Tag: 200-300

Joolakanti, Hima Bindhu; Battu, Satyanarayana; Kamepalli, Ramanjaneyulu; Kolanupaka, Harichandana Reddy; Bobbili, Hasika Reddy published their research in Chemical Data Collections in 2021. The article was titled 《Synthesis, docking and biological activities of novel chromone linked [1,2,3]-triazole derivatives》.Synthetic Route of C7H6BrCl The article contains the following contents:

A series of chromone linked [1,2,3]triazoles I [R = C6H5, 3-MeC6H4, 3-ClC6H4, etc.] were designed based on literature followed by in-silico studies. The in-silico studies indicated good docking score for compounds I when docked into the Human Estrogen Receptor Alpha Ligand-Binding Domain (PDB ID: 1XP6). So compounds I were synthesized, characterized and evaluated for cytotoxicity, antibacterial and antioxidant activities. The compounds I [R = C6H5, 4-ClC6H4] showed promising cytotoxicity with IC50 value of 18.61 and 20.39μg/mL resp. The Compounds I [R = 2-FC6H4, 3-FC6H4, 4-ClC6H4, 2-MeC6H4, 2,4-di-ClC6H3] showed encouraging antioxidant activity with IC50 value of < 30μM i.e. DPPH scavenging activity levels more than that of pos. control, whereas compounds I [R = C6H5, 3-FC6H4, 3-ClC6H4, 4-ClC6H4, 3-MeC6H4, 2,4-di-ClC6H3] exhibited moderate antibacterial activities with the MIC value of <240μM. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Synthetic Route of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Synthetic Route of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Asian Journal of Organic Chemistry included an article by Tang, Jia-Kang; Yu, Shang-Bo; Liu, Chuan-Zhi; Wang, Hui; Zhang, Dan-Wei; Li, Zhan-Ting. Computed Properties of C7H6BrCl. The article was titled 《A Highly Stable Porous Viologen Polymer for the Catalysis of Debromination Coupling of Benzyl Bromides with High Recyclability》. The information in the text is summarized as follows:

A highly stable porous organic polymer bipy-POP has been prepared from the reaction of 4,4′-bipyridine and tetrakis(4-(bromomethyl)phenyl)methane in N-methylpyrrolidone at 110°. Bipy-POP exhibited high efficiency in catalyzing the reductive debromination of a variety of benzyl bromides in N,N-dimethylformamide with dithionite as reductive reagent. For substrates that bear electron-donating group(s) on the benzene ring, the reactions selectively afforded dibenzyl sulfone derivatives Generally, substrates that bear an electron-withdrawing group on the benzene ring gave rise to coupling products ethane derivatives As exceptions, F, Cl or CF3-contained substrates were found to selectively produce sulfone derivatives The recyclability of bipy-POP for the catalysis of the reaction of (4-fluorophenyl)methyl bromide and diphenylmethyl bromide, which afforded the corresponding sulfone or ethane derivative, revealed that, after 40 times of repeated use, the heterogeneous catalysis did not exhibit important decrease of the activity. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Computed Properties of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Computed Properties of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 56966-48-4On May 4, 1984 ,《The Halogen-activated Smiles rearrangement. 2》 appeared in Journal of Organic Chemistry. The author of the article were Schmidt, Diane M.; Bonvicino, Guido E.. The article conveys some information:

The cyclization of diaryl ethers I (R = H, R1 = Cl; R = Cl, R1 = H) with K2CO3/DMF gave phenoxazines II via the Smiles-rearranged intermediates III. III, isolated as the betaines, were cyclized to II. In the part of experimental materials, we found many familiar compounds, such as 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Application of 56966-48-4)

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Application of 56966-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: 37908-97-7On October 8, 2020 ,《Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity》 was published in ACS Medicinal Chemistry Letters. The article was written by Uda, Junichiro; Kobashi, Seiichi; Miyata, Sachiho; Ashizawa, Naoki; Matsumoto, Koji; Iwanaga, Takashi. The article contains the following contents:

To derive new uricosuric agents, novel phenol derivatives were synthesized to overcome the disadvantages of benzbromarone (BBR), attributed by its structural features. Herein, we report the discovery of new phenol derivatives with a 1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole scaffold. The selected compound 11 (dotinurad, 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole, FYU-981, [1285572-51-1]) demonstrated remarkable inhibitory activity on uric acid uptake by primary human renal proximal tubule epithelial cells (RPTECs) and URAT1-mediated uric acid transport, with weak inhibitory activity against mitochondrial respiration. Dotinurad also displayed favorable pharmacokinetic profiles and higher potency in decreasing uric acid than BBR did in Cebus monkeys. Dotinurad has been approved as a new uricosuric medicine in Japan. Our strategy, which focuses on the structural features resulting in unfavorable effects, could be applied to the future developments of other drugs with disadvantages, particularly those having a bis-aryl ketone structure.3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7HPLC of Formula: 37908-97-7) was used in this study.

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. HPLC of Formula: 37908-97-7 The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Imidazo-Fused Isoindoles by Pd(II)/Ag(I)-Promoted Intramolecular Dehydrogenative Coupling》 was written by Lessi, Marco; Lucci, Antonio; Cuzzola, Angela; Bellina, Fabio. HPLC of Formula: 622-95-7 And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

An effective Pd(II)/Ag(I)-promoted intramol. cross-dehydrogenative coupling (CDC) of substituted 1-benzylimidazoles under air provides, for the first time, a simple access to several functionalized imidazo[2,1-a]isoindoles, an interesting class of polycyclic heteroaromatic compounds The direct involvement of two unactivated carbon-hydrogen bonds, without any directing group, grants an elevated atom economy of the whole process. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7HPLC of Formula: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.HPLC of Formula: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Li, Lu-Lu; Ding, Du; Song, Jin; Han, Zhi-Yong; Gong, Liu-Zhu. Product Details of 622-95-7. The article was titled 《Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions》. The information in the text is summarized as follows:

A general strategy for the design of asym. cascade reactions using readily available halides and carbon monoxide (CO) as substrates is developed. The key is the catalytic generation of C1-ammonium enolates for the subsequent asym. cascade reactions through the combination of palladium-catalyzed carbonylation and chiral Lewis base catalysis. Utilizing this strategy, we have established asym. formal [1+1+4] and [1+1+2] reactions to afford chiral dihydropyridones and β-lactams with high yields and high enantio- and diastereoselectivities. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Product Details of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Product Details of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Verhagen, Frank J. M.; Van Assema, Friso B. J.; Boekema, Bouke K. H. L.; Swarts, Henk J.; Wijnberg, Joannes B. P. A.; Field, Jim A. published an article on January 15 ,1998. The article was titled 《Dynamics of organohalogen production by the ecologically important fungus Hypholoma fasciculare》, and you may find the article in FEMS Microbiology Letters.Reference of 3,5-Dichloro-4-methoxybenzoic acid The information in the text is summarized as follows:

The ecol. important white rot basidiomycete Hypholoma fasciculare was previously shown to produce large amounts of adsorbable organic halogens (AOX). The purposes of this study were to identify the time period of AOX production in relation to the primary and secondary metabolic phases of the growth cycle of the fungus, to determine the maximal specific AOX production rates and final AOX yields on the different substrates and to account for the measured AOX in identifiable compounds The AOX production was observed to take place during the transition between the primary and secondary metabolic phases of the growth cycle of the fungus. The maximum AOX production rates ranged from 0.63 to 3.23 mg AOX per g of dry mycelium per day and the final AOX yields ranged from 0.88 and 1.50 percent of dry weight of mycelium on five different substrates including natural woody substrates. The AOX produced by the fungus was stable in all five substrates, even after prolonged incubation periods. However, the composition of the AOX changed drastically. Initially most of the AOX was accounted for by the compound 3,5-dichloro-p-anisyl alc.; however, after prolonged incubation this compound was largely converted into 3,5-dichloro-p-anisic acid in N-rich medium and into unidentified organohalogens in N-limited medium. The experimental process involved the reaction of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Reference of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Reference of 3,5-Dichloro-4-methoxybenzoic acid Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 3,5-Dichloro-4-methoxybenzoic acidOn November 30, 1999 ,《Reduction of aryl acids by white-rot fungi for the biocatalytic production of aryl aldehydes and alcohols》 appeared in Applied Microbiology and Biotechnology. The author of the article were Hage, A.; Schoemaker, H. E.; Field, J. A.. The article conveys some information:

Ligninolytic basidiomycetes were screened for their ability to reduce aryl acids to the corresponding aldehydes and alcs. Seven fungal strains converted p-anisic acid in high molar yields to the reduced products. The white-rot fungus Bjerkandera sp. strain BOS55 was one of the best reducing strains and was highly tolerant towards high concentrations of different aromatic acids. It was tested for the reduction of p-anisic, veratric, 3-chloro-4-methoxybenzoic, 3,5-dichloro-4-methoxybenzoic, 3,4-dichlorobenzoic, 4-fluorobenzoic, and 3-nitrobenzoic acids. All of these compounds were reduced to their corresponding aldehydes and alcs. In the experiment, the researchers used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Recommanded Product: 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Recommanded Product: 3,5-Dichloro-4-methoxybenzoic acid Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Cs2CO3-Mediated Vicinal Thiosulfonylation of 1,1-Dibromo-1-Alkenes with Thiosulfonates: An Expedient Synthesis of (E)-1,2-Thiosulfonylethenes》 was written by Reddy, Raju Jannapu; Kumari, Arram Haritha; Kumar, Jangam Jagadesh; Nanubolu, Jagadeesh Babu. Application of 98-60-2This research focused onthiosulfonylethene preparation diastereoselective; dibromoalkene thiosulfonate vicinal thiosulfonylation. The article conveys some information:

A new and highly efficient vicinal thiosulfonylation of 1,1-dibromo-1-alkenes ArCH=CBr2 (Ar = 3,4-dimethoxyphenyl, naphth-1-yl, furan-2-yl, etc.) with thiosulfonates R1S(O)2SR2 (R1 = Ph, 4-methylphenyl, naphth-2-yl, 4-chlorophenyl; R2 = Ph, 4-methylphenyl, naphth-2-yl, 4-chlorophenyl) in the presence of cesium carbonate has been developed. The metal-free diheterofunctionalization is operationally simple to access a wide range of (E)-1,2-thiosulfonylethenes (α-aryl-β-thioarylvinyl sulfones) ArC(S(O)2R1)=CHSR2 in moderate to high yields with high levels of stereoselectivities. Further, scalable reactions have been demonstrated for this transformation, thus illustrating its efficiency and practicality. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Application of 98-60-2 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of 4-Chlorobenzenesulfonyl chlorideIn 2021 ,《Structure based design, synthesis and evaluation of new thienopyrimidine derivatives as anti-bacterial agents》 was published in Journal of Molecular Structure. The article was written by Malasala, Satyaveni; Polomoni, Anusha; Ahmad, Naiyaz Md.; Shukla, Manjulika; Kaul, Grace; Dasgupta, Arunav; Chopra, Sidharth; Nanduri, Srinivas. The article contains the following contents:

A number of TrmD inhibitors including thienopyrimidines and fused thienopyrimidines were reported as potent antibacterial and anti-mycobacterial agents. A library of ∼200 structurally diverse thienopyrimidines were designed and subjected to preliminary in-silico studies. Among the library of compounds, 22 thienopyrimidines and fused thienopyrimidines compounds I [R = Ph,2-MeC6H4, 2,4-di-ClC6H3, etc.] II and III [R2 = benzyl, 3-nitrobenzyl, 2-(1H-indol-3-ylsulfanyl)acetyl, etc.] were selected, synthesized and were evaluated for their inhibitory activities against a panel of pathogens consisting E. coli, S. aureus, K. pneuminiae, A. baumannii and P. aeruginosa and M. tuberculosis (ATCC 27294). Among the tested compounds, II [R = 2-ClC6H4] III [R2 = benzyl, 3-nitrobenzyl, (2,4-dichlorophenyl)methyl, 2-oxo-2-(p-tolyl)ethyl, 2-(2-naphthyl)-2-oxo-ethyl] were found to inhibit M. tuberculosis (ATCC 27294) with the MIC of 16-32μg/mL. The compounds III [R2 = 3-nitrobenzyl, 2-(1H-indol-3-ylsulfanyl)acetyl] were found to be selective against S. aureus with the MIC of 4μg/mL and moderate activity against M. tuberculosis. The selected compounds were further subjected to docking, 3D-QSAR and ADMET studies to understand the mechanism of action and also their physico chem. profile. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Quality Control of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Quality Control of 4-Chlorobenzenesulfonyl chloride Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics