Tag: 200-300

Computed Properties of C6H4Cl2O2SIn 2022 ,《Synthesis and bioactivity of novel sulfonate scaffold-containing pyrazolecarbamide derivatives as antifungal and antiviral agents》 appeared in Frontiers in Chemistry (Lausanne, Switzerland). The author of the article were Lei, Zhi-Wei; Yao, Jianmei; Liu, Huifang; Ma, Chiyu; Yang, Wen. The article conveys some information:

Novel I [R = Ph, 4-methylphenyl, 2-chlorophenyl, etc] bearing a sulfonate fragment were synthesized to identify potential antifungal and antiviral agents. All the structures of the key intermediates and target compounds were confirmed by NMR and high-resolution mass spectrometry. The single-crystal X-ray diffraction of the compound I [R = 3-trifluoromethyl phenyl] showed that pyrazole carbamide is a sulfonate. The in vitro antifungal activities of the target compounds against Colletotrichum camelliae, Pestalotiopsis theae, Gibberella zeae, and Rhizoctonia solani were evaluated at 50μg/mL. Among the four pathogens, the target compounds exhibited the highest antifungal activity against Rhizoctonia solani. The compound I [R = phenylethyl] (EC50 = 0.45 mg/L) had higher antifungal activity than the com. fungicide hymexazol (EC50 = 10.49 mg/L) against R. solani, almost similar to bixafen (EC50 = 0.25 mg/L). Addnl., the target compounds exhibited protective effects in vivo against TMV. Thus, this study reveals that I. bearing a sulfonate fragment exhibited potential antifungal and antiviral activities. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C6H4Cl2O2S Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nasrollahzadeh, Mahmoud; Nezafat, Zahra; Pakzad, Khatereh; Ahmadpoor, Fatemeh published an article in 2021. The article was titled 《Synthesis of magnetic chitosan supported metformin-Cu(II) complex as a recyclable catalyst for N-arylation of primary sulfonamides》, and you may find the article in Journal of Organometallic Chemistry.Recommanded Product: 4-Chlorobenzenesulfonyl chloride The information in the text is summarized as follows:

Immobilization of a copper complex on the magnetic chitosan bearing metformin ligand was developed through immobilizing structurally defined metformin with long tail of (3-chloropropyl)trimethoxysilane (TMOS). The synthesized Fe3O4-chitosan@metformin-Cu(II) complex (Fe3O4-CS@Met-Cu(II)) were used as an effective, reusable and magnetic catalyst in the N-arylation of different derivatives of primary sulfonamides with arylboronic acids in ethanol. The primary sulfonamides were prepared from the reaction of sulfonyl chlorides with sodium cyanate in water under ultrasonic irradiation Utilizing a wide variety of substrates in EtOH as a green solvent, high yields of the primary and secondary sulfonamides, easy work-up along with the excellent recovery and reusability of the catalyst, make this process a simple, economic and environmentally benign method. The synthesized Fe3O4-CS@Met-Cu(II) were characterized using various techniques such as XRD (X-ray diffraction), EDS (energy-dispersive X-ray spectroscopy), elemental mapping, TEM (transmission electron microscopy), FESEM (field emission SEM), VSM (vibrating sample magnetometer), ICP-MS (inductively coupled plasma mass spectroscopy), TGA (thermogravimetric anal.) and FT-IR (Fourier-transform IR spectroscopy) analyses. The catalyst was recycled and reused 5 times with no considerable loss of catalytic activity. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Samanta, Partha Kumar; Biswas, Rima; Bhaduri, Samanka Narayan; Ray, Shounak; Biswas, Papu published their research in Microporous and Mesoporous Materials in 2021. The article was titled 《Copper(0) nanoparticles immobilized on SBA-15: a versatile recyclable heterogeneous catalyst for solvent and ligand free C-S coupling reaction from diverse substrates》.HPLC of Formula: 622-95-7 The article contains the following contents:

A SBA-15 supported copper(0) nanoparticles based catalyst (Cu(0)MS) has been prepared using wet impregnation method. The catalyst was thoroughly characterized by several techniques including powder X-ray diffraction, nitrogen adsorption-desorption, field emission SEM-energy dispersive X-ray, transmission electron microscopy, high angle annular dark field scanning transmission electron microscopy and inductively coupled plasma-optical emission spectrometry. This mesoporous silica supported copper(0) nanoparticles had been exploited as a catalyst for ligand-free and solvent-free C-S cross-coupling reactions. Sym./unsym. aryl/alkyl sulfides R1SR2 (R1 = Ph, 2-MeOC6H4, PhCH2, PhCH:CH, 2-thienyl, etc.; R2 = Ph, n-octyl, PhCH2CH2, 2-pyridyl, etc.) had been synthesized by the S-arylation of aromatic, heteroaromatic and aliphatic thiols R2SH with aryl, heteroaryl or vinyl halides R1X (X = I, Br). Aryl chlorides also responded the reaction very well to produce aryl sulfides. The applicability of the current protocol had also been explored for the synthesis of the starting materials of different C-S bond containing pharmaceuticals. In addition, the present catalytic system was also suitable for the synthesis of a variety of sym. diaryl sulfides from aryl halides using thiourea as a sulfur source. Furthermore, it was also found that the Cu(0)MS catalyst could be reused five times without substantial loss in activity. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7HPLC of Formula: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.HPLC of Formula: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication》 were Skerlj, Renato; Bridger, Gary; Zhou, Yuanxi; Bourque, Elyse; McEachern, Ernest; Langille, Jonathan; Harwig, Curtis; Veale, Duane; Yang, Wen; Li, Tongshong; Zhu, Yongbao; Bey, Michael; Baird, Ian; Sartori, Michael; Metz, Markus; Mosi, Renee; Nelson, Kim; Bodart, Veronique; Wong, Rebecca; Fricker, Simon; MacFarland, Ron; Huskens, Dana; Schols, Dominique. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2011. Reference of Ethyl 6-chloro-2,4-dimethylnicotinate The author mentioned the following in the article:

A series of CCR5 antagonists, e.g. I, were optimized for potent inhibition of R5 HIV-1 replication in peripheral blood mononuclear cells. Compounds that met acceptable ADME criteria, selectivity, human plasma protein binding, potency shift in the presence of α-glycoprotein were evaluated in rat and dog pharmacokinetics. In the experimental materials used by the author, we found Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0Reference of Ethyl 6-chloro-2,4-dimethylnicotinate)

Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Reference of Ethyl 6-chloro-2,4-dimethylnicotinate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1976,European Journal of Medicinal Chemistry included an article by Flammang, Michel; Wermuth, Camille G.. Quality Control of Ethyl 3-(4-chlorophenyl)propanoate. The article was titled 《2,3-Benzodiazepine systems. II. 4-Oxo-3,5-dihydro(4H)-2,3-benzodiazepines. Synthesis and pharmacological study》. The information in the text is summarized as follows:

Benzodiazepinones I (R = H, Cl; R1 = H, Me; R2 = H, Me, morpholinoethyl, morpholinopropyl, pyrrolidinoethyl; R3 = H, OMe, Cl) (11 compounds) were prepared by treating 4-RC6H4CHO with CH2(CO2H)2, cyclizing 4-RC6H4CH:CHCO2H, treating II (X = O) with 4-R3C6H4MgBr, dehydrating II (X = OH,C6H4R3-4), oxidizing the indenes, and condensing 4,2-R(4-R3C6H4CO)C6H3CH2CO2H with R2NHNH2. I had much lower tranquilizing activity than diazepam. In the experimental materials used by the author, we found Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Quality Control of Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Quality Control of Ethyl 3-(4-chlorophenyl)propanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Brown, Thomas H.; Blakemore, Robert C.; Durant, Graham J.; Emmett, John C.; Ganellin, C. Robin; Parsons, Michael E.; Rawlings, D. Anthony; Walker, Terence F. published their research in European Journal of Medicinal Chemistry on February 29 ,1988. The article was titled 《Isocytosine H2-receptor histamine antagonists. I. Oxmetidine and related compounds》.Name: Ethyl 3-(4-chlorophenyl)propanoate The article contains the following contents:

2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-4-pyrimidones I (R = H, Me, PhO, substituted benzyl, etc.; R1 = H, Me, Pr, PhCH2) were prepared via substitution of (methylthio)pyrimidinones with 5-methyl-4-[(2-aminomethyl)thiomethyl]imidazole. The model compound I (R = R1 = H) has modest H2-antagonist activity as shown by its ability to antagonize histamine-stimulated tachycardia in guinea pig right atrium in vitro and inhibit histamine-stimulated gastric acid secretion in the lumen-perfused stomach of the anesthetized rat. Investigation of the effect of substituents in the pyrimidone ring showed that suitable substitution at the 5-position gave compounds with greatly increased activity, whereas substituents at other positions in the ring were not favorable for activity. Some structure-activity and structure-toxicity correlations are discussed. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Name: Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Name: Ethyl 3-(4-chlorophenyl)propanoate However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and evaluation of nematicidal activity of compounds derived from norbornadiene》 was published in Journal of the Brazilian Chemical Society in 2020. These research results belong to Gomes, Anni C. S.; Demuner, Antonio J.; Alvarenga, Elson S.; Gondim, Joao P. E.; Fonseca, Andressa R.; Buonicontro, Dalila S.; Pilau, Eduardo J.; Silva, Evandro. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:

Nematode is a major problem in agriculture, the effective way to control this pest is through chem. control, but the efficient mols. present in the market have great toxicity to mammals and birds. Thus, there is a constant demand for the development of new nematicide mols. This study describes the synthesis of norbornadiene derived esters I (R = H, Me, Bn, etc.) and evaluation of their potential activity against Meloidogyne javanica. The esters I presented 50% mortality of the nematodes. The compounds acid II and the ester I (R = Me) caused 96 and 93% mortality of the nematodes, resp. The lethal concentration to kill 50% of the nematodes (LD50) were determined as being 11.8μg mL-1 for the acid II and 99.4μg mL-1 for the ester I (R = Me). According to the results obtained it is believed that polarity seems to be a key factor for the higher activity of compound II compared to structurally similar ester derivatives After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Journal of the Brazilian Chemical Society included an article by Dias, Maria C. F.; Gularte, Thiago Q.; Teixeira, Robson R.; Santos, Jorge A. N.; Pilau, Eduardo J.; Mendes, Tiago A. O.; Demuner, Antonio J.; dos Santos, Marcelo H.. Safety of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Synthesis of 1,2,3-triazole derivatives of 4,4′-dihydroxybenzophenone and evaluation of their elastase inhibitory activity》. The information in the text is summarized as follows:

The synthesis of a series of novel triazole derivatives I (R = 4-iodophenyl, 2-methylphenyl, 2,6-dichlorophenyl, etc.) from 4,4′-dihydroxybenzophenone along with their elastase inhibitory activity has been described. The 1,2,3-triazoles I were obtained via the copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC), also known as click reaction, between bis(4-(prop-2-yn-1-yloxy))benzophenone and several benzyl azides RCH2N3. It was found that five derivatives exhibited significant inhibitory effects, presenting half maximal inhibitory concentration (IC50) values in the range of 16.6 to 72.1 μM. The most active compound, namely I (R = 4-iodophenyl) (IC50 = 16.6 ± 1.9 μM), was found to bind to elastase with the inhibition constant (Ki) of 11.12 μM, thereby illustrating competitive inhibitory behavior. Further, docking investigations provided insights on the possible binding mode of the most active compound with the elastase. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Safety of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Safety of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Shouming; Miller, Warren; Milton, John; Vicker, Nigel; Stewart, Alistair; Charlton, Peter; Mistry, Prakash; Hardick, David; Denny, William A. published an article on February 11 ,2002. The article was titled 《Structure-activity relationships for analogues of the phenazine-based dual topoisomerase I/II inhibitor XR11576》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Formula: C15H10N2O2 The information in the text is summarized as follows:

As part of a program to identify further analogs of the dual topo I/II inhibitor XR11576, we describe here the syntheses and SAR studies of various ‘minimal’ and 3,4-benzofused phenazine chromophores of the phenazine template of XR11576. In the experiment, the researchers used 3-Phenylquinoxaline-5-carboxylic acid(cas: 162135-93-5Formula: C15H10N2O2)

3-Phenylquinoxaline-5-carboxylic acid(cas: 162135-93-5) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Formula: C15H10N2O2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sugimoto, Yuichi; Shimizu, Atsushi; Kato, Tetsuya; Satoh, Atsushi; Ozaki, Satoshi; Ohta, Hisashi; Okamoto, Osamu published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Design, synthesis, and biological evaluation of indole derivatives as novel nociceptin/orphanin FQ (N/OFQ) receptor antagonists》.Formula: C11H13ClO2 The author mentioned the following in the article:

A novel series of 2-(1,2,4-oxadiazol-5-yl)-1H-indole derivatives as nociceptin/orphanin FQ (N/OFQ) receptor antagonists was discovered. Systematic modification of our original lead by changing the pendant functional groups, linker, heterocyclic core, and basic side chain revealed the structure-activity requirements for this novel template and resulted in the identification of more potent analog with improved potency as compared to the parent compound The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Formula: C11H13ClO2)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Formula: C11H13ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics