Tag: 200-300

Category: chlorides-buliding-blocksIn 2019 ,《Regioselective Sulfonylvinylation of the Unactivated C(sp3)-H Bond via a C-Centered Radical-Mediated Hydrogen Atom Transfer (HAT) Process》 appeared in Organic Letters. The author of the article were Yang, Shan; Wu, Xinxin; Wu, Shuo; Zhu, Chen. The article conveys some information:

Given the similarity of multiple sp3 C-H bonds in electronic properties and bond dissociation energy (BDE), regioselective sp3 C-H bond functionalization remains a paramount challenge. Here, the authors report a C-centered radical-mediated approach for site-specific sulfonylvinylation of the C(sp3)-H bond via the hydrogen atom transfer (HAT) process. The reaction features mild conditions, broad substrate scope, and high regioselectivity and stereoselectivity, manifesting the nontrivial synthetic potential. In the experimental materials used by the author, we found 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Category: chlorides-buliding-blocks)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Yi-Xin; Liang, Yu-Qing; Cai, Zhong-Jian; Ji, Shun-Jun published an article in 2022. The article was titled 《Ruthenium(II)-Catalyzed Chelation-Assisted Desulfitative Arylation of Benzo[h]quinolines with Arylsulfonyl Chlorides》, and you may find the article in Organic Letters.Related Products of 98-60-2 The information in the text is summarized as follows:

Herein, a novel chelation-assisted C-H arylation reaction of benzo[h]quinoline is described. This transformation, using [RuCl2(p-cymene)]2 as the catalyst and cheap and easily accessible arylsulfonyl chlorides as the arylation source, featured simple reaction conditions, a broad substrate scope, and functional group tolerance. The successful application of some bioactive-mol.-based sulfonyl chlorides further highlighted the potential utility and importance of this desulfitative C-H arylation protocol. In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Related Products of 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Shan; Liu, Lingling; Zhou, Zheng; Huang, Zhibin; Zhao, Yingsheng published their research in Organic Letters in 2021. The article was titled 《Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives》.Electric Literature of C6H4Cl2O2S The article contains the following contents:

Herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction is reported. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive. In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Electric Literature of C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Electric Literature of C6H4Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Pd-Catalyzed Regioselective Olefination of N-Tosylhydrazones with Benzyl Bromides》 was written by Sun, Zhenze; He, Jing; Li, Weiwei; Li, Xuezhen; Feng, Yijiao; Liu, Yan; Liu, Ping; Han, Sheng. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene And the article was included in ChemistrySelect in 2020. The article conveys some information:

A palladium-catalyzed regioselective olefination of cycloalkylphenylmethylene N-tosylhydrazones and benzyl bromide was developed. A series of E-type tri-substituted olefin compounds were obtained in 43-95% through the highly selective β-H elimination. The results showed that the β-H at the benzyl position took precedence over the β-H at the cycloalkyl position for the alkylpalladium intermediate, avoiding the formation of tetra-substituted olefins. High regioselectivity, wide substrate scope, and good functional group tolerance were the advantages of this reaction. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Copper-Catalyzed Selective 1,2-Difunctionalization of N-Heteroaromatics through Cascade C-N/C=C/C=O Bond Formation》 was written by He, Qianlin; Xie, Feng; Xia, Chuanjiang; Liang, Wanyi; Guo, Ziyin; Zhu, Zhongzhi; Li, Yibiao; Chen, Xiuwen. COA of Formula: C7H6BrCl And the article was included in Organic Letters in 2020. The article conveys some information:

This study presents an efficient strategy for constructing 1,2-difunctionalized quinoline derivatives via the multicomponent cascade coupling of N-heteroaromatics with alkyl halides and different terminal alkynes. This reaction was achieved through sequential functionalization at the one- and two-positions of quinolines, which displayed a broad substrate scope, environmental friendliness, excellent functional group tolerance, high atom efficiency, and chemoselectivity. The multicomponent coupling involved the abnormal construction of new C-N, C=C, and C=O bonds in one pot. The applicability of this method was further demonstrated by the late-stage functionalization of complex drug mols. under the established conditions.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Catalyst/Additive Free Oxidation of Benzyl Bromides to Benzaldehydes》 was published in ChemistrySelect in 2020. These research results belong to Aman, Hasil; Chen, Yuan-Ching; Tu, Jing-Wen; Chang, Chia-Chi; Chuang, Gary Jing. Formula: C7H6BrCl The article mentions the following:

An effective approach for the synthesis of aryl aldehydes from the corresponding benzyl bromides was accomplished. Without need of addnl. additives or stoichiometric oxidants, this environmental friendly and milder version of Kornblum oxidation simply utilized the irradiation of visible light in DMSO under O2, and was compatible with the substrate with different functional groups.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Hou, Yuxuan; Hu, Jinjin; Xu, Ruigang; Pan, Shulei; Zeng, Xiaofei; Zhong, Guofu. Quality Control of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Indium-Mediated Synthesis of Benzylic Hydroperoxides》. The information in the text is summarized as follows:

An indium(0)-metal-mediated efficient synthesis of benzylic hydroperoxides is described. The reaction proceeds efficiently with a broad range of benzyl bromides under aerobic conditions at room temperature to afford benzyl hydroperoxides in good to excellent yields. In addition, the tandem hydroperoxidn.-Michael addition of (E)-1-(bromomethyl)-2-(2-nitrovinyl)benzene was also demonstrated. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Quality Control of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Quality Control of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: Sodium 2,6-dichlorobenzoateOn May 31, 1989, Dekoninck, J. M.; Legras, R.; Mercier, J. P. published an article in Polymer. The article was 《Nucleation of poly(ethylene terephthalate) by sodium compounds: a unique mechanism》. The article mentions the following:

The high nucleation efficiency of Na salts in PET is not due to additives but to reaction products. Ester linkages of PET are broken and Na carboxylate chain ends are created. The ionic chain ends are the effective nucleating species. After reading the article, we found that the author used Sodium 2,6-dichlorobenzoate(cas: 10007-84-8Name: Sodium 2,6-dichlorobenzoate)

Sodium 2,6-dichlorobenzoate(cas: 10007-84-8) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Name: Sodium 2,6-dichlorobenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

COA of Formula: C6H4Cl2O2SIn 2022 ,《Electrochemically-promoted synthesis of benzo[b]thiophene-1,1-dioxides via strained quaternary spirocyclization》 was published in Chemical Science. The article was written by Li, Ruitao; Yuan, Dafu; Ping, Mengqi; Zhu, Yuyi; Ni, Shaofei; Li, Ming; Wen, Lirong; Zhang, Lin-Bao. The article contains the following contents:

An approach for the synthesis of benzothiophene motifs under electrochem. conditions by the reaction of sulfonhydrazides with internal alkynes was reported. Upon the formation of a quaternary spirocyclization intermediate by the selective ipso-addition instead of an ortho-attack, the S-migration process was rationalized to lead to the products. Computational studies revealed the selectivity and the compatibility of drug mols. showcased the potential application of the protocols. In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2COA of Formula: C6H4Cl2O2S)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C6H4Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Niedbala, Patryk; Majdecki, Maciej; Grodek, Piotr; Jurczak, Janusz published an article in Molecules. The title of the article was 《H-Bond Mediated Phase-Transfer Catalysis: Enantioselective Generating of Quaternary Stereogenic Centers in β-Keto Esters》.Quality Control of 1-(Bromomethyl)-4-chlorobenzene The author mentioned the following in the article:

In this work, the development of a highly optimized method for generating the quaternary stereogenic centers in β-keto esters I (R = Me, i-Pr, t-Bu; R1 = H, 2-Me, 3-Me, 4-Me, 4-Cl; R2 = R3 = H; R2R3 = -CH=CH-CH=CH-) was presented. This enantioselective phase-transfer alkylation catalyzed by hybrid Cinchona catalysts II (R4 = naphthalen-2-yl, naphthalen-1-yl, quinolin-8-yl) allows for the efficient generation of the optically active products I with excellent enantioselectivity, using only 1 mol% of the catalyst. The vast majority of phase-transfer catalysts in asym. synthesis work is made by creating ionic pairs with the nucleophile-attacking anionic substrate. Therefore, it is a sensible approach to search for new methodologies capable of introducing functional groups into the precursor’s structure, maintaining high yields and enantiomeric purity. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Quality Control of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Quality Control of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics