Tag: 200-300

Arylsulfonic acid derivatives. XIV. Synthesis and antibacterial activity of new derivatives of 4-alkoxybenzylsulfonamides was written by Grigoryan, L. A.;Kaldrikyan, M. A.;Engoyan, A. P.;Paronikyan, R. V.. And the article was included in Armyanskii Khimicheskii Zhurnal in 1987.Electric Literature of C10H13ClO3S This article mentions the following:

p-ROC₆H₄SO₂Cl (I; R = C₁-C₄ n-alkyl, Me₂CHCH₂) reacted with R¹(CH₂)_nNH₂ (R¹ = Ph, p-MeOC₆H₄; n = 1, 2) in aqueous NaOH to give 15 corresponding p-ROC₆H₄SO₂NH(CH₂)_nR¹ (II) in 55-83% yield. II (same R; R¹ = Ph, n = 1, 2; R = Me, R¹ = p-MeOC₆H₄, n = 1) reacted with addnl. I (same R) or with p-R²C₆H₄CH₂Cl (R² = H, MeO) in dry DMF containing LiH to give 14 corresponding (p-ROC₆H₄SO₂)₂N(CH₂)_nR¹ (III) in 38-61% yield and 31-33% p-MeOC₆H₄CH₂N(CH₂C₆H₄R²–p)SO₂C₆H₄OEt-p (same R²), resp. III had antibacterial activity, but II did not. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Electric Literature of C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Intermolecular Reductive Heck Reaction of Unactivated Aliphatic Alkenes with Organohalides was written by Zheng, Kewang;Xiao, Guanlin;Guo, Tao;Ding, Yalan;Wang, Chengdong;Loh, Teck-Peng;Wu, Xiaojin. And the article was included in Organic Letters in 2020.Application In Synthesis of 5-Bromo-2-chloro-m-xylene This article mentions the following:

A general intermol. reductive Heck reaction of organohalides with both terminal and internal unactivated aliphatic alkenes has been first realized in high yield with complete anti-Markovnikov selectivity. The challenging vinyl bromides, aryl chlorides, and polysubstituted internal alkenes were first applied. More than 100 remote carbofunctionalized alkyl carboxylic acid derivatives were rapidly synthesized from easily accessible starting materials. The synthesis of drug mols. has further demonstrated the wide synthetic utility of this scalable strategy. Preliminary mechanistic studies are consistent with the proposed catalytic cycle. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloro-m-xylene (cas: 206559-40-2Application In Synthesis of 5-Bromo-2-chloro-m-xylene).

5-Bromo-2-chloro-m-xylene (cas: 206559-40-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 5-Bromo-2-chloro-m-xylene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tailored design of highly permeable polyamide-based nanofiltration membrane via a complex-dissociation regulated interfacial polymerization was written by Hao, Yufan;Yang, Na;Zhang, Longfei;Fang, Yao;Sun, Yongli;Jiang, Bin;Zhang, Luhong. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2023.Related Products of 4422-95-1 This article mentions the following:

Nanofiltration (NF) that can sep. neutral/charged solutes is considered as a key industrial technol. in water softening and wastewater treatment. However, com. polyamide (PA) NF membranes, with undesirable surface properties and excessive mass transfer resistance, seriously restrict the permeability and are easily attached by pollutants. In this study, a novel CDRIP strategy was proposed to prepare highly permeable polyamide-based NF membranes, in which tannic acid (TA)/Ca(II) complex was in situ formed on substrate surface and then dissociated by sodium citrate (SC) after interfacial polymerization Interestingly, SC can not only adjust surface properties of PA, such as hydrophilicity and surface charge, but also form water-soluble SC/Ca(II) complexes for constructing addnl. transport channels within the separation layer to reduce mass transfer resistance. After the dissociation of TA/Ca(II) complex, TA remained on the membrane surface to further regulate the surface properties of separation layer. The results showed that the PA/TA/Ca(II)-SC NF membrane maintained a high Na₂SO₄ rejection (98.5%) and a remarkable water permeability of 31.7 L.m^-2.h^-1.bar^-1. The prepared NF membrane exhibits favorable operation stability and anti-fouling ability. Therefore, by employing the CDRIP method, the permeability of NF membrane can be further improved almost without sacrificing the rejection of Na₂SO₄, which provides a green and efficient strategy for the fabrication of high-performance PA-based NF membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Related Products of 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Determination of Cadmium in Tap, Sea and Waste Water Samples by Vortex-Assisted Dispersive Liquid-Liquid-Solidified Floating Organic Drop Microextraction and Slotted Quartz Tube FAAS After Complexation with a Imidazole Based Ligand was written by Findikoglu, Maral Selin;Firat, Merve;Chormey, Dotse Selali;Turak, Fatma;Sahin, Cigdem;Bakirdere, Sezgin. And the article was included in Water, Air, & Soil Pollution in 2018.SDS of cas: 3386-33-2 This article mentions the following:

This study presents a combination of dispersive liquid-liquid-solidified floating organic drop microextraction (DLLSFODM) and slotted quartz tube (SQT) with conventional flame at. absorption spectrometry (FAAS) to improve the sensitivity for cadmium determination A ligand namely 2-(4-methylphenyl)-1H-imidazo-[4,5-f]-[1,10]-phenanthroline which has not been used in trace analyte determination was used to form a cadmium complex. Stepwise optimization of parameters affecting complex formation (pH, ligand, and buffer solution) and extraction (extraction and dispersive solvents, salt effect and mixing) was done to maximize cadmium absorbance. The slotted quartz tube was fitted onto the flame burner and optimized to increase residence time of atoms in the flame. Instrumental parameters such as sample and fuel flow rate were also optimized to further enhance the absorbance signal for cadmium. Using optimal parameters and values, the limits of detection and quantification were determined to be 0.81 and 2.69 μg L^-1, resp. Low percent relative standard deviations (< 6.0%) indicated good precision for both extraction and instrumental measurements. Recovery tests were used to determine the accuracy of the method and the recovery results obtained were between 88 and 113%. [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2SDS of cas: 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Direct and Divergent Solid-Phase Synthesis of Azobenzene and Spiropyran Derivatives was written by Kollarigowda, Ravichandran H.;Braun, Paul V.. And the article was included in Journal of Organic Chemistry in 2021.Related Products of 76-83-5 This article mentions the following:

Here a solid-phase approach to synthesize azobenzenes I [Ar = 4-NH₂C₆H₄, 2,6-di-PhC₆H₃, 1-naphthyl, etc.] and spiropyran derivatives e.g., II was reported. The divergent synthesis process required no purification steps to obtain the desired product with 28-55% yield, depending on the specific compound For the spiropyran compounds, solid-phase resin cleavage was performed under mild condition to minimize spiropyran ring opening. The solid-phase method enabled synthesis of a library of azobenzene and spiropyran derivatives without the need of developing purification strategies for each derivative In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Related Products of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Comparison of polyamide, polyesteramide and polyester nanofiltration membranes: properties and separation performance was written by Fan, Kaiming;Liu, Yanling;Wang, Xiaoping;Cheng, Peng;Xia, Shengji. And the article was included in Separation and Purification Technology in 2022.Application In Synthesis of Trimesoylchloride This article mentions the following:

In this study, three different kinds of nanofiltration membranes with polyamide (PA), polyesteramide (PEA), and polyester (PE) active layers were resp. synthesized by using piperazine, serinol and meso-erythritol as the aqueous monomers for interfacial polymerization The three types of membranes achieved comparable rejections for the reference organic solute (i.e., xylose) via optimization of preparation conditions, based on which the characteristics of different active layers were comprehensively investigated. Results showed that the PA, PEA and PE membranes exhibited distinct surface morphologies. The special surface structures of PEA membranes and the larger active layer thickness of PE membranes resulted in their lower water permeance compared to PA membranes. Different than PA active layers, the absence of pos. charged regions in the PEA and PA active layers was beneficial for the passage of divalent cations and the rejection of NaCl. Moreover, despite the comparable mean pore size, PA membranes exhibited a more uniform membrane pore size resulting in a higher rejection of organic matters in natural water than PEA and PE membranes. This study presented the differences in physicochem. properties and separation performance among the different membrane active layers, which could provide references for the rational selection of nanofiltration membrane types during application. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application In Synthesis of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and molecular docking studies of novel N-arylsulfonyl-benzimidazoles with anti Trypanosoma cruzi activity was written by Miana, Gisele E.;Ribone, Sergio R.;Vera, Domingo M. A.;Sanchez-Moreno, Manuel;Mazzieri, Maria R.;Quevedo, Mario A.. And the article was included in European Journal of Medicinal Chemistry in 2019.Application of 777-44-6 This article mentions the following:

In this report, we present the synthesis and biol. activity of 11 novel and 3 already reported N-arylsulfonyl-benzimidazole derivatives (NBSBZD, I [R¹ = H, CH₃], F etc. ) currently in development as potential anti-Tc compounds These compounds were designed as part of a library of synthetic arylsulfonyl heterocycle derivatives constructed from privileged structures exhibiting drug-like properties. Based on bioactivity assays against Tc, (in both the extracellular and intracellular forms), we observed that 10 compounds exhibited bioactivity against the epimastigote form, while six of them exhibited activity against the amastigote counterpart. Also, the compounds showed less cytotoxicity compared to the reference drug BZN as measured in Vero cell culture. In order to elucidate the potential mechanism of action, metabolite excretion profiles studies were performed, and complemented with mol. modeling studies performed over known Tc druggable targets. Consistency was observed between exptl. and theor. findings, with metabolic profiles showing that compounds I [R¹ H, CF₃, NHCOCH₃; R²= R³ H, CH₃, NO₂; R⁴ = R₅ H, CH₃ ] interfered with the normal glycolysis cycle of Tc, while mol. modeling studies were able to establish a solid structure-activity relationship towards the inhibition of 6-phospho-1-fructokinase, a key enzyme involved in the parasite glycolytic cascade. Overall, the present study constitutes a multidisciplinary contribution to the development of new anti-Chagas compounds In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and mesomorphic properties of laterally fluorinated alkyl 4”-alkylterphenyl-4-yl carbonate liquid crystals was written by Choluj, Artur;Kula, Przemyslaw;Dabrowski, Roman;Tykarska, Marzena;Jaroszewicz, Leszek. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2014.Quality Control of Chloroformicacidn-nonylester This article mentions the following:

Fifteen series of homologues of a variety of mono-, di- and trifluorosubstituted alkyl 4”-alkylterphenyl-4-yl carbonates have been synthesized and their mesomorphic properties have been determined From among 95 prepared compounds, 40 pure nematogens have been found, as well as 55 mesogens with orthogonal and tilted smectic phases in broad temperature ranges. The type and combination of the LC phase strongly depend on the position and number of the fluorine atoms. Phys. properties and correlations between the mol. core fluorosubstitution, the length of the terminal chains and the type and sequence of the liquid crystalline phases, have been determined The compounds are useful for the formulation of nematic mixtures as well as ferroelec. ones. In the experiment, the researchers used many compounds, for example, Chloroformicacidn-nonylester (cas: 57045-82-6Quality Control of Chloroformicacidn-nonylester).

Chloroformicacidn-nonylester (cas: 57045-82-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Quality Control of Chloroformicacidn-nonylester

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists was written by Epple, Robert;Russo, Ross;Azimioara, Mihai;Cow, Christopher;Xie, Yongping;Wang, Xing;Wityak, John;Karanewsky, Don;Gerken, Andrea;Iskandar, Maya;Saez, Enrique;Seidel, H. Martin;Tian, Shin-Shay. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Reference of 57017-95-5 This article mentions the following:

The authors report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5Reference of 57017-95-5).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 57017-95-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel 1H-Pyrrolo[3,2-c]quinoline Based 5-HT₆ Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer’s Disease was written by Grychowska, Katarzyna;Satala, Grzegorz;Kos, Tomasz;Partyka, Anna;Colacino, Evelina;Chaumont-Dubel, Severine;Bantreil, Xavier;Wesolowska, Anna;Pawlowski, Maciej;Martinez, Jean;Marin, Philippe;Subra, Gilles;Bojarski, Andrzej J.;Lamaty, Frederic;Popik, Piotr;Zajdel, Pawel. And the article was included in ACS Chemical Neuroscience in 2016.Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Modulators of the serotonin 5-HT₆ receptor (5-HT₆R) offer a promising strategy for the treatment of the cognitive deficits that are associated with dementia and Alzheimer’s disease. Herein, we report the design, synthesis, and characterization of a novel class of 5-HT₆R antagonists that is based on the 1H-pyrrolo[3,2-c]quinoline core. The most active compounds exhibited comparable binding affinity to the reference compound, SB-742457, and markedly improved selectivity. Lead optimization led to the identification of (S)-1-[(3-chlorophenyl)sulfonyl]-4-(pyrrolidine-3-yl-amino)-1H-pyrrolo[3,2-c]quinoline (14) (K_i = 3 nM and K_b = 0.41 nM). Pharmacol. characterization of the 5-HT₆R’s constitutive activity at Gs signaling revealed that 14 behaved as a neutral antagonist, while SB-742457 was classified as an inverse agonist. Both compounds 14 and SB-742457 reversed phencyclidine-induced memory deficits and displayed distinct procognitive properties in cognitively unimpaired animals (3 mg/kg) in NOR tasks. Compounds 14 and SB-742457 were also active in the Vogel test, yet the anxiolytic effect of 14 was 2-fold higher (MED = 3 mg/kg). Moreover, 14 produced, in a 3-fold higher dose (MED = 10 mg/kg), antidepressant-like effects that were similar to those produced by SB-742457 (MED = 3 mg/kg). Together, these data suggest that the 4-(pyrrolidine-3-yl-amino)-1H-pyrrolo[3,2-c]quinoline scaffold is an attractive mol. framework for the development of procognitive agents. The results are promising enough to warrant further detailed mechanistic studies on the therapeutic potential of 5-HT₆R antagonists and inverse agonists for the treatment of cognitive decline and depression/anxiety symptoms that are comorbidities of Alzheimer’s disease. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics