Tag: 200-300

Sim, T. B.; Yoon, N. M. published an article in Synlett. The title of the article was 《Selective reduction of α,β-unsaturated acid derivatives using borohydride exchange resin-CuSO4 in methanol》.Name: Ethyl 3-(4-chlorophenyl)propanoate The author mentioned the following in the article:

Borohydride exchange resin-copper sulfate in methanol readily reduces α,β-unsaturated esters, amides, and nitriles quant. to the corresponding saturated acid derivative at room temperature In the experiment, the researchers used Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Name: Ethyl 3-(4-chlorophenyl)propanoate)

Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Name: Ethyl 3-(4-chlorophenyl)propanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Zhou, Yu; Yang, Cheng-Li; Ye, Lei; Dong, Zhi-Bing published an article in Synthesis. The title of the article was 《Copper-Catalyzed C-S Formation for the Synthesis of Benzyl Phenyl Sulfides from Dithiocarbamates》.Category: chlorides-buliding-blocks The author mentioned the following in the article:

An odorless and efficient protocol for the synthesis of benzyl Ph sulfides RSCH2R1 [R = Ph, 2-MeC6H4, 4-ClC6H4, etc.; R1 = Ph, 4-MeOC6H4, 2-BrC6H4, etc.] was reported. Starting from environmentally friendly Ph dithiocarbamates and com. available benzyl halides as starting materials, the target compounds (benzyl Ph sulfides) could be obtained smoothly and easily by using copper salt as catalyst and Cs2CO3as base. This method featured ligand/additive-free, the use of readily available starting materials, inexpensive catalysts, and good substrate suitability, illustrating its potentially synthetic value for the convenient preparation of some biol. active mols. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Category: chlorides-buliding-blocks)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Category: chlorides-buliding-blocks It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 98-60-2In 2021 ,《Regio- and stereoselective electrochemical synthesis of sulfonylated enethers from alkynes and sulfonyl hydrazides》 was published in Green Chemistry. The article was written by Du, Wu-Bo; Wang, Ning-Ning; Pan, Chao; Ni, Shao-Fei; Wen, Li-Rong; Li, Ming; Zhang, Lin-Bao. The article contains the following contents:

An electrooxidative direct difunctionalization of internal alkynes RCCR1 [R = Ph, 2-chlorophenyl, thiophen-2-yl, etc.; R1 = Me, cyclopropyl, 2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)ethyl, etc.] with sulfonyl hydrazides R2S(O)2NHNH2 (R2 = 4-methylphenyl, 3-bromophenyl, cyclopropyl, etc.) has been developed for the construction of sulfonated enethers (E)-RC(OR3)=C(R1)S(O)2R2 (R3 = Et, 2,2,2-trifluoroethyl, cyclohexyl, etc.). In this transformation, metal catalysts or stoichiometric amount of oxidants are not required and mol. nitrogen and hydrogen are the sole byproducts, providing a simple and green approach for preparing various sulfonyl tetrasubstituted alkenes. Notably, the protocol could be efficiently scaled up and the follow-up procedures of the corresponding functionalized alkenes demonstrate the practicality of the electrochem. synthesis. In the part of experimental materials, we found many familiar compounds, such as 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Recommanded Product: 98-60-2)

4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 98-60-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Constitution of the Naphthols AS and their bases》 were Semard, Andre. And the article was published in Teintex in 1939. Reference of 2-Amino-2,4-dichlorodiphenyl ether The author mentioned the following in the article:

Thirty-one different AS couplings have been put on the market by several countries. Their constitutions have been explained in the references furnished in this article. S. would add the following compounds to the above lists: Naphthol AS-LC (2,5-dimethoxy-4-chloroanilide of 2-hydroxy-3-naphthoic acid (I)); Cibanaphthol RPH (p-phenetide of I); Cibanaphthol RT (p-toluide of I); Naphthol AS-SG (p-aniside of 3′-hydroxy-2′-carboxy-7,8-benzocarbazole (II); Naphthol AS-SR (o-methyl-p-aniside of II); Naphthol AS-LB (p-chloroanilide of 7-hydroxy-6-carboxycarbazole) ; Naphthol AS-BT (2,5-dimethoxyanilide of 6-hydroxy-7-carboxybiphenylene oxide); Naphthol AS-L3G (2-methoxy-5-methyl-4-chloroanilide of terephthalylethanoic acid (III)); Naphthol AS-LG (2,4-dimethoxy-5-chloroanilide of III); Red FG base (4-chloro-2-aminodiphenyl oxide); Scarlet Ciba IV base (2-amino-2′,4-dichlorodiphenyl oxide); Red FR base (4,4′-dichloro-2-aminodiphenyl oxide); Scarlet LG base [1-methoxy-2-amino-4-(benzylsulfonyl)benzene]; Red GTR base [1-methoxy-2-amino-4-(ethylsulfonyl)benzene]; Bordeaux Ciba III base (4-amino-3-methoxyazobenzene); Corinthe LB base (1-benzoylamino-2-methoxy-4-amino-5-chlorobenzene); Blue RR base (5-amino-2-benzoylamino-1,4-dimethoxybenzene); Blue BB base (5-amino-2-benzoylamino-1,4-diethoxybenzene); Violet Ciba III base [1-amino-2,5-dimethoxy-4-(tolylacetylamino)benzene]; and Brown B base [o-chloro-p-nitro-p’-amino-o’-(cresol methyl ether)azobenzene].2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Reference of 2-Amino-2,4-dichlorodiphenyl ether) was used in this study.

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Reference of 2-Amino-2,4-dichlorodiphenyl ether

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《One-pot synthesis of N-alkyl indole from indoline-2-carboxylic acids and alkyl halides by 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) mediated oxidative decarboxylative aromatization》 was published in Youji Huaxue in 2020. These research results belong to Zhu, Runyu; Zhai, Min; Liu, Shuang; Liu, Xingtong; Wang, Zhen; Ju, Ruijun; Yu, Xinhong. Name: 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:

Synthesis of N-alkyl indoles via 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) mediated intramol. oxidative decarboxylative aromatization of N-alkylindoline-2-carboxylic acids was reported. The good compatibility of this process leaded to the development of a mild and metal-free one-pot synthesis of N-alkyl indoles from alkyl halides and indoline carboxylic acid. The one-pot three-component synthesis of 1,4-bis((1H-indol-1-yl)methyl)benzene was also disclosed in satisfied yields. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,RSC Advances included an article by Xiao, Jing; Ma, Yonghao; Wu, Xiaofang; Gao, Jing; Tang, Zilong; Han, Li-Biao. SDS of cas: 622-95-7. The article was titled 《Phosphonic acid mediated practical dehalogenation and benzylation with benzyl halides》. The information in the text is summarized as follows:

For the first time, by using H3PO3/I2 system, various benzyl chlorides and bromides RCH2X (R = C6H5, 4-O2NC6H4, 1-naphthyl, etc.; X = Cl, Br) were dehalogenated successfully. In the presence of H3PO3, benzyl halides underwent electrophilic substitution reactions with electron-rich arenes, leading to a broad range of diarylmethanes RCH2R1 (R1 = C6H5, 2,4,6-(CH3)3C6H2, 4-CH3OC6H4, etc.) in good yields. These transformations feature green, cheap reducing reagents and metal-free conditions. In the experiment, the researchers used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7SDS of cas: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.SDS of cas: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zang, Yingda; Liu, Ke; Wang, Weiping; Li, Chuangjun; Ma, Jie; Yang, Jingzhi; Chen, Xinyi; Wang, Xiaoliang; Zhang, Dongming published their research in Molecules in 2021. The article was titled 《Claulansine F-donepezil hybrids as anti-Alzheimer’s disease agents with cholinergic, free-radical scavenging, and neuroprotective activities》.Name: 1-(Bromomethyl)-4-chlorobenzene The article contains the following contents:

The multifactorial nature of Alzheimer’s disease (AD) calls for the development of multitarget agents addressing key pathogenic processes. Twenty-six Claulansine F-donepezil hybrids I (X = nothing, CH2, CH2CH2; R1 = OMe, t-Bu; R2 = PhCH2, 2-FC6H4CH2, 4-ClC6H4CH2, etc.) were designed and synthesized as multitarget drugs. Among these compounds, six compounds exhibited excellent acetylcholinesterase (AChE) inhibitory activity (half maximal inhibitory concentration (IC50) 1.63-4.62μM). Moreover, the compound I [X = CH2; R1 = t-Bu; R2 = 2-ClC6H4CH2; (II)] exhibited better neuroprotective effects against OGD/R (oxygen-glucose deprivation/reoxygenation) than lead compound Claulansine F. Furthermore, the compound II could cross the blood-brain barrier in vitro. More importantly, compared to edaravone, the compound II had stronger free-radical scavenging activity. Mol. docking studies revealed that II could interact with the catalytic active site of AChE. All of these outstanding in vitro results indicate the compound II as a leading structure worthy of further investigation.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Yaru; Ren, Pengju; Zhang, Dongsheng; Qiao, Wei; Wang, Dan; Yang, Xiaoqin; Wen, Xiaodong; Rummeli, Mark H.; Niemantsverdriet, Hans; Lewis, James P.; Besenbacher, Flemming; Xiang, Hongwei; Li, Yongwang; Su, Ren published their research in ACS Catalysis in 2021. The article was titled 《Rationally Designed Metal Cocatalyst for Selective Photosynthesis of Bibenzyls via Dehalogenative C-C Homocoupling》.Category: chlorides-buliding-blocks The article contains the following contents:

Cu is a promising candidate to promote the coupling of aromatic halides RCH2X (Ph, 3,4-dimethylphenyl, 4-chloro-3-methoxyphenyl, etc.; X = Br, Cl) due to the optimized adsorption energy of the reaction intermediates (benzyl radical and Br atom) over a series of transition metals. The Cu-modified TiO2 shows a remarkable apparent quantum efficiency (15%) and a great tolerance of harsh reaction conditions for the homocoupling of benzyl bromides into bibenzyls R(CH2)2R under UV irradiation The low-cost photocatalyst also shows high performance upon scaling-up and selective coupling of a series of benzyl bromide derivatives, demonstrating the heterogeneous photocatalytic C-C coupling as an attractive process for applications. Addnl., the design strategy can be applied to modify other photocatalysts (i.e., g-C3N4) to realize the C-C coupling of benzyl bromide under visible light. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Category: chlorides-buliding-blocks)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Category: chlorides-buliding-blocks It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 3,5-Dichloro-4-methoxybenzoic acidOn May 31, 1996, Hjelm, Olof; Boren, Hans; Oeberg, Gunilla published an article in Chemosphere. The article was 《Analysis of halogenated organic compounds in coniferous forest soil from a Lepista nuda (wood blewitt) fairy ring》. The article mentions the following:

Soil collected at the arc of a Lepista nuda fairy ring growing in a coniferous forest was examined for the occurrence of low-mol.-weight halogenated organic compounds This was done by subjecting organic soil extracts to gas chromatog.-mass spectrometry and gas chromatog.-at. emission detection analyses. Fourteen organohalogens were detected, and a number of these represented the major low-mol.-weight compounds found in the analyzed extracts The fourteen compounds were chlorinated anisoles, dimethoxybenzenes, methoxybenzaldehydes, methoxybenzoic acids, and three brominated methoxybenzaldehydes. This is the first time brominated low-mol.-weight compounds have been found in an unpolluted soil sample. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Application In Synthesis of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of 3,5-Dichloro-4-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Chlorometabolite production by the ecologically important white rot fungus Bjerkandera adusta》 was written by Silk, P. J.; Aubry, C.; Lonergan, G. C.; Macaulay, J. B.. Safety of 3,5-Dichloro-4-methoxybenzoic acid And the article was included in Chemosphere on August 31 ,2001. The article conveys some information:

Two strains of the basidiomycete Bjerkandera adusta (DAOM 215869 and BOS55) produce in static liquid culture Ph, veratryl, anisyl and chloroanisyl metabolites (CAM’s) (alcs., acids and aldehydes) as well as a series of compounds not previously known to be produced by Bjerkandera species: 1-Ph, 1-anisyl, 1-(3-chloro-4-methoxy) and 1-(3,5-dichloro-4-methoxy) propan-1,2-diols, predominantly as erythro diastereomers with 1R,2S absolute configurations. 1-Anisyl-propan-1,2-diol and 1-(3,5-dichloro-4-methoxy)-propan-1,2-diol are new metabolites for which the names bjerkanderol A and B, resp., are proposed. Experiments with static liquid cultures supplied with 13C6- and 13C9-L-phenylalanine showed that all identified aromatic compounds (with the exception of phenol) can be derived from L-phenylalanine. For the aryl propane diols, the 13C label appeared only in the Ph ring and the benzylic carbon, suggesting a stereoselective resynthesis from a C7- and a C2-unit, likely aromatic aldehyde and decarboxylated pyruvate, resp. Other compounds newly discovered to be derived from phenylalanine by this white rot fungus include phenylacetaldehyde and phenylpyruvic, phenylacetic, phenyllactic, mandelic and Ph glyoxylic (benzoyl formic) acids. For both strains, cultures supplied with Na37Cl showed incorporation of 37Cl in all identified chlorometabolites. Veratryl alc. and the CAM alcs., which occur in both strains and can be derived from L-phenylalanine (all 13C-labeled), have reported important physiol. functions in this white rot fungus. Possible mechanisms for their formation through the newly discovered compounds are discussed. After reading the article, we found that the author used 3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7Safety of 3,5-Dichloro-4-methoxybenzoic acid)

3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 3,5-Dichloro-4-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics