Tag: 200-300

In 2022,Roy, Bibhisan; Maisuls, Ivan; Zhang, Jianyu; Niemeyer, Felix C.; Rizzo, Fabio; Wolper, Christoph; Daniliuc, Constantin G.; Tang, Ben Zhong; Strassert, Cristian A.; Voskuhl, Jens published an article in Angewandte Chemie, International Edition. The title of the article was 《Mapping the Regioisomeric Space and Visible Color Range of Purely Organic Dual Emitters with Ultralong Phosphorescence Components: From Violet to Red Towards Pure White Light》.Synthetic Route of C6H4Cl2O2S The author mentioned the following in the article:

We mapped the entire visible range of the electromagnetic spectrum and achieved white light emission (CIE: 0.31, 0.34) by combining the intrinsic ns-fluorescence with ultralong ms-phosphorescence from purely organic dual emitters. We realized small mol. materials showing high photoluminescence quantum yields (ΦL) in the solid state at room temperature, achieved by active exploration of the regioisomeric substitution space. Chromophore stacking-supported stabilization of triplet excitons with assistance from enhanced intersystem crossing channels in the crystalline state played the primary role for the ultra-long phosphorescence. This strategy covers the entire visible spectrum, based on organic phosphorescent emitters with versatile regioisomeric substitution patterns, and provides a single mol. source of white light with long lifetime (up to 163.5 ms) for the phosphorescent component, and high overall photoluminescence quantum yields (up to ΦL=20 %). In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Synthetic Route of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Synthetic Route of C6H4Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Falconnet, Alban; Arndt, Jan-Dirk; Hashmi, A. Stephen K.; Schaub, Thomas published an article in 2022. The article was titled 《Triflic-Acid-Catalyzed Friedel-Crafts Reaction for the Synthesis of Diaryl Sulfones》, and you may find the article in European Journal of Organic Chemistry.Related Products of 98-60-2 The information in the text is summarized as follows:

The Friedel-Crafts sulfonylation for the synthesis of diaryl sulfones derivatives was achieved by using triflic acid (TfOH) as the acidic catalyst with aryl sulfonyl chlorides and arenes at elevated temperatures Different sulfones could be synthesized with this method in good to excellent yield and with high selectivity. In contrast to the previous methodol. reported for this sulfonylation, the catalyst and the excess of arene could be easily recovered and re-used in further batches. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Related Products of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Related Products of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bamoro, Coulibaly; Bamba, Fante; Dindet Steve-Evanes, Koffi Teki; Aurelie, Vallin; Vincent, Chagnault published an article in 2021. The article was titled 《Design, synthesis and antibacterial activity evaluation of 4,5-diphenyl-1H-imidazoles derivatives》, and you may find the article in Open Journal of Medicinal Chemistry.Formula: C7H6BrCl The information in the text is summarized as follows:

Due to the continuous emergence and rapid spread of drug-resistant strains of bacteria, there is an urgent need for the development of novel antimicrobials. Herein, the synthesis and antibacterial activity of 4,5-diphenylimidazol-2-thiol derivatives I (R = Ph, 4-O2NC6H4, 2,4-Cl2C6H3, 5-R’-benzimidazol-5-yl, etc.; R’ = H, O2N, Me, Cl, F3C) have been reported. The structures of the synthesized compounds were confirmed by NMR and high resolution mass spectrometry (HRMS). All compounds were screened in vitro for their antibacterial activity against Pseudomonas aeuroginosa and Escherichia coli (Gram-neg. bacteria) and also against Staphyloccocus aureus and Eterococcus faecalis (Gram-pos. bacteria). The results showed that most of the synthesized compounds have no antibacterial activity. However, the compound I (R = 5-chloro-2-benzimidazolyl) was two-fold potent than ciprofloxacin against Staphylococcus aureus with Min. Inhibitory Concentration (MIC) of 4μg/mL and compound I (R = 5-trifluoromethyl-2-benzimidazolyl) showed moderate biol. activity against Staphylococcus aureus and Eterococcus faecalis.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Shuai; Xiao, Jun-Zhao; Li, Yan-Bo; Shi, Chang-Yun; Yin, Liang published their research in Journal of the American Chemical Society in 2021. The article was titled 《Copper(I)-Catalyzed Asymmetric Alkylation of Unsymmetrical Secondary Phosphines》.Product Details of 622-95-7 The article contains the following contents:

A Cu(I)-catalyzed asym. alkylation of HPAr1Ar2 with alkyl halides is uncovered, which provides an array of P-stereogenic phosphines in generally high yield and enantioselectivity. The electrophilic alkyl halides enjoy a broad substrate scope, including allyl bromides, propargyl bromide, benzyl bromides, and alkyl iodides. Also, 11 unsym. diarylphosphines (HPAr1Ar2) serve as competent pronucleophiles. The present methodol. is also successfully applied to catalytic asym. double and triple alkylation, and the corresponding products were obtained in moderate diastereo- and excellent enantioselectivities. Some 31P NMR experiments indicate that bulky HPPhMes exhibits weak competitively coordinating ability to the Cu(I)-bisphosphine complex, and thus the presence of stoichiometric HPAr1Ar2 does not affect the enantioselectivity significantly. Therefore, the high enantioselectivity in this reaction is attributed to the high performance of the unique Cu(I)-(R,RP)-TANIAPHOS complex in asym. induction. Finally, one monophosphine and two bisphosphines prepared by the present reaction are employed as efficient chiral ligands to afford three structurally diversified Cu(I) complexes, which demonstrates the synthetic utility of the present methodol. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Product Details of 622-95-7) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Product Details of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, synthesis, biological evaluation, and docking study of new acridine-9-carboxamide linked to 1,2,3-triazole derivatives as antidiabetic agents targeting α-glucosidase》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Asgari, Mohammad S.; Tahmasebi, Behnam; Mojtabavi, Somayeh; Faramarzi, Mohammad A.; Rahimi, Rahmatollah; Ranjbar, Parviz R.; Biglar, Mahmood; Larijani, Bagher; Rastegar, Hossein; Mohammadi-Khanaposhtani, Maryam; Mahdavi, Mohammad. Formula: C7H6BrCl The article mentions the following:

A new series of acridine-9-carboxamide-1,2,3-triazole derivatives I [R = H, 2-Me, 4-O2N, etc.] were designed, synthesized and evaluated as novel α-glucosidase inhibitors. Compounds I were designed by combination of effective moieties from potent α-glucosidase inhibitors. Most of the synthesized compounds I were more potent than standard inhibitor acarbose. Among the synthesized compounds, the most potent compounds were I [R = 3-Br, 4-Br, H] with IC50 values of 120.2 ± 1.0, 151.1 ± 1.4, and 157.6 ± 1.6μM, resp. (IC50 value of acarbose = 750.0 ± 10.0μM). Docking study of the most potent compounds I [R = H, 3-Br, 4-Br] reported that these compounds formed stable complexes with α-glucosidase active site. Anti-α-amylase assay of compounds I [R = H, 3-Br, 4-Br] was performed and no activity was observed, meanwhile in-vitro cytotoxicity assay of the latter compounds revealed that these compounds were not cytotoxic toward human normal (HDF) and cancer (MCF-7) cell lines. ADME and toxicity prediction of compounds I [R = H, 3-Br, 4-Br] were also performed. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 203302-92-5On November 26, 2009 ,《Synthesis, Structure-Activity Relationships, and Characterization of Novel Nonsteroidal and Selective Androgen Receptor Modulators》 appeared in Journal of Medicinal Chemistry. The author of the article were Schlienger, Nathalie; Lund, Birgitte W.; Pawlas, Jan; Badalassi, Fabrizio; Bertozzi, Fabio; Lewinsky, Rasmus; Fejzic, Alma; Thygesen, Mikkel B.; Tabatabaei, Ali; Bradley, Stefania Risso; Gardell, Luis R.; Piu, Fabrice; Olsson, Roger. The article conveys some information:

Herein we describe the discovery of ACP-105 (I), a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone. Compound I was developed from a series of compounds found in a HTS screen using the receptor selection and amplification technol. (R-SAT). In vivo, I improved anabolic parameters in a 2-wk chronic study in castrated male rats. In addition to compound I, a number of potent antiandrogens were discovered from the same series of compounds whereof one compound, II, had antagonist activity at the AR T877A mutant involved in prostate cancer. The experimental part of the paper was very detailed, including the reaction process of 3-Bromo-2-chloro-6-fluorotoluene(cas: 203302-92-5Related Products of 203302-92-5)

3-Bromo-2-chloro-6-fluorotoluene(cas: 203302-92-5) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Related Products of 203302-92-5 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Murthy, Indraganti Sreenivasa; Sireesha, Reddymasu; Deepti, Kolli; Srinivasa Rao, P.; Ramesh Raju, R. published their research in Chemical Data Collections in 2021. The article was titled 《Design, synthesis and biological evaluation of sulphonamide derivatives of benzofuran-imidazopyridines as anticancer agents》.Electric Literature of C6H4Cl2O2S The article contains the following contents:

A novel library of sulfonamide derivatives of benzofuran-imidazopyridines I [R = 4-methoxyphenyl, 4-bromophenyl, 2,6-dimethylpyridine-4-yl, etc.] were designed, synthesized and screened for their anticancer activity against four human cancer cell lines such as breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by employing MTT assay. The results were expressed with IC50 μM, which indicated that all of the compounds I showed good to moderate activity on tested cell lines. Among them, compound I [R = 4-methoxyphenyl] showed potent anticancer activities against MCF-7, A549, Colo-205 and A2780 cell lines with IC50 values of 0.011 ± 0.0075μM, 0.073 ± 0.0012μM, 0.10 ± 0.19μM and 0.034 ± 0.0041μM resp. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Electric Literature of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Electric Literature of C6H4Cl2O2S However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, synthesis, and anticancer evaluation of novel benzopyran 1,3,4-oxadiazole derivatives》 was published in Indian Journal of Heterocyclic Chemistry in 2020. These research results belong to Kumar, Piyush; Rahman, Azizur Md.; Wal, Pranay; Rawat, Pinki; Singh, Kuldeep. SDS of cas: 622-95-7 The article mentions the following:

Some new benzopyran 1,3,4-oxadiazole, derivatives I (R = H, benzyl, 4-chlorobenzyl, 3,4-dichlorobenzyl; R1 = benzyl, 4-chlorobenzyl, 3,4-dichlorobenzyl, 3-chlorobenzyl) were designed by docking, in silico absorption, distribution, metabolism, excretion (ADME) and predicted toxicity studies, and then synthesized by S-alkylation of a benzopyran 1,3,4-oxadiazole derivative with different chloro-substituted benzyl bromides. The synthesized compounds were tested for anticancer activity on the MCF-7 cell line. Docking study showed all compounds to have better docking scores than the standard, Adriamycin. In silico, ADME and toxicity studies were also found as significant for most of the compounds The majority of the compounds displayed good to potent anticancer activity on the MCF-7 cell line. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7SDS of cas: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.SDS of cas: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Design, Synthesis, Acaricidal Activities, and Structure-Activity Relationship Studies of Novel Oxazolines Containing Sulfonate Moieties》 were Chen, Shilin; Zhang, Yu; Liu, Yuxiu; Wang, Qingmin. And the article was published in Journal of Agricultural and Food Chemistry in 2019. Category: chlorides-buliding-blocks The author mentioned the following in the article:

With the ultimate goal of addressing pest-related constraints on global agricultural production, combination principles were used to design and synthesize 2,4-diphenyl-1,3-oxazolines I (R = Me, Et, cyclohexyl, 2-FC6H4, 1-naphthyl, etc.) containing a sulfonate moiety at the para-position of the 4-Ph group. The target compounds, which have strong affinity for lipids and can be expected to traverse cell membranes, were characterized by 1H and 13C NMR spectroscopy and high-resolution mass spectrometry. Their activities against the larvae and eggs of carmine spider mites (Tetranychus cinnabarinus) were determined by a leaf-dipping method and compared with the activity of the com. acaricide etoxazole. Most of the test compounds displayed good ovicidal and larvicidal activities. In particular, the compound I (R = 4-t-BuC6H4) possessed better larvicidal activity (LC50 = 0.022 ± 0.009 mg/L) and ovicidal activity (0.044 ± 0.020 mg/L) than etoxazole (0.091 ± 0.051 and 0.095 ± 0.059 mg/L, resp.). Given its outstanding bioactivities, this compound deserves further attention as a pesticide candidate. After reading the article, we found that the author used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Category: chlorides-buliding-blocks)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Category: chlorides-buliding-blocks Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Condon, Sylvie; Dupre, Daniel; Falgayrac, Gilles; Nedelec, Jean-Yves published an article on January 31 ,2002. The article was titled 《Nickel-catalyzed electrochemical arylation of activated olefins》, and you may find the article in European Journal of Organic Chemistry.Name: Ethyl 3-(4-chlorophenyl)propanoate The information in the text is summarized as follows:

Ni-catalyzed electrochem. conjugate additions of substituted aryl bromides to activated olefins under recently optimized reaction conditions are reported. Good to high yields were obtained, whatever the nature of substituents in the meta- and para-positions of the benzene ring. In the ortho-substituted series, yields were good with electron-donating substituents, but low with electron-withdrawing groups. The activation of aryl chlorides and the sequential functionalization of aryl dihalides were also studied. In the experimental materials used by the author, we found Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Name: Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: Ethyl 3-(4-chlorophenyl)propanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics