Tag: 200-300

Electric Literature of C8H6Cl2O3On October 14, 2021 ,《Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer》 was published in Journal of Medicinal Chemistry. The article was written by Zhang, Jin; Zou, Ling; Shi, Danfeng; Liu, Jie; Zhang, Jifa; Zhao, Rongyan; Wang, Guan; Zhang, Lan; Ouyang, Liang; Liu, Bo. The article contains the following contents:

Sirtuin-3 (SIRT3) is an NAD+-dependent protein deacetylase localized primarily in the mitochondria with many links to different types of human cancers. Autophagy, which is a highly conserved lysosomal degradation process in eukaryotic cells, has been recently reported to be pos. regulated by SIRT3 in cancer; therefore, activating SIRT3-modulated autophagy may be a promising strategy for drug discovery. In this study, we discovered a small-mol. activator of SIRT3 compound 33c (ADTL-SA1215) with specific SIRT3 deacetylase activity by structure-guided design and high-throughput screening. Subsequently, compound 33c inhibited the proliferation and migration of human breast carcinoma MDA-MB-231 cells by SIRT3-driven autophagy/mitophagy signaling pathways in vitro and in vivo. Collectively, these results demonstrate that pharmacol. activation of SIRT3 is a potential therapeutic approach of triple neg. breast cancer (TNBC). More importantly, compound 33c may be a first-in-class specific small-mol. activator of SIRT3 that would be utilized for future cancer drug development. In the experimental materials used by the author, we found 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Electric Literature of C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Electric Literature of C8H6Cl2O3 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《The organocatalytic synthesis of perfluorophenylsulfides via the thiolation of trimethyl(perfluorophenyl)silanes and thiosulfonates》 was written by Luo, Jinyun; Lin, Muze; Wu, Leifang; Cai, Zhihua; He, Lin; Du, Guangfen. Product Details of 98-60-2This research focused ontrimethyl perfluorophenyl silane thiosulfonate phosphazene catalyst thiolation green chem; perfluorophenylsulfide preparation. The article conveys some information:

The organic superbase t-Bu-P4-catalyzed direct thiolation of trimethyl(perfluorophenyl)silanes and thiosulfonates was developed. Yields of perfluorophenylsulfides of up to 97% under catalysis of 5 mol% t-Bu-P4 were achieved. This method was shown to provide an efficient way to construct the perfluorophenyl-sulfur bond under mild metal-free reaction conditions. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Product Details of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Product Details of 98-60-2 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Korkmaz, Adem; Bursal, Ercan published an article in Journal of Molecular Structure. The title of the article was 《Benzothiazole sulfonate derivatives bearing azomethine: Synthesis, characterization, enzyme inhibition and molecular docking study》.Name: 4-Chlorobenzenesulfonyl chloride The author mentioned the following in the article:

Enzyme inhibition is one of the most applied ways to find new diagnostic facilities for the prevention and treatment of many health problems. For example, tyrosinase and pancreatic lipase inhibition have been used for the treatment of skin pigmentation problems and obesity, resp. This study mainly focused on evaluating inhibition of tyrosinase and pancreatic lipase by newly synthesized sulfonate derivatives I [R = 2,4,6-Me3C6H2, 2-naphthyl, 4-BrC6H4, etc.]. The structural characterizations of the compounds were performed by 1H NMR, 13C NMR and HR-MS analyses. According to the in-vitro enzyme inhibition methods, compound I [R = 4-FC6H4] had the highest tyrosinase inhibitory activity (46.9 ± 3.6μM IC50 value). On the other hand, effective pancreatic lipase inhibitory activities of I [R = 4-MeOC6H4, 4-FC6H4, 4-MeC6H4] were determined from their low IC50 values 58.3 ± 6.7μM, 59.5 ± 13.8μM and 64.8 ± 6.3μM, resp. Mol. docking studies were also conducted with tyrosinase and pancreatic lipase enzymes sep. Finally, the ADME studies were carried out to determine the pharmacokinetics, drug similarities and medicinal properties of the target compounds4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Name: 4-Chlorobenzenesulfonyl chloride) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Name: 4-Chlorobenzenesulfonyl chloride Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Zhang, Tianyuan; Zheng, Shumin; You, Shuyan; Huang, Danling; Cheng, Yong-Xian published an article in Medicinal Chemistry Research. The title of the article was 《Design and synthesis of potential fungicidal compounds derived from natural products, (-)-menthol and (-)-borneol》.Product Details of 98-60-2 The author mentioned the following in the article:

Twelve Novel compounds I[ R1=R2 = H, CH3, Cl etc], II[ R1= R2 = H, CH3, Cl etc] derived from (-)-menthol and (-)-borneol were designed, synthesized and characterized by 1H NMR, 13C NMR, and HRMS. The fungicidal activities of these novel compounds I and II against Botrytis cinerea, Curvularia lunata and Alternaria alternata were evaluated. The results indicated that II[ R1 = R2 = F] displayed potential fungicidal activities against B. cinerea and C. lunata. Especially, II[ R1 = R2 = F] exhibited IC50 value of 22.9 mg/L against C. lunata, which was higher fungicidal activity than com. product hymexazol and amicarthiazol. In addition, the superficial structure-activity relationship were discussed. This study provided a structural template for the design of novel fungicides. In addition to this study using 4-Chlorobenzenesulfonyl chloride, there are many other studies that have used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Product Details of 98-60-2) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Taha, Muhammad; Ahmad Khan, Aftab; Rahim, Fazal; Imran, Syahrul; Salahuddin, Mohammed; Uddin, Nizam; Mohammed Khan, Khalid; Adnan Ali Shah, Syed; Zafar, Ameeduzzafar; Amiruddin Zakaria, Zainul published an article in Arabian Journal of Chemistry. The title of the article was 《Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of β-Glucuronidase and in silico study》.SDS of cas: 622-95-7 The author mentioned the following in the article:

New benzimidazole analogs I were synthesized and characterized through different spectroscopic techniques such as 1H NMR, 13C NMR and HREI-MS. All analogs were screened for β-glucuronidase inhibitory potential. All analogs showed varied degree of inhibitory potentials with IC50 values ranging between 1.10 ± 0.10 to 39.60 ± 0.70μM when compared with standard D-saccharic acid-1,4- lactone having IC50 value 48.30μM. Analogs I [R1 = 2,5-dichlorophenyl, R2 = 4-nitrobenzyl], I [R1 = 4-chlorophenyl, R2 = 2,4-dichlorobenzyl], I [R1 = 4-nitrophenyl, R2 = 4-nitrobenzyl], I [R1 = 4-chlorophenyl, R2 = 4-nitrobenzyl], I [R1 = p-tolyl, R2 = 4-nitrobenzyl] and I [R1 = 4-chlorophenyl, R2 = 4-chlorobenzyl] having IC50 values 1.10 ± 0.10, 1.70 ± 0.10, 2.30 ± 0.10, 5.30 ± 0.20, 6.20 ± 0.20 and 8.10 ± 0.20μM resp., showed excellent β-glucuronidase inhibitory potential many folds better than the standard All other analogs also showed good inhibitory potential better as compared to standard Structure activity relationships (SAR) had been established for all compounds The results from mol. docking studies supports the established SAR and developed a strong correlation with the results from in to vitro assay. The mol. docking results clearly highlighted how substituents like nitro and chloro affect the binding position of the active compounds in the active site. The docking results were also used to properly establish the effect of bulky substituents of least active compounds on reduced β-glucuronidase inhibitory activity. Compounds I [R1 = Ph, p-tolyl, 3-methoxyphenyl; R2 = 4-methoxybenzyl, 4-bromobenzyl, 4-methylbenzyl, etc] were found non-toxic. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7SDS of cas: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.SDS of cas: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocksIn 2021 ,《Design, synthesis, in vitro determination and molecular docking studies of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl)pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.7 macrophage cells》 was published in Medicinal Chemistry Research. The article was written by Mersal, Karim I.; Abdel-Maksoud, Mohammed S.; Ali, Eslam M. H.; Ammar, Usama M.; Zaraei, Seyed-Omar; Kim, Jae-Min; Kim, Su-Yeon; Lee, Kyung-Tae; Lee, Kwan Hyi; Kim, Si-Won; Park, Hyun-Mee; Ji, Mi-Jung; Oh, Chang-Hyun. The article contains the following contents:

In the present work, a new series of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl)pyridine possessing terminal Et or Pr sulfonamides I (R = H, F; n = 2,3; Ar = Ph, 4-FC6H4, 1-naphthyl, etc.) was designed and synthesized. The cytotoxic effect of the final compounds was measured by applying MTT assay in LPS-Induced RAW264.7 macrophage cells. The final target compounds were screened for their anti-inflammatory effect through their ability to inhibit NO and PGE2 production and cytokines production (TNF-α, IL-6, IL-1β) in LPS-induced RAW264.7 macrophage at 10μM concentration Compounds I (R = H; n = 3; Ar = 1-naphthyl), I (R = F; n = 3; Ar = 4-BrC6H4), and I (R = F; n = 3; Ar = 1-naphthyl) showed the highest inhibitory effect on NO production Compounds I (R = H, F; n = 3; Ar = 1-naphthyl) exhibited high PGE2 inhibition with IC50 values of 3.47, 2.54μM, resp. Compounds I (R = H, F; n = 3; Ar = 1-naphthyl) exhibited high cytokines inhibition >/= 60%. The most potent compounds I (R = H, F; n = 3; Ar = 1-naphthyl) were tested to determine their effect on iNOS and COX-2 mRNA expression level. Compound I (R = F; n = 3; Ar = 1-naphthyl) were activity on iNOS and COX-2 proteins level, pro-inflammatory mediators and cytokines was determined and showed remarkable inhibition for both proteins level. Compounds I (R = H, F; n = 3; Ar = 1-naphthyl) showed high binding affinity to COX-2 active site and exhibited similar binding interactions of the native ligand celecoxib. In addition to this study using 4-Chlorobenzenesulfonyl chloride, there are many other studies that have used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Category: chlorides-buliding-blocks) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C7H6BrClIn 2020 ,《Selective C-P(O) Bond Cleavage of Organophosphine Oxides by Sodium》 was published in Journal of Organic Chemistry. The article was written by Zhang, Jian-Qiu; Ikawa, Eiichi; Fujino, Hiroyoshi; Naganawa, Yuki; Nakajima, Yumiko; Han, Li-Biao. The article contains the following contents:

Na exhibits better efficacy and selectivity than Li and K for converting Ph3P(O) to Ph2P(OM). The destiny of PhNa co-generated is disclosed. Alkyl halides R4X and aryl halides ArX all react with Ph2P(ONa) to produce the corresponding phosphine oxides in good to excellent yields. In the experiment, the researchers used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Computed Properties of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Computed Properties of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Xu, Zekun; Jiang, Jun; Lu, Qianqian; Chen, Jingyun; Chen, Shufang; Shi, Liyang; Yimei Zhao published an article in Journal of Organometallic Chemistry. The title of the article was 《Photoredox Catalyzed Sulfonylation of Multisubstituted Allenes with Ru(bpy)3Cl2 or Rhodamine B》.COA of Formula: C6H4Cl2O2S The author mentioned the following in the article:

A highly regio- and stereoselective sulfonylation of allenes was developed that provided direct access to α,β-substituted unsaturated sulfones I [R1 = Ph, 4-ClC6H4, 4-MeC6H4, etc.; R2 = H, Ph; R3 = Ph, 4-MeC6H4, 4-ClC6H4, etc.; R4 = Me, CH2C(O)OEt]. By means of visible-light photoredox catalysis, the free radicals produced by p-toluenesulfonic acid reacted with multisubstituted allenes to obtain Markovnikov-type vinyl sulfones with Ru(bpy)3Cl2 or Rhodamine B as photocatalyst. The yield of this reaction could reach up to 91%. A series of unsaturated sulfones would be used for further transformation to some valuable compounds After reading the article, we found that the author used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2COA of Formula: C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. COA of Formula: C6H4Cl2O2S However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Gong, Bozhen; Zhu, Haibo; Yang, Liu; Wang, Haifeng; Fan, Qiangwen; Xie, Zongbo; Le, Zhanggao published an article in Organic & Biomolecular Chemistry. The title of the article was 《Base-promoted synthesis of diarylsulfones from sulfonyl hydrazines and diaryliodonium salts》.Related Products of 98-60-2 The author mentioned the following in the article:

An efficient and concise method for the synthesis of diaryl sulfones ArS(O)2Ar1 [Ar = Ph, 4-MeC6H4, 4-NCC6H4, etc.; Ar1 = Ph, 4-FC6H4, 3-MeC6H4, etc.] via metal-free sulfonylation from sulfonyl hydrazines with sym. or unsym. diaryliodonium salts using n-PrOH as the solvent was developed with high selectivity. Using n-PrOH as the solvent, diaryl sulfones are formed even on a gram scale. After reading the article, we found that the author used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Related Products of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Related Products of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cellnik, Torsten; Healy, Alan R. published an article in 2022. The article was titled 《Sulfonyl Chlorides as Thiol Surrogates for Carbon-Sulfur Bond Formation: One-Pot Synthesis of Thioethers and Thioesters》, and you may find the article in Journal of Organic Chemistry.Safety of 4-Chlorobenzenesulfonyl chloride The information in the text is summarized as follows:

A method to synthesize thioethers and thioesters directly from readily available sulfonyl chlorides was reported. A transient intermediate formed during phosphine-mediated deoxygenation of sulfonyl chlorides was trapped in situ by activated alcs. or carboxylic acids to effect carbon-sulfur bond formation. The method is operationally simple and tolerates a broad range of functional groups. Special attention was focused on the late-stage diversification of densely functionalized natural products and pharmaceuticals. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Safety of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Safety of 4-Chlorobenzenesulfonyl chloride Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics