Tag: 200-300

In 2022,Yuan, Ye; Guo, Dou; Liu, Yibo; Wan, Congcong; Lu, Dongbiao; Yang, Hongxiang; Lu, Yufan; Meng, Wei; Wang, Hongling; Zhang, Xiang published an article in European Journal of Organic Chemistry. The title of the article was 《Iron(III)-Mediated Nucleophilic Halogenation of Phenols Using an Amido Directing Group》.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride The author mentioned the following in the article:

A regioselective and nucleophilic halogenation of electron-rich amidophenols was realized in the presence of Fe(III) reagents and amido-directing groups. Halides could be sequentially introduced to specific positions to form mono-, di- and mixed di- halogenated amidophenols I [R = 3-NHC(O)Ph, 2-NHC(O)Ph, 2-NHC(O)Cy, etc.; X = 4-Cl, 4-Br, 2-Br-4-Cl, etc.] using using ferric chloride/bromide . Furthermore, this protocol provided new methods for the syntheses of IKK2 inhibitor (IMD-0354), muscle relaxant (Chlorzoxazone) and related derivatives The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Kumar N, Manoj; Nukala, Satheesh Kumar; Swamy T, Narasimha; M, Ravinder; Krishna, Thupurani Murali; Narsimha, Sirassu published an article in Journal of Molecular Structure. The title of the article was 《Benzothiazole-[1,2,3]triazolo[5,1-a]isoindoles: Synthesis, anticancer activity, bioavailability and in silico studies against Gama-Tubulin protein》.Synthetic Route of C7H6BrCl The author mentioned the following in the article:

The CuI catalyzed synthesis of some novel fused benzothiazole-1,2,3-triazole hybrids I (R = H, 5-Me, 4,6-dichloro, 4,5,6-trimethoxy, etc.) in one-pot was reported . The in vitro anticancer activity of these compounds revealed that the compounds I (R = 5-Cl (II), 5-F (III), 5-nitro (IV), 4,5,6-trimethoxy (V), 4,6-dimethoxy (VI)) showed superior activity against human cancer cell lines like MCF-7, A-549, DU-145 and HeLa than the standard Etoposide. Remarkably, the in vitro tubulin polymerization inhibitory assay of compounds (II), (III), (IV), (V) and (VI) revealed that the compounds (III) and (IV) showed superior activity than the standard CA-4, while the compounds (II), (V) and (VI) were shown comparable activity with the CA-4. Besides, the results of in vitro and in silico ADME studies of most potent compounds (III), (V), (VI), (III) and (IV) were supported the corresponding in vitro anticancer activity data. Finally, the mol. docking studies of compounds I on human γ-tubulin receptor suggested that the most potent compounds (III), (V), (VI), (II) and (IV) strongly bind to the protein and energy calculations were in good agreement with the corresponding IC50 values. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Synthetic Route of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Synthetic Route of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Enhanced performance of organic/inorganic hybrid nanomaterials bearing impregnated [PdL2] complexes as counter-electrode catalyst for dye-sensitized solar cells》 were Dayan, Serkan; Oezdemir, Namik; Oezpozan, Nilguen Kalaycioglu. And the article was published in Applied Organometallic Chemistry in 2019. Category: chlorides-buliding-blocks The author mentioned the following in the article:

N-coordinate Pd2+ complexes [PdL2] (L: N-N-quinoline-8-yl-R-benzenesulfonamides) (6-10) and [PdL2] complexes assembled on multi-wall carbon nanotubes (MWCNTs) hybrid nanomaterials were fabricated and characterized by various techniques. The [PdL2] impregnated MWCNTs materials (11-15) were applied as a counter electrode (CE) catalyst for triiodide to iodide reduction reaction in the dye-sensitized solar cells (DSSC) and investigated electro-catalytic activities. The MWCNTs-supported [PdL2] CEs (11-15) are exhibits as Pt-free CE with good power conversion efficiencies (PCEs), and compared to platinum and bare MWCNTs CEs and the PCE of bare MWCNTs was clearly improved by means of [PdL2] complexes (6-10). The DSSCs based on the hybrid counter electrodes (CEs) (11-15) and bare MWCNTs are indicated a relative efficiency (ƞrel) of 64.27%, 54.07%, 53.75%, 51.52% 44.82% and 27.27% concerning a Pt CE control device set at 100%. The report emphasizes that [PdL2] impregnated MWCNTs type counter electrodes (CEs) (11-15) are promising as effectively catalyst in working device design, particularly taking into account the eco-friendly approach of the hybrids. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Category: chlorides-buliding-blocks)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of Sodium 2,6-dichlorobenzoateOn May 1, 2013 ,《Quantitative correlation between counterion (X) affinity to cationic micelles and X-induced micellar growth for X = 2,4-; 2,5-; 2,6- and 3,4-dichlorobenzoate ions》 appeared in Journal of Oleo Science. The author of the article were Yusof, Nor Saadah M.; Razak, Norazizah A.; Khan, M. Niyaz. The article conveys some information:

A semi empirical kinetic (SEK) method has been used to determine the ratio of cetyltrimethylammonium bromide (CTABr) micellar binding constants of counterion X- and Br- (a reference counterion), i.e. KX/KBr (=RXBr). The values of KX and KBr have been derived from the kinetic parameters obtained in the presence spherical/non-spherical and spherical micelles, resp. This rather new method gives the resp. mean values of RXBr as 45 ± 2, 25 ± 3, 4.7 ± 0.6 and 119 ± 10 for X = 2,4-, 2,5-, 2,6- and 3,4-Cl2C6H3CO2- (Cl2Bz’Na). Literature lacks the report on the values of RXBr for all X except for X = 2,6-Cl2C6H3CO2- (2,6-Cl2Bz’-) for which the reported value is 5.0. Rheol. properties, such as shear thinning behavior, reveal indirectly the presence of wormlike micelles (WM) in the CTABr micellar solutions containing MX for all X except X = 2,6-Cl2Bz’-. The micelles remain spherical within [2,6-Cl2Bz’-] range 0.01 – 0.34 M at 0.015 M CTABr. The maxima of the plots of zero shear viscosity, η0, (obtained from the initial plateau region of flow curves, i.e. η vs. γ̇ curve) vs. [MX] (MX = 2,4-, 2,5- and 3,4-Cl2Bz’Na) at 0.015 M CTABr also support indirectly the presence of linear, entangled and branched WM. After reading the article, we found that the author used Sodium 2,6-dichlorobenzoate(cas: 10007-84-8Safety of Sodium 2,6-dichlorobenzoate)

Sodium 2,6-dichlorobenzoate(cas: 10007-84-8) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of Sodium 2,6-dichlorobenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Visible-light Driven Hydrolysis of Benzyl Halides with Water for Preparation of Benzyl Alcohols》 was written by Xu, Jianbin; Liu, Na; Zou, Lingling; Cheng, Feixiang; Shen, Xianfu; Liu, Teng; Lv, Haiping; Khan, Ruhima; Fan, Baomin. Application of 622-95-7This research focused onwater benzyl halide rhodamine B catalyst photochem hydrolysis; benzyl alc preparation. The article conveys some information:

Visible-light-mediated hydrolysis of benzyl halides were achieved that was efficiently catalyzed by metal-free catalyst rhodamine B. Benzyl bromides and chlorides were smoothly reacted with water to prepare a series of benzyl alc. compounds in good yields. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Application of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Approach to the Synthesis of Unsymmetrical/Symmetrical Maleimides via Desulfitative Arylation at Different Temperatures》 was written by Abbasnia, Masoumeh; Sheykhan, Mehdi; Ghaffari, Tahereh; Safari, Elham. SDS of cas: 98-60-2This research focused onunsym maleimide variable temperature synthesis desulfitative arylation; sym maleimide variable temperature synthesis desulfitative arylation. The article conveys some information:

New routes toward selective synthesis of both mono- and diaryl maleimides have been innovated. The mere requirement to this end is through the increase of temperature The method works effectively for maleic anhydride and maleic acid as well. Also, the first expedient synthesis of 2-arylnaphthoquinones via the reaction of naphthoquinone with arenesulfonyl chlorides is revealed. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2SDS of cas: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 98-60-2In 2019 ,《TBAI-catalyzed selective synthesis of sulfonamides and β-aryl sulfonyl enamines: coupling of arenesulfonyl chlorides and sodium sulfinates with tert-amines》 was published in Organic & Biomolecular Chemistry. The article was written by Jiang, Hongmei; Tang, Xiaoyue; Xu, Zhihui; Wang, Huixian; Han, Kang; Yang, Xiaolan; Zhou, Yuanyuan; Feng, Yong-Lai; Yu, Xian-Yong; Gui, Qingwen. The article contains the following contents:

A simple, practical and metal-free method has been developed for the synthesis of sulfonamides RS(O)2N(R1)R2 (R = Ph, pyridin-3-yl, naphthalen-1-yl, 4-methoxyphenyl, etc.; R1 = Et, n-Pr, Me, benzyl; R2 = Et, Ph, benzyl, n-Pr; R1R2 = -(CH2)4-, -(CH2)5-, -(CH2)2O(CH2)2-) and β-arylsulfonyl enamines (E)-ArS(O)2CH=CHN(R3)R4 [Ar = Ph, thiophen-2-yl, naphthalen-2-yl, etc.; R3 = Et, Ph, i-Pr; R4 = Et, i-Pr] via the selective cleavage of C-N and C-H bonds through the iodine-catalyzed oxidation of arenesulfonyl chlorides RS(O)2Cl and sodium sulfinates ArS(O)2Na with tert-amines N(R1)(R2)R3 (R3 = H, Et, Me, Bn). The method uses com. available inexpensive catalysts and oxidants, and has a wide substrate scope and operational simplicity.4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application of 98-60-2) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Application of 98-60-2 The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors》 were Abdel-Maksoud, Mohammed S.; Ammar, Usama M.; El-Gamal, Mohammed I.; Gamal El-Din, Mahmoud M.; Mersal, Karim I.; Ali, Eslam M. H.; Yoo, Kyung Ho; Lee, Kyung-Tae; Oh, Chang-Hyun. And the article was published in Bioorganic Chemistry in 2019. Application of 98-60-2 The author mentioned the following in the article:

A novel series of B-RAF kinase inhibitors having imidazo[2,1-b]oxazole scaffold I [R = H, F; n = 1, 2; Ar = 4-methylphenyl, naphthalen-1-yl, 4-(trifluoromethyl)phenyl, etc.] was designed and synthesized based on the structures of the well-known B-RAF inhibitors. The twenty two final compounds I were tested over A375 and SKMEL28 cell lines to determine the primary cytotoxic activity of these compounds and their activities were compared with that of sorafenib as a standard Compounds I [R = H, n = 1, Ar = 4-chlorophenyl; R = H, n = 2, Ar = 4-(trifluoromethyl)phenyl; R = F, n = 2, Ar = phenyl; R = F, n = 2, Ar = 4-methylphenyl; R = F, n = 2, Ar = 4-(trifluoromethyl)phenyl, R = F, n = 2, Ar = 4-fluorophenyl] exhibited higher cellular activity compared to sorafenib with IC50 values of 7.25, 8.03, 9.81, 8.47, 4.70 and 9.04 μM, resp. and 10.38 μM for sorafenib. In addition, the target compounds were screened for their anticancer activity by the NCI-60 cell line assay. Compounds I [R = F, n = 2, Ar = naphthalen-1-yl; R = F, n = 2, Ar = 4-fluorophenyl] were the most active compounds with percent inhibition reached 95.99% for I [R = F, n = 2, Ar = naphthalen-1-yl] and 87.03% for I [R = F, n = 2, Ar = 4-fluorophenyl] over K562 cell line at 10 μM concentration Compound I [R = F, n = 2, Ar = naphthalen-1-yl] was selected for 5-dose test mode. Furthermore, the kinase inhibitory activities of I [R = H, n = 1, Ar = 4-methylphenyl; R = H, n = 1, Ar = 4-chlorophenyl; R = H, n = 2, Ar = 4-(trifluoromethyl)phenyl; R = F, n = 1, Ar = 4-methylphenyl; R = F, n = 2, Ar = phenyl; R = F, n = 2, Ar = 4-methylphenyl; R = F, n = 2, Ar = 4-(trifluoromethyl)phenyl; R = F, n = 2, Ar = 4-fluorophenyl; R = F, n = 2, Ar = naphthalen-1-yl] were determined against wild-type B-RAF, V600E-B-RAF and RAF1. Compound I [R = F, n = 2, Ar = phenyl] was the most potent against V600E-B-RAF with IC50 34 nM followed by I [R = F, n = 2, Ar = 4-methylphenyl; R = F, n = 2, Ar = 4-fluorophenyl] with IC50 92 and 93 nM, resp. In addition to this study using 4-Chlorobenzenesulfonyl chloride, there are many other studies that have used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application of 98-60-2) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Novel Furochromone Derivatives: Synthesis and Anticancer Activity Studies》 were Demir, Senem; Oezen, Cigdem; Ceylan-Uenluesoy, Meltem; Oeztuerk, Mehmet; Bozdag-Duendar, Oya. And the article was published in Journal of Heterocyclic Chemistry in 2019. Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene The author mentioned the following in the article:

In this study, khellin having furochromone structure, which was obtained from a well-known traditional medicinal plant, was selected. A series of furochromonyl compounds I (X = O, S; R = H, CH3, CH2C(O)OC2H5, 4-FC6H4CH2, 4-H3COC6H4C(O)CH2, etc.) was synthesized for their anticancer activities. Furochromonyl compounds I were synthesized by Knoevenagel reaction of substituted 2,4-thiazolidinediones/rhodanines II with khellin-2-carboxaldehyde, and their cytotoxicity was investigated in 22 cancer cell lines, which were originated from tissues such as liver, breast, colon, and cervix. As the first step, two hepatocellular carcinoma cell lines Huh7 and PLC/PRF/5 (Alexander cells) were treated with 10 μM of each compound for 72 h, and then sulforhodamine B assay was performed to analyze their anti-growth activities. Compound I (X = S; R = CH2C(O)OC2H5) was found as the most cytotoxic compound of primary screening. Afterwards, 12 hepatocellular carcinoma, seven breast cancer, two colon cancer, and cervical cancer cell lines were selected to test I (X = S; R = CH2C(O)OC2H5) for 72 h at multiple concentrations to determine 50% EDs. Results showed that 14 cell lines were affected by I (X = S; R = CH2C(O)OC2H5) quantities lower than 10 μM. The structure of I (X = S; R = CH2C(O)OC2H5), which is particularly effective on breast cancers, can be used to slow down the progression of tumors. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic & Biomolecular Chemistry included an article by Wang, Qiao-Lin; Zhang, Wen-Zheng; Zhou, Quan; Zhou, Cong-Shan; Xiong, Bi-Quan; Tang, Ke-Wen; Liu, Yu. Formula: C6H4Cl2O2S. The article was titled 《Visible-light-mediated difunctionalization of vinylcyclopropanes for the synthesis of 1-sulfonylmethyl-3,4-dihydronaphthalenes》. The information in the text is summarized as follows:

An efficient method for visible-light-mediated sulfonylation/arylation of the C-C σ-bond in vinylcyclopropanes with sulfonyl chlorides to synthesize 1-sulfonylmethyl-substituted 3,4-dihydronaphalenes was developed. A radical-type pathway was proved in this transformation. This difunctionalization procedure showed a series of advantages, such as the use of com. and easily available sulfonyl chlorides, mild conditions and eco-friendly energy. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Formula: C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Formula: C6H4Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics