Tag: 200-300

《Catalytic Detoxification of Organophosphorus Nerve Agents by Butyrylcholinesterase-Polymer-Oxime Bioscavengers》 was published in Biomacromolecules in 2020. These research results belong to Zhang, Libin; Murata, Hironobu; Amitai, Gabriel; Smith, Paige N.; Matyjaszewski, Krzysztof; Russell, Alan J.. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:

Organophosphorus nerve agents (OPNAs), used in chem. warfare, irreversibly inhibit essential cholinesterases (ChEs) in the cholinergic neurotransmission system. Several potent nucleophilic oximes have been approved for the treatment of acute poisoning by OPNAs, but they are rapidly cleared from blood circulation. Butyrylcholinesterase (BChE) stoichiometrically binds nerve agents, but because the mol. weight of a nerve agent is about 500-fold less than the enzyme, the bioscavenger has had limited utility. We synthesized BChE-polymer-oxime conjugates using atom transfer radical polymerization (ATRP) and azide-alkyne “”click”” chem. The activity of the BChE-polymer-oxime conjugates was dependent on the degree of oxime loading within the copolymer side chains. The covalent modification of oxime-containing copolymers prolonged the activity of BChE in the presence of the VX- and cyclosarin-fluorogenic analogs EMP-MeCyC and CMP-MeCyC, resp. After complete inactivation by VX and cyclosarin fluorogenic analogs, the conjugates demonstrated efficient self-reactivation of up to 80% within 3-6 h. Repeated inhibition and high-level self-reactivation assays revealed that the BChE-polymer-oxime conjugates were excellent reactivators of OPNA-inhibited BChE. Recurring self-reactivation of BChE-polymer-oxime conjugates following repeated BChE inhibition by fluorogenic OPNAs (Flu-OPNAs) opens the door to developing the next generation of nerve agent “”catalytic”” bioscavengers. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2015,RSC Advances included an article by Saoudi, Besma; Debache, Adbelmadjid; Soule, Jean-Francois; Doucet, Henri. Related Products of 306936-53-8. The article was titled 《Synthesis of heteroarenes dyads from heteroarenes and heteroarylsulfonyl chlorides via Pd-catalyzed desulfitative C-H bond heteroarylations》. The information in the text is summarized as follows:

A series of heteroaryl dyads, e.g., I, were synthesized from palladium-catalyzed direct heteroarylation of heteroarenes RH [R = 1-Me pyrrol-2-yl, benzofuran-2-yl, 1-(furan-2-yl)propan-2-one, etc.] in which heteroarylsulfonyl chlorides, e.g., II, are used as coupling partners through a desulfitative cross-coupling. These C-H bond functionalizations occurred at the α-position in the case of pyrrole and furan derivatives, while in the case of thiophenes the C-H bonds at the βposition have been heteroarylated. This methodol. represents a very simple route to heteroaryl dyads. Moreover, some examples of heteroaryl triads, e.g., III, have been synthesized via iterative C-H bond arylations. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate(cas: 306936-53-8Related Products of 306936-53-8)

Methyl 5-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate(cas: 306936-53-8) belongs to pyrroles. Pyrroles are components of more complex macrocycles, including the porphyrinogens and products derived therefrom, including porphyrins of heme, the chlorins, bacteriochlorins, and chlorophylls. Porphobilinogen, a trisubstituted pyrrole, is the biosynthetic precursor to many natural products such as heme.Related Products of 306936-53-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Pd-Catalyzed Cross-Coupling of Sb-Aryl Stibines with Halogenomethyl Arenes to Give Unsymmetric Diarylmethanes》 was written by Zhang, Dejiang; Xu, Zhi; Tang, Ting; Le, Liyuan; Wang, Cairong; Kambe, Nobuaki; Qiu, Renhua. Recommanded Product: 622-95-7This research focused onunsym diarylmethane preparation; halogenomethyl arene aryl stibine cross coupling palladium catalyst. The article conveys some information:

Herein, a general method for the synthesis of unsym. diarylmethanes RCH2R1 (R = 4-cyanophenyl, 3-fluorophenyl, 2-chloro-4-fluorophenyl, etc.; R1 = Ph, 4-methoxyphenyl, 3-furanyl, etc.) from (hetero)aryl Me halides RCH2X (X = Br, Cl) and Sb-aryl stibines I was described. This protocol shows a broad substrate scope and a good functional group tolerance. Drug mols., including beclobrate and bifemelane, and drug derivatives, including celecoxib, ibuprofen, and probenecid, were efficiently synthesized on a gram scale. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Recommanded Product: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Ion-Pair Selective Conformational Rearrangement of Sulfonamide Calix[6]arene-Based Pseudorotaxanes》 was written by Cera, Gianpiero; Bazzoni, Margherita; Arduini, Arturo; Secchi, Andrea. Application In Synthesis of 4-Chlorobenzenesulfonyl chlorideThis research focused ontrisulfonamide calixarene viologen ion pair pseudorotaxane conformation. The article conveys some information:

We describe the synthesis of a new class of trisulfonamide calix[6]arene-based wheels that can bind dialkylviologen salts, in apolar media. The threading process occurs through a selective ion-pair recognition, established by the sulfonamide groups with the counterions of the bipyridinium salts, that dictates a conformational rearrangement of the corresponding pseudorotaxanes. In the experiment, the researchers used many compounds, for example, 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Application In Synthesis of 4-Chlorobenzenesulfonyl chloride The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of 4-Chlorobenzenesulfonyl chlorideIn 2019 ,《Direct coupling of haloquinolines and sulfonyl chlorides leading to sulfonylated quinolines in water》 was published in Tetrahedron Letters. The article was written by Bao, Pengli; Wang, Leilei; Liu, Qishun; Yang, Daoshan; Wang, Hua; Zhao, Xiaohui; Yue, Huilan; Wei, Wei. The article contains the following contents:

A simple and efficient method has been developed for construction of sulfonylated quinolines via coupling of haloquinolines and sulfonyl chlorides in water [e.g., 2-chloroquinoline + tosyl chloride → 2-tosylquinoline (93%, 89% isolated) using Zn powder as reductant at 80° in water]. The present methodol. provides an attractive approach to various sulfonylated quinolines in moderate to good yields with favorable functional group tolerance, which has the advantages of operation simplicity, readily available starting materials, excellent regioselectivity, scale-up synthesis, and organic solvent-free conditions. The experimental process involved the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Safety of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,ChemistrySelect included an article by Di Mola, Antonia; Macchia, Antonio; Tedesco, Consiglia; Pierri, Giovanni; Palombi, Laura; Filosa, Rosanna; Massa, Antonio. COA of Formula: C7H6BrCl. The article was titled 《Synthetic Strategies and Cascade Reactions of 2-Cyanobenzophenones for the Access to Diverse 3,3-Disubstituted Isoindolinones and 3-Aryl-3-Hydroxyisoindolinones》. The information in the text is summarized as follows:

New methodologies for the synthesis of the challenging ketones 2-cyanobenzophenones, based on Suzuki-Miyaura type cross-coupling reactions and very mild oxidation of 2-benzylbenzonitriles. The investigation of the reactivity of the obtained ketones highlighted a very good electrophilicity in the presence of mild carbon- and hetero-nucleophiles, allowing the synthesis of 3,3-disubstituted isoindolin-1-ones. All the developed methodologies were highly efficient and tolerated combinations of functional groups present on both the aromatic rings. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,ChemMedChem included an article by Campanico, Andre; Carrasco, Marta P.; Njoroge, Mathew; Seldon, Ronnett; Chibale, Kelly; Perdigao, Joao; Portugal, Isabel; Warner, Digby F.; Moreira, Rui; Lopes, Francisca. Related Products of 139502-80-0. The article was titled 《Azaaurones as potent antimycobacterial agents active against MDR- and XDR-TB》. The information in the text is summarized as follows:

Herein we report the screening of a small library of aurones and their isosteric counterparts, azaaurones and N-acetylazaaurones, against Mycobacterium tuberculosis. Aurones were found to be inactive at 20 μM, whereas azaaurones and N-acetylazaaurones emerged as the most potent compounds, with nine derivatives displaying MIC99 values ranging from 0.4 to 2.0 μM. In addition, several N-acetylazaaurones were found to be active against multidrug-resistant (MDR) and extensively drug-resistant (XDR) clin. M. tuberculosis isolates. The antimycobacterial mechanism of action of these compounds remains to be determined; however, a preliminary mechanistic study confirmed that they do not inhibit the mycobacterial cytochrome bc1 complex. Addnl., microsomal metabolic stability and metabolite identification studies revealed that N-acetylazaaurones are deacetylated to their azaaurone counterparts. Overall, these results demonstrate that azaaurones and their N-acetyl counterparts represent a new entry in the toolbox of chemotypes capable of inhibiting M. tuberculosis growth. In the experimental materials used by the author, we found 4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde(cas: 139502-80-0Related Products of 139502-80-0)

4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde(cas: 139502-80-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Related Products of 139502-80-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 98-60-2In 2021 ,《Synthesis of symmetrical / unsymmetrical thiosulfonates through the disproportionate coupling reaction of sulfonyl hydrazide mediated by phosphomolybdic acid》 was published in Tetrahedron Letters. The article was written by Lv, Mengting; Liu, Yufeng; Li, Ke; Yang, Guoping. The article contains the following contents:

Phosphomolybdic acid (H3PMo12O40) was reported as a green low-cost catalyst for the synthesis of sym. / unsym. thiosulfonates via the disproportionate coupling reaction of sulfonyl hydrazide. The attributes of this reported catalytic system included low catalyst loadings (1 mol%), efficient turnover, and high yields (up to 94%). Addnl., this reaction mechanism involved the formation of a thiyl radical and sulfonyl radical via sulfinyl radical disproportionation. In the experiment, the researchers used many compounds, for example, 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Application of 98-60-2 The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and biological evaluation of imidazo[2,1-b]thiazole based sulfonyl piperazines as novel carbonic anhydrase II inhibitors》 was written by Manasa, Kesari Lakshmi; Pujitha, Sravya; Sethi, Aaftaab; Arifuddin, Mohammed; Alvala, Mallika; Angeli, Andrea; Supuran, Claudiu T.. Application of 98-60-2 And the article was included in Metabolites in 2020. The article conveys some information:

A novel series of imidazo[2,1-b]thiazole-sulfonyl piperazine conjugates I [R = H, 4-Me, 4-F, 4-MeO, 4-Cl; R1 = H, 4-Me, 4-MeO, 4-Cl, 4-(CH3)3C] synthesized and evaluated for carbonic anhydrase (CA, EC 4.2.1.1) inhibitory potency against four isoforms: The cytosolic isoenzyme hCA I, II and trans-membrane tumor-associated isoform hCA IX and hCA XII, taking acetazolamide (AAZ) as standard drug, using a stopped flow CO2 hydrase assay. The results revealed that most of the compounds showed selective activity against hCA II whereas none of them were active against hCA I, IX, XII (Ki > 100μM). The physiol. dominant cytosolic isoform hCA II was inhibited by these mols. with inhibition constants in the range of 57.7-98.2μM. This new derivative I, thus, selectively inhibited hCA II over the hCA I, IX, XII isoforms, which may be used for further understanding the physiol. roles of some of these isoforms in various pathologies. The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,ChemistrySelect included an article by Chavan, Pramod V.; Charate, Shrinivas P.; Desai, Uday V.; Rode, Chandrashekhar V.; Wadgaonkar, Prakash P.. Formula: C7H6BrCl. The article was titled 《Bentonite-Clay-Supported Cuprous Iodide Nanoparticles (BENT-CuI NPs): A New Heterogeneous Catalyst in Diversity-Oriented Synthesis of 1,2,3-Triazoles in Aqueous Medium》. The information in the text is summarized as follows:

Bentonite clay supported cuprous iodide nanoparticles (BENT-CuI NPs) were prepared and demonstrated for the first time as an efficient heterogeneous catalyst in diversity oriented, green synthesis of 1,2,3-triazoles by one-pot, three component reaction between alkyl halides, arylboronic acids or epoxides with alkynes and sodium azide in aqueous medium. The catalyst was characterized by Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), Energy Dispersive X-ray Spectroscopy (EDS), SEM, X-Ray Powder Diffraction (XRD), Transmission Electron Microscopy (TEM) as well as Brunauer-Emmett-Teller (BET) techniques and was found to be reusable for five consecutive runs without significant loss of activity. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics