Tag: 200-300

Zhang, Jie; Song, Xue; Chen, Zhi-Chao; Du, Wei; Chen, Ying-Chun published an article in 2022. The article was titled 《Phosphine-catalysed intermolecular cyclopropanation reaction between benzyl bromides and activated alkenes》, and you may find the article in New Journal of Chemistry.COA of Formula: C7H6BrCl The information in the text is summarized as follows:

While phosphine-mediated reactions were extensively explored over the past few decades, the catalytic cyclopropanation reaction via a phosphonium ylide pathway has been significantly underdeveloped, and an intermol. version still remains to be disclosed. Presented herein was a catalytic cyclopropanation reaction between readily available benzyl bromides and activated alkenes, such as α-cyano chalcones, through in situ formation of phosphonium ylide intermediates. A spectrum of densely functionalized cyclopropane derivatives was efficiently constructed with excellent diastereoselectivity, which can be further converted to five-membered heterocycles after simple transformations. Moreover, moderate enantioselectivity can be obtained by using a com. available DuPhos catalyst. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Exploration of certain 1,3-oxazole- and 1,3-thiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents》 was written by Anh, Duong Tien; Hai, Pham-The; Huong, Le-Thi-Thu; Park, Eun Jae; Jun, Hye Won; Kang, Jong Soon; Kwon, Joo-Hee; Dung, Do Thi Mai; Anh, Vu Tran; Hue, Van Thi My; Han, Sang-Bae; Nam, Nguyen-Hai. Reference of 4-Chlorobenzenesulfonyl chloride And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

Several novel series of hydroxamic acids bearing 2-benzamido-1,3-oxazole/1,3-thiazole I (R = H, 4-Cl, 4-Me, etc.; R1 = C(O); X = O, S) or 2-phenylsulfonamido-1,3-thiazole I (R = H, 4-Cl, 4-Me; R1 = SO2; X = S) were designed and synthesized. The compounds I were obtained straightforward via a two step pathway, starting from com. available Et 2-aminooxazole-4-carboxylate or Et 2-aminothiazole-4-carboxylate. Biol. evaluation showed that these hydroxamic acids I generally exhibited good cytotoxicity against three human cancer cell lines (SW620, colon; PC-3, prostate; NCI-H23, lung cancer), with IC50 values in low micromolar range and comparable to that of SAHA. These compounds I also comparably inhibited HDACs with IC50 values in sub-micromolar range (0.010-0.131μM) and some compounds (e.g., I (R = 4-Me; R1 = C(O); X = O), IC50, 0.010μM) were even more potent than SAHA (IC50, 0.025μM) in HDAC inhibition. Representative compounds I (R = H, R1 = C(O), X = O; R = H, R1 = SO2, X = S) appeared to arrest the SW620 cell cycle at G2 phase and significantly induced both early and late apoptosis of SW620 colon cancer cells. Docking experiments on HDAC2 and HDAC6 isoenzymes revealed favorable interactions at the tunnel of the HDAC active site which pos. contributed to the inhibitory activity of synthesized compound The binding affinity predicted by docking program showed good correlation with the exptl. IC50 values. This study demonstrates that simple 1,3-oxazole- and 1,3-thiazole-based hydroxamic acids I are also promising as antitumor agents and HDAC inhibitors and these results should provide valuable information for further design of more potent HDAC inhibitors and antitumor agents. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Reference of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Reference of 4-Chlorobenzenesulfonyl chloride The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Structural optimization of imidazothiazole derivatives affords a new promising series as B-Raf V600E inhibitors; synthesis, in vitro assay and in silico screening》 was written by Ammar, Usama M.; Abdel-Maksoud, Mohammed S.; Ali, Eslam M. H.; Mersal, Karim I.; Ho Yoo, Kyung; Oh, Chang-Hyun. COA of Formula: C6H4Cl2O2S And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

In this study, based on structural optimization of previously reported inhibitors (3-fluro substituted derivatives of imidazo[2,1-b]thiazole-based scaffold), sixteen new imidazo[2,1-b]thiazole derivatives with m-nitrophenyl group at position 6 I (n = 1, 2; Ar = 3-fluorophenyl, 4-chlorophenyl, 1-naphthyl, etc.) were designed and synthesized. The electron withdrawing properties were reserved while the polarity was modified in comparison to the previously synthesized compounds (-F). Furthermore, the new substituted group (-NO2) provided an addnl. H-bond acceptor(s) which may bind with the target enzyme through addnl. interaction(s). In vitro cytotoxicity evaluation was performed against human cancer cell line (A375). In addition, in vitro enzyme assay was performed against mutated B-Raf (B-Raf V600E). Compounds I (n = 2; Ar = 3-fluorophenyl, 4-fluorophenyl, 4-bromophenyl) showed highest activity on mutated B-Raf with IC50 0.021, 0.035 and 0.020μM. All target compounds were tested for in vitro cytotoxicity against NCI 60 cell lines. Compounds (n = 2; Ar = 3-fluorophenyl, 4-fluorophenyl) were selected for 5 doses test mode. Moreover, in silico mol. simulation was explored in order to explore the possible interactions between the designed compounds and the B-Raf V600E active site. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2COA of Formula: C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. COA of Formula: C6H4Cl2O2S Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Anodic benzylic C(sp3)-H amination: unified access to pyrrolidines and piperidines》 were Herold, Sebastian; Bafaluy, Daniel; Muniz, Kilian. And the article was published in Green Chemistry in 2018. Computed Properties of C11H13ClO2 The author mentioned the following in the article:

An electrochem. aliphatic C-H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C-H amination strategy involved anodic C-H activation to generate a benzylic cation, which was efficiently trapped by a nitrogen nucleophile. The applicability of the process was demonstrated for 40 examples comprising both 5- and 6-membered ring formations. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Computed Properties of C11H13ClO2)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Computed Properties of C11H13ClO2 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《A novel method for carbon-carbon bond formation. Palladium-catalyzed cross-coupling reaction of phenyl fluoroalkanesulfonates with organozinc reagents》 were Chen, Qingyun; He, Yabo. And the article was published in Tetrahedron Letters in 1987. Safety of Ethyl 3-(4-chlorophenyl)propanoate The author mentioned the following in the article:

Cross-coupling reaction of Ph fluoroalkanesulfonates with organozinc reagents in the presence of palladium gives the corresponding alkylbenzenes in good yields. Thus, PhOSO2CF3 and MeOCH2CCZnCl in DMF-THF in the presence of (Ph3P)4Pd at 70° for 12 h gives 67% PhCCCH2OMe. In the experimental materials used by the author, we found Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Safety of Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Safety of Ethyl 3-(4-chlorophenyl)propanoate Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Phenolic and chlorophenolic oligomers in chlorinated pine kraft pulp and in bleach plant effluents》 was written by Erickson, M.; Dence, C. W.. Related Products of 37908-97-7 And the article was included in Svensk Papperstidning in 1976. The article conveys some information:

The estimated total concentration of phenolic substances in the undiluted oxidized spent chlorination liquor of softwood kraft pulp (kappa number 28.2) chlorinated with 6.0% Cl was ∼100 ppm but was ∼190 ppm in the oxidized caustic extraction liquor of pulp chlorinated with 3.6% Cl. Eleven phenolic derivatives were detected in the spent chlorination liquors of the 2 levels of Cl application using gas chromatog. and mass spectrometric anal. The combined yields of the phenolic oxidation products indicated a concentration of ∼10 ppm for phenolic residues in each of the original liquors. The permanganate oxidation products of the chlorinated pulps were the same as those found in the spent chlorination and caustic extraction liquors but in higher total concentration In the experimental materials used by the author, we found 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Related Products of 37908-97-7)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Related Products of 37908-97-7 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Biocatalytic hydrolysis of various esters using Baker’s yeast under neutral conditions without sucrose》 was written by Noguchi, Takuya; Satoh, Shin; Daitoku, Hideyuki; Kawashima, Yuya; Imai, Nobuyuki. Quality Control of Ethyl 3-(4-chlorophenyl)propanoate And the article was included in Tetrahedron Letters on August 17 ,2022. The article conveys some information:

It was found that biocatalytic hydrolysis of various esters using Baker’s yeast proceeds efficiently under neutral conditions without sucrose. Hydrolysis of Et, Me, Pr, iso-Pr, benzyl, allyl, prenyl, and vinyl esters of 3-phenylpropanoic acid using Baker’s yeast gave easily 3-phenylpropanoic acid in 52-86% yields. In contrast, Baker’s yeast did not hydrolyze the rigid structural esters such as cinnamyl and Ph 3-phenylpropanoates. Then, Baker’s yeast hydrolyzed various Et esters of 3-arylpropanoic acids, 4-phenylbutanoic acid, and fatty acids to afford the corresponding acids in 29-85% yields. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Quality Control of Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Quality Control of Ethyl 3-(4-chlorophenyl)propanoate However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design and Synthesis of Sulfonamide-Attached 2-(Isoxazol-3-yl)-1H-imidazoles as Anticancer Agents》 was written by Dende, Satheesh Kumar; Korupolu, Raghu Babu; Leleti, Krishnakanth Reddy. Quality Control of 4-Chlorobenzenesulfonyl chloride And the article was included in ChemistrySelect in 2020. The article conveys some information:

Library of 2-(isoxazol-3-yl)-1H-imidazole sulfonamides I [R = H, 4-Me, 3,4-di-Cl, etc.] were synthesized and structures were confirmed by 1HNMR, 13CNMR and mass spectral anal. Further these compounds I were tested for their anticancer activity against four human cancer cell lines, such as MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) and A2780 (ovarian cancer) by MTT assay and etoposide used as pos. control. Among them, compounds I [R = 2,3,5-tri-MeO, 3,5-di-Cl, 4-MeO, 4-Cl, 4-CN, 4-NO2, 3-NO2] showed more potent anticancer activity against human cancer cell lines.4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Quality Control of 4-Chlorobenzenesulfonyl chloride) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Quality Control of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2003,Organic Syntheses included an article by Jensen, Anne Eeg; Kneisel, Florian; Knochel, Paul. Product Details of 7116-36-1. The article was titled 《Ethyl 3-(p-cyanophenyl)propionate from ethyl 3-iodopropionate and p-cyanophenylzinc bromide》. The information in the text is summarized as follows:

The reaction of bromo(4-cyanophenyl)zinc with 3-iodopropanoic acid Et ester in the presence of bis(acetylacetonato)nickel and 4-fluorostyrene gave the title compound, 4-cyanobenzenepropanoic acid Et ester. The role of 4-fluorostyrene is to reduce the electron d. of an [(aryl)nickel(alkyl)] intermediate by coordinating the nickel center and consequently favoring a reductive elimination leading to an aryl-alkyl product. The reaction represents a cross-coupling between an aryl organometallic reactant and an alkyl iodide derivative The nickel-catalyzed cross-coupling of other arylzinc bromides with alkyl iodides in the presence of 4-(trifluoromethyl)styrene was also reported. Arylzinc bromides can be prepared from aryllithium or arylmagnesium precursors. The experimental process involved the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Product Details of 7116-36-1)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Product Details of 7116-36-1 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Razak, Norazizah A.; Khan, M. Niyaz published their research in Rheologica Acta on December 31 ,2013. The article was titled 《Determination of flow activation energy at viscosity maximum for spherical and wormlike micelles of different lengths and flexibility》.Safety of Sodium 2,6-dichlorobenzoate The article contains the following contents:

Steady shear rheol. measurements were carried out on aqueous solutions containing 15 mM cetyltrimethylammonium bromide (CTABr) and a constant value of [MX] and temperature for MX = 2,3-; 2,4-; 2,5-; 2,6-; 3,4-; and 3,5-Cl2BzNa with Bz-representing C6H3CO-2. Plots of zero shear viscosity (η0) vs. [MX] at 35 °C and 15 mM CTABr show the presence of single maximum and double maxima for MX = 2,3- and 3,5-Cl2BzNa, resp. Turbidity data (absorbance at 600 nm vs. [MX]) coupled with η0vs. [MX] data at 35 °C reveal indirectly the presence of vesicles along with wormlike micelles (WM) at[MX]/[CTABr] > 0. 7 for MX = 3,5-Cl2BzNa. Temperature dependence of η0in the vicinity of the viscosity maximum shows nonlinear and linear Arrhenius behavior, within the temperature range of 20-55 °C, for MX = 2,3-; 2,4-; 2,5-; 3,4-; and 3,5-Cl2BzNa, resp. The values of η0, γ̇cr (critical shear rate), and flow activation energy correlate with CTABr micellar binding constants of counterions. After reading the article, we found that the author used Sodium 2,6-dichlorobenzoate(cas: 10007-84-8Safety of Sodium 2,6-dichlorobenzoate)

Sodium 2,6-dichlorobenzoate(cas: 10007-84-8) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of Sodium 2,6-dichlorobenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics