Tag: 200-300

In 2019,ChemistrySelect included an article by Gojiya, Dinesh G.; Vekariya, Mitesh B.; Kapupara, Vimal H.; Bhatt, Tejal D.; Kalavadiya, Prakash L.; Joshi, Hitendra S.. Quality Control of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Rapid, Simple and Efficient Microwave-Assisted Alkylation of 6-Acetyl-2H-Benzo[e][1, 3]Oxazine-2,4(3H)-Dione》. The information in the text is summarized as follows:

A simple, efficient and eco-friendly method has been developed for the synthesis of biol. active alkyl derivatives of 6-acetyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione I (R = 3-n- Bu, MeC6H4, 4-O2NC6H4, etc.) by using microwave irradiations. The N-alkylation of 6-acetyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione with substituted alkyl derivatives under microwave radiations in presence of tetra-Bu ammonium bromide as a phase transfer catalyst to give the desired products. Comparison between conventional and microwave-assisted synthesis revealed that it reduced the reaction time, improve the yield and purity of 6-acetyl-3-(substituted alkyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-diones analog mols. All the final compounds were characterized by FT-IR, 1HNMR, 13CNMR, HRMS and Mass spectroscopic anal., also succeeded to develop and analyze the single crystal XRD of compound I (R = C6H5). The antimicrobial evaluation studies show moderate activities against used microbes. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Quality Control of 1-(Bromomethyl)-4-chlorobenzene) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Quality Control of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Swarts, Henk J.; Verhagen, Frank J. M.; Field, Jim A.; Wijnberg, Joannes B. P. A. published an article in Phytochemistry. The title of the article was 《Novel chlorometabolites produced by Bjerkandera species》.COA of Formula: C8H6Cl2O3 The author mentioned the following in the article:

The EtOAc extract from the extracellular fluid of the mycelium of Bjerkandera sp. BOS55 contained four novel chlorinated benzoic acid derivatives, i.e. 3-chloro-4-hydroxybenzoic acid, 3,5-dichloro-4-hydroxy-benzoic acid, Me 3,5-dichloro-4-hydroxybenzoate and Me 3,5-dichloro-p-anisate. 3-Chloro-4-hydroxybenzoic acid was also produced by B. adusta. In addition to this study using 3,5-Dichloro-4-methoxybenzoic acid, there are many other studies that have used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7COA of Formula: C8H6Cl2O3) was used in this study.

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. COA of Formula: C8H6Cl2O3 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sugimura, Rie; Qiao, Kun; Tomida, Daisuke; Kume, Yohei; Yokoyama, Chiaki published an article in Chemistry Letters. The title of the article was 《Immobilization of palladium acetate on ionic liquid copolymerized polystyrene: a way to eliminate inhibiting effect of imidazolium chloride and enhance catalytic performance》.Product Details of 7116-36-1 The author mentioned the following in the article:

Immobilization of palladium acetate on a novel polymeric support that is prepared by copolymerization of 3-butyl-1-vinylimidazolium chloride with styrene is demonstrated to be an effective way to eliminate inhibiting effect of imidazolium chloride and enhance catalytic performance. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Product Details of 7116-36-1)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Product Details of 7116-36-1 However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1957,Yakugaku Zasshi included an article by Matsuura, Shin; Matsuura, Akira. Recommanded Product: 56966-48-4. The article was titled 《Synthesis of 2′-hydroxy-3′ (and 5′)-acetyl-4,4′-dimethoxychalcone》. The information in the text is summarized as follows:

2,4-HO(MeO)C6H3COCH:CH6C6H4OMe-4 (I) (2.8 g.), 1 g. AcCl,40 ml. PhNO2, and 1.5 g. AlCl3, let stand 2 days, let stand 2 days with an addnl. 1 g. AlCl3 the product decomposed with HCl, steam distilled, the residue extracted with C6H6, the C6H6 removed, and the residue in 150 ml. EtOH evaporated to one-half separated 0.48 g. 3′-Ac derivative (II) of I, needles, m. 145.5°. The above reaction at 15° yielded 0.3 g. 5′-Ac derivative (III) of I, needles, m. 171.5°. Reaction of 5 g. 2,4-AcO(MeO)C6H3COCH: CHC6H4OMe-4 (IV), 4 g. AlCl3, and 50 ml. PhNO2 yielded 0.1 g. II, m. 145.5°. Condensation of 1 g. 2,4-diacetyl-resorcinol mono-Me ether and 1 g. p-MeOC6H6CHO (V) in 10 ml. EtOH and 4 ml. 50% KOH gave 1.6 g. 2′-hydroxy-3′-( 4-methoxycinnamoyl)-4,4′-dimethoxychalcone (VI), needles, m. 171° (from dilute AcOH). Condensation of 0.1 g. II and 0.2 g. V in 5 ml. EtOH and 1 g. 50% KOH yielded 0.07 g. VI, m. 171°. Similarly, 0.1 g. III and 0.5 g. V in 5 ml. EtOH and 1 g. 50% KOH gave 0.12 g. 2′-hydroxy-4,4′-dimethoxy-5′-(4-methoxycinnamoyl)chalcone, m. 190°. The experimental process involved the reaction of 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Recommanded Product: 56966-48-4)

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Recommanded Product: 56966-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: 3,5-Dichloro-4-methoxybenzoic acidOn November 30, 1998 ,《Organohalogen production is a ubiquitous capacity among Basidiomycetes》 appeared in Chemosphere. The author of the article were Verhagen, F. J. M.; Swarts, H. J.; Wijnberg, J. B. P. A.; Field, J. A.. The article conveys some information:

Several species of Basidiomycetes are capable of producing de novo high concentrations of chloroarom. metabolites. However, the extent to which Basidiomycetes contribute to the natural pool of adsorbable organic halogen (AOOX) found in the environment is unknown yet. The purpose of this study was to determine the ubiquity of organohalogen production among Basidiomycetes and to determine maximal specific organohalogen production rates. Finally, the fate of the fungal chloroarom. compounds in the environment was studied. Some 191 fungal strains were tested for AOX production when grown on defined liquid medium. Approx 50% of the strains tested and 55% of the genera tested produced AOX. Organohalogen production seemed to be a ubiquitous capacity among Basidiomycetes. Many highly ecol. significant fungal species were identified among the moderate and high producers. Although it was found that the final AOX concentrations produced by Hypholoma fasciculare were strongly influenced by the substrate used, all maximal specific AOX production rates on different substrates were in the same order of magnitude. Seven new species and four new genera of Basidiomycetes could be added to the list of known chlorinated anisyl metabolite (CAM)-producing Basidiomycetes. In degradation studies of the major fungal metabolite 3,5-dichloro-anisyl alc., it was found that in forest soils there seems to be ubiquitous mineralizing capacity for this chlorinated aromatic compound Burkholderia cepacia was responsible for the fast degradation of this compound in oak forest soils. The experimental process involved the reaction of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Name: 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Name: 3,5-Dichloro-4-methoxybenzoic acid However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: 1-(Bromomethyl)-4-chlorobenzeneIn 2021 ,《Tandem Conjugate Addition/Aromatization/Acyl Transfer Reaction between 3-Aryl-2-nitropropanoates and Quinone Monoimines》 appeared in ChemistrySelect. The author of the article were Cheng, Shao-Bing; Liu, Hui; Jing, Yi; Cao, Lian-Yi; Zhang, Xiao-Mei. The article conveys some information:

A tandem conjugate addition/aromatization/acyl transfer reaction between 3-aryl-2-nitropropanoates and quinone monoimines was described. In the presence of NMM, the reaction proceeded smoothly gave various 1,2-diarylnitroethanes in low to good yields. The structure of one product was determined by an X-ray crystal structural anal. Accordingly, a plausible reaction mechanism was proposed. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis, inhibition properties against xanthine oxidase and molecular docking studies of dimethyl N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives》 was written by Yagiz, Guler; Noma, Samir Abbas Ali; Altundas, Aliye; Al-khafaji, Khattab; Taskin-Tok, Tugba; Ates, Burhan. Recommanded Product: 1-(Bromomethyl)-4-chlorobenzeneThis research focused ontriazole preparation green chem mol docking xanthine oxidase inhibitor; Double docking; Enzyme inhibition; Green synthesis; Triazole derivatives; Xanthine oxidase. The article conveys some information:

This study was focused on synthesis of various di-Me N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives I (R = methoxycarbonyl, hydroxymethyl; X = 2-OH, 3-Br, 4-OMe, 2-OH-5-Cl, etc.) under the conditions of green chem. without the use of solvent and catalysts. Their inhibition properties were also investigated on xanthine oxidase (XO) activity. All dimethanol and dicarboxylate derivatives I exhibited significant inhibition activities with IC50 values ranging from 0.71 to 2.25μM. Especially, I [R = hydroxymethyl, X = 3-Br; and R = methoxycarbonyl, X = 4-Cl] compounds were found to be the most promising derivatives on the XO enzyme inhibition with IC50 values 0.71 and 0.73μM, resp. Moreover, the double docking procedure was used to evaluate compound modes of inhibition and their interactions with the protein (XO) at at. level. Surprisingly, the docking results showed a good correlation with IC50 [correlation coefficient (R2 = 0.7455)]. Also, the docking results exhibited that the I [R = hydroxymethyl, X = 3-Br; R = methoxycarbonyl, X = 4-OH; and R = methoxycarbonyl, X = 4-Cl] have lowest docking scores -4.790, -4.755, and -4.730, resp. These data were in agreement with the IC50 values. These results give promising beginning stages to assist in the improvement of novel and powerful inhibitor against XO. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain》 was published in Chemical Science in 2016. These research results belong to Cox, Oakley B.; Krojer, Tobias; Collins, Patrick; Monteiro, Octovia; Talon, Romain; Bradley, Anthony; Fedorov, Oleg; Amin, Jahangir; Marsden, Brian D.; Spencer, John; von Delft, Frank; Brennan, Paul E.. Electric Literature of C8H10Cl3N The article mentions the following:

Research into the chem. biol. of bromodomains has been driven by the development of acetyl-lysine mimetics. The ligands are typically anchored by binding to a highly conserved asparagine residue. Atypical bromodomains, for which the asparagine is mutated, have thus far proven elusive targets, including PHIP(2) whose parent protein, PHIP, has been linked to disease progression in diabetes and cancers. The PHIP(2) binding site contains a threonine in place of asparagine, and solution screening have yielded no convincing hits. We have overcome this hurdle by combining the sensitivity of X-ray crystallog., used as the primary fragment screen, with a strategy for rapid follow-up synthesis using a chem.-poised fragment library, which allows hits to be readily modified by parallel chem. both peripherally and in the core. Our approach yielded the first reported hit compounds of PHIP(2) with measurable IC50 values by an AlphaScreen competition assay. The follow-up libraries of four poised fragment hits improved potency into the sub-mM range while showing good ligand efficiency and detailed structural data. In the experiment, the researchers used many compounds, for example, 1-(2,6-Dichlorophenyl)-N-methylmethanamine hydrochloride(cas: 90389-15-4Electric Literature of C8H10Cl3N)

1-(2,6-Dichlorophenyl)-N-methylmethanamine hydrochloride(cas: 90389-15-4) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Electric Literature of C8H10Cl3N

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Suraj; Swamy, K. C. Kumara published an article in Journal of Organic Chemistry. The title of the article was 《Ring-Expansion Reactions of Epoxy Amides and Enamides: Functionalized Azetidines, Dihydrofurans, Diazocanes, or Dioxa-3-azabicyclonon-4-enes?》.Reference of 4-Chlorobenzenesulfonyl chloride The author mentioned the following in the article:

Functionalized azetidines I [R1 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2 = Ph, 2-BrC6H4, 2-IC6H4, etc.], 2,3-dihydrofurans II [R3 = Ph, 4-MeC6H4, 4-ClC6H4, etc.] or the unorthodox dioxa-3-azabicyclonone-4-ene motifs III [R4 = Ph, 4-BrC6H4, 2-naphthyl, etc.; R5 = Ph, 4-MeC6H4, 2-BrC6H4, etc.] were the products from transition metal-free reaction between N-oxiranylmethyl benzenesulfonamide and β-chloro-cinnamaldehyde, depending on whether one uses either NaI/K2CO3 or LiBr/K2CO3. These ring expansion reactions involved enamide (X-ray evidence) derived from N-oxiranylmethyl benzenesulfonamide and β-chloro-cinnamaldehyde as an intermediate. The N-oxiranylmethyl benzenesulfonamide itself upon heating gave readily separable and crystalline isomeric diazocanes that could be characterized by X-ray crystallog. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Reference of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Reference of 4-Chlorobenzenesulfonyl chloride However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Su, Shijun; Zhou, Qing; Tang, Xuemei; Peng, Feng; Liu, Tingting; Liu, Liwei; Xie, Chengwei; He, Ming; Xue, Wei published their research in Monatshefte fuer Chemie in 2021. The article was titled 《Design, synthesis, and antibacterial activity of novel myricetin derivatives containing sulfonate》.Application of 98-60-2 The article contains the following contents:

A series of myricetin derivatives containing sulfonate groups I (R = Ph, 2-chlorophenyl, 2-thienyl, etc.) was designed and synthesized. Preliminary antibacterial activity showed that most of the target compounds I exhibited significant biol. activities against Xanthomonas axonopodis pv. In particular, the EC50 value of compound I (R = 4-nitrophenyl) was 13.76μg/cm3 against Xac, which was better than com. reagents bismerthiazol (50.32μg/cm3) and thiodiazole copper. (83.27μG/cm3), and the EC50 value of compound I (3-chlorophenyl) was 11.92μg/cm3 against Xoo in vitro and the result was better than that of bismerthiazol (72.08μg/cm3) and thiodiazole copper (99.26μg/cm3). Compound I (R = 3-chlorophenyl) displayed the better in vivo activity against rice bacterial leaf blight than bismerthiazol and thiodiazole copper. Meanwhile, the antibacterial mechanism of compounds I (R = 4-nitrophenyl) and I (R = 3-chlorophenyl) was studied by scanning electron microscope (SEM). These results suggested that myricetin derivatives containing sulfonate I can be considered as new antibacterial reagents. The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Application of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics