Tag: 200-300

Air-stable nickel(II) borohydrides as prohydrides: Reactions with halocarbons and aerial carbon dioxide was written by Mani, Kalaikodikumaran;Pal, Parameswar;Anandababu, Karunanithi;Raje, Sakthi;Angamuthu, Raja. And the article was included in Inorganica Chimica Acta in 2021.Application In Synthesis of (Chloromethanetriyl)tribenzene This article mentions the following:

Non-noble metal hydrides are highly attractive reagents owing to their involvement in the reactions of environmental and industrial interest. However, they are often cumbersome to isolate as a shelf-stable reagent. Herein, the authors have described the synthesis of non-noble metal hydrides by simple manual grinding of Ni(II)-chelates and NaBH₄ in open air at room temperature without using organic solvents. Two Ni(II) complexes of tetradentate N4 ligands, (L^NHCy = N,N’-bis(pyrid-2-ylmethyl)cyclohexanediamine) [(L^NHCy)Ni(MeCN)(H₂O)](ClO₄)₂ and [(tren)Ni(MeCN)₂](BPh₄)₂, were synthesized and their solid-state structures were confirmed by single crystal x-ray diffraction studies. Both the Ni complexes were manually ground with Na borohydride in open air to produce corresponding Ni(II)-borohydrides that were characterized using FTIR spectroscopy and powder x-ray diffraction techniques. Further, the borohydrides (prohydrides) activate the C-X bond in benzyl bromide, CDCl₃, trityl chloride and iodobenzene to yield toluene, CHDCl₂, triphenylmethane and benzene; the borohydrides reacted with trityl cation and air in MeCN solution to yield triphenylmethane and carbonate. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Application In Synthesis of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

8-cyanobenzothiazinone analogs with potent antitubercular activity was written by Zhang, Gang;Sheng, Li;Hegde, Pooja;Li, Yan;Aldrich, Courtney C.. And the article was included in Medicinal Chemistry Research in 2021.Computed Properties of C8H3ClF3NO4 This article mentions the following:

8-Nitrobenzothiazinones (BTZs) exemplified by macozinone are a new class of antitubercular agents with exceptionally potent activity. The aryl nitro group has been considered indispensable for activity since this is bioactivated within mycobacteria by the flavoenzyme DprE1 to a reactive nitroso metabolite that covalently labels Cys387. However, the aryl nitro group is a potential liability with regards to safety, stability, and resistance. In this paper, we introduced a nitrile as a bioisosteric replacement of the nitro group, which we hypothesize can maintain a similar covalent mechanism of inhibition, but mitigate against the aforementioned concerns. 8-cyanobenzothiazinone 1d displayed potent antitubercular activity with an MIC of 130 nM and had an improved volume of distribution in mice that increased the intrinsic half-life by twofold compared to macozinone. Anal. of the C-2 substituent of 1d revealed similar structure-activity relationships as observed for macozinone. Overall, the results confirm the 8-nitro group of benzothiazinones can be successfully replaced with a nitrile to retain useful activity and favorable pharmacokinetic properties. In the experiment, the researchers used many compounds, for example, 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid (cas: 22227-59-4Computed Properties of C8H3ClF3NO4).

2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid (cas: 22227-59-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H3ClF3NO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sialic acid conjugate-modified liposomes enable tumor homing of epirubicin via neutrophil/monocyte infiltration for tumor therapy was written by Ding, Junqiang;Sui, Dezhi;Liu, Mingqi;Su, Yuqing;Wang, Yang;Liu, Mengyang;Luo, Xiang;Liu, Xinrong;Deng, Yihui;Song, Yanzhi. And the article was included in Acta Biomaterialia in 2021.Recommanded Product: 1-Chlorooctadecane This article mentions the following:

Neutrophils and monocytes (N/Ms) are potential candidates for the delivery of therapeutic agents to the tumor microenvironment (TME) because of their tumor-accumulating nature. L-selectin and Siglec-1, receptors for sialic acid (SA), are highly expressed in circulating neutrophils and monocytes, resp., in tumor-bearing mice, and N/Ms are recruited to tumors in response to inflammatory cytokines secreted by the TME, promoting tumor growth and invasion. Therefore, we constructed a drug delivery nano-platform using N/Ms as vehicles. SA-stearic acid conjugate was synthesized and utilized to modify epirubicin-loaded liposomes (EPI-SL) for enhanced endocytosis of liposomes by circulating N/Ms. Cellular uptake studies showed that SA modification improved the accumulation of EPI in N/Ms and did not alter the inherent chemotaxis of N/Ms. In tumor-bearing mice, EPI-SL significantly improved the tumor-targeting efficiency and therapeutic efficacy of EPI compared to other preparations and even eradicated tumors because of the tumor-accumulating and inhibitory effects of N/Ms containing EPI-SL. Our research showed, for the first time, that as an N/M-based drug delivery platform, EPI-SL remedied the limited tumor targeting in the conventional EPR effect-based treatment strategy, contributing to the exploitation of a new drug delivery platform for cancer treatment. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Recommanded Product: 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation of several active N-chloro compounds from trichloroisocyanuric acid was written by Shiri, Azam;Khoramabadi-zad, Ahmad. And the article was included in Synthesis in 2009.Name: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

A very simple method for the preparation of several active N-chloro compounds that have extensive applications in organic synthesis, industry, and medicine was developed. Tetrachloroglycolurils, chloramine-T, N-chlorosaccharin, N-chlorosuccinimide, N-chlorophthalimide, N,N’-dichlorophenobarbital, and N,N’-dichlorobarbital were synthesized by chlorination with trichloroisocyanuric acid under mild reaction conditions at room temperature This method is clean, fast, and efficient; the yields are also good to excellent. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Name: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalyst-free water-mediated N-Boc deprotection was written by Wang, Gan;Li, Chunju;Li, Jian;Jia, Xueshun. And the article was included in Tetrahedron Letters in 2009.Category: chlorides-buliding-blocks This article mentions the following:

A catalyst-free water-mediated N-Boc deprotection of N-Boc amines is reported. In the absence of any addnl. reagents, the free amines were formed from a variety of aromatic and aliphatic N-Boc amines as well as from some N-Boc amino acid derivatives In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Category: chlorides-buliding-blocks).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antimicrobial activity of new urea and thiourea derivatives of (2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methanamine was written by Vedavathi, Pandreti;Sudhamani, Hasti;Raju, Chamarthi Naga. And the article was included in Research on Chemical Intermediates in 2017.Recommanded Product: 6590-96-1 This article mentions the following:

Synthesis of a series of novel urea and thiourea derivatives of (2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methanamine (valsartan intermediate) was accomplished by its reaction with various substituted aryl isocyanates and aryl isothiocyanates in presence of N,N-dimethylpiperazine (DMP). All synthesized compounds were evaluated for their antibacterial and antifungal activities and their min. inhibitory concentration (MIC) values determined A few of the title compounds showed good in-vitro antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. The title compounds also exhibited high antifungal activity. The title compounds were characterized by IR, ¹H and ¹³C NMR and mass spectral data. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Recommanded Product: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Convenient Access to C10- and C11-(di)arylated dibenzo[b,f]azepines via Palladium-catalyzed C-H Bonds Cleavages was written by Li, Haoran;Roisnel, Thierry;Soule, Jean-Francois;Doucet, Henri. And the article was included in Advanced Synthesis & Catalysis in 2019.Related Products of 777-44-6 This article mentions the following:

Conditions allowing the C10- and C11-arylations of dibenzo[b,f]azepines via successive palladium-catalyzed reactions are reported. Using aryl bromides as the aryl source, the C10-arylation of dibenzo[b,f]azepines is very selective. Then, using benzenesulfonyl chlorides as the aryl source, the second arylation at C11-position is achieved affording non-sym. C10,C11-diarylated dibenzo[b,f]azepines I (R = n-Pr, i-Pr, Bn, Ph; Ar¹ = Ph, 4-MeC₆H₄, 3-OMeC₆H₄, 2-MeC₆H₄, 3-Py, 2-Naph, etc; Ar² = Ph, 4-tBuC₆H₄, 3-CF₃C₆H₄, 2-MeC₆H₄, etc). Both reactions tolerate a variety of substituents on the aryl source. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Related Products of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antitumor activity of (4-hydroxyphenyl)[5-substituted alkyl/aryl)-2-thioxo-1,3,4-thiadiazol-3-yl]methanone and [(3,4-disubstituted)-1,3-thiazol-2-ylidene]-4-hydroxybenzohydrazide was written by Bhole, Ritesh P.;Bhusari, Kishore P.. And the article was included in Medicinal Chemistry Research in 2011.Reference of 6590-96-1 This article mentions the following:

To examine new drug leads with potential anticancer activity, some (4-hydroxyphenyl)[5-substituted alkyl/aryl-2-thioxo-1,3,4-thiadiazol-3-yl]methanones e.g., I and [-(3,4-disubstituted)-1,3-thiazol-2-ylidene]-4-hydroxybenzohydrazides e.g., II were synthesized using appropriate synthetic route. The newly prepared compounds, e.g., I and II demonstrated inhibitory effects on the growth of a wide range of cancer cell lines especially on leukemia (HL-60), non-small lung cancer (HOP-92), renal cancer (ACHN) at the range of GI₅₀ -4.23 to -7.23. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Reference of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of safe one-pot synthesis of N-1- and C-2-substituted benzimidazole via reductive cyclization of o-nitroarylamine using Na₂S₂O₄ was written by Oda, Shinichi;Shimizu, Hideki;Aoyama, Yasunori;Ueki, Tatsuo;Shimizu, Sumio;Osato, Hiroshi;Takeuchi, Yoshiyuki. And the article was included in Organic Process Research & Development in 2012.Computed Properties of C9H8ClNO4 This article mentions the following:

We report that the reductive cyclization of o-nitroarylamine with aldehyde using sodium dithionite (Na₂S₂O₄) could be accelerated by addition of H₂O, which made it possible to control the heat release of the reaction by semibatch-type operation. Safety evaluation was performed using DSC, ARSST, in situ IR anal., and Multimax. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Computed Properties of C9H8ClNO4).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C9H8ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evaluation of 4-(4-Fluorobenzyl)piperazin-1-yl]-Based Compounds as Competitive Tyrosinase Inhibitors Endowed with Antimelanogenic Effects was written by Mirabile, Salvatore;Vittorio, Serena;Paola Germano, Maria;Adornato, Ilenia;Ielo, Laura;Rapisarda, Antonio;Gitto, Rosaria;Pintus, Francesca;Fais, Antonella;De Luca, Laura. And the article was included in ChemMedChem in 2021.Electric Literature of C7H4ClNO4 This article mentions the following:

There is a considerable attention for the development of inhibitors of tyrosinase (TYR) as therapeutic strategy for the treatment of hyperpigmentation disorders in humans. Continuing in our efforts to identify TYR inhibitors, we describe the design, synthesis and pharmacophore exploration of new small mols. structurally characterized by the presence of the 4-fluorobenzylpiperazine moiety as key pharmacophoric feature for the inhibition of TYR from Agaricus bisporus (AbTYR). Our investigations resulted in the discovery of the competitive inhibitor [4-(4-fluorobenzyl)piperazin-1-yl]-(3-chloro-2-nitro-phenyl)methanone 26 (I, IC₅₀=0.18μM) that proved to be ∼100-fold more active than reference compound kojic acid (IC₅₀=17.76μM). Notably, compound 26 exerted antimelanogenic effect on B16F10 cells in absence of cytotoxicity. Docking anal. suggested its binding mode into AbTYR and into modelled human TYR. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Electric Literature of C7H4ClNO4).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics