Tag: 200-300

Electric Literature of C10H13ClO3《Highly Efficient Kinetic Resolution of Aryl-Alkenyl Alcohols by Ru-Catalyzed Hydrogen Transfer》 was published in 2021. The authors were You, Yipeng;Jin, Ming Yu;Tao, Guanyu;Xing, Xiangyou, and the article was included in《Molecules》. The author mentioned the following in the article:

By exploiting the recently developed Ru-catalysts of minimal stereogenicity, herein a highly efficient kinetic resolution of aryl-alkenyl alcs. through hydrogen transfer weas reported. This method enabled such versatile chiral building blocks for organic synthesis as allylic alcs., to be readily accessed with excellent enantiomeric excesses at practically useful conversions. The experimental procedure involved many compounds, such as (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Electric Literature of C10H13ClO3) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of C10H13ClO3《Silver-Catalyzed Dibromotrifluoromethoxylation of Terminal Alkynes》 was published in 2021. The authors were Wang, Feng;Guo, Yuecong;Zhang, Yutong;Tang, Pingping, and the article was included in《ACS Catalysis》. The author mentioned the following in the article:

A silver-catalyzed dibromotrifluoromethoxylation of terminal alkynes has been reported, which provides the corresponding 1,1-dibromo-2-(trifluoromethoxy)alkenes in good yields and high regioselectivity under mild reaction conditions. The reaction exhibits a broad substrate scope and applies to late-stage trifluoromethoxylation of complex small mols. Moreover, the products can be further modified, which provides a convenient method for the synthesis of compounds containing the OCF₃ group. And (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) was used in the research process.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Electric Literature of C10H13ClO3) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 39637-74-6《Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide》 was published in 2018. The authors were Mukhopadhyay, Sushobhan;Batra, Sanjay, and the article was included in《Chemistry – A European Journal》. The author mentioned the following in the article:

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO₂) and N-halosuccinimides (NXS) in DMF at room temperature under metal- and acid-free condition was described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide. And (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) was used in the research process.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 SDS of cas: 39637-74-6) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of C10H13ClO3《Chiral probe for mass spectrometric identification and quantitation of levodropropizine and its enantiomer, dextrodropropizine》 was published in 2022. The authors were Zhang, Caiyu;Liu, Yang;Liu, Rui;Li, Wei;Liu, Changxiao;He, Lan, and the article was included in《Chirality》. The author mentioned the following in the article:

Acyl chlorides react rapidly with hydroxyl and amino groups in the absence of catalysts and therefore hold great promise for chiral mass spectrometry. Herein, a tandem mass spectrometry method based on derivatization with (-)-camphanic acid chloride as a simple chiral probe was developed for the highly sensitive detection and quantitation of levodropropizine and its enantiomer, namely, dextrodropropizine. The diastereomeric derivatization products were quantified based on the relative abundances of their fragment ions produced upon collision-induced dissociation in pos.-ion mode. The reactive site was elucidated using NMR spectroscopy and two-dimensional total correlation spectroscopy, and the reaction mechanism was proved by stoichiometry studies. The degree of isomer recognition was investigated at different collision energies and determined as Rchiral ≈ 1.5. Thus, this study gives the way to the mass spectrometric identification and quantitation of levodropropizine and its enantiomer, and the developed method represents a new and practical technique for rapid and sensitive determination and quality control of enantiomers of chiral drugs. To complete the study, the researchers used (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Synthetic Route of C10H13ClO3) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 39637-74-6In 2017, Huang, Zhongping;Williams, Russell B.;O’Neil-Johnson, Mark;Eldridge, Gary R.;Mangette, John E.;Starks, Courtney M. published 《A Total Synthesis of Bifidenone》. 《Journal of Organic Chemistry》published the findings. The article contains the following contents:

The first total synthesis of bifidenone (I), a novel natural tubulin polymerization inhibitor, has been achieved in 12 steps starting from com. available 1,4-dioxaspiro[4.5]decan-8-one. The synthesis includes a newly developed method to generate the dihydrobenzodioxolone core by palladium-catalyzed aerobic dehydrogenation. The three stereocenters were installed with an AD-mix-β dihydroxylation step followed by a late-stage palladium-catalyzed decarboxylation-allylation procedure. The absolute stereochem. was determined by single-crystal X-ray anal. of a derivative To complete the study, the researchers used (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Application of 39637-74-6) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kikuchi, Katsuaki;Nakamura, Jun;Nagata, Yuuya;Tsuchida, Hiromu;Kakuta, Takahiro;Ogoshi, Tomoki;Morisaki, Yasuhiro published 《Control of Circularly Polarized Luminescence by Orientation of Stacked π-Electron Systems》 in 2019. The article was appeared in 《Chemistry – An Asian Journal》. They have made some progress in their research.Electric Literature of C10H13ClO3 The article mentions the following:

V-shaped bis(arylethynylarylethynyl) para-cyclophane I (R = 4-MeOC₆H₄) and its enantiomer were prepared to determine the relative circularly polarized luminescence of X-shaped and V-shaped luminescent mols. A racemic para-cyclophanediol was esterified with a camphanic chloride to yield a mixture of diastereomers which was brominated and then separated; hydrolysis of the camphanate esters, O-methylation, Sonogashira coupling with trimethylsilylacetylene, desilylation, and Sonogashira coupling with an iodoaryl alkyne yielded I (R = 4-MeOC₆H₄) and its enantiomer. I emitted intense circularly polarized luminescence (CPL); the sign of CPL emitted by a related X-shaped mol. was opposite to that of I, indicating that the sign of CPL can be controlled by the relative orientation of stacked fluorophores.(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) were involved in the experimental procedure.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Electric Literature of C10H13ClO3) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Jian;Zhao, He;Tan, Zhenda;Cao, Liang;Jiang, Huanfeng;Ci, Chenggang;Dixneuf, Pierre H.;Zhang, Min published 《syn-Selective Construction of Fused Heterocycles by Catalytic Reductive Tandem Functionalization of N-Heteroarenes》 in 2021. The article was appeared in 《ACS Catalysis》. They have made some progress in their research.Formula: C10H13ClO3 The article mentions the following:

To date, numerous methods have been successfully developed to functionalize N-heteroaryl C-H bonds. In contrast, dearomative tandem functionalization of N-heteroarenes is still a subject to be explored. Reported herein is an example on reductive dearomatization-induced tandem functionalization of N-heteroarenes by ruthenium catalysis, which offers a general method for diastereoselective construction of fused heterocycles featuring a cyclic syn-N, O-acetal motif from N-heteroarenes, phenols, and paraformaldehyde. Mechanistic study reveals that the products are formed via a tandem sequence of pyridyl C₃-benzylation and hydroxymethylation followed by C₂-aryloxylation of N-heteroarenium salts, proceeding with broad substrate scope, good functional group tolerance, high atom efficiency, and applicability for postfunctionalization of some biomedical mols.(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) were involved in the experimental procedure.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Formula: C10H13ClO3) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cai, Libo;Zhu, Xiaoyi;Chen, Jiayi;Lin, Aijun;Yao, Hequan published 《Rh(III)-Catalyzed C-H activation/annulation of salicylaldehydes with sulfoxonium ylides for the synthesis of chromones》 in 2019. The article was appeared in 《Organic Chemistry Frontiers》. They have made some progress in their research.Application In Synthesis of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) The article mentions the following:

A rhodium(III)-catalyzed C-H activation/annulation of salicylaldehydes e.g., 2-OHC₆H₄CHO with sulfoxonium ylides RC(O)CH=S(O)(CH₃)CH₃ (R = Ph, t-Bu, cyclohexyl, thiophen-2-yl, etc.) has been developed for the formation of 2-substituted chromones e.g., I in good yields with broad functional group tolerance. The utility of this strategy was showcased by the late-stage modification of some biol. active mols. Moreover, structurally diverse 2,3-disubstituted chromones II (R¹ = Cl, CF₃, diethoxyphosphoroso, etc.) were also constructed by the C3 C-H functionalization reactions. To complete the study, the researchers used (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Application In Synthesis of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets)) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets)In 2017, Patil, Nivedita T.;Shashidhar, Mysore S.;Tamboli, Majid I.;Gonnade, Rajesh G. published 《Clues from Crystal Structures Pave the Way to Access Chiral myo-Inositol Derived Versatile Synthons: Resolution of Racemic 4-O-Allyl-myo-Inositol-1,3,5-Orthoesters via Corresponding Dicamphanates by Crystallization》. 《Crystal Growth & Design》published the findings. The article contains the following contents:

Racemic 4-O-allyl-myo-inositol-1,3,5-orthoesters were resolved as the corresponding diastereomeric dicamphanates by crystallization from alc. solvents. Crystals of the two diastereomers of myo-inositol orthoacetate and one diastereomer each of myo-inositol orthoformate and myo-inositol orthobenzoate were obtained in >99% purity, on gram scale. The configuration of all these diastereomers was established by conversion to known chiral myo-inositol derivatives as well as by single crystal structure anal. It is interesting to note that the procedures for the separation of diastereomeric myo-inositol orthoesters could be evolved due to the knowledge of crystal growth and crystal structures of inositol derivatives of comparable mol. structures. Due to the synthetic versatility of myo-inositol orthoesters, the methods described provide rapid and convenient access to a variety of chiral inositol derivatives with high synthetic potential. To complete the study, the researchers used (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Safety of (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets)) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Noguchi, Hiroki;Takafuji, Makoto;Maurizot, Victor;Huc, Ivan;Ihara, Hirotaka published 《Chiral separation by a terminal chirality triggered P-helical quinoline oligoamide foldamer》. The research results were published in《Journal of Chromatography A》 in 2016.Product Details of 39637-74-6 The article conveys some information:

A P-helical quinoline oligoamide foldamer was grafted on silica and applied as an HPLC stationary phase for chiral separation The P-handedness of the quinoline oligoamide foldamer was induced by a (1S)-camphanyl group, which was introduced at the N-terminus of a tetrameric quinoline oligoamide foldamer (Cmp-Q₄). To immobilize the foldamer on porous silica particles, a trimethoxysilyl group was introduced at the opposing end of the foldamer. Elemental anal. indicated that the amount of foldamer on the silica surface was 0.57 μmol/m². CD and vibrational CD spectra of Cmp-Q₄ and Cmp-Q₄-immobilized silica (Sil-Q₄-Cmp) suggested that the helical structure of Cmp-Q₄ was altered on the silica surface while retaining a chiral structure. The chiral recognition ability of Sil-Q₄-Cmp was evaluated with various aromatic enantiomers. Sil-Q₄-Cmp showed enantio-selectivity for axially chiral mols. (e.g., α_{Trigger’s base} = 1.26 and α_Binaphthol = 1.07). Sil-Q₄-Cmp showed remarkable recognition of helical octameric quinoline oligoamides with isobutoxy and triethylene glycol side chains (α 10.35and 14.98, resp.). In contrast, an (1S)-camphanyl group-immobilized porous silica showed no chiral recognition for any enantiomers tested. To elucidate the chiral separation mechanism of Sil-Q₄-Cmp, thermodn. parameters were calculated using van’t Hoff plots. HPLC results and thermodn. parameters suggested that the chiral recognition of Sil-Q₄-Cmp is based on the helical structure of Cmp-Q₄ and other thermally dependent interactions such as hydrophobic effects associated with aromatic stacking. This work represents the 1st known application of aromatic foldamers in chiral separation The experimental procedure involved many compounds, such as (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Product Details of 39637-74-6) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics