Tag: 200-300

Enhancement of compatibility between covalent organic framework and polyamide membrane via an interfacial bridging method: Toward highly efficient water purification was written by Chen, Li;Zhou, Cailong;Tan, Luxi;Zhou, Wei;Shen, Huizhen;Lu, Chenyang;Dong, Lichun. And the article was included in Journal of Membrane Science in 2022.Electric Literature of C9H3Cl3O3 This article mentions the following:

A key challenge in polyamide (PA) based nanocomposite membranes is to achieve non-accumulation filler and defect-free features, based on proper compatibility and great dispersion between the particles in the matrix. To address this issue, herein, an interfacial bridging strategy was introduced to fabricate the nanocomposite membrane. A covalent organic framework (COF), TAPB-BPTA (TAPB = 1,3,5-tris(4-aminophenyl)benzene and BPTA = 1,4-benzenedicarboxaldehyde), containing alkynyl was synthesized by a microwave-assisted solvothermal route and preliminarily grafted with the cysteine (CYS) bridge via a click reaction. Furthermore, the short chain of amine moieties in TAPB-BPTA not only makes more amine groups and carboxy groups in the COF pore wall, thereby elevating its hydrophilicity and improving its dispersion in the polyethyleneimine coating solution, but also presumably brings further free motion for amine groups to react with acyl functions in trimesoyl chloride (TMC). The COF was copolymerized using TMC to finally obtain the crosslinked top skin layer without the defect formation between filler and polymer during the interfacial reaction. The pure water permeance of the optimized nanocomposite membrane is higher than that of the pristine PA membrane. Accordingly, the optimized membrane exhibited good permeability and competitive selectivity for dyes and antibiotics. Meanwhile, it had a highly rejection of 92% for methylene blue after multi-cycle separation test, showing excellent industrial wastewater treating capability. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Electric Literature of C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nitro and nitroamino derivatives of o-chlorobenzoic acid was written by Goldstein, Henri;Preitner, Gaston. And the article was included in Helvetica Chimica Acta in 1944.Category: chlorides-buliding-blocks This article mentions the following:

It has been shown that nitration of 2,5-Cl(AcNH)C₆H₃CO₂H gives 2,5,6-Cl(AcNH) (O₂N)C₆H₂CO₂H (I) (C. A. 32, 2521.2). I (1.08 g.) in 10 cc. absolute alc. and 0.6 cc. concentrated H₂SO₄ at -10° was treated with 1.1 g. of iso-AmNO₂ at 0° for 1 h. The reaction product was refluxed for 1 h. in the presence of a trace of Zn and worked up, yielding 0.32 g. (30%) of 2,6-Cl(O₂N)C₆H₃CO₂H, m. 163°, identical with the compound obtained by Lehmstedt and Schrader by the oxidation of 2,6-Cl(O₂N)C₆H₃Me (C. A. 31, 4670.7), transformed by refluxing with SOCl₂ to 6-nitro-2-chlorobenzoyl chloride, m. 32-4°, b_12-13 160°; Me ester, m. 94-5°; Et ester, m. 49-50°; amide, C₇H₅ClN₂O₃, m. 186-7°; anilide, m. 176-7°. The nitration of 2,5-Cl(AcNH)C₆H₃Me (prepared by the chlorination of 18 g. m-MeC₆H₄NHAc) in a mixture of 18 cc. HNO₃ (d. 1.40) and 18 cc. HNO₃ (d. 1.52) below 15° for 2 h. yielded 4.0-4.5 g. of 4-nitro-5-acetamido-2-chlorotoluene (II), m. 113°, and a small amount of the isomeric 6-nitro-5-acetamido-2-chlorotoluene (IIa), m. 152-3° (from alc.). Oxidation of 1.15 g. II in 100 cc. H₂O containing 2 g. MgSO₄ at 100° by addition of 3 g. KMnO₄ in 60 cc. H₂O for 3 h. and recrystallization of the product from AcOH produced 0.5 g. of 4-nitro-5-acetamido-2-chlorobenzoic acid, m. 214°, saponified to the corresponding 4-nitro-5-amino-2-chlorobenzoic acid, m. 239-40° (decomposition). A similar oxidation of IIa gave I, saponified to the corresponding 2,5,6-Cl(H₂N) (O₂N)C₆H₂CO₂H. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Category: chlorides-buliding-blocks).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Polyamide membranes with a ZIF-8@Tannic acid core-shell nanoparticles interlayer to enhance nanofiltration performance was written by Xia, Mengjiao;Zhang, Wentian;Xu, Yanchao;Lin, Hongjun;Jiao, Yang;Shen, Liguo;Li, Renjie;Zhang, Meijia;Hong, Huachang. And the article was included in Desalination in 2022.Safety of Trimesoylchloride This article mentions the following:

Polyamide nanofiltration membranes with an interlayer of either a plant polyphenol tannic acid (TA) coating to improve polyamide formation or zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (NPs) as a sacrificial template have been recently attracting great interest, although none has reported such a dual-functional interlayer. In this study, we demonstrated a facile and controllable one-pot synthesis of novel ZIF-8@TA core-shell NPs. Mixing Zn²⁺, Hmim, and TA in an aqueous solution could readily give rise to these NPs. Microscopy characterizations showed that composition and morphol. of NPs could be easily controlled by the amount of TA used. Comparing with the thin film nanocomposite (TFN) membrane prepared with ZIF-8 NPs as an interlayer, which had significant defects in its polyamide layer due to the aggregation of hydrophobic ZIF-8 NPs, the homogeneous and hydrophilic ZIF-8@TA NPs interlayered TFN membranes demonstrated intact polyamide layers. It was found that when 0.5 mg [email protected] NPs were used, the obtained TFN membrane showed a high water permeance of 20.7 L m^-2 h^-1 bar^-1 and Na₂SO₄ rejection of 96.6%, typically outperforming other interlayer-based PA membranes reported elsewhere. This work provided not only a novel interlayer material but also deep insights into design of high-performance polyamide membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Safety of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Selective Silylation of Alcohols, Phenols and Oximes Using N-Chlorosaccharin as an Efficient Catalyst under Mild and Solvent-Free Conditions was written by Aghapour, Ghasem;Kazemi Moghaddam, Ali;Nadali, Samaneh. And the article was included in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2015.Application In Synthesis of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

Efficient silylation of OH group in alcs., phenols and oximes using a catalytic amount of N-chlorosaccharin and hexamethyldisilazane (HMDS) under mild and solvent-free conditions is described. This silylation reaction can be carried out with excellent and interesting selectivities. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Application In Synthesis of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Manipulation of Surface Hydration States by Tuning the Oligo(Ethylene Glycol) Moieties on PEDOT to Achieve Platelet-Resistant Bioelectrode Applications was written by Huang, Jing-Ju;Lin, Chia-Hsuan;Tanaka, Yukiko;Yamamoto, Aki;Luo, Shyh-Chyang;Tanaka, Masaru. And the article was included in Advanced Materials Interfaces.SDS of cas: 76-83-5 This article mentions the following:

Poly(3,4-ethylenedioxythiophene) (PEDOT) and its derivatives have demonstrated potential in the development of bioelectrodes because of their superior conductivity However, developing reliable implanted bioelectrodes requires improvements in biocompatibility and the prevention of nonspecific adhesion. In this study, a six ethylene glycol (EG)-functionalized EDOTs with three different EG lengths (tri-EG, tetra-EG, and hexa-EG) and two types of end groups, hydroxyl (-OH) and methoxy (-OCH₃) is synthesized and systematically investigated. By coating them on gold electrodes using electropolymerization, the surface and electrochem. properties of these functionalized PEDOT-coated electrodes are investigated. Although PEDOT with -OH groups on the surface is more hydrophilic, those with -OCH₃ groups on the surface exhibit higher electrochem. activity and lower impedance. The increase in EG units and -OCH₃ groups on the surface effectively reduces the adhesion between the PEDOT and at. force microscopy tips. PEDOT with longer EG lengths and -OCH₃ groups exhibits relatively few adhered platelets, and the results of the anal. of hydrated states through differential scanning calorimetry are consistent with those of the platelet adhesion test. This study suggests that a tetra(EG)-functionalized PEDOT with -OCH₃ groups on the surface is a promising coating for implanted bioelectrode applications. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5SDS of cas: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel antiprotozoal products: Imidazole and benzimidazole N-oxide derivatives and related compounds was written by Aguirre, Gabriela;Boiani, Mariana;Cerecetto, Hugo;Gerpe, Alejandra;Gonzalez, Mercedes;Sainz, Yolanda Fernandez;Denicola, Ana;De Ocariz, Carmen Ochoa;Nogal, Juan Jose;Montero, David;Escario, Jose Antonio. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2004.Safety of Ethyl 4-chloro-3-nitrobenzoate This article mentions the following:

The syntheses and biol. evaluation of the first anti-protozoa imidazole N-oxide and benzimidazole N-oxide and their derivatives are reported. They were tested in vitro against two different protozoa, Trypanosoma cruzi and Trichomonas vaginalis. Derivative I, ethyl-1-(i-butyloxycarbonyloxy)-6-nitrobenzimidazole-2-carboxylate, displayed activity on both protozoa. Lipophilicity and redox potential were exptl. determined in order to study the relationship with activity of the compounds These properties are well related with the observed bioactivity. Imidazole and benzimidazole N-oxide derivatives are becoming leaders for further chem. modifications and advanced biol. studies. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Safety of Ethyl 4-chloro-3-nitrobenzoate).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of Ethyl 4-chloro-3-nitrobenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Changes in bacterial community structure and quality characteristics during fermentation of stinky variegated carp (Aristichthys nobilis) was written by Pang, Chunxia;Li, Yi;Yu, Renying;Wang, Junhao;Li, Xuerui;Chen, Yuru;Yu, Lijuan;Luo, Haibo. And the article was included in Journal of Food Processing and Preservation in 2022.Recommanded Product: Chloroformicacidn-nonylester This article mentions the following:

Bacterial metabolism greatly affects the quality and flavor of traditional, low-salt fermented fish. We assessed changes in the bacterial community structure and quality characteristics of “stinky” variegated carp (Aristichthys nobilis) during fermentation at 20°C. The total viable count (TVC), firmness, chewiness, tackiness, total volatile base nitrogen (TVB-N) and thiobarbituric acid-reactive substance (TBARS) levels, and relative peak area of volatile compounds significantly (p < .05) increased, while the pH, weight, and elasticity dramatically decreased, during fermentation The total free amino acid (FAA) content decreased early during fermentation (from 0-2 d) and then significantly (p < .05) increased (from 3-5 d). The levels of flavorful AAs (aspartic acid, glutamate, phenylalanine, tyrosine, alanine, and glycine) increased markedly after 4 d of fermentation Solid-phase microextraction-gas chromatog.-mass spectrometry (SPME-GC-MS) revealed that the levels of ketones, ethers, and nitrogenous compounds increased significantly (p < .05) during fermentation Illumina MiSeq sequencing identified Plesiomonas as the dominant bacterial genus during fermentation, followed by Aeromonas, Cetobacterium, Vibrio, and Hathewaya. These bacteria may contribute to the flavor and aroma of stinky variegated carp. The association between bacterial succession and the flavor and taste of stinky fish was also discussed. Practical applications : Variegated carp could be processed to create stinky fish. In this study, bacterial community structure and quality characteristics anal. were assessed. FAAs and volatile compounds related to flavor and aroma were found. A potential starter culture that could improve the quality of stinky variegated carp was identified. Our findings provide a theor. basis for the industrial production of fermented stinky fish. In the experiment, the researchers used many compounds, for example, Chloroformicacidn-nonylester (cas: 57045-82-6Recommanded Product: Chloroformicacidn-nonylester).

Chloroformicacidn-nonylester (cas: 57045-82-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: Chloroformicacidn-nonylester

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP was written by Kang, Dongwei;Ding, Xiao;Wu, Gaochan;Huo, Zhipeng;Zhou, Zhongxia;Zhao, Tong;Feng, Da;Wang, Zhao;Tian, Ye;Daelemans, Dirk;De Clercq, Erik;Pannecouque, Christophe;Zhan, Peng;Liu, Xinyong. And the article was included in ACS Medicinal Chemistry Letters in 2017.Application of 777-44-6 This article mentions the following:

The authors’ previous studies led the authors to conclude that thiophene[3,2-d]pyrimidine is a promising scaffold for diarylpyrimidine (DAPY)-type anti-HIV agents with potent activity against resistance-associated human immunodeficiency virus (HIV) variants. In the present study, the authors designed and synthesized a series of thiophenepyrimidine derivatives with various substituents in the right wing region of the structure with the aim of developing new interactions with the tolerant region I of the binding pocket of the HIV-1 non-nucleoside reverse transcriptase (NNRTI), and the authors evaluated their activity against a panel of mutant HIV-1 strains. All the derivatives exhibited moderate to excellent potency against wild-type (WT) HIV-1 in MT-4 cells. Among them, sulfonamide compounds 9b (N-(4-((4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)cyclohexyl)-4-fluorobenzenesulfonamide) and 9d (4-cyano-N-(4-((4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)cyclohexyl)benzenesulfonamide) were single-figure-nanomolar inhibitors with EC₅₀ values of 9.2 and 7.1 nM, resp. Indeed, 9a (N-(4-(N-(4-((4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)cyclohexyl)sulfamoyl)phenyl)acetamide) and 9d were effective against the whole viral panel except RES056. Notably, both compounds showed potent antiviral activity against K103N (EC₅₀ = 0.032 and 0.070 μM) and E138K (EC₅₀ = 0.035 and 0.045 μM, resp.). Furthermore, 9a and 9d exhibited high affinity for WT HIV-1 RT (IC₅₀ = 1.041 and 1.138 μM, resp.) and acted as classical NNRT inhibitors (NNRTIs). These results are expected to be helpful in the design of thiophenepyrimidine-based NNRTIs with more potent activity against HIV strains with RT mutations. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed Oxidative Carbonylation of Aromatic C-H Bonds of N-Alkylanilines with CO and Alcohols for the Synthesis of o-Aminobenzoates was written by Chen, Ming;Ren, Zhi-Hui;Wang, Yao-Yu;Guan, Zheng-Hui. And the article was included in Journal of Organic Chemistry in 2015.Reference of 18437-66-6 This article mentions the following:

A Pd(II)-catalyzed C-H monocarbonylation of N-alkylanilines for the synthesis of o-aminobenzoates has been developed. Various aliphatic alcs. and phenol were tolerated in the reaction to afford the corresponding o-aminobenzoates in good yields under mild balloon pressure of CO. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery and optimization of efficacious neutral 4-amino-6-biphenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one diacylglycerol acyl transferase-1 (DGAT1) inhibitors was written by Goldberg, Frederick W.;Birch, Alan M.;Leach, Andrew G.;Groombridge, Sam D.;Snelson, Wendy L.;Gutierrez, Pablo Morentin;Hammond, Clare D.;Birtles, Susan;Buckett, Linda K.. And the article was included in MedChemComm in 2013.Computed Properties of C9H9ClO3 This article mentions the following:

A series of neutral DGAT1 inhibitors with good potency and pharmacokinetics (PK) has been designed by modification of an acidic startpoint. This was achieved by selecting the acid with the highest ligand lipophilicity efficiency (LLE) and replacing the acid with neutral isosteres. PK properties (F_abs) were then improved by removing the sidechain to reduce mol. weight and polar surface area (PSA). Compound 13 has shown good cross-species PK, with pre-clin. efficacy and PK/PD relationships comparable to those previously described for acidic inhibitors. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5Computed Properties of C9H9ClO3).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C9H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics