Tag: 200-300

《Reaction of chlorine dioxide and sodium chlorite with some organic compounds. XVIII. Recation of 4-methoxybenzyl and 4-hydroxybenzyl alcohols with sodium chlorite》 was published in Roczniki Chemii in 1972. These research results belong to Paluch, Karolina; Otto, Jan; Baran, Janusz. Reference of 3,5-Dichloro-4-methoxybenzoic acid The article mentions the following:

In 2N H2SO4 or 6N HCl at 45°, p-MeOC6H4CH2OH and NaClO2 gave a mixture of 4-methoxybenzoic acid, its chloro derivatives, chloroanisoles, and quinones. Similarly, 4-HOC6H4CH2OH at 14° gave a mixture of chlorinated quinones. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Reference of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Reference of 3,5-Dichloro-4-methoxybenzoic acid Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 622-95-7In 2021 ,《Photocatalytic N-benzylation of NH-sulfoximines》 was published in Synthetic Communications. The article was written by Feng, Tao; Luo, Xiaoli; Dong, Jingru; Mo, Junming. The article contains the following contents:

N-Benzylation of NH-sulfoximines via visible light photocatalysis is realized. Under mild reaction conditions, photocatalyst promotes the direct cross-coupling of NH-sulfoximines with benzyl bromides to form N-benzyl sulfoximines. Superbases which are usually used in reported coupling of NH-sulfoximines with alkyl halides were not needed. This method is also suitable for the synthesis of N-allyl sulfoximines.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7SDS of cas: 622-95-7) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.SDS of cas: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: 4-Chlorobenzenesulfonyl chlorideIn 2022 ,《Atom-economic synthesis of β-ketosulfones based on gold-catalyzed highly regioselective hydration of alkynylsulfones》 was published in Green Chemistry. The article was written by Chikunova, Elena I.; Kukushkin, Vadim Yu.; Dubovtsev, Alexey Yu.. The article contains the following contents:

Gold(I)-catalyzed highly regioselective hydration of alkynylsulfones comprised an efficient 100% atom-economic route to β-ketosulfones. The reaction proceeded under mild mercury-free conditions (Ph3PAuNTf2 0.5-5 mol%, THF, rt or 60°C), it demonstrated a high functional group tolerance (more than 30 examples; yields up to 99%), and was easily scaled up. The developed hydration methodol. were successfully integrated into the one-pot syntheses of valuable heterocycles.4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Name: 4-Chlorobenzenesulfonyl chloride) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Name: 4-Chlorobenzenesulfonyl chloride Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Product Details of 98-60-2In 2021 ,《Photoredox-catalyzed synthesis of N-unsubstituted enaminosulfones from vinyl azides and sulfinates》 was published in Tetrahedron Letters. The article was written by Mulina, Olga M.; Ilovaisky, Alexey I.; Opatz, Till; Terent’ev, Alexander O.. The article contains the following contents:

A metal-free visible light photoredox-catalyzed synthesis of N-unsubstituted enaminosulfones from vinyl azides and sodium sulfinates in moderate to high yields were described. The reaction proceeded in ethanol and used Eosin Y as a readily available photocatalyst in combination with nitrobenzene as an electron shuttle. Took into account the number of steps involved (generation of the sulfonyl radical, its addition to the double bond, elimination of mol. nitrogen with formation of an iminyl radical, followed by its reduction and protonation) as well as the number of redox-active reaction partners involved, the selectivity of the process was quite impressive. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Product Details of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Product Details of 98-60-2 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 98-60-2In 2022 ,《Boron-promoted reductive deoxygenation coupling reaction of sulfonyl chlorides for the C(sp3)-S bond construction》 was published in Chinese Chemical Letters. The article was written by Chen, Shuo; Wen, Qingru; Zhu, Yanqing; Ji, Yanru; Pu, Yu; Liu, Zhengli; He, Yun; Feng, Zhang. The article contains the following contents:

Herein, authors report a borane-promoted reductive deoxygenation coupling reaction to synthesize sulfides. This reaction features excellent functional group compatibility, high efficiency, broad substrate scope, and application in late-stage functionalization of biomols. Preliminary mechanistic studies suggest diaryl sulfides are the intermediates of this reaction. Moreover, the real active aryl sulfide anions may be generated in situ with the aid of B2pin2 and react with alkyl tosylates through a concerted SN2 pathway. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2SDS of cas: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Alkene versus alkyne reactivity in unactivated 1,6-enynes: regio- and chemoselective radical cyclization with chalcogens under metal- and oxidant-free conditions》 was written by Mutra, Mohana Reddy; Kudale, Vishal Suresh; Li, Jing; Tsai, Wu-Hsun; Wang, Jeh-Jeng. Application of 98-60-2 And the article was included in Green Chemistry in 2020. The article conveys some information:

Herein, we have developed metal and oxidant-free visible light-promoted alkene vs. alkyne regio- and chemoselective radical cascade cyclization of electronically unbiased 1,6-enynes with chalcogens to synthesize substituted pyrrolidines bearing chalcogens. The reaction generated three new bonds, namely, C-SO2, C-C, and C-Se under extremely mild conditions. Furthermore, we achieved regio- and chemoselective mono-addition of aromatic thiophenols with unactivated 1,6-enynes. The key features of this protocol are broad substrate scope, environment-friendly conditions, operational simplicity, atom economy, and amenability to gram-scale synthesis. The mechanistic studies corroborate that the reaction proceeds via a radical pathway. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Application of 98-60-2 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Metabolism of 2,3-, 2,6-, and 3,5-dichloronitrobenzene and the formation of a mercapturic acid from 2,3,4,5-tetrachloronitrobenzene in the rabbit》 were Bray, H. G.; James, Sybil P.; Thorpe, W. V.. And the article was published in Biochemical Journal in 1957. Safety of 2,4-Dichloro-3-nitrophenol The author mentioned the following in the article:

cf. C.A. 52, 16882f. The metabolism of 2,3-, 2,6-, and 3,5-dichloronitrobenzene has been studied in the rabbit. The main products excreted are phenols, conjugated with glucuronic and sulfuric acids, and dichloroanilines (2,3-dichloroaniline (acetyl and picrate derivatives), 4-amino-3,5-dichlorophenol, 3,5-dichloroaniline (acetyl derivative), 3,5,3′,5′-tetrachloroazoxybenzene, 2-amino-4,6-dichlorophenol, 4-amino-2,6-dichlorophenol). A small amount of a pyrocatechol derivative is probably formed from the 2,6-isomer. No mercapturic acids were detected in the urines. A mercapturic acid (N-acetyl-S-(2,3,4-trichloro-6-nitrophenyl)-L-cysteine) has been isolated from the urine of rabbits given 2,3,4,5-tetrachloronitrobenzene. The chief features of the metabolism of 19 chloromononitrobenzenes have been summarized and discussed. The experimental process involved the reaction of 2,4-Dichloro-3-nitrophenol(cas: 38902-87-3Safety of 2,4-Dichloro-3-nitrophenol)

2,4-Dichloro-3-nitrophenol(cas: 38902-87-3) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Safety of 2,4-Dichloro-3-nitrophenol Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kosal, Andrew D.; Ashfeld, Brandon L. published an article in Organic Letters. The title of the article was 《Titanocene-catalyzed conjugate reduction of α,β-unsaturated carbonyl derivatives》.Electric Literature of C11H13ClO2 The author mentioned the following in the article:

A titanocene-catalyzed conjugate reduction of α,β-unsaturated carbonyl derivatives has been developed. A series of carbonyl compounds including aldehydes, ketones, esters, and amides proved viable in the reduction process providing an efficient, chemoselective method for the catalytic reduction of unsaturated carbonyl derivatives After reading the article, we found that the author used Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Electric Literature of C11H13ClO2)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Electric Literature of C11H13ClO2 The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 98-60-2In 2019 ,《Visible-Light-Catalyzed C-C Bond Difunctionalization of Methylenecyclopropanes with Sulfonyl Chlorides for the Synthesis of 3-Sulfonyl-1,2-dihydronaphthalenes》 was published in Journal of Organic Chemistry. The article was written by Liu, Yu; Wang, Qiao-Lin; Chen, Zan; Zhou, Quan; Li, Hua; Zhou, Cong-Shan; Xiong, Bi-Quan; Zhang, Pan-Liang; Tang, Ke-Wen. The article contains the following contents:

A novel visible-light-catalyzed sulfonylation/arylation of carbon-carbon σ-bond with sulfonyl chlorides for the synthesis of 3-sulfonylated 1,2-dihydronaphthalenes is developed. This difunctionalization proceeds via a sequence of C=C bond sulfonylation, C-C σ-bond cleavage, and intramol. cyclization, and the experiment result shows that the C-C σ-bond difunctionalization reaction includes a radical process. This strategy provides a simple and convenient route for difunctionalization of C-C bonds with an aromatic carbon and a sulfonyl radical by one-pot construction of a C-S bond and a new C-C bond. In the experiment, the researchers used many compounds, for example, 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Recommanded Product: 98-60-2 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Sabita, G.; Savitha, R.; Divya, K.; Bhaskar, K. published an article in Chemical Data Collections. The title of the article was 《Synthesis and biological evaluation of aryl sulfonyl linked isoxazol(pyridin-4-yl)pyrazolo[1,5-a]pyrimidines as cytotoxicity agents》.Computed Properties of C6H4Cl2O2S The author mentioned the following in the article:

A new bunch of aryl sulfonyl linked isoxazol(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine compounds I [R = 4-Me, 3,4-di-Cl, 3,4,5-tri-MeO, etc.] was designed, developed and their structure were characterized by anal. techniques. Further, compounds I were tested for their cytotoxicity activities towards human cancer cell lines like SiHa (cervix cancer), A549 (Lung cancer), MCF-7 (Breast cancer) and Colo-205 (colon cancer) using MTT assay and compared with standard drug, etoposide. Among all, compounds, compounds I [R = 3,4,5-tri-MeO, 3,4-di-MeO, 4-MeO, 4-O2N, 4-MeO-3,5-di-O2N] demonstrated good cytotoxicity effects as standard drug. Specifically, two compounds I [R = 3,4,5-tri-MeO, 4-MeO-3,5-di-O2N] displayed more potent activity.4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Computed Properties of C6H4Cl2O2S) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C6H4Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics