Tag: 200-300

Firoozi, Somayeh; Hosseini-Sarvari, Mona published their research in Journal of Organic Chemistry in 2021. The article was titled 《Nanosized CdS as a Reusable Photocatalyst: The Study of Different Reaction Pathways between Tertiary Amines and Aryl Sulfonyl Chlorides through Visible-Light-Induced N-Dealkylation and C-H Activation Processes》.Name: 4-Chlorobenzenesulfonyl chloride The article contains the following contents:

The final products of the reaction of sulfonyl chlorides and tertiary amines in the presence of cadmium sulfide nanoparticles under visible light irradiation are highly dependent on the applied reaction conditions. Interestingly, with the change of a reaction condition, different pathways were conducted (visible-light-induced N-dealkylation or sp3 and sp2 C-H activation) that lead to different products such as secondary amines and various sulfonyl compounds Remarkably, all of these reactions were performed under visible light irradiation and an air atm. without any additive or oxidant in benign solvents or under solvent-free conditions. During this study, the CdS nanoparticles as affordable, heterogeneous, and recyclable photocatalysts were designed, successfully synthesized, and fully characterized and applied for these protocols. During these studies, intermediates resulting from the oxidation of tertiary amines are trapped during the photoinduced electron transfer (PET) process. The reaction was carried out efficiently with a variety of substrates to give the corresponding products at relatively short times in good to excellent yields in parallel with the use of the visible light irradiation as a renewable energy source. Most of these processes are novel or are superior in terms of cost effectiveness, safety, and simplicity to published reports. In addition to this study using 4-Chlorobenzenesulfonyl chloride, there are many other studies that have used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Name: 4-Chlorobenzenesulfonyl chloride) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Palladium-Catalyzed ortho-Benzoylation of Sulfonamides through C-H Activation: Expedient Synthesis of Cyclic N-Sulfonyl Ketimines》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Ojha, Subhadra; Panda, Niranjan. Recommanded Product: 98-60-2 The article mentions the following:

The ortho-carbonylation of sulfonylarenes by non-hazardous aryl aldehydes as a carbonyl precursor was reported. In this method, the sulfonamide group served as a directing group for C-H activation in the presence of a Pd catalyst under ligand-free conditions. The scope of this strategy was extended to the one-pot two-step synthesis of cyclic N-sulfonyl ketimines under mild reaction conditions. Our approach could be considered as an alternative by circumventing the use of highly reactive organolithium or Grignard reagents to access a wide range of biol. potent cyclic N-sulfonyl ketimines. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kiruthika, Selvarangam E.; Perumal, Paramasivan Thirumalai published an article on January 17 ,2014. The article was titled 《CuI-Catalyzed Coupling of gem-Dibromovinylanilides and Sulfonamides: An Efficient Method for the Synthesis of 2-Amidoindoles and Indolo[1,2-a]quinazolines》, and you may find the article in Organic Letters.Quality Control of 3,5-Dichloro-2-nitrobenzaldehyde The information in the text is summarized as follows:

N-[(Dibromovinyl)aryl]acetamides I (R = H, Cl; R1 = H, Cl, Br) underwent chemoselective cyclocondensation with sulfonamides such as N-(ar)alkyl-p-toluenesulfonamides TsNHCH2R2 [R2 = Ph, 4-MeC6H4, 4-MeOC6H4, 3,4-(MeO)2C6H3, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 1-naphthyl, 2-fluorenyl, 2-thienyl, 3,4-(MeO)2C6H3CH2, n-Pr] in the presence of CuI and 1,10-phenanthroline with Cs2CO3 in THF to give (sulfonylamino)indoles such as II [R = H, Cl; R1 = H, Cl, Br; R2 = Ph, 4-MeC6H4, 4-MeOC6H4, 3,4-(MeO)2C6H3, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 1-naphthyl, 2-fluorenyl, 2-thienyl, 3,4-(MeO)2C6H3CH2, n-Pr] in 75-89% yields. Reaction of I (R = R1 = H) with ortho-bromoarylmethyltosylamides TsNHCH2R2 [R2 = 2-BrC6H4, 2-Br-4,5-(MeO)2C6H2, 2-Br-3-pyridinyl, 1-Br-3,4-dihydro-2-naphthyl, 2-Br-3,4,5-(MeO)3C6H] under analogous conditions yielded dihydroindoloquinazolines such as III; treatment of III with Cs2CO3 at 110° yielded the indoloquinazoline IV. Ynamide intermediates in the preparation of sulfonamidoindoles were isolated in some cases. The structure of a trimethoxydihydroquinazolinoindole was determined by X-ray crystallog. After reading the article, we found that the author used 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Quality Control of 3,5-Dichloro-2-nitrobenzaldehyde)

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Quality Control of 3,5-Dichloro-2-nitrobenzaldehyde Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Transmission of electronic effects by the cyclopropane ring. Rates of alkaline hydrolysis of ethyl cis- and trans-2-phenylcyclopropanecarboxylates》 were Fuchs, Richard; Bloomfield, Jordan J.. And the article was published in Journal of Organic Chemistry in 1963. Name: Ethyl 3-(4-chlorophenyl)propanoate The author mentioned the following in the article:

The rates of alk. hydrolysis of a series of m- and p-substituted Et β-phenylpropionates and of Et trans- and cis-2-(substituted phenyl)cyclopropanecarboxylates in 7.8% ethanol at 30° were measured. A comparison of Hammett ρ-values for these series, Et cis- and trans-cinnamates, and Et phenylpropiolates indicates that the influence of substituents on the reactivity increases in the six ester series in the order given above. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Name: Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Name: Ethyl 3-(4-chlorophenyl)propanoate Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2011,Synthetic Communications included an article by Telvekar, Vikas N.; Patile, Hemlata V.. Computed Properties of C11H13ClO2. The article was titled 《Synthesis of α-azido ketones and esters using recyclable hypervalent iodine reagent》. The information in the text is summarized as follows:

A simple and mild method for the preparation of α-azido ketones and esters using hypervalent iodine reagent, 4,4′-bis(dichloroiodo)biphenyl, and sodium azide in 1,4-dioxane was discussed. Advantages of this system are easy workup, a recyclable reagent, and moderate to good yields. The results came from multiple reactions, including the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Computed Properties of C11H13ClO2)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C11H13ClO2 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: 954238-81-4On May 11, 2017 ,《2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Mo, Cheng; Zhang, Zhang; Guise, Christopher P.; Li, Xueqiang; Luo, Jinfeng; Tu, Zhengchao; Xu, Yong; Patterson, Adam V.; Smaill, Jeff B.; Ren, Xiaomei; Lu, Xiaoyun; Ding, Ke. The article conveys some information:

A series of 2-aminopyrimidine derivatives were designed and synthesized as highly selective FGFR4 inhibitors. One of the most promising compounds I tightly bound FGFR4 with a Kd value of 3.3 nM and potently inhibited its enzymic activity with an IC50 value of 2.6 nM, but completely spared FGFR1/2/3. The compound selectively suppressed proliferation of breast cancer cells harboring dysregulated FGFR4 signaling with an IC50 value of 0.38 μM. Furthermore, I exhibited extraordinary target specificity in a Kinome-wide screen against 468 kinases, with S(35) and S(10) selectivity scores of 0.01 and 0.007 at 1.0 μM, resp. In addition to this study using tert-Butyl (2-amino-3-chlorophenyl)carbamate, there are many other studies that have used tert-Butyl (2-amino-3-chlorophenyl)carbamate(cas: 954238-81-4HPLC of Formula: 954238-81-4) was used in this study.

tert-Butyl (2-amino-3-chlorophenyl)carbamate(cas: 954238-81-4) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 954238-81-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis of unsymmetrical disulfides via PPh3-mediated reductive coupling of thiophenols with sulfonyl chlorides》 was written by Wang, Dungai; Liang, Xiao; Xiong, Mingteng; Zhu, Heping; Zhou, Yifeng; Pan, Yuanjiang. Recommanded Product: 98-60-2This research focused onunsym disulfide preparation; thiophenol aryl sulfonyl chloride reductive coupling triphenylphosphine mediated. The article conveys some information:

A facile and rapid synthesis of unsym. aryl disulfides R1-S-S-R2 [R1 = 4-MeC6H4, 4-FC6H4, 2-naphthyl, etc.; R2 = 4-MeOC6H4, 2-NCC6H44, 4-ClC6H4, etc.] using PPh3-mediated reductive coupling of thiophenols with aryl sulfonyl chlorides under catalyst- and base-free conditions in moderate to excellent isolated yields was described. Good functional group tolerance and scalability were achieved in this strategy. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Recommanded Product: 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Rates of alkaline hydrolysis of meta-and para-substituted ethyl β-phenylpropionates and correlation with σ0》 was published in Journal of Organic Chemistry in 1966. These research results belong to Fuchs, Richard; Caputo, Joseph A.. Product Details of 7116-36-1 The article mentions the following:

A series of 20 meta-and para-substituted Et β-phenylpropionates were prepared, and the rates of alk. hydrolysis in 87.8% ethanol at 30° measured. The rates generally follow the σ0 values for the substituents estimated from other reactivities and from F19 N.M.R. shielding in similar solvents. The unexpectedly high rate of the m-Me3N+ compound may be due to a direct, short-range electrostatic interaction in the transition state for hydroxide ion attack of the ester. The results came from multiple reactions, including the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Product Details of 7116-36-1)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Product Details of 7116-36-1 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Substituted 3-phenylpropenoates and related analogs: electron ionization mass spectral fragmentation and density functional theory calculations》 was written by Wheelock, C. E.; Colvin, M. E.; Sanborn, J. R.; Hammock, B. D.. Formula: C11H13ClO2 And the article was included in Journal of Mass Spectrometry on August 31 ,2008. The article conveys some information:

Anal. of Et 3-(2-chlorophenyl)propenoate by electron ionization mass spectrometry showed the distinct loss of an ortho chlorine. To characterize the structural requisites for the observed mass fragmentation, a series of 30 halogen-substituted 3-phenylpropenoate-related structures were examined All ester-containing alkene derivatives exhibited loss of the distinctive chlorine from the 2-position of the Ph ring. Analogous derivatives with the halogen (chlorine or bromine) in the para position did not evidence selective halogen loss. Results demonstrated that substituted 3-phenylpropenoates and their analogs fragment via the formation of a previously reported benzopyrylium intermediate. To understand the correlation between the intramol. radical substitution and the abundance and selectivity of the chlorine (or other halogen) displacement, d. functional theory calculations were performed to determine the charge on the principal cation involved in the chlorine loss (in the ortho, meta, and para positions), the charge for the neutral radical (noncation), the excess alpha-electron d. on the relevant atom and the energy to form the cation from the neutral atom (ionization energy). Results showed that the selectivity and extent of halogen displacement correlated highly to the electrophilicity of the radical cation as well as the neutral radical. These data further support the proposed fragmentation mechanism involving intramol. radical elimination. In the experiment, the researchers used Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Formula: C11H13ClO2)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Formula: C11H13ClO2 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Black TiO2 nanoparticles with efficient photocatalytic activity under visible light at low temperature: regioselective C-N bond cleavage toward the synthesis of thioureas, sulfonamides, and propargylamines》 was written by Koohgard, Mehdi; Hosseini-Sarvari, Mona. HPLC of Formula: 98-60-2This research focused onthiourea sulfonamide propargylamine preparation regioselective photochem; tertiary amine carbon nitrogen bond cleavage black titanium dioxide; black titanium dioxide nanoparticle catalyst preparation. The article conveys some information:

Several different colored forms of TiO2 were prepared through the easy treatment of white TiO2 and NaBH4 as a safe hydrogen source. These types of modified TiO2 showed a quite acceptable visible light response. Then, tertiary amines were harnessed toward the regioselective synthesis of three prominent scaffolds, namely sulfonamides, thioureas, and propargylamines, using black TiO2 under visible light. For the first time, this type of modified TiO2 was easily prepared and exploited to handle organic transformations under visible light. Black TiO2-catalyzed oxidative C-N cleavage of tertiary amines was the key point of these transformations. Herein, the first report of the visible-light-driven synthesis of unsym. thioureas and propargylamines from tertiary amines has been presented. In the experiment, the researchers used many compounds, for example, 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2HPLC of Formula: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.HPLC of Formula: 98-60-2 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics