Tag: 200-300

In 2022,Hong, Feng-Lin; Shi, Chong-Yang; Hong, Pan; Zhai, Tong-Yi; Zhu, Xin-Qi; Lu, Xin; Ye, Long-Wu published an article in Angewandte Chemie, International Edition. The title of the article was 《Copper-Catalyzed Asymmetric Diyne Cyclization via [1,2]-Stevens-Type Rearrangement for the Synthesis of Chiral Chromeno[3,4-c]pyrroles》.COA of Formula: C7H6BrCl The author mentioned the following in the article:

Here, authors report a copper-catalyzed asym. cascade cyclization/[1,2]-Stevens-type rearrangement via a non-diazo approach, leading to the practical and atom-economic assembly of various valuable chiral chromeno[3,4-c]pyrroles bearing a quaternary carbon stereocenter in generally moderate to good yields with wide substrate scope and excellent enantioselectivities (up to 99% ee). Importantly, this protocol not only represents the first example of catalytic asym. [1,2]-Stevens-type rearrangement based on alkynes but also constitutes the first asym. formal carbene insertion into the Si-O bond.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ali, Eslam M. H.; El-Telbany, Rania Farag A.; Abdel-Maksoud, Mohammed S.; Ammar, Usama M.; Mersal, Karim I.; Zaraei, Seyed-Omar; El-Gamal, Mohammed I.; Choi, Se-In; Lee, Kyung-Tae; Kim, Hee-Kwon; Lee, Kwan Hyi; Oh, Chang-Hyun published an article in 2021. The article was titled 《Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAFV600E/p38α inhibitors》, and you may find the article in European Journal of Medicinal Chemistry.Computed Properties of C6H4Cl2O2S The information in the text is summarized as follows:

In the present work, a new series of (imidazol-5-yl)pyrimidine I ( Ar = C6H5, 4-ClC6H4, 4-BrC6H4 etc.; X = F, Cl; R = OCH3, OH) was designed and synthesized as dual inhibitors of BRAFV600E and p38α kinases which are considered as key regulators in mitogen-activated protein kinase signalling pathway. The target compounds were evaluated for dual kinase inhibitory activity. The tested compounds exhibited nanomolar scale IC50 values against BRAFV600E and low to sub-micromolar IC50 range against p38α. Compound I (Ar = 4-OHC6H4; X = F; R = OH) was identified as the most potent dual BRAFV600E/p38α inhibitor with IC50 values of 2.49 and 85 nM, resp. Further deep investigation revealed that Compound I (Ar = 4-OHC6H5; X = F; R = OH) possesses inhibitory activity of TNF-α production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 value of 96.3 nM. Addnl., the target compounds efficiently frustrated the proliferation of LOX-IMVI melanoma cell line. Compound I (Ar = 4-OHC6H5; X = F; R = OH) showed a satisfactory antiproliferative activity with IC50 value of 13μM, while, compound I (Ar = 3-FC6H4; X = F; R = OCH3) exhibited the highest cytotoxicity potency with IC50 value of 0.9μM. Compound I (Ar = 3-FC6H4; X = F; R = OCH3) is 11.11-fold more selective toward LOX-IMVI melanoma cells than IOSE-80PC normal cells. The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C6H4Cl2O2S Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: Ethyl 3-(4-chlorophenyl)propanoateOn September 30, 2011 ,《Synthesis, antibacterial activities and molecular docking studies of ethyl 3-(4-substituted phenyl) propanoates as targeted antibiotics》 was published in Latin American Journal of Pharmacy. The article was written by Ramaraj, Sivakumar; Vasanthakumari, Pradeepchandran R.; Narasimha, Jayaveera K.; Rajarathnam, Vijaianand; Palani, Kumamallasivan; Panneerselvam, Arulraj; Ramasamy, Venkatnarayanan. The article contains the following contents:

The type II fatty acid synthesis (FAS II) pathway has been recently reported as an attractive target for their efficacy against infections caused by multistrain-resistant Gram-pos. and Gram-neg. bacteria. Among the related FAS II enzymes, beta keto acyl-acyl carrier protein synthase [KAS 3-oxoacyl-[acyl carrier protein] synthase ], is an essential target for novel antibacterial drug design. Several 3-(phenyl)propanoic acid esters (I) were designed, the synthesis of the target compounds was achieved by a multistep process and the products were characterized. I were screened for their inhibitory activity against Escherichia coli β-keto acyl-acyl carrier protein synthase III (ecKAS III) was investigated by mol. docking simulation. I which posses both good inhibitory activity and binding affinity were compared their antibacterial activities against Gram-neg. and Gram-pos. bacterial strains, expecting to discover broad-spectrum antibacterial activity. I displayed significant activity and Et 3-(4-chlorophenyl)propanaoate exhibited the highest antibacterial activity against all tested bacteria. The results came from multiple reactions, including the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Name: Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: Ethyl 3-(4-chlorophenyl)propanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Neerathilingam, Nalladhambi; Bhargava Reddy, Mandapati; Anandhan, Ramasamy published their research in Journal of Organic Chemistry in 2021. The article was titled 《Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C-N Cleavage of N,N-Dibenzylanilines》.Recommanded Product: 622-95-7 The article contains the following contents:

A visible-light-driven photoredox-catalyzed nonaqueous oxidative C-N cleavage of N,N-dibenzylanilines to 2° amides is reported. Further, this protocol is applied on 2-(dibenzylamino)benzamide to afford quinazolinones with (NH4)2S2O8 as an additive has been applied. Mechanistic studies imply that the reaction might underwent in situ generation of α-amino radical to imine by C-N bond cleavage followed by the addition of superoxide ion to form amides. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Recommanded Product: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Unprecedented Reactivity of β-Iodovinyl Sulfones: An Efficient Synthesis of β-Keto Sulfones and β-Keto Thiosulfones》 were Reddy, Raju Jannapu; Kumar, Jangam Jagadesh; Kumari, Arram Haritha. And the article was published in European Journal of Organic Chemistry in 2019. Reference of 4-Chlorobenzenesulfonyl chloride The author mentioned the following in the article:

An unprecedented reactivity of (E)-β-iodovinyl sulfones in the presence of NaOAc is reported. The (E)-β-iodovinyl sulfones were treated with NaOAc in DMSO/H2O to yield β-keto sulfones in moderate to high yields. A novel oxidative difunctionalization of β-iodovinyl sulfones with thiosulfonates and NaOAc in DMF has been developed. This metal-free oxosulfenylation is an operationally simple to access a wide range of β-keto thiosulfones (α-thioaryl-β-keto sulfones) in moderate to high yields. The transformations were reliable at gram-scale, thus illustrating its efficiency and practicality. A plausible mechanism for the protocol is also proposed. In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Reference of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Journal of Heterocyclic Chemistry included an article by Sawkmie, Micky Lanster; Paul, Dipankar; Kalita, Gitumoni; Agarwala, Khushboo; Maji, Pradip K.; Chatterjee, Paresh Nath. Related Products of 622-95-7. The article was titled 《Synthesis and characterization of active cuprous oxide particles and their catalytic application in 1,2,3-triazole synthesis via alkyne-azide cycloaddition reaction in water》. The information in the text is summarized as follows:

Active cuprous oxide materials were synthesized from CuSO4.5H2O using sodium stannite as reducing agent in the presence of various stabilizers, viz., cetyl tri-Me ammonium bromide, sodium dodecyl sulfate and polyvinyl pyrrolidone. The synthesized cuprous oxide materials were well characterized by powder X-ray diffraction and Fourier transform IR spectroscopy to ascertain their identity, while field emission SEM and energy-dispersive spectroscopy anal. were used to study their morphol. and composition, resp. The various cuprous oxide materials were used in the cycloaddition reaction of alkynes, benzyl halides and azides to synthesize 1,4-disubstituted-1,2,3-triazoles I [R = allyl, Bn, 3-ClC6H4CH2, etc.; R1 = CH2OH, Ph, 4-MeC6H4, 4-FC6H4, 4-BrC6H4, 2-pyridyl]. A wide variety of substitutions could nicely be tolerated in our optimized reaction conditions to produce very good to excellent yields of the corresponding triazoles in water at 55 °C. The reactions were carried out in water without any assistance of organic cosolvent or other additives, which renders the catalytic method as economical and environment friendly. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Related Products of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Related Products of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Muthu Ramalingam, Bose; Dhatchana Moorthy, Nachiappan; Chowdhury, Somenath Roy; Mageshwaran, Thiyagarajan; Vellaichamy, Elangovan; Saha, Sourav; Ganesan, Karthikeyan; Rajesh, B. Navin; Iqbal, Saleem; Majumder, Hemanta K.; Gunasekaran, Krishnasamy; Siva, Ramamoorthy; Mohanakrishnan, Arasambattu K. published an article on February 8 ,2018. The article was titled 《Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues》, and you may find the article in Journal of Medicinal Chemistry.Safety of 3,5-Dichloro-2-nitrobenzaldehyde The information in the text is summarized as follows:

A series of calothrixin B analogs bearing substituents at the ‘E’ ring and their corresponding deoxygenated quinocarbazoles lacking quinone unit were synthesized. The cytotoxicities of calothrixins and quinocarbazole analogs were investigated against nine cancer cell lines. Two quinocarbazoles inhibited the catalytic activity of human topoisomerase II. The plasmid DNA cleavage abilities of calothrixins identified compound I causing DNA cleavage comparable to that of calothrixin A. Calothrixin A, 3-fluorocalothrixin I and 4-fluoroquinocarbazole II induced extensive DNA damage followed by apoptotic cell death. Spectral and plasmid unwinding studies demonstrated an intercalative mode of binding for quinocarbazoles. We identified two promising drug candidates, the 3-fluorocalothrixin B I with low toxicity in animal model and its deoxygenated derivative 4-fluoroquinocarbazole II as having potent cytotoxicity against NCI-H460 cell line with a GI50 of 1 nM. In the experiment, the researchers used 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Safety of 3,5-Dichloro-2-nitrobenzaldehyde)

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Safety of 3,5-Dichloro-2-nitrobenzaldehyde The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2017,Research Journal of Chemical Sciences included an article by Mali, Anil C.; Deshmuh, Dattatray G.; Medhane, Vijay J.; Math, Vijayavitthal T.. Recommanded Product: 1450877-56-1. The article was titled 《Practical synthetic approach to related substances of Rivaroxaban; an anticoagulant drug substance》. The information in the text is summarized as follows:

During the process development of an anticoagulant drug, Rivaroxaban (1), three related substances were detected by a gradient high performance liquid chromatotog. (HPLC) method. Liquid chromatog. mass spectrometry (LC-MS) was performed to identify the mol. mass of these impurities. A detailed study was undertaken to characterize the impurities. Based on the spectral data (1 H NMR, 13C NMR and MS), these impurities were characterized as [(2S)-2,3-dihydroxypropyl]-1H-indene-1,3(2H)-dionn(impurity-1), -({[[{[(5-chloro-2-thienyl)carbonyl]amino}oxo-1,3-oxazolidin-3-yl]phenyl}amino ethoxy]acetic acid (impurity)) and {[(5-chloro-N-oxomorpholin-4-yl)phenyl]amino}propylsynthesis of these impurities with good yields and purities by HPLC is described in this report. The structures of the synthesized impurities (impurity-1, impurity-2 and impurity-3) were further confirmed by co-injecting these impurities with the standard Rivaroxaban sample containing all the three impurities. The retention times of synthesized impurities matches (co-eluted) with the retention times of the impurities present in the standard sample. In the experiment, the researchers used many compounds, for example, 4-Nitrophenyl 5-chlorothiophene-2-carboxylate(cas: 1450877-56-1Recommanded Product: 1450877-56-1)

4-Nitrophenyl 5-chlorothiophene-2-carboxylate(cas: 1450877-56-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Recommanded Product: 1450877-56-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Unusual Reactivity of Aryl Aldehydes with Triethyl Phosphite and Zinc Bromide: A Facile Preparation of Epoxides, Benzisoxazoles, and α-Hydroxy Phosphonate Esters》 was published in European Journal of Organic Chemistry in 2015. These research results belong to Raju, Potharaju; Gobi Rajeshwaran, Ganesan; Nandakumar, Meganathan; Mohanakrishnan, Arasambattu K.. Computed Properties of C7H3Cl2NO3 The article mentions the following:

A facile preparation of trans-epoxides was achieved by a (EtO)3P-ZnBr2-mediated deoxygenation reaction of the corresponding 2-nitrobenzaldehydes. The sterically hindered analogs of 2-nitrobenzaldehyde underwent a reaction with tri-Et phosphite in the presence of ZnBr2 as the catalyst to form benzisoxazoles as the sole product. Under identical conditions, the reactions of electron-rich as well as moderately electron-deficient aryl aldehydes furnished the corresponding α-hydroxy phosphonate esters. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Computed Properties of C7H3Cl2NO3)

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C7H3Cl2NO3 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocksIn 2020 ,《Hydroarylation of Arenes via Reductive Radical-Polar Crossover》 was published in Journal of the American Chemical Society. The article was written by Flynn, Autumn R.; McDaniel, Kelly A.; Hughes, Meredith E.; Vogt, David B.; Jui, Nathan T.. The article contains the following contents:

A photocatalytic system for the dearomative hydroarylation of benzene derivatives has been developed. Using a combination of an organic photoredox catalyst and an amine reductant, this process operates through a reductive radical-polar crossover mechanism where aryl halide reduction triggers a regioselective radical cyclization event, followed by anion formation and quenching to produce a range of complex spirocyclic cyclohexadienes. This light-driven protocol functions at room temperature in a green solvent system (aqueous MeCN) without the need for precious metal-based catalysts or reagents or the generation of stoichiometric metal byproducts. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Category: chlorides-buliding-blocks)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Category: chlorides-buliding-blocks It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics