Tag: 200-300

Kamala, L.; Kumar, B. Sathish; Lakshmi, P. V. Anantha published their research in Russian Journal of Bioorganic Chemistry in 2021. The article was titled 《Synthesis and Docking Studies of Novel Carbazole-Thiazolidinedione Hybrid Derivatives as Antibacterial Agents》.Name: 1-(Bromomethyl)-4-chlorobenzene The article contains the following contents:

A series of novel carbazole-thiazolidinedione hybrids I (R = Ph, 4-O2NC6H4, 2,4-Cl2C6H3, etc.) was designed, synthesized and screened for antimicrobial activity against Gram-pos. and Gram-neg. bacterial species. All the novel compounds were characterized by 1H, 13C NMR, IR and mass spectral anal. data. The results of antibacterial study indicated that compounds I (R = 2-O2NC6H4, 2-BrC6H4) showed appreciable antibacterial activity. Furthermore, mol. docking of selected compounds was performed to study the interaction between active compound and binding site. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sankar, Rathinam; Bhattacharya, Debabrata; Arulananda Babu, Srinivasarao published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Synthesis of 1-Naphthol-based Unsymmetrical Triarylmethanes: Heck-type Desulfitative Reaction of Arylsulfonyl Chlorides with Tetralone-derived Chalcones》.Name: 4-Chlorobenzenesulfonyl chloride The article contains the following contents:

Synthesis of 1-naphthol-based unsym. triarylmethanes via the Pd-catalyzed Heck-type desulfitative reaction and conjugate addition of arylsulfonyl chlorides with tetralone-derived chalcones was reported. Unsym. triarylmethanes were valuable mols. in organic-, medicinal and materials chem. Contributed towards enriching the library of unsym. triarylmethanes. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Name: 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Name: 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zotova, S. A.; Gololobova, T. M.; Stolyarchuk, A. A.; Stepanyuk, G. I.; Bobruk, V. P.; Ivanova, N. I.; Mostovaya, N. I. published an article on January 31 ,1988. The article was titled 《Synthesis and pharmacological activity of 2-aryl-3-carbethoxy-5-oxybenzofuran derivatives》, and you may find the article in Khimiko-Farmatsevticheskii Zhurnal.Electric Literature of C8H6Cl2O3 The information in the text is summarized as follows:

A series of 9 title derivatives (I, R1 = H, OMe, Br, Cl, I; R2 = H, CH2NMe2; R3 = H, OMe, Br, Cl, I) was prepared by condensation of substituted 5-methoxybenzoylacetic Et esters with p-benzoquinone and subsequent reaction with Me2NH. Acute toxicity and cardiotropic and neurotropic effects of I were tested in mice and isolated rabbit intestine. I had a hypotonic effect on intestinal smooth muscles and some increased coronary circulation. However, their activities were inferior to those of the related known drugs fenikaberan and cordarone. After reading the article, we found that the author used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Electric Literature of C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Electric Literature of C8H6Cl2O3 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ma, Menglin; Xiang, Feng; Xin, Ying; Wang, Yuliang; Chen, Shuhua published their research in Sichuan Daxue Xuebao, Ziran Kexueban on February 29 ,2004. The article was titled 《Studies on synthesis of halogenated hydroxyl diphenyl ethers》.Reference of 2-Amino-2,4-dichlorodiphenyl ether The article contains the following contents:

Hydroxydiphenyl ethers were synthesized from halogenated phenol and dinitrochlorobenzene via modified Williamson etherification, reduction and diazotization. The modified Williamson etherification was performed by melting in a solvent free system to prepare substituted nitro-diphenyl ethers. The process for hydrolyzation of diazonium salt was improved by adjusting the acidity of the reaction. In the experiment, the researchers used many compounds, for example, 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Reference of 2-Amino-2,4-dichlorodiphenyl ether)

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Reference of 2-Amino-2,4-dichlorodiphenyl ether

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Huang, Horng-Chih; Li, James J.; Garland, Danny J.; Chamberlain, Timothy S.; Reinhard, Emily J.; Manning, Robert E.; Seibert, Karen; Koboldt, Carol M.; Gregory, Susan A. published an article on January 5 ,1996. The article was titled 《Diarylspiro[2.4]heptenes as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors: Synthesis and Structure-Activity Relationships》, and you may find the article in Journal of Medicinal Chemistry.Formula: C8H6Cl2O3 The information in the text is summarized as follows:

A novel series of 5,6-diarylspiro[2.4]hept-5-enes was shown to provide highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. A study of structure-activity relationships in this series suggests that 3,4-disubstituted Ph analogs are generally more selective than 4-substituted Ph analogs and that replacement of the Me sulfone group on the 6-Ph ring with a sulfonamide moiety results in compounds with superior in vivo pharmacol. properties, although with lower COX-2 selectivity. Several compounds have been shown to possess promising pharmacol. properties in adjuvant-induced arthritis and edema analgesia models. The absence of gastrointestinal (GI) toxicity at 200 mpk of several selected compounds in rats and mice corresponds well with the weak potency for inhibition of COX-1 observed in the enzyme assay. Thus, 5-(3,5-dichloro-4-methoxyphenyl)-6-[4-(methylsulfonyl)phenyl]spiro[2.4]hept-5-ene was shown to have superior in vivo pharmacol. profiles, low GI toxicity, and good oral bioavailability and duration of action. In the experiment, the researchers used many compounds, for example, 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Formula: C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C8H6Cl2O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《CuO-NiO bimetallic nanoparticles supported on graphitic carbon nitride with enhanced catalytic performance for the synthesis of 1,2,3-triazoles, bis-1,2,3-triazoles, and tetrazoles in parts per million level》 was written by Gajurel, Sushmita; Dam, Binoyargha; Bhushan, Mayank; Singh, L. Robindro; Pal, Amarta Kumar. Product Details of 622-95-7This research focused ontriazole preparation green chem; arylboronic acid arylacetylene heterocyclization copper nickel dioxide nanocatalyst; benzylhalide arylacetylene heterocyclization copper nickel dioxide nanocatalyst; epoxide phenyl acetylene heterocyclization copper nickel dioxide nanocatalyst; bistriazolyl methane preparation green chem; diazidomethyl methoxybenzene alkyne heterocyclization copper nickel dioxide nanocatalyst; tetrazole preparation green chem; aromatic nitrile heterocyclization copper nickel dioxide nano catalyst. The article conveys some information:

The unification of CuCl2 ·2H2O and NiCl2·6H2O with the support of graphitic carbon nitride yielded to form an efficient, synergistic, bimetallic nano-catalyst CuO-NiO@g-C3N4. Catalyst with three different molar ratios of Cu and Ni, i.e., Cu75Ni25 (Cu:Ni = 3:1; catalyst-a), Cu50Ni50 (Cu:Ni = 1:1; catalyst-b), and Ni66Cu33 (Ni:Cu = 2:1; catalyst-c), was synthesized, and their catalytic activity was examined The synergistic interaction of one metal with the other on the surface of extremely stable graphitic carbon nitride has enhanced the catalytic performance in the synthesis of triazoles I (R1 = Ph, (4-bromophenyl)methyl, 2-hydroxy-1-phenylethyl, etc.; R2 = H, 4-F, 3-Me, 4-Me, 4-OMe), tetrazoles II (R3 = Ph, pyrazin-2-yl, 4-formylphenyl, etc.), and bis-triazole derivatives III to such a distinguished level (in ppm level), which a monometal fail to possess. The aforementioned statement has been supported by the catalytic activity data provided for both the monometallic and bimetallic catalyst herein. In addition to this, benign reaction conditions, in situ generation of azides, wide reaction scopes, and reusability of the catalyst were also the major advantages leading toward safe and sustainable chem. beyond doubt. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Product Details of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Product Details of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Condensed Thiophenes and Selenophenes: Thionyl Chloride and Selenium Oxychloride as Sulfur and Selenium Transfer Reagents》 was written by Amaresh, Ramiya R.; Lakshmikantham, M. V.; Baldwin, Jeffrey W.; Cava, Michael. P.; Metzger, Robert M.; Rogers, Robin D.. HPLC of Formula: 425394-71-4 And the article was included in Journal of Organic Chemistry on April 19 ,2002. The article conveys some information:

3,4-Bis(cyanomethyl) substituted thiophenes reacted with thionyl chloride in the presence of base to give dicyano substituted thieno[3,4-c]thiophenes. The use of selenium oxychloride furnished the corresponding cyano substituted seleno[3,4-c]thiophene. 1,2-Phenylenediacetonitriles gave the corresponding cyano substituted benzo[c]thiophenes and benzo[c]selenenophenes, resp., upon reaction with thionyl chloride and selenium oxychloride in the presence of base. In the experimental materials used by the author, we found 1-Bromo-4-chloro-2,3-dimethylbenzene(cas: 425394-71-4HPLC of Formula: 425394-71-4)

1-Bromo-4-chloro-2,3-dimethylbenzene(cas: 425394-71-4) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. HPLC of Formula: 425394-71-4 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of C7H6BrClIn 2021 ,《Syntheses and Crystal Structures of Benzyl Substituted Thiazolidin-2-cyanamide Derivatives》 was published in Journal of Chemical Crystallography. The article was written by Wang, Jun-Ling; Ma, Sen; Jia, Ai-Quan; Zhang, Qian-Feng. The article contains the following contents:

Reaction of thiazolidin-2-cyanamide and substituted benzyl bromide compounds 2-R-3-R1-4-R2C6H2CH2Br (R = Me, H, CN, Br; R1 = H, Me, CN, F; R2 = H, Me, CN, F, Cl, t-Bu) in acetonitrile at room temperature afforded the 3-(2′-substituted benzyl)thiazolidin-2-cyanamide derivatives I in good yields. Compounds I were characterized by proton NMR (1H NMR) and IR spectroscopies, of which the structures of the isomeric o-, m-, and p-fluoro derivatives I (R = F, R1 = H, R2 = H; R = H, R1 = F, R2 = H; R = H, R1 = H, R2 = F) were established by single crystal X-ray crystallog. Compound I (R = F, R1 = H, R2 = H) crystallizes in the monoclinic space group P21/n, with a = 9.177(19), b = 8.551(18), c = 14.090(3) Å, β = 98.243(3)°, and Z = 4. The unit cell of I (R = H, R1 = F, R2 = H) has a monoclinic P21/c symmetry with the cell parameters a = 9.289(2), b = 14.057(4), c = 8.574(2) Å, β = 100.350(3)°, and Z = 4. The unit cell of I (R2 = FR = H, R1 = H, R2 = F) also has a monoclinic P21/c symmetry with the cell parameters a = 9.333(4), b = 14.034(5), c = 8.508(3) Å, β = 99.15(5)°, and Z = 4. A series of 3-(2′-substituted benzyl)thiazolidin-2-cyanamide derivatives I was efficiently synthesized via the reaction of benzyl bromide compounds with thiazolidin-2-cyanamide, of which the structures of the isomeric o-, m-, and p-fluoro derivatives were characterized by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Electric Literature of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Electric Literature of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Jannapu Reddy, Raju; Waheed, Md.; Haritha Kumari, Arram; Rama Krishna, Gamidi published an article in Advanced Synthesis & Catalysis. The title of the article was 《Interrupted CuAAC-Thiolation for the Construction of 1,2,3-Triazole-Fused Eight-Membered Heterocycles from O-/N-Propargyl derived Benzyl Thiosulfonates with Organic Azides》.COA of Formula: C7H6BrCl The author mentioned the following in the article:

A copper(I)-catalyzed interrupted click-sulfenylation of O-/N-propargyl benzyl thiosulfonates with organic azides has been disclosed. The unified CuAAC-thiolation provides a wide range of triazole-fused eight-membered heterocycles in good to high (51-94%) yields under mild reaction conditions. Moreover, a three-component reaction is also achieved involving O-/N-propargyl benzyl thiosulfonates, benzyl bromide, and sodium azide to deliver fused-triazoles in 61-74% yields. From a synthetic point of view, the present protocol has been demonstrated at gram-scale reactions. A plausible mechanism is also proposed based on exptl. results and control experiments In the experiment, the researchers used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Liyu; Yin, Wenbo; Sun, Yin; Sun, Nannan; Tian, Linfeng; Zheng, Yang; Zhang, Chu; Zhao, Shizhen; Su, Xin; Zhao, Dongmei; Cheng, Maosheng published an article in 2021. The article was titled 《Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives》, and you may find the article in European Journal of Medicinal Chemistry.SDS of cas: 622-95-7 The information in the text is summarized as follows:

L-Amino alc. derivatives exhibited high antifungal activity, but the metabolic stability of human liver microsomes in vitro was poor, and the half-life of optimal compound 5 was less than 5 min. To improve the metabolic properties of the compounds, the scaffold hopping strategy was adopted and a series of antifungal compounds with a dihydrooxazole scaffold was designed and synthesized. Compounds substituted with 4-Ph group on dihydrooxazole ring exhibited excellent antifungal activities against C. albicans, C. tropicalis and C. krusei, with MIC values in the range of 0.03-0.25μg/mL. In addition, the metabolic stability of compounds A33 and A34 (I and II, resp.) in human liver microsomes in vitro was improved significantly, with the half-life greater than 145 min and the half-life of 59.1 min, resp. Moreover, pharmacokinetic studies in SD rats showed that A33 exhibited favorable pharmacokinetic properties, with a bioavailability of 77.69%, and half-life (i.v. administration) of 9.35 h, indicating that A33 is worthy of further study. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7SDS of cas: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.SDS of cas: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics