Tag: 200-300

In 1997,Australian Journal of Chemistry included an article by Deady, Leslie W.; Kaye, Anthony J.. Electric Literature of C15H10N2O2. The article was titled 《Fused tetracyclic quinoxalines from reactions of o-phenylenediamines in polyphosphoric acid》. The information in the text is summarized as follows:

The condensation of 2,3-diaminobenzoic acid, and the 5-chloro derivative with o-hydroxyphenylglyoxylic acid, isatin and benzothiophen-2,3-dione in polyphosphoric acid leads to the appropriate tetracycles, e.g., I. Isomeric products are formed from these unsym. diamines, and methods of assigning particular structures are described. The results came from multiple reactions, including the reaction of 3-Phenylquinoxaline-5-carboxylic acid(cas: 162135-93-5Electric Literature of C15H10N2O2)

3-Phenylquinoxaline-5-carboxylic acid(cas: 162135-93-5) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Electric Literature of C15H10N2O2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,European Journal of Organic Chemistry included an article by Cheng, Xinqiang; Shan, Jiankai; Tian, Xinshe; Ren, Yun-Lai; Zhu, Yanyan. Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Benzylation of Arenes with Benzyl Halides under Promoter-Free and Additive-Free Conditions》. The information in the text is summarized as follows:

It was found that benzyl chlorides and bromides could directly reacted with electron-rich arenes which provided an example of promoter-free and additive-free benzylation of arenes. A variety of benzyl chlorides and bromides were treated with benzene rings to give the targeted products in low to high yields. The present conditions tolerated the vinyl group of the substrates. Preliminary mechanistic investigation suggested that the present reactions possibly proceeded via an autocatalytic mechanism pathway. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《New compounds obtained by direct condensation of 2-halopyridines with benzo-1,2,3-triazole》 were Nantka-Namirski, Pawel; Kalinowski, Jerzy. And the article was published in Acta Poloniae Pharmaceutica in 1974. SDS of cas: 54453-94-0 The author mentioned the following in the article:

1-(2-Pyridyl)-1,2,3-benzotriazoles I (R = H, Me; R1 = H, NO2, CN, CO2H, CO2Et; R2 = H, Et, Me, NO2, NH2, CN, CO2H, CO2Et; R3 = H, NO2) were prepared in 33-84% yield by fusing 1,2,3-benzotriazole with the appropriately substituted 2-chloroor 2-bromopyridine at 140-80°. II and III were isolated as byproducts in the preparation of I (R = R1 = R3 = H, R2 = NO2). A detailed discussion of the NMR spectra was presented. The experimental process involved the reaction of Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0SDS of cas: 54453-94-0)

Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 54453-94-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Schiffler, Matthew A.; Antonysamy, Stephen; Bhattachar, Shobha N.; Campanale, Kristina M.; Chandrasekhar, Srinivasan; Condon, Bradley; Desai, Prashant V.; Fisher, Matthew J.; Groshong, Christopher; Harvey, Anita; Hickey, Michael J.; Hughes, Norman E.; Jones, Scott A.; Kim, Euibong J.; Kuklish, Steven L.; Luz, John G.; Norman, Bryan H.; Rathmell, Richard E.; Rizzo, John R.; Seng, Thomas W.; Thibodeaux, Stefan J.; Woods, Timothy A.; York, Jeremy S.; Yu, Xiao-Peng published an article on January 14 ,2016. The article was titled 《Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors》, and you may find the article in Journal of Medicinal Chemistry.Application In Synthesis of 5-Chloro-2-(trifluoromethyl)benzoic acid The information in the text is summarized as follows:

As part of a program aimed at the discovery of antinociceptive therapy for inflammatory conditions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 17.4 μM. Structural information was used to improve enzyme potency by over 1000-fold. Addition of an appropriate substituent alleviated time-dependent cytochrome P 450 3A4 (CYP3A4) inhibition. Further structure-activity relationship (SAR) studies led to 8, which had desirable potency (IC50 = 12 nM in an ex vivo human whole blood (HWB) assay) and absorption, distribution, metabolism, and excretion (ADME) properties. Studies on the formulation of 8 identified 8·H3PO4 as suitable for clin. development. Omission of a lipophilic portion of the compound led to 26, a readily orally bioavailable inhibitor with potency in HWB comparable to celecoxib. Furthermore, 26 was selective for mPGES-1 inhibition vs. other mechanisms in the prostanoid pathway. These factors led to the selection of 26 as a second clin. candidate. The results came from multiple reactions, including the reaction of 5-Chloro-2-(trifluoromethyl)benzoic acid(cas: 654-98-8Application In Synthesis of 5-Chloro-2-(trifluoromethyl)benzoic acid)

5-Chloro-2-(trifluoromethyl)benzoic acid(cas: 654-98-8) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Application In Synthesis of 5-Chloro-2-(trifluoromethyl)benzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1984,Journal of Medicinal Chemistry included an article by Meindl, Wolfgang R.; Von Angerer, Erwin; Schoenenberger, Helmut; Ruckdeschel, Gotthard. Formula: C8H10Cl3N. The article was titled 《Benzylamines: synthesis and evaluation of antimycobacterial properties》. The information in the text is summarized as follows:

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra were described. The most active compounds: I.HCl (MIC 10.2 μg/mL), II. HCl (MIC 10.2 μg/mL), and III.HCl (MIC 6.4 μg/mL), also had a marked inhibitory effect on M. marinum and M. lufu. The combination of II with aminosalicylic acid, streptomycin, or dapsone had marked supra-additive effects on M. tuberculosis H 37 Ra. In the experiment, the researchers used many compounds, for example, 1-(2,6-Dichlorophenyl)-N-methylmethanamine hydrochloride(cas: 90389-15-4Formula: C8H10Cl3N)

1-(2,6-Dichlorophenyl)-N-methylmethanamine hydrochloride(cas: 90389-15-4) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Formula: C8H10Cl3N

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hauke, Tobias J.; Hoefner, Georg; Wanner, Klaus T. published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4》.Quality Control of 4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde The author mentioned the following in the article:

The γ-aminobutyric acid (GABA) transporter mGAT4 represents a promising drug target for the treatment of epilepsy and other neurol. disorders; however, the lack of highly potent and selective inhibitors for mGAT4 still retards its pharmacol. elucidation. Herein, the generation and screening of pseudostatic combinatorial hydrazone libraries at the murine GABA transporter mGAT4 for the search of novel GABA uptake inhibitors is described. The hydrazone libraries contained more than 1100 compounds derived from nipecotic acid derivatives substituted at the 5-position instead, as common, at the 1-position of the core structure. Two hits were found and evaluated, which display potencies in the lower micromolar range at mGAT4 and its human equivalent hGAT3. These compounds possess a lipophilic moiety derived from a biphenyl residue attached to the 5-position of the hydrophilic nipecotic acid moiety via a three-atom spacer. Thus, the novel structures with potencies close to that of the bench mark mGAT4 inhibitor (S)-SNAP-5114 add new insights into the structure-activity relationship of mGAT4 inhibitors and could provide a promising starting point for the development of new mGAT4 inhibitors with even higher potencies. The experimental part of the paper was very detailed, including the reaction process of 4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde(cas: 139502-80-0Quality Control of 4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde)

4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde(cas: 139502-80-0) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Quality Control of 4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Alacid, Emilio; Najera, Carmen published an article in European Journal of Organic Chemistry. The title of the article was 《Acrolein diethyl acetal: a three-carbon homologating reagent for the synthesis of β-arylpropanoates and cinnamaldehydes by Heck reaction catalyzed by a Kaiser oxime resin derived palladacycle》.Electric Literature of C11H13ClO2 The author mentioned the following in the article:

A polymer palladacycle derived from Kaiser oxime resin was used as a source of palladium(0) in the chemoselective Heck reaction of acrolein di-Et acetal with aryl halides under ligand-free conditions. The use of typical Heck conditions afforded 3-arylpropionic esters, and the process can be directed to the synthesis of cinnamaldehydes under Cacchi conditions. These processes take place with rather low loading of the catalyst, which can be recovered by simple filtration and reused for at least five runs without competitive dehalogenation. This is the first time that a supported palladium complex has been reused under Cacchi conditions. ICP-OES analyses of the Pd content of the crude products in both transformations indicated lower leaching for the esters than for the aldehydes in the range up to 0.08 ppm for the esters and 0.8 ppm for the aldehydes. In the experiment, the researchers used Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Electric Literature of C11H13ClO2)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Electric Literature of C11H13ClO2 The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: Ethyl 3-(4-chlorophenyl)propanoateOn October 31, 2007 ,《Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-substituted phenyl alkyl triazole-based compounds as potential inhibitors of 17α-hydroxylase/17,20-lyase (P45017α)》 appeared in Letters in Drug Design & Discovery. The author of the article were Owen, Caroline P.; Dhanani, Sachin; Patel, Chirag H.; Ahmed, Sabbir. The article conveys some information:

We report the preliminary results into the synthesis and evaluation of triazole-based compounds against the components of 17α-hydroxylase/17,20-lyase (P 45017α), namely 17α-hydroxylase (17α-OHase) and 17,20-lyase (lyase). The results show that the compounds are weaker than ketoconazole but are good lead compounds in the search for inhibitors of P 45017α, in particular, lyase. In the experiment, the researchers used Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Name: Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Name: Ethyl 3-(4-chlorophenyl)propanoate Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocksOn June 9, 2022, Lesniak, Robert K.; Nichols, R. Jeremy; Schonemann, Marcus; Zhao, Jing; Gajera, Chandresh R.; Lam, Grace; Nguyen, Khanh C.; Langston, J. William; Smith, Mark; Montine, Thomas J. published an article in ACS Medicinal Chemistry Letters. The article was 《Discovery of 1H-Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors》. The article mentions the following:

G2019S (GS) is the most prevalent mutation in the leucine rich repeat protein kinase 2 gene (LRRK2), a genetic predisposition that is common for Parkinson’s disease, as well as for some forms of cancer, and is a shared risk allele for Crohn’s disease. GS-LRRK2 has a hyperactive kinase, and although numerous drug discovery programs have targeted LRRK2 kinase, few have reached clin. development. We report the discovery and preliminary development of an entirely novel structural class of potent and selective GS-LRRK2 kinase inhibitors: biaryl-1H-pyrazoles. After reading the article, we found that the author used 2-(4-Chloro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 627525-96-6Category: chlorides-buliding-blocks)

2-(4-Chloro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 627525-96-6) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Category: chlorides-buliding-blocks Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of Methyl 5-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylateOn June 1, 2008, Teng, Xin; Keys, Heather; Yuan, Junying; Degterev, Alexei; Cuny, Gregory D. published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors》. The article mentions the following:

Necroptosis is a regulated caspase-independent cell death pathway resulting in morphol. reminiscent of passive nonregulated necrosis. Several diverse structure classes of necroptosis inhibitors have been reported to date, including a series of [1,2,3]thiadiazole benzylamide derivatives However, initial evaluation of mouse liver microsome stability indicated that this series of compounds was rapidly degraded. A structure-activity relationship (SAR) study of the [1,2,3]thiadiazole benzylamide series revealed that increased mouse liver microsome stability and increased necroptosis inhibitory activity could be accomplished by replacement of the 4-cyclopropyl-[1,2,3]thiadiazole with a 5-cyano-1-methylpyrrole. In addition, the SAR and the cellular activity profiles, utilizing different cell types and necroptosis-inducing stimuli, of representative [1,2,3]thiadiazole and pyrrole derivatives were very similar suggesting that the two compound series inhibit necroptosis in the same manner. In the experiment, the researchers used many compounds, for example, Methyl 5-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate(cas: 306936-53-8Reference of Methyl 5-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate)

Methyl 5-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate(cas: 306936-53-8) belongs to pyrroles. Pyrroles are components of more complex macrocycles, including the porphyrinogens and products derived therefrom, including porphyrins of heme, the chlorins, bacteriochlorins, and chlorophylls. Porphobilinogen, a trisubstituted pyrrole, is the biosynthetic precursor to many natural products such as heme.Reference of Methyl 5-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics