Tag: 200-300

SDS of cas: 10007-84-8On May 31, 2015, Solyanikova, Inna P.; Emelyanova, Elena V.; Shumkova, Ekaterina S.; Egorova, Darya O.; Korsakova, Ekaterina S.; Plotnikova, Elena G.; Golovleva, Ludmila A. published an article in International Biodeterioration & Biodegradation. The article was 《Peculiarities of degradation of benzoate and its chloro- and hydroxy-substituted analogs by actinobacteria》. The article mentions the following:

This work investigates the ability of representatives of four actinobacterial genera (Arthrobacter, Microbacterium, Rhodococcus, Gordonia) to degrade benzoic acid and its hydroxylated or chlorinated analogs. Benzoate, 3-chlorobenzoate and 4-hydroxybenzoate were shown to support growth of most strains. We determined the maximal specific growth rates and doubling times for bacteria grown on these substrates. We examined the substrate specificities of actinobacterial benzoate dioxygenases towards 16 aromatic chems. The specificities varied among species, they were narrow for Rhodococcus opacus 1CP and Gordonia polyisoprenivorans 135 and broad for Rhodococcus ruber P25 and Microbacterium sp. B51. The genes encoding the benzoate dioxygenase α-subunit from R. opacus 1CP, R. opacus 6a, R. ruber P25, Rhodococcus wratislaviensis P1 and R. wratislaviensis G10 which were isolated at distant sites exhibited between 88 and 97% homol. with the homologous gene of Rhodococcus jostii RHA1. This indicates a common origin of these genes. Notably, in some strains, catechol 1,2-dioxygenase and gentisate dioxygenase were induced simultaneously during growth on benzoate. In the part of experimental materials, we found many familiar compounds, such as Sodium 2,6-dichlorobenzoate(cas: 10007-84-8SDS of cas: 10007-84-8)

Sodium 2,6-dichlorobenzoate(cas: 10007-84-8) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 10007-84-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1950,Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science included an article by Barry, Vincent C.; Belton, J. G.; Conalty, M. L.; O’Rourke, L.; Twomey, D.. Safety of 2-Amino-2,4-dichlorodiphenyl ether. The article was titled 《Antituberculous substances. VII. Derivatives of diphenyl ether》. The information in the text is summarized as follows:

An attempt is made to relate antitubercular activity to chem. structure among Ph2O derivatives The dilution which completely inhibits the growth of Mycobacterium tuberculosis for 6 wk was determined in each case. The compounds tested and their effective dilution (in the presence and in the absence of blood serum, resp.) are given as follows: Ph2O, -, 1000. Derivatives containing 1 solubilizing group: 4-H2N, -, 35,000; 4-HO, -, 100,000; 4-HO2C, -, <5,000; 4-HO3S, -, <1,000; 4-guanyl, 10,000, 25,000; and 2-H2N, -, 10,000. Derivatives containing 1 halogen atom: 4-chloro-4'-amino, 10,000, 200,000; 2-chloro-4'-amino, -, 250,000; 2-chloro-4-amino, 10,000, 250,000; 2-chloro-4'-guanyl, 10,000, 50,000; 2-chloro-4-guanyl, 25,000, 25,000; 4-chloro-4'-guanyl, 50,000, 150,000; 4-chloro-4'-hydroxy, -, 300,000; 4-chloro-4'-carboxy, -, 50,000; 4,4'-diguanyl, 1,000, 10,000; 2-chloro-4,4'-diguanyl, 10,000, 25,000; 4-chloro-2'-amino, -, 10,000; and 4-chloro-2',4'-diamino, -, 10,000. Dihalogenated derivatives: 2,4'-dichloro-4-guanyl, 50,000, 100,000; 2,4-dibromo-4'-amino, -, 400,000; 2,4-dichloro-4'-amino, 10,000, 600,000; 4-amino-2,4'-dichloro, 25,000, 1,000,000; 4-amino-2,2'-dichloro, 10,000, 400,000; 2-amino-2',4-dichloro, -, 100,000; 2-amino-4,4'-dichloro, 10,000, 150,000; 4-amino-2',4'-dichloro, 5,000, 400,000; and 2,3-diiodo-4-amino, -, 600,000. Trihalogenated derivatives: 2,2-diiodo-4-amino-4'-chloro, 25,000, 1,000,000; 2,4,5-trichloro-4'-amino, 50,000, 500,000; 2,4,6-trichloro-4'-amino, 25,000, 500,000; 2,4,5-trichloro-4'-hydroxy, -, 400,000; 2,4,5-trichloro-2',4'-diamino, -, 25,000; 2,2',4-trichloro-4'-amino, 10,000, 1,000,000. Miscellaneous derivatives and other compounds: 3,4-dimethyl-4'-amino, 10,000, 50,000; 2-chloro-4-isobutyl-4'-amino, 10,000, 750,000; 3,5-dimethyl-4-chloro-4'-amino, 25,000, 500,000; 2-methyl-4-amino-4'-chloro, -, 300,000; 2-amino-4-methyl-2'-bromo, -, 25,000; 2-bromo-4-methyl-2'-amino, -, 25,000; 2-amino-4-nitro-4'-chloro, 5,000, 10,000; 2,2',4,5-tetrachloro-4'-amino-, 25,000, 1,000,000; 4,4'-diamino, -, 1,000; 4-amino-4'-hydroxy, 10,000, 50,000; 4-amino-4'-carboxy, -, 5,000; and 4-nitro-4'-carboxy, -, 25,000; 2-hydroxy-4-aminobenzoic acid (PAS), 200, 300; sulphetrone, <1000, <1000; and streptomycin, 500,000, 1,000,000. Similar tests were run to determine the dilution needed to inhibit growth of M. smegmatus for 6 days and data are given. The most active compounds are those in which the hydrophilic group occupies the para position to the O bridge and its basic or acidic character is not significant. A grouping which possesses high water solubility depresses biol. activity, as when 2 HO, 2 H2N, or 2 guanyl groups are present. Introduction of 1 or 2 Cl substituents increases the antitubercular activity; further halogenation has little addnl. effect. The greatest activity is shown by compounds in which the halogens are shared by both Bz nuclei. Compounds which most strongly depress O uptake of yeast cells have the highest antitubercular activity. All of the Ph2O derivatives tested required a dilution of 50,000 or less in the presence of serum (in vivo) as compared to an active dilution of 1:500,000 for streptomycin.2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Safety of 2-Amino-2,4-dichlorodiphenyl ether) was used in this study.

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Safety of 2-Amino-2,4-dichlorodiphenyl ether

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kelkar, S. V.; Joshi, G. S.; Kulkarni, G. H.; Mitra, R. B. published an article on January 31 ,1987. The article was titled 《Synthesis of 3-phenoxybenzyl 3-alkyl-3-(p-substituted phenyl)propionates and 3-phenoxybenzyl 2-alkyl-3-(p-substituted phenyl)propionates》, and you may find the article in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry.Product Details of 7116-36-1 The information in the text is summarized as follows:

Alkylation of (EtO2C)2CH2 with 4-RC6H4CHR1Br (R = Cl, NO2, H; R1 = Me, Et, H), followed by decarbethoxylation and transesterification with R2OH(R2 = 3-PhOC6H4CH2) gave 4-RC6HCHR1CH2CO2R2 (I). Alkylation of 4-R3C6H4CH2CHR4CO2Et (R3 = H, R4 = Ac; R3 = Cl, R4 = CO2Et) with alkyl halides, followed by deacylation or decarbethoxylation and transesterification with R2OH, gave 4-R3C6H4CH2CHR5CO2R2 (II, R5 = Me2CH, Et, Me). I and II are potential insecticides and acaricides. The experimental process involved the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Product Details of 7116-36-1)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Product Details of 7116-36-1 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry included an article by Taywade, Amol; Berad, Baliram. Safety of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Hunig’s base a facile and green alternative for C-N bond formation reactions》. The information in the text is summarized as follows:

A new dimension to Hunig’s base i.e. diisopropylethylamine (DIPEA) utilization in the organic reaction were studied. Present study projects DIPEA as a green alternative for C-N bond formation reactions. In terms of optimization of yield of C-N coupling reactions, DIPEA exclusively serves as base, catalyst and solvent in mild conditions to fulfill criteria for green reaction methodol. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Safety of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Safety of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Baliah, V.; Balasubramanian, Theymoli Mrs. published an article in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. The title of the article was 《Steric enhancement of resonance: Part I. Dissociation constants of some mono-, di- and tri-substituted benzoic acids》.Reference of 3,5-Dichloro-4-methoxybenzoic acid The author mentioned the following in the article:

The dissociation constants of 20 benzoic acids were determined in 50 volume % EtOH-H2O using the conductometric method. The calculated acidity constants of 3,4-R(MeO)C6H3CO2H (R = halo, Me) are appreciably higher than exptl. determined acidity constants which indicates that the 3-substituent enhances the resonance interaction between the MeO and CO2H groups. The expected steric inhibition of resonance is observed in 3,5,4-R2(MeO)C6H2CO2H. The acidity constants were also analyzed in terms of their free energies of ionization. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Reference of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 3,5-Dichloro-4-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pritykin, L. M.; Selyutin, O. B.; Nikolaev, A. L. published their research in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) on December 31 ,1999. The article was titled 《Quantitative evaluation of the conjugation effect in the hydrolysis of para-substituted aromatic acid esters》.Product Details of 7116-36-1 The article contains the following contents:

The rate constants of alk. and acid hydrolysis of 10 series of para-substituted benzoic, cinnamic, phenylpropynoic, biphenylcarboxylic, phenylacetic, and 3-phenylpropionic acids linearly correlate with the population of the pz-orbital of the phenylene C atom bearing the substituent. This parameter can be regarded as a quant. measure of the conjugation effect. The experimental process involved the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Product Details of 7116-36-1)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 7116-36-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Intramolecular interactions. Dipole moments and rotational isomerism of a series of 1-substituted 2-arylethanes》 were Camail, Michel; Dicko, Dankoulodo D.. And the article was published in Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques in 1971. COA of Formula: C11H13ClO2 The author mentioned the following in the article:

The dipole moments are determined for 12 p-AC6H4CH2CH2X (A = H, Me, Cl; X = Cl, Br, CN, CO2-Et) and used to estimate the anti-gauche isomer equilibrium In the experiment, the researchers used Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1COA of Formula: C11H13ClO2)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. COA of Formula: C11H13ClO2 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yeung, Chi-Tung;Chan, Wesley Ting Kwok;Lo, Wai-Sum;Law, Ga-Lai;Wong, Wing-Tak published 《Synthesis of a conformationally stable atropisomeric pair of biphenyl scaffold containing additional stereogenic centers》 in 2019. The article was appeared in 《Molecules》. They have made some progress in their research.Synthetic Route of C10H13ClO3 The article mentions the following:

The synthesis of a new CF₃-containing stereogenic atropisomeric pair of ortho-disubstituted biphenyl scaffolds I and II is presented. The atropisomers are surprisingly conformationally stable for isolation. X-ray structures show that their stability comes from an intramol. hydrogen bond formation from their two hydroxyl groups and renders the spatial arrangement of their peripheral CF₃ and CH₃ groups very different. The synthesized stereogenic scaffolds proved to be effective in catalyzing the asym. N-nitroso aldol reaction of enamines III [X = O, C, Y = (CH₂)_n, n = 1; X = C, Y = (CH₂)_n, n = 0] and nitrosobenzene. Compared to similar scaffolds without CF₃ groups, one of the atropisomers exhibits an increase in enantioselectivity in this reaction.(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) were involved in the experimental procedure.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Synthetic Route of C10H13ClO3) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Kun;Rombach, David;Notel, Nicolas Yannick;Jeschke, Gunnar;Katayev, Dmitry published 《Radical Trifluoroacetylation of Alkenes Triggered by a Visible-Light-Promoted C-O Bond Fragmentation of Trifluoroacetic Anhydride》 in 2021. The article was appeared in 《Angewandte Chemie, International Edition》. They have made some progress in their research.Formula: C10H13ClO3 The article mentions the following:

A mild and operationally simple trifluoroacylation strategy of olefines was reported, that utilized trifluoroacetic anhydride as a low-cost and readily available reagent. This light-mediated process was fundamentally different from conventional methodologies and occurs through a trifluoroacyl radical mechanism promoted by a photocatalyst, which triggers a C-O bond fragmentation. Mechanistic studies (kinetic isotope effects, spectroelectrochem., optical spectroscopy, theor. investigations) highlighted the evidence of a fleeting CF₃CO radical under photoredox conditions. The trifluoroacyl radical could be stabilized under CO atm., delivering the trifluoroacetylation product with higher chem. efficiency. Furthermore, the method could be turned into a trifluoromethylation protocol by simply changing the reaction parameters. Beyond simple alkenes, this method allows for chemo- and regioselective functionalization of small-mol. drugs and common pharmacophores. And (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) was used in the research process.

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Formula: C10H13ClO3) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 39637-74-6In 2019, Medena, Caleb;Calogero, Francesco;Lemoine, Quentin;Aubert, Corinne;Derat, Etienne;Fensterbank, Louis;Gontard, Geoffrey;Khaled, Omar;Vanthuyne, Nicolas;Moussa, Jamal;Ollivier, Cyril;Petit, Marc;Barbazanges, Marion published 《A HELIXOL-Derived Bisphosphinite Ligand: Synthesis and Application in Gold-Catalyzed Enynes Cycloisomerization》. 《European Journal of Organic Chemistry》published the findings. The article contains the following contents:

The synthesis, optical resolution through derivatization, characterization, and utilization of a new helical bis(phosphinite gold)complex derived from 2,15-bishydroxy[6]helicene (HELIXOL) are described. By using an efficient cobalt catalyst, neither irradiation nor high catalytic loading was required to access the helicene of interest. The latter was phosphorylated to afford a new chiral ligand that was studied. Especially, treatment with AuCl(SMe₂) gives a dinuclear gold complex that was used in cycloisomerization reactions. The experimental procedure involved many compounds, such as (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) .

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Related Products of 39637-74-6) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics