Tag: 200-300

Fabrication of polyarylate thin-film nanocomposite membrane based on graphene quantum dots interlayer for enhanced gas separation performance was written by Niu, Yuhui;Chen, Yuhao;Bao, Shanshan;Sun, Haixiang;Wang, Yaxuan;Ge, Baosheng;Li, Peng;Hou, Yingfei. And the article was included in Separation and Purification Technology in 2022.Safety of Trimesoylchloride This article mentions the following:

Interlayered-thin film nanocomposite (i-TFN) membranes with nanomaterials as the interlayer has attracted more and more attention of researchers in recent years due to the effective regulation of the separation layer structure in the membrane separation field. In this work, the amino-functionalized graphene quantum dots (N-GQDs) were synthesized and applied as an interlayer to modify the polyethersulfone (PES) ultrafiltration substrate. Then interfacial polymerization (IP) between trimesoyl chloride (TMC) and β-cyclodextrin (β-CD) was performed to prepare novel i-TFN polyarylate membranes for CO₂/N₂ separation The effect of the N-GQDs deposition amount on the structure and gas separation performance of the composite membrane was studied thoroughly. The results indicated that the i-TFN polyarylate membrane presented a particular sandwich structure and provided an effective transport channel for the diffusion of CO₂. Moreover, the affinity of the N-containing groups (e. g. amino and amide groups) in the i-TFN membrane and the CO₂ mols. helped to increase the CO₂/N₂ separation selectivity. At the optimal preparation condition, the obtained i-TFN membrane showed CO₂/N₂ selectivity of 23.3 with CO₂ permeance of 174.5 GPU. This work proposes a novel nanomaterial interlayer to effectively improve the gas permselectivity by regulating the structure of i-TFN membranes, which has significant instruction for the preparation of high-performance i-TFN by exploring the interlayer of other nanomaterials. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Safety of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Molecular Insight into the Discrepancy of Antitubercular Activity between 8-Nitro and 8-Cyano Benzothiazinones was written by Zhang, Gang;Chen, Daoxing;Wang, Sufang;Chen, Hualong;Wei, Ning;Chen, Guirong. And the article was included in ChemistrySelect in 2020.Recommanded Product: 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid This article mentions the following:

Benzothiazinones with 8-NO₂ group was a novel class of compounds with potent antitubercular activity, especially BTZ043 I and PBTZ169 II, which covalently inhibit DprE1. 8-CN benzothiazinones III [R = H, Me; R¹ = H, Me; R² = cyclopropyl, cyclopentyl, oxetan-3-yl, etc.] was reported as another type of benzothiazinones with potent antitubercular activity. Taking this as the starting point, a series of 8-CN benzothiazinones III were synthesized and evaluated for their antitubercular activity. To better understand the antitubercular activity of this series of benzothiazinones III, the difference between the mol. structures of CN01 and PBTZ169 in crystal were analyzed. CN01 III [R = H; R¹ = H; R² = cyclohexyl] and PBTZ169 II showed completely different conformations of the piperazine ring. D. functional theory anal. (DFT) and mol. dynamics (MD) simulation were performed to provide more details to explain the different antitubercular activity. All the anal. based on crystallog., quantum chem., and mol. modeling lay a foundation for the subsequent structural optimization of 8-CN benzothiazinones III. In the experiment, the researchers used many compounds, for example, 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid (cas: 22227-59-4Recommanded Product: 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid).

2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid (cas: 22227-59-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zika Virus Inhibitors Based on a 1,3-Disubstituted 1H-Pyrazolo[3,4-d]pyrimidine-amine Scaffold was written by Jung, Eunkyung;Soto-Acosta, Ruben;Geraghty, Robert J.;Chen, Liqiang. And the article was included in Molecules in 2022.Application In Synthesis of (Chloromethanetriyl)tribenzene This article mentions the following:

To search for Zika virus (ZIKV) antivirals, the previously reported 7H-pyrrolo[2,3-d]pyrimidines I (X = NH, O) have been explored by examining an alternative substitution pattern of their central scaffold, leading to compound I (X = O) with low micromolar antiviral activity. To circumvent the synthetic difficulties associated with compound I (X = O), a 1H-pyrazolo[3,4-d]pyrimidine II (R = H, 2-Me, 3-Cl, 4-Cl, etc.; R¹ = Ph, 4-nitrophenyl, 6-chloropyridin-3-yl, etc.) scaffold and structure-activity relationship studies pefromed on its peripheral rings A and B have been exploited . While ring B is less sensitive to structural modifications, an electron-withdrawing group at the para position of ring A is preferred for enhanced antiviral activity. Overall, we have not only discovered an alternative substitution pattern centered on a 1H-pyrazolo[3,4-d]pyrimidines IIscaffold but also generated anti-ZIKV compounds including 6 and 13, II (R = H, R¹ = 4-nitrophenyl; R = H, R¹ = 4-(trifluoromethyl)phenyl) which possess low micromolar antiviral activity and relatively low cytotoxicity. These compounds represent new chemotypes that will be further optimized in the continued efforts to discover anti-ZIKV agents. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Application In Synthesis of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Peptidotriazolamers Inhibit Aβ(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model was written by Tonali, Nicolo;Hericks, Loreen;Schroeder, David C.;Kracker, Oliver;Krzemieniecki, Radoslaw;Kaffy, Julia;Le Joncour, Vadim;Laakkonen, Pirjo;Marion, Antoine;Ongeri, Sandrine;Dodero, Veronica I.;Sewald, Norbert. And the article was included in ChemPlusChem in 2021.Recommanded Product: (Chloromethanetriyl)tribenzene This article mentions the following:

In peptidotriazolamers every second peptide bond is replaced by a 1H-1,2,3-triazole. Such foldamers are expected to bridge the gap in mol. weight between small-mol. drugs and protein-based drugs. Amyloid β (Aβ) aggregates play an important role in Alzheimer′s disease. We studied the impact of amide bond replacements by 1,4-disubstituted 1H-1,2,3-triazoles on the inhibitory activity of the aggregation “hot spots” K16LVFF20 and G39VVIA42 in Aβ(1-42). We found that peptidotriazolamers act as modulators of the Aβ(1-42) oligomerization. Some peptidotriazolamers are able to interfere with the formation of toxic early Aβ oligomers, depending on the position of the triazoles, which is also supported by computational studies. Preliminary in vitro results demonstrate that a highly active peptidotriazolamer is also able to cross the blood-brain-barrier. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives was written by Liu, Wukun;Zhou, Jinpei;Bensdorf, Kerstin;Zhang, Huibin;Liu, Haoran;Wang, Yubin;Qian, Hai;Zhang, Yanchun;Wellner, Anja;Rubner, Gerhard;Huang, Wenlong;Guo, Cancheng;Gust, Ronald. And the article was included in European Journal of Medicinal Chemistry in 2011.Synthetic Route of C7H4ClNO4 This article mentions the following:

A series of C(5)-substituted licofelone ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid) derivatives were developed by a parallel synthesis approach and investigated for cytotoxicity against MCF-7 and MDA-MB-231 cells as well as for anti-inflammatory potency in vitro and in vivo. Dependent on the substituent, the compounds showed high selectivity for MCF-7 cells. Especially benzoyloxyacetyl derivatives were inactive at the MDA-MB-231 cell line and as active as 5-FU at MCF-7 cells. The acetyl, formyloxyacetyl,, acetoxyacetyl, and propionyloxyacetyl derivatives showed growth inhibition at both cell lines, comparable with cisplatin. Modifications significantly reduced the inhibitory potency at COX-1 and COX-2 in vitro and in the xylene-induced ear swelling assay in mice. Only the acetyl derivative was equipotent to licofelone, ibuprofen and celecoxib in vivo. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7Synthetic Route of C7H4ClNO4).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactions of 3-R-5-nitropyridines with nucleophiles: Nucleophilic substitution vs conjugate addition was written by Bastrakov, Maxim A.;Nikol’skiy, Vladislav V.;Starosotnikov, Alexey M.;Fedyanin, Ivan V.;Shevelev, Svyatoslav A.;Knyazev, Daniil A.. And the article was included in Tetrahedron in 2019.Related Products of 59237-53-5 This article mentions the following:

A number of 3-R-5-nitropyridines I (R¹ = H, NO₂, Cl, Br, C(O)OMe) were synthesized and their reactions with various types of nucleophiles such as OMe, N₃, furan-2-ylmethylsulfanyl, cyclohexylsulfanyl, etc. were investigated. The reaction outcome depends on the nature of a nucleophile, where, in case of anionic O-, N- and S-nucleophiles, the previously unreported substitution of non-activated nitro group occurred while carbon nucleophiles underwent dearomatization of the pyridine ring with the formation of products of 1,2-I (R¹ = 4-hydroxy-3,5-dimethylphenyl, 2-cyclopropyl-2-oxoethyl, 3,3-dimethyl-2-oxobutyl, 1H-indol-3-yl, etc.) and 1,4-addition II (R² = Me, cyclopropyl, t-Bu, Ph, etc.). In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5Related Products of 59237-53-5).

Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 59237-53-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, structural optimization, SAR, in silico prediction of physicochemical properties and pharmacological evaluation of novel & potent thiazolo[4,5-d]pyrimidine corticotropin releasing factor (CRF) receptor antagonists was written by Islam, Rabiul Md;Teleb, Mohamed;Karageorgos, Vlasios;Sakellaris, Stelios;Papadopoulos, Minas;Pirmettis, Ioannis;Fronczek, Frank R.;Liapakis, George;Fahmy, Hesham. And the article was included in European Journal of Pharmaceutical Sciences in 2022.Reference of 6590-96-1 This article mentions the following:

Corticotropin-releasing factor (CRF) is a 41-amino-acid neuropeptide secreted from the hypothalamus and is the main regulator of the hypothalamus-pituitary-adrenocortical (HPA) axis. CRF is the master hormone which modulates physiol. and behavioral responses to stress. Many disorders including anxiety, depression, addictive disorders and others are related to over activation of the CRF system. This suggests that new mols. which can interfere with CRF binding to its receptors may be potential candidates for neuropsychiatric drugs to treat stress-related disorders. Previously, three series of pyrimidine and fused pyrimidine CRF1 receptor antagonists were synthesized by our group and specific binding assays, competitive binding studies and determination of the ability to antagonize the agonist-stimulated accumulation of cAMP (the second messenger for CRF receptors) were reported. In continuation of our efforts in this direction, in the current manuscript, we report the synthesis & biol. evaluation of a new series of CRF1 receptor antagonists. Seven compounds showed promising binding affinity with the best two compounds (compounds 6 & 43) displaying a superior binding affinity to all of our previous compounds Compounds 6 & 43 have only 4 times and 2 times less binding affinity than the standard CRF antagonist antalarmin, resp. Thus, our two best lead compounds (compound 6 & 43) can be considered potent CRF receptor antagonists with binding affinity of 41.0 & 19.2 nM vs. 9.7 nM for antalarmin. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Reference of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness was written by Abdeen, Sanofar;Salim, Nilshad;Mammadova, Najiba;Summers, Corey M.;Goldsmith-Pestana, Karen;McMahon-Pratt, Diane;Schultz, Peter G.;Horwich, Arthur L.;Chapman, Eli;Johnson, Steven M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Trypanosoma brucei are protozoan parasites that cause African sleeping sickness in humans (also known as Human African Trypanosomiasis-HAT). Without treatment, T. brucei infections are fatal. There is an urgent need for new therapeutic strategies as current drugs are toxic, have complex treatment regimens, and are becoming less effective owing to rising antibiotic resistance in parasites. The authors hypothesize that targeting the HSP60/10 chaperonin systems in T. brucei is a viable anti-trypanosomal strategy as parasites rely on these stress response elements for their development and survival. The authors recently discovered several hundred inhibitors of the prototypical HSP60/10 chaperonin system from Escherichia coli, termed GroEL/ES. One of the most potent GroEL/ES inhibitors the authors discovered was compound (I). While examining the PubChem database, the authors found that a related analog, 4-methyl-N-(4-(5-((4-methylphenyl)sulfonamido)benzo[d]oxazol-2-yl)phenyl)benzenesulfonamide (2e-p), exhibited cytotoxicity to Leishmania major promastigotes, which are trypanosomatids highly related to Trypanosoma brucei. Through initial counter-screening, the authors found that compounds (I) and 2e-p were also cytotoxic to Trypanosoma brucei parasites (EC₅₀ = 7.9 and 3.1 μM, resp.). These encouraging initial results prompted the authors to develop a library of inhibitor analogs and examine their anti-parasitic potential in vitro. Of the 49 new chaperonin inhibitors developed, 39% exhibit greater cytotoxicity to T. brucei parasites than parent compound (I). While many analogs exhibit moderate cytotoxicity to human liver and kidney cells, the authors identified mol. substructures to pursue for further medicinal chem. optimization to increase the therapeutic windows of this novel class of chaperonin-targeting anti-parasitic candidates. An intriguing finding from this study is that suramin, the first-line drug for treating early stage T. brucei infections, is also a potent inhibitor of GroEL/ES and HSP60/10 chaperonin systems. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Factorial design, physical studies and rapid arsenic adsorption using newly prepared polymer modified perlite adsorbent was written by Saleh, Tawfik A.;Tuzen, Mustafa;Sar, Ahmet;Altunay, Nail. And the article was included in Chemical Engineering Research and Design in 2022.Recommanded Product: Trimesoylchloride This article mentions the following:

In this work, expanded perlite (EP) was modified with a polymer of trimesoyl chloride and phenylenediamine, and evaluated as a novel competent adsorbent for aquatic arsenic (As(III)) removal. The chem. structure and morphol. of the developed polymer-modified EP (PM-EP) adsorbent were investigated by Fourier transform IR spectroscopy, as well as scanning electron microscope /energy equipped with dispersive X-ray spectroscope. The conditions of batch removal such as the solution pH, contact time, sorbent dosage, and initial As(III) concentration were analyzed by factorial design. Based on the non-linear and linear Langmuir model that well correlates equilibrium data, the removal capacity of the produced PM-EP adsorbent was estimated as 447.9 mg g^-1 and 454.5 mg g^-1, resp. at optimized conditions (pH: 6; contact time: 60 min; adsorbent dosage: 10 g L^-1 and temperature: 24°C). The As(III) adsorption mechanism onto PM-EP adsorbent was well described by the non-linear pseudo-second-order kinetic model. The prepared PM-EP adsorbent was subjected to a ten cycling-adsorption/desorption test and the results demonstrated that it had appreciated reuse performance until seven cycles. The removal efficiency of PM-EP was determined in the case of wastewater samples. The overall evaluation suggested that the synthesized PM-EP adsorbent could be a powerful alternative adsorbent for decontamination of As(III) ions from wastewaters and drinking waters. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Recommanded Product: Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

One-pot regio- and chemo-selective synthesis of thiaazatricyclododecane was written by Alizadeh, Abdolali;Bagherinejad, Akram;Bayat, Fahimeh;Zhu, Long-Guan. And the article was included in Tetrahedron in 2016.Formula: C7H3Cl2NS This article mentions the following:

A highly regio- and chemo-selective heteroannulation protocol for the synthesis of unreported polysubstituted thiaazatricyclododecanes I (R¹ = H, Br, Cl, OCH₃; R² = H, Cl; R³ = H, Br; R⁴ = H, Cl, F) has been developed by a sequential four-component reaction of isoquinoline, 2-bromoacetophenones R¹C₆H₄C(O)CH₂Br, aryl isothiocyanates 2-R²-3-R³-4-R⁴-C6H2NCS, and Me 4-chloro-3-oxobutanoate under mild conditions in CH₃CN. The method features formation of various C-N, C-S, and C-C bonds, low-cost and readily available substrates, as well as simple one-pot operation, which makes this process highly profitable. This synthesis serves as a nice addition to chem. in which purification via chromatog. and recrystallization can be avoided, and the pure products were obtained simply by washing the crude products with hexane-Et acetate (10:1). In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics