chemists in 1987.Category: chlorides-buliding-blocks This article mentions the following:

Three simple titrimetric methods were developed to determine I-Br numbers of some edible oils, such as coconut, gingelly, peanut, mustard, olive, palm olein, and sunflower, by using 3 N-chloroimides. The chloroimides are N-chlorophthalimide, N-chlorosuccinimide, and N-chlorosaccharin, all of which have recently been developed as potential oxidimetric titrants for use in aqueous HOAc medium. The proposed excess back-titration methods have advantages over existing methods in terms of ease of extraction into aqueous HOAc layer, shorter reaction time of the N-chlorosaccharin method, and stability of N-chloroimides in solid state. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Category: chlorides-buliding-blocks).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia was written by Zhang, Mao-feng;Luo, Xiao-yu;Zhang, Cheng;Wang, Chao;Wu, Xi-shan;Xiang, Qiu-ping;Xu, Yong;Zhang, Yan. And the article was included in Acta Pharmacologica Sinica in 2022.Reference of 63624-28-2 This article mentions the following:

BRD4 plays a key role in the regulation of gene transcription and has been identified as an attractive target for cancer treatment. In this study, we designed 26 new compounds by modifying 3-ethyl-benzo[d]isoxazole core with sulfonamides. Most compounds exhibited potent BRD4 binding activities with ΔT_m values exceeding 6°C. Two crystal structures of N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-2methoxybenzenesulfonamide and N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide in complex with BRD4(1) were obtained to characterize the binding patterns. Compounds N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-2methoxybenzenesulfonamide and N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide were effective for BRD4(1) binding and showed remarkable anti-proliferative activity against MV4-11 cells with IC₅₀ values of 0.78 and 0.87μM. Furthermore, N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide (0.5-10μM) concentration-dependently inhibited the expression levels of oncogenes including c-Myc and CDK6 in MV4-11 cells. Moreover, N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide (0.5-10μM) concentration-dependently blocked cell cycle in MV4-11 cells at G₀/G₁ phase and induced cell apoptosis. Compound N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide may serve as a new lead compound for further drug development. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Reference of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Robust polyamide-PTFE hollow fibre membranes for harsh organic solvent nanofiltration was written by Francis, Verona Nithya;Chong, Jeng Yi;Yang, Guoying;Che, Lei;Wang, Rong. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2023.Category: chlorides-buliding-blocks This article mentions the following:

Polymeric membranes have been extensively studied for organic solvent nanofiltration (OSN) but many fail to show sufficient chem. resistance in strong solvents like DMF (DMF) and DMSO (DMSO). This study focuses on harnessing the outstanding chem. resistance of polytetrafluoroethylene (PTFE), to develop polyamide-PTFE thin film composite (TFC) membranes that are resistant to such aprotic solvents. A defect-free polyamide thin film layer was successfully synthesized on the microfiltration PTFE hollow fiber substrates, overcoming challenges such as large and uneven pore size, and hydrophobicity of the PTFE substrates. A simple polydopamine (PDA) coating was carried out to improve the substrate’s hydrophilicity prior to the polyamide synthesis via interfacial polymerization (IP). Polyethyleneimine (PEI) and trimesoyl chloride (TMC) were used as the monomers and a two-time IP method was employed to obtain a defect-free polyamide coating. The synthesized membranes showed high acetonitrile (ACN) and DMF permeabilities of 7.94 and 3.70 lm^-2h^-1bar^-1, resp., with acid fuchsin (585 Da) rejections of > 90%. The mol. weight cut-off (MWCO) of the membranes could be further reduced to ∼300 Da by the addition of piperazine (PIP) monomers. The membranes also showed excellent stability and performance in a 72-h OSN test performed in DMF indicating their great potential in effective mol. separation in harsh solvents. This study demonstrates how a simple modification and coating technique can transform com. available microfiltration PTFE hollow fibers into durable and high value OSN membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Category: chlorides-buliding-blocks).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A mild light-induced cleavage of the S-O bond of aryl sulfonate esters enables efficient sulfonylation of vinylarenes was written by Ratushnyy, Maxim;Kamenova, Monika;Gevorgyan, Vladimir. And the article was included in Chemical Science in 2018.Related Products of 777-44-6 This article mentions the following:

A new mode of S-O bond activation has been discovered, which constitutes novel reactivity of easily available and bench-stable arylsulfonate phenol esters. This protocol enables access to putative sulfonyl radical intermediates, which enable straightforward access to valuable vinyl sulfones I (R = H, 4-OMe, 4-CN, 2-Cl, etc…). In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Related Products of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Related Products of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA) was written by Abdeen, Sanofar;Kunkle, Trent;Salim, Nilshad;Ray, Anne-Marie;Mammadova, Najiba;Summers, Corey;Stevens, Mckayla;Ambrose, Andrew J.;Park, Yangshin;Schultz, Peter G.;Horwich, Arthur L.;Hoang, Quyen Q.;Chapman, Eli;Johnson, Steven M.. And the article was included in Journal of Medicinal Chemistry in 2018.Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Extending from a study we recently published examining the anti-trypanosomal effects of a series of GroEL/ES inhibitors based on a pseudo-sym. bis-sulfonamido-2-phenylbenzoxazole scaffold, here, we report the antibiotic effects of asym. analogs of this scaffold against a panel of bacteria known as the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). While GroEL/ES inhibitors were largely ineffective against K. pneumoniae, A. baumannii, P. aeruginosa, and E. cloacae (Gram-neg. bacteria), many analogs were potent inhibitors of E. faecium and S. aureus proliferation (Gram-pos. bacteria – EC₅₀ values of the most potent analogs were in the 1-2 μM range). Furthermore, even though some compounds inhibit human HSP60/10 biochem. functions in vitro (IC₅₀ values in the 1-10 μM range), many of these exhibited moderate to low cytotoxicity to human liver and kidney cells (CC₅₀ values >20 μM). In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structural (X-ray), spectral (FT-IR and Raman) and quantum chemical investigations of a series of 6-benzylaminopurine derivatives was written by Cajan, Michal;Travnicek, Zdenek. And the article was included in Journal of Molecular Structure in 2011.Name: 2,6-Dichloro-9-isopropyl-9H-purine This article mentions the following:

The structural and spectroscopic properties of 6-(2-methylbenzylamino)purine 1, 6-(4-methylbenzylamino)purine 2, 6-(3,4-dimethoxybenzylamino)purine 3, 2-chloro-6-(3-bromobenzylamino)-9-isopropylpurine 4 and 2-chloro-6-(3,4-dichlorobenzylamino)-9-isopropylpurine 5 have been investigated by means of single crystal X-ray diffraction anal., FT-IR and Raman spectroscopy, and quantum chem. calculations, where HF, DFT, RI-MP2 and MP2 methods in combination with the cc-pVDZ basis set have been used. The theor. obtained structural as well as spectral parameters have been compared with those exptl. obtained. One of the unusual structural features is the finding that the electroneutral form of 6-(2-methylbenzylamino)purine 1 is protonated at the N7 position of the purine ring, which is not a typical protonation site for N9-unsubstituted adenine derivatives In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Name: 2,6-Dichloro-9-isopropyl-9H-purine).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 2,6-Dichloro-9-isopropyl-9H-purine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Finding of the low molecular weight inhibitors of resuscitation promoting factor enzymatic and resuscitation activity was written by Demina, Galina R.;Makarov, Vadim A.;Nikitushkin, Vadim D.;Ryabova, Olga B.;Vostroknutova, Galina N.;Salina, Elena G.;Shleeva, Margarita O.;Goncharenko, Anna V.;Kaprelyants, Arseny S.. And the article was included in PLoS One in 2009.Recommanded Product: 16588-16-2 This article mentions the following:

Background: Resuscitation promoting factors (RPF) are secreted proteins involved in reactivation of dormant actinobacteria, including Mycobacterium tuberculosis. They have been considered as prospective targets for the development of new anti-tuberculosis drugs preventing reactivation of dormant tubercle bacilli, generally associated with latent tuberculosis. However, no inhibitors of Rpf activity have been reported so far. The goal of this study was to find low mol. weight compounds inhibiting the enzymic and biol. activities of Rpfs. Methodol./Principal Findings: Here the authors describe a novel class of 2-nitrophenylthiocyanates (NPT) compounds that inhibit muralytic activity of Rpfs with IC₅₀ 1-7 μg/mL. Fluorescence studies revealed interaction of active NPTs with the internal regions of the Rpf mol. Candidate inhibitors of Rpf enzymic activity showed a bacteriostatic effect on growth of Micrococcus luteus (in which Rpf is essential for growth protein) at concentrations close to IC₅₀. The candidate compounds suppressed resuscitation of dormant (“non-culturable”) cells of M. smegmatis at 1 μg/mL or delayed resuscitation of dormant M. tuberculosis obtained in laboratory conditions at 10 μg/mL. However, they did not inhibit growth of active mycobacteria under these concentrations Conclusions/Significance: NPT are the first example of low mol. weight compounds that inhibit the enzymic and biol. activities of Rpf proteins. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Recommanded Product: 16588-16-2).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 16588-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

One stone two birds: cobalt-catalyzed in-situ generation of isocyanates and benzyl alcohols for the synthesis of N-aryl carbamates was written by Li, Sida;Khan, Ruhima;Zhang, Xia;Yang, Yong;Wang, Zheting;Zhan, Yong;Dai, Yuze;Liu, Yue-e;Fan, Baomin. And the article was included in Organic & Biomolecular Chemistry in 2019.Category: chlorides-buliding-blocks This article mentions the following:

An efficient method for the synthesis of N-aryl carbamates RNHC(O)OR¹ [R = Ph, 4-FC₆H₄, 4-O₂NC₆H₄, etc.; R¹ = Et, Bn, 4-BrC₆H₄CH₂, etc.] from N-Boc-protected amines and benzyl formates/alcs. was developed. The cobalt-catalyzed in situ generation of isocyanates from N-Boc-protected amines and benzyl alcs. from benzyl formates was achieved for the first time, which in turn furnished the corresponding benzyl carbamates in moderate to high yields. The reaction was catalyzed by CoI₂ with tris-(4-dimethylaminophenyl)-phosphine as the ligand and zinc powder as the reductant. The developed reaction conditions were found to be compatible for aromatic amines with both electron-donating and -withdrawing substituents. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Category: chlorides-buliding-blocks).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics