Tag: 200-300

Synthesis of new 1,4- and 1,5-disubstituted N-ethyl acetate and N-α-butyro-γ-lactone alkylimidazole derivatives as N-acylhomoserine lactone analogs was written by Qiang, Zhang;Li, Si-Zhe;Queneau, Yves;Soulere, Laurent. And the article was included in Journal of Heterocyclic Chemistry in 2021.Recommanded Product: (Chloromethanetriyl)tribenzene This article mentions the following:

New alkylimidazoles functionalized with a homoserine lactone or an alkyloxycarbonyl moiety was synthesized as N-acylhomoserine lactones (AHLs) analogs. The 1,4-disubstituted imidazole derivatives were prepared by alkylation of 4(5)-alkylimidazoles with α-bromo-γ-butyrolactone or Et α-bromoacetate. An alternative route was preferred for the synthesis of their 1,5-disubstituted counterparts based on the use of a N₁-protected alkylimidazole, its alkylation to an N₃-imidazolyl-α-acetate and deprotection to the desired 1,5-disubstituted esters and subsequent alkylation of the acetate moiety with cyclic ethylene sulfate followed by acid-catalyzed cyclization. The ability to modulate bacterial quorum sensing of all new compounds was compared to that of previously reported AHL analogs in which the amide bond is replaced by a heterocyclic group. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Effect of different drying techniques on the volatile compounds, morphological characteristics and thermal stability of Stevia rebaudiana Bertoni leaf was written by Gasmalla, Mohammed Abdalbasit A.;Tessema, Habtamu A.;Alahmed, Kamal;Hua, Xiao;Liao, Xiangru;Yang, Ruijin. And the article was included in Tropical Journal of Pharmaceutical Research in 2017.Related Products of 3386-33-2 This article mentions the following:

Purpose: To examine the volatile compounds, thermal stability and morphol. characteristics of stevia (Stevia rebaudiana Bertoni) leaves after sun, oven and microwave drying. Methods: Gas chromatog.-mass spectrometry with a spectral anal. manager was used to sep. the volatile compounds Dried stevia leaf powder was characterized morphol. by SEM while thermal properties were determined by differential scanning calorimetry (DSC). Results: The plant material contained large amounts of spathulenol and caryophyllene oxide. The main compounds were 1-docosanol and hexanoic acid; trans-β-ionone, 5-methylundecane, 2,5,6- trimethyldecane, (+) spathulenol, propanoic acid and 1-chlorononadecane. The surface of the dried leaf powder varied with the treatment applied. Following microwave drying, the particles were even, regular, and compact while the sun- and oven dried particles resembled angular bricks. All samples exhibited a strong endothermic response, indicating stability up to 150 °C; from 150 to 200 °C, thermal decomposition occurred. Conclusion: Drying method has a significant effect on the structure, thermal stability and volatile compounds contents of stevia leaves. All drying methods examined in this study have potential applications in the preparation of stevia as a functional ingredient for the food and pharmaceutical industries. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Related Products of 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Base-Mediated Generation of Ketenimines from Ynamides: [3+2] Annulation with Azaallyl Anions was written by D’Hollander, Agathe C. A.;Romero, Eugenie;Vijayakumar, Kamsana;Le Houerou, Camille;Retailleau, Pascal;Dodd, Robert H.;Iorga, Bogdan I.;Cariou, Kevin. And the article was included in Advanced Synthesis & Catalysis in 2021.Application of 18437-66-6 This article mentions the following:

Ynamides was underwent a [3+2] cycloaddition with 2-azaallyl anions, obtained from benzylimines under the basic conditions and heat was reported. This reaction between two highly reactive intermediates, both generated in situ from bench stable starting materials, gave access to various nitrogen-rich heterocycles. The reaction usually proceeded with excellent diastereoselectivity, in favor of the cis adduct. Deuteration experiments and DFT calculations helped rationalize the regio- and stereoselectivity of the process as well as the formation of side products. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Application of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

S-(Methyl-d₃) Arylsulfonothioates: A Family of Robust, Shelf-stable, and Easily Scalable Reagents for Direct Trideuteromethylthiolation was written by Zhang, Yan;Liu, Wen;Xu, Yuenian;Liu, Yong;Peng, Jiajian;Wang, Minyan;Bai, Ying;Lu, Hua;Shi, Zhuangzhi;Shao, Xinxin. And the article was included in Organic Letters in 2022.Category: chlorides-buliding-blocks This article mentions the following:

A family of electrophilic deuterated methylthiolating reagents, S-(Methyl-d₃) arylsulfonothioates, was developed in two or three steps from cheap d₄-MeOH in high yields. S-(Methyl-d₃) arylsulfonothioates represent a kind of powerful deuterated methylthiolating reagent and allow modular (trideuteromethyl)thiolation with a variety of nucleophiles or electrophiles including aryl(hetero) iodides, boronic acids esters, terminal alkynes, β-ketoester, and oxindole under mild reaction conditions. A structure-reactivity research study was conducted and provided a new avenue for the development of deuterated methylthiolating reagents and efficient methodol. for (trideuteromethyl)thiolation. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anticancer and immunomodulatory activities of novel 1,8-naphthyridine derivatives was written by Kumar, Vivek;Madaan, Alka;Sanna, Vinod K.;Vishnoi, Manupriya;Joshi, Narendra;Singh, Anu T.;Jaggi, Manu;Sharma, Pramod K.;Irchhaiya, Raghuveer;Burman, Anand C.. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2009.Name: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:

A number of 1,8-naphthyridine derivatives (22-62) have been synthesized and screened for their in vitro cytotoxicity against eight tumors and two non-tumor cell lines. Halogen substituted 1,8-naphthyridine-3-caboxamide derivatives showed potent activity with compound 47 (I) having IC₅₀ of 0.41 and 0.77 μM on MIAPaCa and K-562 cancer cell lines, resp. while, compound 36 had IC₅₀ of 1.19 μM on PA-1 cancer cell line. However, one of the unsubstituted 1,8-naphthyridine-C-3′-heteroaryl derivative 29 showed potent cytotoxicity with IC₅₀ of 0.41 and 1.4 μM on PA-1 and SW620 cancer cell lines, resp. These compounds were also evaluated for anti-inflammatory activity as suggested by downregulation of proinflammatory cytokines. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Name: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

NMR Analysis of a Series of 6,14-Ethenomorphinan Derivatives as PET Precursors and Reference Substances was written by Marton, Janos;Sipos, Attila;Henriksen, Gjermund;Cumming, Paul;Berenyi, Sandor;Schmitt, Bettina M.;Szabo, Zoltan. And the article was included in ChemistrySelect in 2021.Safety of (Chloromethanetriyl)tribenzene This article mentions the following:

The new semisynthetic oripavine derivative 3-O-trityl-6-O-desmethyl-dihydroetorphine was synthesized from the poppy alkaloid thebaine in a six-step procedure. This compound can be applied as precursor for the radiosynthesis of [6-O-methyl-¹¹C]-dihydroetorphine ([¹¹C]DHE) I. A detailed description of ¹H and ¹³C NMR data of reference standards and precursors for [6-O-methyl-¹¹C]- and [6-O-(2-[¹⁸F]fluoroethyl)]orvinols was presented. This includes the complete assignment for 19 oripavine derivatives, e.g., I examined in 1D and 2D NMR experiments The mol. basis for regioselectivity of fluoroalkylation of 3-O-trityl-6-O-desmethyl-phenethyl-orvinol (TDPEO) using computational methods was also investigated. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Safety of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparations of carboxylic acid esters containing heptafluoroisopropyl groups was written by Suyama, T.;Kato, S.;Mizutani, Y.. And the article was included in Journal of Fluorine Chemistry in 1992.Reference of 57045-82-6 This article mentions the following:

The reaction of fluoroglyoxylic acid esters and fluoroformic acid esters with perfluoropropene yielded perfluoro(3-methyl-2-oxobutyric) acid esters and perfluoroisobutyric acid esters, resp. Oxamide derivatives and 2,3-quinoxalinediol have been prepared by the reaction of perfluoro(3-methyl-2-oxobutyric) acid esters with amines and o-phenylenediamine, resp. Perfluoro(3-methyl-2-oxobutyric) acid esters give perfluoroisobutyric acid esters on heating in the presence of fluoride ion in an aprotic solvent. In the experiment, the researchers used many compounds, for example, Chloroformicacidn-nonylester (cas: 57045-82-6Reference of 57045-82-6).

Chloroformicacidn-nonylester (cas: 57045-82-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 57045-82-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed Three-Component Diaryl Sulfone Synthesis Exploiting the Sulfur Dioxide Surrogate DABSO was written by Emmett, Edward J.;Hayter, Barry R.;Willis, Michael C.. And the article was included in Angewandte Chemie, International Edition in 2013.COA of Formula: C8H8BrCl This article mentions the following:

The authors report on a three-component convergent synthesis of aryl, heteroaryl, and alkenyl sulfones employing palladium catalysis and DABSO. DABSO is a solid bench-stable complex formed between DABCO and two sulfur dioxide mols. and is an easy-to-handle surrogate for sulfur dioxide gas. E.g., reaction of 3-MeC₆H₄Br with tert-butyllithium, followed by DABSO, and then with 2-bromonaphthalene in presence of Pd(OAc)₂, ligand I, and Cs₂CO₃ gave 88% sulfone derivative (II). In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloro-m-xylene (cas: 206559-40-2COA of Formula: C8H8BrCl).

5-Bromo-2-chloro-m-xylene (cas: 206559-40-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C8H8BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An efficient silver tetrafluoroborate-catalyzed cycloisomerization of ynamides was written by Ieawsuwan, Winai;Ruchirawat, Somsak. And the article was included in Heterocycles in 2019.Synthetic Route of C11H14ClNO2 This article mentions the following:

A silver catalyzed-cycloisomerization of N-Boc protected ynamides was developed under mild reaction conditions to provide a wide range of oxazolones I [R¹ = (CH₂)₈OTIPS, Ph, 4-FC₆H₄, etc.; R² = Ph, 4-ClC₆H₄, (CH₂)₂Ph, etc.] in good to excellent yields. Moreover, the acid-promoted Pictet-Spengler cyclization of oxazolones I was described to furnish the corresponding trans-oxazolidones II [R³ = H, OMe; R⁴ = R⁵ = OMe] in moderate yields. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Synthetic Route of C11H14ClNO2).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C11H14ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Monosaccharide derivatives: synthesis, antimicrobial, pass, antiviral and molecular docking studies against SARS-CoV-2 Mpro inhibitors was written by Yasmin, Farhana;Amin, Mohammed R.;Hosen, Mohammed A.;Bulbul, Mohammed Z. H.;Dey, Sujan;Kawsar, Sarkar M. A.. And the article was included in Cellulose Chemistry and Technology in 2021.Related Products of 76-83-5 This article mentions the following:

Several carbohydrate-based drugs are currently being used to treat a number of diseases in humans worldwide. Thus, our research group has focused on the synthesis of new Me α-D-mannopyranoside (MDM) derivatives and their antimicrobial evaluation through computational studies. A series of MDM derivatives (2-6) were synthesized through facile regioselective acylation, using the direct method affording 6-O-(3-chlorobenzoyl) derivatives This isolated 6-O-derivative was further transformed to 2,3,4-tri-O-acyl derivatives, bearing a wide variety of functionalities in a single mol. framework. The structures of the newly designed mols. were elucidated with the aid of IR, ¹H NMR, mass spectroscopy, and elemental anal. The prediction of the activity spectra for the compounds (PASS) and their in vitro antimicrobial evaluation were performed, demonstrating them to be potential antimicrobial agents. The antimicrobial tests demonstrated that the compounds 3 and 5 were the most potent with the min. inhibitory concentration (MIC) values, ranging from 0.312 ± 0.01 to 1.25 ± 0.03 mg/mL, and min. bactericidal concentration (MBC) values, ranging from 0.625 ± 0.02 to 2.50 ± 0.05 mg/mL. A quantum chem. study was performed to calculate the thermodn., MO and electrostatic potential properties of the designed compounds Mol. docking simulation was carried out against SARS-CoV-2 Mpro protein 7BQY and 6Y84 to investigate their binding energy and binding tactics with the viral protein, and better binding affinity than that of the parent drug was observed Also, pharmacokinetic prediction revealed an improved drug-likeness profile for all MDM derivatives In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Related Products of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics