Tag: 200-300

The author of 《Nitration of 3,5-dichlorobenzaldehyde and 3,5-dichlorobenzoic acid》 were Asinger, Fritz. And the article was published in Monatshefte fuer Chemie in 1933. Computed Properties of C7H3Cl2NO3 The author mentioned the following in the article:

3,5-Cl2C6H3CHO (10 g.) and 100 cc. HNO3 (d. 1.48) at room temperature for 3-4 hrs. give 99% (crude yield) of 2-nitro-3,5-dichlorobenzaldehyde (I), m. 91.5°; oxidation gives 3,5,2-Cl2(O2N)C6H2CO2H, m. 194° I yields an aldoxime, m. 97°, and a phenylhydrazone, blood-red, m. 175°. I and PCl5 in C6H6 give 2-nitro-3,5-dichlorobenzal chloride, m. 45°; this also results by nitration of 3,5-Cl2C6H3CHCl2. I, heated with Ac2O and AcONa 7 hrs. at 180°, gives 65% of 2-nitro-3,5-dichlorocinnamic acid, pale yellow, m. 227°. I and NAOH in Me2CO give 97% of 5,7,5′,7′-tetrachloroindigo. Reduction of I with FeSO4 and NH4OH gives 84% of the 2-NH2 derivative, pale yellow, m. 123°; aldoxime, m. 175°; phenylhydrazone, yellow-green, m. 118°. 3,5-Cl2C6H3CO2H and HNO3 (d. 1.48) at 70° give 83% of the 2-NO2 derivative (II), m. 194°; the Ca salt seps. with 4.5 mols. H2O; the Ba salt has 2.5 mols. H2O; the Ag salt is anhydrous; acid chloride, m. 94.5°; amide, m. 180°; Me ester, m. 73°; Et ester, m. 69°. Reduction of II gives the 2-NH2 derivative, m. 230-1° (98% yield). In the experiment, the researchers used 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Computed Properties of C7H3Cl2NO3)

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C7H3Cl2NO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Chlorination of the esters of anisic acid》 were Szilagyi, Geza; Kasztreiner, Endre; Meszaros, Laszlone; Vargha, Laszlo. And the article was published in Magyar Kemiai Folyoirat in 1969. Synthetic Route of C8H6Cl2O3 The author mentioned the following in the article:

Esters of anisic acid (I) were chlorinated in CHCl3. Cl is passed through a solution of 200 g ethyl ester (II) of I in 40 ml CHCl3 in the presence of 2 g iodine at a rate so that no Cl leaves the reaction mixture The reaction is exothermic and yields 86.5% ethyl 4-methoxy-3,5-dichlorobenzoate, m 60-2°. Similarly were prepared 85.5% Me 4-methoxy-3,5-dichlorobenzoate, m. 75-7° (MeOH), 86.5% Pr 4-methoxy-3,5-dichlorobenzoate, m. 35-7° (EtOH), 76% Bu 4-methoxy-3,5-dichlorobenzoate, m. 28-30° (EtOH). Et 4-methoxy-3-chlorobenzoate, m. 76-6°, was prepared by chlorination of II in the presence of 1% water at 75° (method A) or in the presence of iodine (method B); the yield for method A was 28.8% and for method B 70.5%. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Synthetic Route of C8H6Cl2O3)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Synthetic Route of C8H6Cl2O3

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor [Erratum to document cited in CA160:125148]》 were Bach, Peter; Bostroem, Jonas; Brickmann, Kay; Burgess, Laurence E.; Clarke, David; Groneberg, Robert D.; Harvey, Darren M.; Laird, Ellen R.; O’Sullivan, Michael; Zetterberg, Fredrik. And the article was published in Future Medicinal Chemistry in 2014. Computed Properties of C10H12ClNO2 The author mentioned the following in the article:

On page 2037, the author affiliations were incorrect; the corrected affiliations are given. On pages 2051 and 2052, Tables 3 and 4, resp., were incomplete; the corrected tables are given. In addition to this study using Ethyl 6-chloro-2,4-dimethylnicotinate, there are many other studies that have used Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0Computed Properties of C10H12ClNO2) was used in this study.

Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Computed Properties of C10H12ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1954,Nippon Kagaku Zasshi included an article by Yamashiro, Seishi; Matsueda, Sumu. Application of 56966-48-4. The article was titled 《Chlorodiphenylene oxides. I. Synthesis of 1,6- and 2,6-dichlorodiphenylene oxides》. The information in the text is summarized as follows:

2,6-Dichlorodiphenylene oxide, m. 149°, has been synthesized from 2,6-diaminodiphenylene oxide sulfate by the Sandmeyer method in 40.5% yield. o-Chlorophenol (25 g.) and 11 g. KOH melted, treated with 37 g. 2,5-Cl2C6H3NO2, and heated 7 hrs. at 170-80° yielded 35 g. 2-nitro-2′,4-dichlorodiphenyl ether (I), m. 62°. I was converted to the corresponding 2-amino compound (II), m. 167° by action of SnCl2-HCl in MeOH in 95% yield. Direct chlorination of II by addition of a CCl4 solution of Cl afforded 1,6-dichlorodiphenylene oxide, m. 135°, 7.7% yield, and 2-hydroxy-2′,4-dichlorodiphenyl ether, m. 66° 7.5% yield. The results came from multiple reactions, including the reaction of 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Application of 56966-48-4)

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 56966-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Desai, C. K.; Desai, K. R. published an article in High Performance Polymers. The title of the article was 《Azo dyes based on 2-naphthol-formaldehyde oligomer》.Safety of 2-Amino-2,4-dichlorodiphenyl ether The author mentioned the following in the article:

A series of new oligomeric disperse dyes were prepared by coupling various diazonium salts of aniline ethers to a 2-naphthol-formaldehyde oligomer. They were characterized in terms of their softening points, color, solubility, and IR and UV-visible spectral studies. The structural property relationships were discussed. Application to polyester and nylon resulted in yellow, orange, and pink-to-red shades having good to excellent light- and washfastness properties. In addition to this study using 2-Amino-2,4-dichlorodiphenyl ether, there are many other studies that have used 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Safety of 2-Amino-2,4-dichlorodiphenyl ether) was used in this study.

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Safety of 2-Amino-2,4-dichlorodiphenyl ether

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Product Details of 4949-85-3On November 30, 2020 ,《Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds》 appeared in Bioorganic Chemistry. The author of the article were Grytsai, Oleksandr; Valiashko, Oksana; Penco-Campillo, Manon; Dufies, Maeva; Hagege, Anais; Demange, Luc; Martial, Sonia; Pages, Gilles; Ronco, Cyril; Benhida, Rachid. The article conveys some information:

Two series of compounds I (R = H, 2-Cl, 3-Br, etc.; X = CH or N) carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivs I (X = N). The biol. results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series I (R = 3-Br; X = CH or N) on several cell lines tested. Moreover, results point out an antiangiogenic activity of these compds I. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity. In the experiment, the researchers used many compounds, for example, 1-(2,5-Dichlorophenyl)thiourea(cas: 4949-85-3Product Details of 4949-85-3)

1-(2,5-Dichlorophenyl)thiourea(cas: 4949-85-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Product Details of 4949-85-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic & Biomolecular Chemistry included an article by Yu, Yanbo; Liang, Qianwa; Liu, Hui; Luo, Zonghua; Hu, Hongzheng; Perlmutter, Joel S.; Tu, Zhude. Related Products of 622-95-7. The article was titled 《Development of a carbon-11 PET radiotracer for imaging TRPC5 in the brain》. The information in the text is summarized as follows:

The transient receptor potential channel subfamily member 5 (TRPC5) is a calcium permeable cation channel widely expressed in the brain. Accumulating evidence indicates that it plays a crucial role in psychiatric disorders including depression and anxiety. Positron emission tomog. (PET) combined with a TRPC5 specific radioligand may provide a unique tool to investigate the functions of TRPC5 in animal disease models to guide drug development targeting TRPC5. To develop a TRPC5 PET radiotracer, the potent TRPC5 inhibitor HC608 was chosen for C-11 radiosynthesis through the N-demethyl amide precursor 7 reacting with [11C]methyl iodide. Under optimized conditions, [11C]HC608 was achieved with good radiochem. yield (25 ± 5%), high chem. and radiochem. purity (>99%), and high specific activity (204-377 GBq μmol-1, decay corrected to the end of bombardment, EOB). The in vitro autoradiog. study revealed that [11C]HC608 specifically binds to TRPC5. Moreover, initial in vivo evaluation of [11C]HC608 performed in rodents and the microPET study in the brain of non-human primates further demonstrated that [11C]HC608 was able to penetrate the blood brain barrier and sufficiently accumulate in the brain. These results suggest that [11C]HC608 has the potential to be a PET tracer for imaging TRPC5 in vivo. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Related Products of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Related Products of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Hongjian; Lv, Kai; Li, Xiaoning; Wang, Bo; Wang, Apeng; Tao, Zeyu; Geng, Yunhe; Wang, Bin; Huang, Menghao; Liu, Mingliang; Guo, Huiyuan; Lu, Yu published an article on February 28 ,2019. The article was titled 《Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives》, and you may find the article in Chinese Chemical Letters.Category: chlorides-buliding-blocks The information in the text is summarized as follows:

A series of nitrobenzamide derivatives containing N-benzyl or N-pyridinylmethyl moieties I [R = H, 5-CF3, 5-F, etc.; R1 = F, 4-chloro-1-piperidyl, 4-(4-fluorophenyl)piperazin-1-yl, etc.; X = Y = CH; X = CH, Y = N; X = N, Y = CH] was designed and synthesized as new anti-tubercular agents. Many of synthesized compounds I exhibited potent in vitro antitubercular activity. Four compounds I [R = 5-NO2; R1 = 4-MeO, 4-(trifluoromethyl)-1-piperidyl, 4-chloro-1-piperidyl, 4-(4-fluorophenyl)piperazin-1-yl] had not only the same excellent MIC values against both drug-sensitive MTB strain H37Rv and two drug-resistant clin. isolates as PBTZ169 and the lead I [R = 5-NO2; R1 = 4-(trifluoromethyl)-1-piperidyl; X = Y = CH], but also acceptable safety indexes. In the part of experimental materials, we found many familiar compounds, such as 2,4-Dichloro-5-nitrobenzoic acid(cas: 19861-62-2Category: chlorides-buliding-blocks)

2,4-Dichloro-5-nitrobenzoic acid(cas: 19861-62-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Category: chlorides-buliding-blocks Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gonzalez-Bello, C.; Castedo, L. published an article in Science of Synthesis. The title of the article was 《Product class: monohydric phenol, and corresponding phenolates – synthesis by rearrangement》.Related Products of 56966-48-4 The author mentioned the following in the article:

A review of methods to prepare monohydric phenols and corresponding phenolates by rearrangement. The experimental part of the paper was very detailed, including the reaction process of 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Related Products of 56966-48-4)

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Related Products of 56966-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Discovery of novel 1,3,5-triazine derivatives as potent inhibitor of cervical cancer via dual inhibition of PI3K/mTOR》 was written by Hu, Junbo; Zhang, Yanli; Tang, Na; Lu, Yanju; Guo, Peng; Huang, Ziming. Quality Control of 4-Chlorobenzenesulfonyl chlorideThis research focused ontriazine preparation cervical antitumor activity enzyme inhibitor SAR; 1,3,5-triazine; Apoptosis; Cell cycle; Cell viability; Cervical cancer; PI3K; mTOR. The article conveys some information:

This study describes the synthesis of novel 1,3,5-triazine derivatives I (R = H, 2-OMe, 3-NO2, 4-Cl, etc.) as potent inhibitors of cervical cancer. The compounds I were initially tested for inhibition of PI3K/mTOR, where they showed significant inhibitory activity. The top-ranking mol. [compound I (R = 4-OH) (II)] was further tested against class I PI3K isoforms, such as PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, where it showed the most significant activity against PI3Kα. Compound II was then tested for anti-cancer activity against triple-neg. breast cancer cells (MDA-MB321), human breast cancer cells (MCF-7), human cervical cancer cells (HeLa) and human liver cancer cells (HepG2), and it showed the greatest potency against HeLa cells. The effects of compound II were further evaluated against the HeLa cells, where it showed significant attenuation of cell viability by inducing cell cycle arrest in the G1 phase. Compound II induced apoptosis and reduced migration and invasion of HeLa cells. Western blotting anal. showed that II inhibited PI3K and mTOR with pos. modulation of Bcl-2 and Bax levels in HeLa cells. The effects of compound II were also investigated in a tumor xenograft mouse model, where it showed reduction of tumor volume and weight It also inhibited the PI3K/Akt/mTOR signaling cascade in xenograft tumor tissues, as evidenced by western blotting anal. The results of the present study suggest the possible utility of the designed 1,3,5-triazine derivative I as a potent inhibitor of cervical cancer. After reading the article, we found that the author used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Quality Control of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Quality Control of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics