Tag: 200-300

Chen, Dan; Lin, Li; Peng, Xiaoyan; Yu, Xinyi; Yang, Zhonglie; Liu, Yutong; Zhang, Xiaobin; Li, Jiahong; Jiang, Hezhong published their research in Tetrahedron Letters in 2021. The article was titled 《Transition-metal-free NaI-mediated reaction of aryl sulfonyl chloride with alkynes: Synthesis of (E)-β-iodovinyl sulfones》.Electric Literature of C6H4Cl2O2S The article contains the following contents:

A novel protocol for synthesis of (E)-β-iodovinyl sulfones via NaI-mediated aryl sulfonyl chloride with alkynes were described, featuring transition-metal-free condition, com. available substrates, convenient operation, as well as good functional group compatibility. A wide variety of substrate application and good functional group tolerance were provided by this approach, giving multiple (E)-β-iodovinyl sulfones analogs with excellent yields (up to 98%, >4 g scale).4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Electric Literature of C6H4Cl2O2S) was used in this study.

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Electric Literature of C6H4Cl2O2S Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Borsoi, Ana Flavia; Paz, Josiane Delgado; Pissinate, Kenia; Rambo, Raoni Scheibler; Pestana, Victor Zajaczkowski; Bizarro, Cristiano Valim; Basso, Luiz Augusto; Machado, Pablo published their research in Molecules in 2021. The article was titled 《Ultrasound-assisted synthesis of 4-alkoxy-2-methylquinolines: an efficient method toward antitubercular drug candidates》.Formula: C7H6BrCl The article contains the following contents:

Herein, a new synthetic approach was established providing efficient and rapid access (15 min) to a series of 4-alkoxy-6-methoxy-2-methylquinolines I (R = 4-nitrophenyl, 3,4-difluorophenyl, naphthalen-2-yl, etc.) using ultrasound energy. The new synthetic protocol provides a simple procedure utilizing an open vessel system that affords the target products I at satisfactory yields (45-84%) and elevated purities (≳95%). The methodol. allows the evaluation of a larger number of mols. in assays against the bacillus, facilitating the determination of the structure-activity relationship with a reduced environmental cost. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Abas, Hossay; Amer, Mostafa M.; Olaizola, Olatz; Clayden, Jonathan. Related Products of 622-95-7. The article was titled 《N-Chloroformylimidazolidinone Enolates as 1,3-Dipolar Reagents for the Stereoselective Synthesis of 3,4-Dihydroisoquinolones》. The information in the text is summarized as follows:

N-Chloroformyl imidazolidinone derivatives of enantiopure amino acids may be deprotonated to give remarkably well-behaved enolates with both nucleophilic and electrophilic character. The enolates undergo diastereoselective C-alkylation with benzylic halides. A Bischler-Napieralski-like cyclization reaction onto the chloroformyl group, induced by either nucleophilic (KI, 2,6-lutidine) or Lewis acid (AlCl3) catalysis, gives substituted 3,4-dihydroisoquinolone derivatives in enantioenriched form. The reaction sequence constitutes a formal [3 + 3] route to the six-membered lactam ring of the dihydroisoquinolones. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Related Products of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Related Products of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of Ethyl 3-(4-chlorophenyl)propanoateOn October 10, 2005 ,《Chemoselective Heck arylation of acrolein diethyl acetal catalyzed by an oxime-derived palladacycle》 was published in Tetrahedron. The article was written by Najera, Carmen; Botella, Luis. The article contains the following contents:

A dimeric 4-hydroxyacetophenone oxime-derived palladacycle has been used as a very efficient precatalyst for the chemoselective arylation of CH2:CH(OEt)2 (I) to give either cinnamaldehyde derivatives or 3-arylpropanoate esters by proper choice of the reaction conditions. The synthesis of cinnamaldehyde derivatives can be performed by Heck reaction of I with haloarenes in Me2NAc using K2CO3 as base at 120 °C and Bu4N OAc and KCl as additives, followed by acid workup. In the case of 3-arylpropanoate esters the arylation of I with iodoarenes can be performed at 90 °C in aqueous DMA using (dicyclohexyl)methylamine as base, whereas for bromoarenes the reaction has to be performed at 120 °C using Bu4NBr as additive. Alternatively, this process can be performed under microwave irradiation These couplings take place in good yields and with lower catalyst loading than with palladium(II) acetate as well as in shorter reaction times and with lower excess of I. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Quality Control of Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Quality Control of Ethyl 3-(4-chlorophenyl)propanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Copper-Catalyzed Trifluoromethylation/Cyclization of Alkynes for Synthesis of Dioxodibenzothiazepines》 was written by Zhang, Zi-Qi; Xu, Yi-Hao; Dai, Jing-Cheng; Li, Yan; Sheng, Jie; Wang, Xi-Sheng. Application In Synthesis of 4-Chlorobenzenesulfonyl chlorideThis research focused ontrifluoroethylidene dioxodibenzothiazepine regioselective diastereoselective preparation; ethynylphenyl benzenesulfonamide Tognis reagent copper trifluromethylation tandem radical cyclization. The article conveys some information:

A facile and efficient approach for the synthesis of the CF3-containing dioxodibenzothiazepines was developed via copper-catalyzed trifluoromethylation/cyclization of alkynes utilizing a radical relay strategy. This method showed demonstrated low catalyst loading, high regiocontrol and broad scope under mild conditions. Good compatibility for the N-protecting group, gram-scale experiment, and further derivation of product proved the versatility of this transformation. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 4-Chlorobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Hou, Liting; Huang, Wenyi; Wu, Xianqing; Qu, Jingping; Chen, Yifeng published an article in Organic Letters. The title of the article was 《Nickel-Catalyzed Carbonylation of Cyclopropanol with Benzyl Bromide for Multisubstituted Cyclopentenone Synthesis》.Category: chlorides-buliding-blocks The author mentioned the following in the article:

Herein, the authors report a Ni-catalyzed carbonylation of cyclopropanol with benzyl bromide to afford multisubstituted cyclopentenone under 1 atm of CO. The reaction proceeds through a cascade carbonylation of benzyl bromides, followed by generation of nickel homoenolate from cyclopropanols via β-C elimination to afford 1,4-diketones, which undergoes intramol. aldol condensation to furnish highly substituted cyclopentenone derivatives I [Ar = Ph, R = Ph, 4-MeOC6H4, 3-ClC6H4, etc.; Ar = 2-naphthyl, 3-MeOC6H4, 4-ClC6H4, etc., R = Ph] in moderate to good yields. The reaction exhibited high functional group tolerance with broad substrate scope. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Category: chlorides-buliding-blocks)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Category: chlorides-buliding-blocks It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,ChemistrySelect included an article by Dandia, Anshu; Saini, Pratibha; Bansal, Sarika; Parewa, Vijay. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《One-Pot Copper(I)-Catalyzed Synthesis of 2-Aryl-quinazolin-4(3H)-ones via N-benzylation/Csp3-H Oxidation/CN Hydrolysis/Cyclization》. The information in the text is summarized as follows:

A Cu(I)-catalyzed straightforward synthesis of quinazolin-4(3H)-ones was attained by the reaction of 2-aminobenzonitrile with benzyl bromides. The reaction proceeded via one pot N-benzylation/CSp3- H oxidation/CN hydrolysis/cyclization sequence. Numerous controlled experiments were carried out to establish the appropriate mechanism and prerequisite of the reactions. The process was truly selective as only quinazolinones formed as desired product over dihydrogenated quinazolinones. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yuan, Xiao; Yan, Ning; Xiao, Chaoxian; Li, Changning; Fei, Zhaofu; Cai, Zhipeng; Kou, Yuan; Dyson, Paul J. published an article on February 28 ,2010. The article was titled 《Highly selective hydrogenation of aromatic chloronitro compounds to aromatic chloroamines with ionic-liquid-like copolymer stabilized platinum nanocatalysts in ionic liquids》, and you may find the article in Green Chemistry.HPLC of Formula: 38902-87-3 The information in the text is summarized as follows:

Platinum nanoparticles (PtNPs stabilized by an ionic-liquid-like-copolymer (IP) immobilized in various ionic liquids (ILs)) effectively catalyze the selective hydrogenation of aromatic chloronitro compounds to aromatic chloroamines, a reaction of considerable com. significance. The preparation of 2,4-dichloro-3-aminophenol (DAP) has been primarily studied due to its important industrial applications. DAP is usually prepared from 2,4-dichloro-3-nitrophenol (DNP) by reduction with hydrogen using Ni- or Pt-based catalysts. Compared to reactions in mol. (organic) solvents, the ILs system provides superior selectivity with functionalized ILs containing an alc. group demonstrating the best recyclability, and ultimately achieving a turnover number of 2025 which is 750 fold higher than Raney nickel catalyst. A universal catalyst-ionic liquid system for the conversion of aromatic chloronitro compounds to aromatic chloroamines was also established. TEM, XPS, IR spectroscopy were used to characterize the morphol. of the nanocatalysts allowing their structure to be correlated to their activity. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-3-nitrophenol(cas: 38902-87-3HPLC of Formula: 38902-87-3)

2,4-Dichloro-3-nitrophenol(cas: 38902-87-3) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.HPLC of Formula: 38902-87-3 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: Ethyl 3-(4-chlorophenyl)propanoateOn November 30, 2019 ,《An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp3)-H bonds》 appeared in Nature Chemistry. The author of the article were Yang, Yang; Cho, Inha; Qi, Xiaotian; Liu, Peng; Arnold, Frances H.. The article conveys some information:

The ability to selectively functionalize ubiquitous C-H bonds streamlines the construction of complex mol. architectures from easily available precursors. Here we report enzyme catalysts derived from a cytochrome P 450 that use a nitrene transfer mechanism for the enantioselective amination of primary, secondary and tertiary C(sp3)-H bonds. These fully genetically encoded enzymes are produced and function in bacteria, where they can be optimized by directed evolution for a broad spectrum of enantioselective C(sp3)-H amination reactions. These catalysts can aminate a variety of benzylic, allylic and aliphatic C-H bonds in excellent enantioselectivity with access to either antipode of product. Enantioselective amination of primary C(sp3)-H bonds in substrates that bear geminal di-Me substituents furnished chiral amines that feature a quaternary stereocenter. Moreover, these enzymes enabled the enantioconvergent transformation of racemic substrates that possess a tertiary C(sp3)-H bond to afford products that bear a tetrasubstituted stereocenter, a process that has eluded small-mol. catalysts. Further engineering allowed for the enantioselective construction of methyl-Et stereocenters, which is notoriously challenging in asym. catalysis. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Name: Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Name: Ethyl 3-(4-chlorophenyl)propanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzeneIn 2019 ,《Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors》 appeared in Bioorganic Chemistry. The author of the article were Mo, Jun; Yang, Hongyu; Chen, Tingkai; Li, Qihang; Lin, Hongzhi; Feng, Feng; Liu, Wenyuan; Qu, Wei; Guo, Qinglong; Chi, Heng; Chen, Yao; Sun, Haopeng. The article conveys some information:

A series of quinoline-ferulic acid hybrids I (R = 1-chloro-4-(2-methoxyphenoxymethyl)benzene, 3-cyanophenyl, 4-(benzyloxy)-3-methoxyphenyl, etc.; R1 = H, Me; n = 1, 2, 3) has been designed, synthesized, and evaluated as cholinesterase inhibitors. Most of the compounds showed good inhibitory activities toward both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Among them, I (R = 1-bromo-4-(2-methoxyphenoxymethyl)benzene; R1 = Me; n = 1 (A)) was found to be the most potent inhibitor against AChE (IC50 = 0.62 ± 0.17 μM), and I (R = phenyl; R1 = Me; n = 3) was the most potent inhibitor against BChE (IC50 = 0.10 ± 0.01 μM). Representative compounds, such as (A) and I (R = 4-(trifluoromethyl)phenyl; R1 = Me; n = 1 (B)), act in a competitive manner when they inhibit AChE or BChE. Mol. docking and dynamic simulation revealed that the synthesized compounds bind to the target by simultaneously interacting with the catalytic active site (CAS) and the peripheral anionic site (PAS) of both AChE and BChE. The U-shaped confirmation was preferred when (B) bound to BChE, which was different from the linear conformation of (A) bound to AChE. Cell-based assays have confirmed the moderate neuroprotective effects of compounds (A) and (B) against H2O2-induced oxidative damage towards PC12 cells. Moreover, the hepatotoxicity of (B) was lower than that of tacrine, indicating its potential safety as an anti-Alzheimer’s agent. In summary, a new chemotype of multifunctional hybrid, which may be further modified to develop new anti-Alzheimer’s agents was reported. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics