Tag: 200-300

Koronka, Daniel; Miyatake, Kenji published an article in 2021. The article was titled 《Anion exchange membranes containing no β-hydrogen atoms on ammonium groups: synthesis, properties, and alkaline stability》, and you may find the article in RSC Advances.Electric Literature of C7H6BrCl The information in the text is summarized as follows:

Novel anion conductive polymer membranes have been designed and synthesized to investigate whether the absence of β-hydrogen atoms of ammonium groups affects the membranes’ properties and chem. stability. The hydrophilic monomer, 2,2-bis(4-chlorobenzyl)-2-phenyl-ethylamine (3), was obtained via a two-step reaction with an overall yield of 98% under mild reaction conditions. Ni(0)-promoted copolymerization of 3 with 2,2-bis(4-chlorophenyl)hexafluoropropane (1) afforded high mol. weight copolymers (Mn = 12.8-19.6 kDa, Mw = 82.1-224.6 kDa). After quaternization with iodomethane, QBAF-BS polymers formed bendable, robust membranes from solution casting. The ion exchange capacity (IEC) of the membranes ranged from 1.50 to 2.44 mequivalent g-1. The membranes exhibited high hydroxide ion conductivity in water (up to 191 mS cm-1 at 80°C for IEC = 2.25 mequivalent g-1), suggesting that the newly designed hydrophilic structure was effective in improving the ion conductivity Based on small-angle X-ray scattering (SAXS) analyses and transmission electron microscopy (TEM) images, all membranes featured nano-phase separated morphol. with a large dependence on the copolymer composition The strain properties were improved on increasing the content of the hydrophilic component up to IEC = 2.25 mequivalent g-1, above which the strain became smaller due to the larger water absorption. The membranes were not stable under harsh alk. conditions (in 8 M KOH at 80°C) gradually losing the hydroxide ion conductivity Compared to our previous AEMs which contained typical aliphatic ammonium groups, the lack of β-hydrogen atoms did not practically improve the alk. stability of AEMs possibly due to the main chain degradation but contributed to higher ion conductivity1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Electric Literature of C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Electric Literature of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yuan, Kedong; Feoktistova, Taisiia; Cheong, Paul Ha-Yeon; Altman, Ryan A. published their research in Chemical Science in 2021. The article was titled 《Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination》.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride The article contains the following contents:

PdII/CuI co-catalyze an arylation reaction of gem-difluoroalkenes using arylsulfonyl chlorides to deliver α,α-difluorobenzyl products. The reaction proceeded through a β,β-difluoroalkyl-Pd intermediate that typically underwent unimol. β-F elimination to deliver monofluorinated alkene products in a net C-F functionalization reaction. However to avoid β-F elimination, the β,β-difluoroalkyl-Pd intermediate were offered, an alternate low-energy route involving β-H elimination to ultimately deliver difluorinated products in a net arylation/isomerization sequence. Overall, this reaction enabled exploration of new reactivities of unstable fluorinated alkyl-metal species, while also providing new opportunities for transforming readily available fluorinated alkenes into more elaborate substructures. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Application In Synthesis of 4-Chlorobenzenesulfonyl chloride Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C11H13ClO2On June 2, 2017, Zhang, Hongwei; Muniz, Kilian published an article in ACS Catalysis. The article was 《Selective Piperidine Synthesis Exploiting Iodine-Catalyzed Csp3-H Amination under Visible Light》. The article mentions the following:

A route to selective piperidine formation through intramol. catalytic Csp3-H amination is described. This hydrocarbon amination reaction employs a homogeneous iodine catalyst derived from halogen coordination between mol. iodine and a terminal oxidant. It relies on visible light initiation and proceeds within two catalytic cycles that comprise a radical C-H functionalization and an iodine-catalyzed C-N bond formation. The protocol is demonstrated for a total of 30 applications. In addition to this study using Ethyl 3-(4-chlorophenyl)propanoate, there are many other studies that have used Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Formula: C11H13ClO2) was used in this study.

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Formula: C11H13ClO2 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《CuCl2-promoted decomposition of sulfonyl hydrazides for the synthesis of thiosulfonates》 was written by Kim, Junsu; Park, Sanggil; Kim, Hyungjun; Kim, Jinho. Application In Synthesis of 4-Chlorobenzenesulfonyl chlorideThis research focused onthiosulfonate preparation copper catalyst; sulfonyl hydrazide decomposition. The article conveys some information:

Sulfonyl hydrazides recently received much attention as reagents for the introduction of sulfur-containing functional groups into organic compounds, because both sulfonyl and sulfenyl sources could be generated by the oxidation and decomposition of the sulfonyl hydrazides, resp. However, the transformations of sulfonyl hydrazides into thiosulfonates, which could be produced by the reaction between sulfonyl and sulfenyl sources, have been less investigated. In this manuscript, CuCl2-promoted selective synthesis of thiosulfonates I (R = 4-Me, 4-NO2, 3-Br, 2-Naph, etc.) from sulfonyl hydrazides is described. A variety of thiosulfonates were produced in moderate to good yields. The mechanism involving radical intermediates such as sulfonyl radical and thiyl radical was proposed on the basis of the previously reported references and mechanistic investigations. In addition, quantum chem. simulations revealed that Cu-promoted decomposition of sulfonyl hydrazides is thermodynamically viable in the developed conditions. In addition to this study using 4-Chlorobenzenesulfonyl chloride, there are many other studies that have used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Application In Synthesis of 4-Chlorobenzenesulfonyl chloride The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Huo, Yong-Wang; Qi, Xinxin; Wu, Xiao-Feng published an article in 2022. The article was titled 《Nickel-Catalyzed Carbonylative Synthesis of α,β-Unsaturated Thioesters from Vinyl Triflates and Arylsulfonyl Chlorides》, and you may find the article in Organic Letters.Electric Literature of C6H4Cl2O2S The information in the text is summarized as follows:

A straightforward and efficient synthesis of α,β-unsaturated thioesters RC(O)SR1 [R = cyclopenten-1-yl, cyclohexen-1-yl, 3,4-dihydronaphthalen-1-yl, etc.; R1 = 4-MeC6H4, 4-FC6H4, 4-MeOC6H4, etc.] had been developed via a nickel-catalyzed thiocarbonylation reaction of vinyl triflates with arylsulfonyl chlorides. With Mo(CO)6 as both CO source and reductant, a variety of α,β-unsaturated thioesters were obtained in moderate to good yields with very good functional group compatibility. It was noteworthy that the present method was the first example on nickel-catalyzed carbonylative synthesis of α,β-unsaturated thioesters by using arylsulfonyl chlorides as the coupling partner. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Electric Literature of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C6H4Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yuan, Zhi-ying; Zhang, Shuai; Teng, Fan; Jin, Xue-Feng; Sheng, Wen-bing; Gui, Qing-Wen published an article in 2022. The article was titled 《Iodide Salt Mediated Synthesis of β-Keto Sulfones Using Arylsulfonyl Chlorides as the Sulfur Sources》, and you may find the article in ChemistrySelect.Recommanded Product: 98-60-2 The information in the text is summarized as follows:

An efficient, green strategy was developed to synthesize β-keto sulfones using available and inexpensive sulfonyl chlorides as a sulfur source in reaction with aromatic alkenes in the presence of cheap iodide. It was particularly pointed out that this method involved the construction of C-S bonds and the desired product can be obtained either through the free radical pathway. This agreement involved a green and simple synthesis method, and was functionalized with styrene and the present method is applicable to a wide range of benzenesulfonyl chloride compounds and styrenes with a variety of functional groups. In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Recommanded Product: 98-60-2 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yan, Tingting; Babu, Kaki Raveendra; Wu, Yong; Li, Yang; Tang, Yuhai; Xu, Silong published their research in Organic Letters in 2021. The article was titled 《Phosphine-Catalyzed Cross-Coupling of Benzyl Halides and Fumarates》.HPLC of Formula: 622-95-7 The article contains the following contents:

A phosphine-catalyzed olefinic cross-coupling between benzyl halides and fumarates was described, which affords trisubstituted alkenes I [R = Me, Et, Bu; R1 = Ph, 4-MeC6H4, 3-MeOC6H4, etc.] in good yields and excellent E-selectivity under metal-free conditions. Mechanistic studies suggested a catalytic cycle involving phosphorus ylide formation, Michael addition, water-assisted hydrogen transfer and phosphine elimination. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7HPLC of Formula: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.HPLC of Formula: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Electrochemical Annulation-Iodosulfonylation of 1,5-Enyne-containing para-Quinone Methides (p-QMs) to Access (E)-Spiroindenes》 was written by Zuo, Hang-Dong; Hao, Wen-Juan; Zhu, Chi-Fan; Guo, Cheng; Tu, Shu-Jiang; Jiang, Bo. Product Details of 98-60-2 And the article was included in Organic Letters in 2020. The article conveys some information:

A new electrochem. three-component annulation-iodosulfonylation of 1,5-enyne-containing para-quinone methides (p-QMs) has been established by using available arylsulfonyl hydrazides and potassium iodide under environmentally benign conditions. The electrosynthesis offers sustainable and efficient access to construct spirocyclohexadienone-containing (E)-indenes without any addnl. catalyst or oxidant through a sulfonyl-radical-triggered 1,6-addition and an I+-mediated ipso-cyclization cascade. Notably, potassium iodide plays the triple role of an electrolyte, a redox catalyst, as well as an iodination reagent. The experimental part of the paper was very detailed, including the reaction process of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Product Details of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《A general and practical sulfonylation of benzylic ammonium salts with sulfonyl hydrazides for the synthesis of sulfones》 was published in Tetrahedron Letters in 2020. These research results belong to Zhu, Haibo; Zhang, Yingying; Liu, Yishuai; Yang, Liu; Xie, Zongbo; Jiang, Guofang; Le, Zhang-Gao. Recommanded Product: 4-Chlorobenzenesulfonyl chloride The article mentions the following:

A practical and efficient approach adopting transition-metal-free cross-coupling of sulfonyl hydrazides with benzyl ammonium salts was developed to synthesize benzyl sulfones using Cs2CO3 as base under mild conditions. The protocol employed stable and easy to handle coupling partners, and was endowed with good substrate compatibility, leading to functional benzyl sulfones in good yields. In the experiment, the researchers used many compounds, for example, 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Recommanded Product: 4-Chlorobenzenesulfonyl chloride However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Microwave-Assisted Tandem Kornblum Oxidation and Biginelli Reaction for the Synthesis of Dihydropyrimidones》 was published in ChemistrySelect in 2020. These research results belong to Malik, Asif A.; Dangroo, Nisar A.; Ara, Tabassum. Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:

A simple and straightforward approach for the synthesis of dihydropyrimidones I (X = O, S; Ar = Ph, 4-FC6H4, pyridin-2-yl, 1H-pyrrol-2-yl, etc.) via sequential Kornblum oxidation/Biginelli reaction has been developed. The protocol involves an in situ oxidation of benzyl bromides ArCH2Br which serve as a carbonyl equivalent followed by cyclocondensation with (thio)urea and Et acetoacetate to furnish dihydropyrimidones I under catalyst- and base-free conditions in a one-pot tandem manner under microwave irradiation Further, the product purification using aqueous recrystallization avoids large quantities of volatile and a toxic organic solvent usually required for work-up and significantly less time required for this process makes the method environmentally friendly. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics