Tag: 200-300

Application In Synthesis of 4-Chlorobenzenesulfonyl chlorideIn 2019 ,《KI-catalyzed synthesis of S-Thiocarbamates by cross-coupling of cyclohexyl isocyanide with sulfonyl chlorides》 was published in Journal of Chemical Research. The article was written by Lin, Liangwei; Fang, Zhengjun; Li, Yajun; Wu, Feng; Au, Chaktong; Luo, Sai. The article contains the following contents:

A simple and efficient process for direct generation of various S-thiocarbamates I (Ar = Ph, 4-MeC6H4, 4-ClC6H4, etc.) is developed by cross-coupling of readily available sulfonyl chlorides with cyclohexyl isocyanide. The yields are excellent and the structures of the generated S-thiocarbamates are characterized by NMR spectroscopy, IR spectroscopy, and high-resolution mass spectrometry together with X-ray crystallog. anal. The protocol has the advantages of using easily available reagents, employs inexpensive KI as the reagent, demonstrates good functional group tolerance, and utilizes mild reaction conditions. The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kumar, Dhirendra; Maury, Suresh Kumar; Kumari, Savita; Kamal, Arsala; Singh, Himanshu Kumar; Singh, Sundaram; Srivastava, Vandana published an article in 2022. The article was titled 《TBAI-catalyzed C-N bond formation through oxidative coupling of benzyl bromides with amines: a new avenue to the synthesis of amides》, and you may find the article in Synthetic Communications.Name: 1-(Bromomethyl)-4-chlorobenzene The information in the text is summarized as follows:

A new green approach for the synthesis of amide R1PhC(O)NR2R3 [R1 = H, NO2, Cl, etc.; R2 = H, n-Bu., Bn, etc.; R3 = H, Me, Et; R2,R3 = (CH2)4, (CH2)5, (CH2)2O] was developed through TBAI-catalyzed oxidative coupling of benzyl bromides with amines in the presence of tert-Bu hydroperoxide as an oxidant. Various electron-donating and withdrawing groups containing benzyl bromides and various amines were subjected to the reaction and transformed to the corresponding amide in good to excellent yields. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yuan, Pan-Feng; Huang, Tao; He, Jian; Huang, Xie-Tian; Jin, Xiao-Ling; Sun, Chunlin; Wu, Li-Zhu; Liu, Qiang published an article in 2021. The article was titled 《Controllable Z/E-selective synthesis of α-amino-ketoximes from N-nitrososulfonamides and aryl alkenes under neutral conditions》, and you may find the article in Organic Chemistry Frontiers.COA of Formula: C6H4Cl2O2S The information in the text is summarized as follows:

Design of a photosensitization strategy to generate the unique triplet state reactivity of N-nitrososulfoximides, specifically N-methyl-N-nitroso-p-toluenesulfonamides (NANS1) and the subsequent installation of both N-centered sulfonamidyl radical and nitric oxide functionalities into aryl alkene feedstocks were reported, which was mild and completely atom economical, exhibited broad functional group tolerance and occur readily under neutral conditions. Furthermore, this newly developed methodol. was also compatible with both terminal and internal 1,3-dienes to afford solely 1,2-amidoximation products in a remarkable regio- and Z/E-selective manner. Compared with traditional methods that are based on the steric hindrance of the substrates to control the reaction selectivity, both the (E)- and (Z)-isomers of α-amino-ketoximes was obtained selectively by the switch of sensitizers in this protocol. The key photophys. properties of NANS1 and DFT calculations were investigated in detail, providing the fact that the reaction proceeded through a sensitized triplet energy transfer pathway. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2COA of Formula: C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.COA of Formula: C6H4Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Non-directed copper-catalyzed regioselective C-H sulfonylation of phenothiazines》 were Liu, Caiyan; Shen, Yongli; Yuan, Kedong. And the article was published in Organic & Biomolecular Chemistry in 2019. Name: 4-Chlorobenzenesulfonyl chloride The author mentioned the following in the article:

A simple and general method for the synthesis of phenothiazinyl sulfones I [R = n-Bu, Ph, Bn, etc.; R1 = cyclopropyl, 4-MeC6H4, 2-naphthyl, etc.; R2 = H, SMe, Cl; R3 = H, Cl] was developed via copper-catalyzed regioselective C-H sulfonylation of phenothiazines with sulfonyl chlorides. The broad scope of aryl/alkyl sulfonyl chlorides was applicable to produce C3 sulfonylation products of phenothiazines in moderate to good yields. The further transformation of the sulfonylation products was successful, which afforded valuable polyheterocycles. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Name: 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Name: 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2003,Jingxi Yu Zhuanyong Huaxuepin included an article by Hua, Yuxia; Jiao, Xiaoyun; Yu, Lixin; Zhu, Sicheng; Zou, Zhichen. Safety of 2-Amino-2,4-dichlorodiphenyl ether. The article was titled 《Study on the bactericides of polychlorophenoxylphenols》. The information in the text is summarized as follows:

Nine polychlorophenoxylphenols were synthesized from chlorophenols and chloronitrobenzenes and their bactericidal activities were tested against Staphylococcus aureus and Escherichia coli. In the part of experimental materials, we found many familiar compounds, such as 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Safety of 2-Amino-2,4-dichlorodiphenyl ether)

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Safety of 2-Amino-2,4-dichlorodiphenyl ether

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1989,Journal of Organic Chemistry included an article by Bui The Khai; Arcelli, Antonio. Related Products of 7116-36-1. The article was titled 《A new hydrogen source. 3. Chemoselective reduction with triethylammonium hypophosphite hydrate/Raney nickel and tris(triphenylphosphine)ruthenium dichloride reagents.》. The information in the text is summarized as follows:

Et3NH+ H2PO2-.nH2O (I) acts as a NaH2PO2·H2O modified reagent. Some advantages are noted, including higher product selectivity. Pure aromatic and aliphatic aldehydes are obtained from nitriles by the I/Raney nickel system. The homogeneous catalyst can be used with this reagent. The I/RuCl2(PPh3)3 system selectively reduces aromatic and aliphatic ketones to the corresponding alcs. with excellent yields at room temperature After reading the article, we found that the author used Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Related Products of 7116-36-1)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 7116-36-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Hong; Zhang, Rong-Hong; Liao, Xiang-Ming; Yang, Dan; Wang, Yu-Chan; Zhao, Yong-Long; Xu, Guo-Bo; Liu, Chun-Hua; Li, Yong-Jun; Liao, Shang-Gao; Zhou, Meng published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Discovery of β-Carboline Derivatives as a Highly Potent Cardioprotectant against Myocardial Ischemia-Reperfusion Injury》.Product Details of 622-95-7 The article contains the following contents:

Timely myocardial reperfusion salvages ischemic myocardium from infarction, whereas reperfusion itself induces cardiomyocyte death, which is called myocardial ischemia/reperfusion (MI/R) injury. Herein, β-carboline derivative I was designed and synthesized with obvious myocardial protective activity for the first time. Pretreatment of compound I effectively protected the cardiomyocyte H9c2 cells from H2O2-induced lactate dehydrogenase leakage and restored the endogenous antioxidants, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Besides, compound I effectively protected the mitochondria through decreasing the reactive oxygen species overproduction and enhancing the mitochondrial membrane potential. As a result, compound I significantly reduced the necrosis of cardiomyocytes in H2O2-induced oxidative stress, which was more potent than polydatin. In MI/R injury rats, compound I pretreatment obviously increased the levels of SOD and GSH-Px and inhibited the apoptosis of cardiomyocytes. Through this way, the size of myocardial infarction was significantly reduced after MI/R injury in vivo, better than that of polydatin, suggesting that compound I is a promising cardioprotectant for the prevention of MI/R injury. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Product Details of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Product Details of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design and synthesis of β-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability》 was published in Bioorganic Chemistry in 2020. These research results belong to Lakshmi Manasa, Kesari; Thatikonda, Sowjanya; Sigalapalli, Dilep Kumar; Sagar, Arpita; Kiranmai, Gaddam; Kalle, Arunasree M.; Alvala, Mallika; Godugu, Chandraiah; Nagesh, Narayana; Nagendra Babu, Bathini. COA of Formula: C6H4Cl2O2S The article mentions the following:

A series of new β-carboline linked aryl sulfonyl piperazine congeners I (R = H, Ph, 3,4,5-trimethoxyphenyl, 4-fluorophenyl, etc.; R1 = H, OMe, Me, Cl, t-Bu) have been synthesized by coupling various β-carboline acids II with substituted aryl sulfonyl piperazines III. Evaluation of their anticancer activity against a panel of human cancer cell lines such as colon (HT-29), breast (MDA-MB-231), bone osteosarcoma (MG-63), brain (U87 MG), prostate (PC- 3) and normal monkey kidney (Vero) cell line has been done. Among the series, compound I (R = Ph, R1 = Cl) and I (R = Ph, R1 = H) has shown most potent cytotoxicity with IC50 values of 2.80 ± 0.10μM and 0.59 ± 0.28μM resp. against MG-63 cell line and also potent on other cell lines tested. Compounds I (R = Ph, R1 = Cl) and I (R = Ph, R1 = H) were found to inhibit Topo II that is confirmed by specific Topo II inhibition assay. DNA binding studies, cell cycle anal., Annexin V study indicate that these compounds have potential anticancer activity. Mol. docking studies for compound I (R = Ph, R1 = Cl) and I (R = Ph, R1 = H) are incorporated to understand the nature of interaction with topoisomerase IIα and dsDNA. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2COA of Formula: C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. COA of Formula: C6H4Cl2O2S The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Khai, Bui The; Arcelli, Antonio published an article on February 17 ,1989. The article was titled 《A new hydrogen source. 3. Chemoselective reduction with triethylammonium hypophosphite hydrate/Raney nickel and tris(triphenylphosphine)ruthenium dichloride reagents》, and you may find the article in Journal of Organic Chemistry.Reference of Ethyl 3-(4-chlorophenyl)propanoate The information in the text is summarized as follows:

Et3NH+ H2PO2-.nH2O (I) acts as a NaH2PO2·H2O modified reagent. Some advantages are noted, including higher product selectivity. Pure aromatic and aliphatic aldehydes are obtained from nitriles by the I/Raney nickel system. The homogeneous catalyst can be used with this reagent. The I/RuCl2(PPh3)3 system selectively reduces aromatic and aliphatic ketones to the corresponding alcs. with excellent yields at room temperature In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Reference of Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Reference of Ethyl 3-(4-chlorophenyl)propanoate The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C11H13ClO2On November 1, 2013 ,《Metal-Catalyzed Benzylic Fluorination as a Synthetic Equivalent to 1,4-Conjugate Addition of Fluoride》 appeared in Journal of Organic Chemistry. The author of the article were Bloom, Steven; Sharber, Seth Andrew; Holl, Maxwell Gargiulo; Knippel, James Levi; Lectka, Thomas. The article conveys some information:

We explore in detail the iron-catalyzed benzylic fluorination of substrates containing aromatic rings and electron-withdrawing groups positioned β to one another, thus providing direct access to β-fluorinated adducts. This operationally convenient process can be thought of not only as a contribution to the timely problem of benzylic fluorination but also as a functional equivalent to a conjugate addition of fluoride, furnishing products in moderate to good yields and in excellent selectivity. The experimental process involved the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Formula: C11H13ClO2)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Formula: C11H13ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics