Tag: 200-300

《Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors》 was written by La Pietra, Valeria; Sartini, Stefania; Botta, Lorenzo; Antonelli, Alessandro; Ferrari, Silvia Martina; Fallahi, Poupak; Moriconi, Alessio; Coviello, Vito; Quattrini, Luca; Ke, Yi-Yu; Hsing-Pang, Hsieh; Da Settimo, Federico; Novellino, Ettore; La Motta, Concettina; Marinelli, Luciana. Application In Synthesis of Ethyl 3-(4-chlorophenyl)propanoate And the article was included in European Journal of Medicinal Chemistry on April 25 ,2018. The article conveys some information:

It is now known that “”gain of function”” mutations of RET (REarranged during Transfection) kinase are specific and key oncogenic events in the onset of thyroid gland cancers such as the Medullary Thyroid Carcinoma (MTC). Although a number of RET inhibitors exist and are capable of inhibiting RET variants, in which mutations are outside the enzyme active site, the majority becomes dramatically ineffective when mutations are within the protein active site (V804L and V804M). Pursuing a receptor-based virtual screening against the kinase domain of RET, the authors found that compound (I) is able to inhibit efficiently both wild type and V804L mutant RET. Compound(I) was able to significantly reduce proliferation of both com. available TT cell lines and surgical thyroid tissues obtained from patients with MTC and displayed a suitable drug-like profile, thus standing out as a promising candidate for further development towards the treatment of clin. unresponsive MTC. The results came from multiple reactions, including the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Application In Synthesis of Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Application In Synthesis of Ethyl 3-(4-chlorophenyl)propanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Zheng, Yu; He, Xian-Chen; Gao, Jie; Xie, Zhen-Zhen; Wang, Zhi-Wei; Liu, Zhi-Lin; Chen, Kai; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Programmable iodization/deuterolysis sequences of phosphonium ylides to access deuterated benzyl iodides and aromatic aldehydes》.Electric Literature of C7H6BrCl The author mentioned the following in the article:

A tunable iodization/deuterolysis protocol for phosphonium ylides by employing D2O as the deuterium source were designed. Notably, this process was manipulated by tuning the base, thus leading to two valuable deuterated building blocks – benzyl iodides and aromatic aldehydes with broad substrate scope, good functional group compatibility and excellent deuteration degree. Concise syntheses of a series of deuterated drug analogs was achieved based on the developed deuteration reaction platform. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Electric Literature of C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Electric Literature of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tanaka, Fred S.; Wien, Ronald G.; Zaylskie, Richard G.; Hoffer, Barry L. published an article on February 28 ,1990. The article was titled 《Synthesis of possible ring-hydroxylated metabolites of diclofop-methyl》, and you may find the article in Journal of Agricultural and Food Chemistry.Reference of 3,5-Dichloro-4-methoxybenzoic acid The information in the text is summarized as follows:

In the metabolism of diclofop-Me by tolerant plant species, three ring-hydroxylated metabolites were formed as major metabolites. For conclusive identification of these metabolites, authentic standards were required. Therefore, the following five isomers of hydroxylated diclofop-Me were synthesized as possible standards for identification of the diclofop-Me metabolites: Me 2-[4-(2,4-dichloro-5-hydroxyphenoxy)phenoxy]propanoate, Me 2-[4-(2,4-dichloro-3-hydroxyphenoxy)phenoxy]propanoate, Me 2-[4-(2,4-dichloro-6-hydroxyphenoxy)phenoxy]propanoate, Me 2-[4-(2,5-dichloro-4-hydroxyphenoxy)phenoxy]propanoate, and Me 2-[4-(2,3-dichloro-4-hydroxyphenoxy)phenoxy]propanoate. In the experiment, the researchers used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Reference of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Reference of 3,5-Dichloro-4-methoxybenzoic acid Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1977,Acta Chimica Academiae Scientiarum Hungaricae included an article by Varsanyi, G.; Horvath, G.; Imre, L.; Schawartz, J.; Sohar, P.; Soti, F.. Formula: C8H6Cl2O3. The article was titled 《Infrared spectra of 1,2,3,5-tetrasubstituted benzene derivatives》. The information in the text is summarized as follows:

The ring vibration in the IR of one-hundred and fifteen 1,2,3,5-tetrasubsituted benzenes are classified into 3 groups, depending on whether all 4 substituents are light or 1 or 2 of them are heavy (constants Cl, Br and/or I). The substituent effects on the fundamental vibrations of the benzene ring and their intensities, and the character of the bands associated with internal substituent vibrations are discussed. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Formula: C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C8H6Cl2O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Li, Shichao; Li, Muyao; Li, Shu-Sen; Wang, Jianbo published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Pd-Catalyzed coupling of benzyl bromides with BMIDA-substituted N-tosylhydrazones: synthesis of trans-alkenyl MIDA boronates》.Synthetic Route of C7H6BrCl The author mentioned the following in the article:

A palladium-catalyzed stereoselective synthesis of alkenyl boronates from N-methyliminodiacetyl boronate (BMIDA)-substituted N-tosylhydrazone and benzyl bromides is developed. A range of trans-alkenyl MIDA boronates as single stereoisomers were obtained in moderate yields with good functional group compatibility. The resultant boronate products may be transformed to other boron-containing compounds and may also be directly used in cross-coupling reactions. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Synthetic Route of C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Synthetic Route of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《The synthesis of sulfonated 4H-3,1-benzoxazines via an electro-chemical radical cascade cyclization》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to He, Tian-Jun; Zhong, Wei-Qiang; Huang, Jing-Mei. Application In Synthesis of 4-Chlorobenzenesulfonyl chloride The article mentions the following:

A new route for the synthesis of sulfonated 4H-3,1-benzoxazines I (R1 = H, Me, C6H5; R2 = H, 4-Me, 4-F, etc.; R3 = C6H5, 4-FC6H4, 2-furyl, etc.) has been accomplished by electrochem. radical cascade cyclizations of styrenyl amides with sulfonylhydrazines. This process demonstrates a wide substrate scope with diverse functional group compatibility under metal- and external oxidant-free conditions at ambient temperature4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Application In Synthesis of 4-Chlorobenzenesulfonyl chloride The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of Ethyl 3-(4-chlorophenyl)propanoateOn November 4, 1998 ,《Ni(II)-Catalyzed Cross-Coupling between Polyfunctional Arylzinc Derivatives and Primary Alkyl Iodides》 appeared in Journal of the American Chemical Society. The author of the article were Giovannini, Riccardo; Knochel, Paul. The article conveys some information:

A novel nickel-catalyzed coupling reaction of arylzinc bromides ArZnBr (Ar = Ph, 4-ClC6H4, 4-MeOC6H4, 4-NCC6H4, 3-EtO2CC6H4, 2-EtO2CC6H4), generated from the aryl iodides, and functionalized primary alkyl iodides R(CH2)nI (n = 2,3,5; R = Me3CCOO, 2-methyl-1,3-dithiolanyl, EtO2C, BuCO, PhS, (CH2)5NCO) to give aralkyl derivative Ar(CH2)nR in 71-80% yield. Arylzinc bromides are generated from aryl iodides by either treatment of the iodide with Me2CHMgBr in THF followed by addition of ZnBr2 to the Grignard reagent, or by treatment of the aryl iodide with BuLi and addition of ZnBr2. E.g., 4-cyanophenylzinc bromide is formed by transmetalation of 4-NCC6H4I at -90° with BuLi in THF and addition of ZnBr2; the arylzinc bromide was then concentrated and added to a THF solution containing 10 mol% Ni(acac)2, 1 equivalent 4-F3CC6H4CH:CH2, and 1 equivalent Me(SCH2CH2S)CH2CH2I to give I in 80% yield. The absence of 4-F3CC6H4CH:CH2 leads to formation of products formed form homocoupling and zinc-iodine transmetalation of the alkyl iodides. The coupling tolerates ketone, amide, ester, and nitrile functionality and allows coupling of sp2-aryl and sp3-alkyl groups fro which few coupling methods exist. After reading the article, we found that the author used Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Quality Control of Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Quality Control of Ethyl 3-(4-chlorophenyl)propanoate The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C8H6Cl2O3On March 31, 2002, Kousaka, Takeshi; Mori, Kenji published an article in Bioscience, Biotechnology, and Biochemistry. The article was 《Synthesis of (1R,2S)-1-(3′-Chloro-4′-methoxyphenyl)-1,2-propanediol (Trametol) and (1R,2S)-1-(3′,5′-dichloro-4′-methoxyphenyl)-1,2-propanediol, chlorinated fungal metabolites in the natural environment》. The article mentions the following:

(1R,2S)-1-(3′-Chloro-4′-methoxyphenyl)-1,2-propanediol (trametol), a metabolite of the fungus Trametes sp. IVP-F640 and Bjerkandera sp. BOS55, was synthesized by employing Sharpless asym. dihydroxylation as the key step. Similarly, the (1R,2S)-isomer of 1-(3′,5′-dichloro-4′-methoxyphenyl)-1,2-propanediol, another metabolite of Bjerkandera sp. BOS55, was synthesized by asym. dihydroxylation. The experimental process involved the reaction of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Computed Properties of C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H6Cl2O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Microwave-assisted organic acid-base-co-catalyzed tandem Meinwald rearrangement and annulation of styrylepoxides》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Shi, Yi; Li, Siqi; Lu, Yang; Zhao, Zizhen; Li, Pingfan; Xu, Jiaxi. HPLC of Formula: 139502-80-0 The article mentions the following:

A novel organic acid-base-co-catalyzed conversion of styrylepoxides I [R = Ph, 2,3-dichlorophenyl, 3-(trifluoromethyl)phenyl, etc.; R1 = H, Me] into [1,1′-biaryl]-3-carbaldehydes 3-RC6H4CHO was realized under microwave irradiation Styrylepoxides I first underwent an acid-catalyzed Meinwald rearrangement followed by a tandem base-catalyzed Michael addition, aldol addition, and aromatization sequence to generate [1,1′-biaryl]-3-carbaldehydes. The experimental process involved the reaction of 4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde(cas: 139502-80-0HPLC of Formula: 139502-80-0)

4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde(cas: 139502-80-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.HPLC of Formula: 139502-80-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Bio-potent sulfonamides》 were Dineshkumar, Selvakumar; Thirunarayanan, Ganesamoorthy. And the article was published in Journal of the Chilean Chemical Society in 2019. Name: 4-Chlorobenzenesulfonyl chloride The author mentioned the following in the article:

Some 4-(substituted phenylsulfonamido)benzoic acids have been synthesized by fly-ash:H3PO3 nano catalyst catalyzed condensation of substituted benzenesulfonyl chlorides and 4-aminobenzoic acid in ultrasound irradiation conditions. The yields of the sulfonamides are more than 90%. The synthesized 4-(substituted phenylsulfonamido) benzoic acid derivatives were characterized by their phys. constants, anal. and spectroscopic data. Antimicrobial activities of all sulfonamides were measured by Bauer-Kirby disk diffusion method. After reading the article, we found that the author used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Name: 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Name: 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics