Tag: 200-300

Thioglycoluril as a highly efficient, recyclable and novel organocatalyst for N-Boc protection of amines was written by Khaksar, Samad;Vahdat, Seyed Mohammad;Tajbakhsh, Mahmood;Jahani, Fatemeh;Heydari, Akbar. And the article was included in Tetrahedron Letters in 2010.Reference of 18437-66-6 This article mentions the following:

A simple and efficient protocol for the chemoselective mono-N-Boc protection of various structurally diverse amines with di-tert-Bu dicarbonate using thioglycoluril as the catalyst is described. The catalyst can be readily separated from the reaction products by simple filtration and recovered for reuse. No competitive side reactions, such as formation of isocyanate, urea, oxazolidinone, and N,N-di-Boc derivatives were observed In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2-Chloro-9-isopropyl-N,N-dimethyl-9H-purin-6-amine was written by Rouchal, Michal;Necas, Marek;Vicha, Robert. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2010.Category: chlorides-buliding-blocks This article mentions the following:

In the title compound, C₁₀H₁₄ClN₅, the imidazole and pyrimidine rings are essentially planar [maximum deviation = 0.0013 (14) and 0.0207 (13) Å, resp.]. In the crystal, the mols. are linked by weak C-H…N interactions into chains parallel to the c axis and the crystal packing is stabilized by addnl. weak C-H…N and C-H…Cl interactions. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Category: chlorides-buliding-blocks).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Water at elevated temperatures (WET): reactant, catalyst, and solvent in the selective hydrolysis of protecting groups was written by Medina-Ramos, Wilmarie;Mojica, Mike A.;Cope, Elizabeth D.;Hart, Ryan J.;Pollet, Pamela;Eckert, Charles A.;Liotta, Charles L.. And the article was included in Green Chemistry in 2014.Recommanded Product: tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:

Water at elevated temperatures (WET) can act simultaneously as reactant, solvent, and catalyst in reaction processes. WET was successfully employed in the removal of protecting groups alleviating the need for added strong acids/bases, subsequent neutralization and waste salt elimination. The protocols for the water-mediated removal of several common protecting groups such as tert-Bu carbamates (N-Boc) from 125 to 150°, acetamide (N-Ac) at 275° and acetate esters (O-Ac) at 250° are reported for different model aryl compounds High yields and selective deprotection of one protecting group in the presence of another by simply tuning the temperature is demonstrated. To gain further insights into reaction processes, the aqueous solubilities of several of the reactants, the kinetics and mechanisms associated with some of these reactions are also discussed. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Recommanded Product: tert-Butyl (4-chlorophenyl)carbamate).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: tert-Butyl (4-chlorophenyl)carbamate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Highly Stable Silver-Loaded Membrane Prepared by Interfacial Polymerization for Olefin Separation was written by Wang, Keying;Ren, Yuling;Luo, Jianquan;Zhuang, Yongbing;Feng, Shichao;Wan, Yinhua. And the article was included in Industrial & Engineering Chemistry Research in 2022.Application of 4422-95-1 This article mentions the following:

The separation of light olefins from paraffins by a silver-loaded facilitated transport membrane has received wide attention in recent years. However, the undesirable instability of carriers Ag⁺ has consistently restricted its further application. In this work, a silver-loaded facilitated transport membrane is developed by interfacial polymerization on PDMS/PSF support. A part of Ag⁺ in the prepared membrane is presented as silver(I)-polyetheramine (Ag(I)-PEA) complexes that can effectively enhance the stability of Ag⁺. To eliminate nonselective voids and bring more carriers (Ag⁺), secondary aqueous phase treatment was conducted. And the effect of PEA and TMC concentrations, ratio of PEA to AgNO₃, as well as secondary aqueous phase treatment on the gas transport is systematically investigated. The results show that the facilitated transport of Ag⁺ to C₃H₆ can offset the increase in diffusion resistance induced by the incremental membrane thickness and crosslinking degree as well as the addnl. AgCl particles on the membrane. Finally, the optimum C₃H₆/C₃H₈ selectivity of the silver-loaded membrane is trebled over the membrane without silver. Remarkably, the TMC_0.6%-PEA_10%(AgNO₃)_10:9-2/PDMS/PSF membranes show great long-term stability of about 29 days. In this work, both monomer synthesis and preparation methods are facile and versatile, presenting a promising strategy for the preparation of silver-loaded membranes with a long-term separation property. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application of 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A whole-animal platform to advance a clinical kinase inhibitor into new disease space was written by Sonoshita, Masahiro;Scopton, Alex P.;Ung, Peter M. U.;Murray, Matthew A.;Silber, Lisa;Maldonado, Andres Y.;Real, Alexander;Schlessinger, Avner;Cagan, Ross L.;Dar, Arvin C.. And the article was included in Nature Chemical Biology in 2018.Synthetic Route of C7H4ClF3O2S This article mentions the following:

Synthetic tailoring of approved drugs for new indications is often difficult, as the most appropriate targets may not be readily apparent, and therefore few roadmaps exist to guide chem. Here, we report a multidisciplinary approach for accessing novel target and chem. space starting from an FDA-approved kinase inhibitor. By combining chem. and genetic modifier screening with computational modeling, we identify distinct kinases that strongly enhance (‘pro-targets’) or limit (‘anti-targets’) whole-animal activity of the clin. kinase inhibitor sorafenib in a Drosophila medullary thyroid carcinoma (MTC) model. We demonstrate that RAF-the original intended sorafenib target-and MKNK kinases function as pharmacol. liabilities because of inhibitor-induced transactivation and neg. feedback, resp. Through progressive synthetic refinement, we report a new class of ‘tumor calibrated inhibitors’ with unique polypharmacol. and strongly improved therapeutic index in fly and human MTC xenograft models. This platform provides a rational approach to creating new high-efficacy and low-toxicity drugs. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Synthetic Route of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and syntheses of some new pyrazolo[3,4-d]-8-(phenyl)-1,2,4-(8H)-triazolo-[2,3-a]-pyrimidin-4(1H)-one derivatives as potent anti-inflammatory agent was written by Kawade, D. P.;Khedekar, P. B.. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2014.Safety of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

Pyrazolo[3,4-d](aryl)-1,2,4-triazolopyrimidinones I [R = 2-Me, 4-Me, 2-Cl, 4-Cl, 2-O₂N, 4-O₂N, etc.] were synthesized from 5-amino-6-arylamino-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-ones which were obtained by the reaction of ethyl-5-amino-1H-pyrazole-4-carboxylate and appropriate phenylisothiocyanate in the presence of toluene followed by cyclization reaction with hydrazine hydrate in absolute ethanol. The most active compounds I [R = 2-O₂N, 4-O₂N] were evaluated for its ulcerogenicity. The results of anti-inflammatory activity (in-vivo) indicated that the compounds I [R = 2-O₂N, 4-O₂N] possessed significant anti-inflammatory activity as compared to standard drug, Indomethacin. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Safety of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thin film nanocomposite membrane incorporated with 2D-MOF nanosheets for highly efficient reverse osmosis desalination was written by Liu, Yi;Wang, Xin-ping;Zong, Zi-ao;Lin, Rijia;Zhang, Xiao-yin;Chen, Fu-shan;Ding, Wan-de;Zhang, Li-li;Meng, Xiang-min;Hou, Jingwei. And the article was included in Journal of Membrane Science in 2022.Product Details of 4422-95-1 This article mentions the following:

Metal-organic frameworks (MOFs) have drawn significant attention in the fabrication of thin film nanocomposite (TFN) membranes. In particular, two-dimensional MOFs (2D-MOFs) are advantageous in improving compatibility and mol. sieving performance depending on the sub-at. surface thickness, high exposure of surface functional groups and controllable pore structure properties. In this study, a robust high performance TFN membrane for reverse osmosis (RO) desalination was fabricated using an interfacial polymerization strategy on the surface of polysulfone (PSF) substrate with embedded ultrasonically exfoliated nickel-based 2D-MOF nanosheet in the selective layer. The TFN membrane modified by adding 0.015 wt% 2D-MOF nanosheet to the aqueous phase exhibits a 2.5 times higher water permeability with a well-maintained salt rejection (water permeance up to 50.0 L m^-2 h^-1·MPa^-1, NaCl rejection of 99.2%) compared to pristine thin film composite (TFC) membrane (water permeance 20.6 L m^-2 h^-1·MPa^-1, NaCl rejection 99.3%). Meanwhile, the modified TFN membrane features outstanding anti-fouling properties against 500 ppm humic acid with a high water permeance recovery ratio of 96.9%. In addition, the diffusions of water mols. both in pristine TFC membrane and modified TFN membrane were investigated by the mol. dynamics (MD) simulation, showing good agreement with the exptl. results. The simulation results reveal that the incorporation of 2D-MOF nanosheets can reduce transfer resistance and increase water diffusion because of the extra pores of 2D-MOF and H bonds between free water mols. and the coordination water of 2D-MOF. This study presents a new strategy to fabricate high-performance RO membranes, and also provides further insights into the great potential of 2D-MOFs in the water-treatment field. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Product Details of 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyl transferase was written by Wang, You;Xu, Feng;Nichols, Connie B.;Shi, Yuqian;Hellinga, Homme W.;Alspaugh, J. Andrew;Distefano, Mark D.;Beese, Lorena S.. And the article was included in Journal of Medicinal Chemistry in 2022.Related Products of 76-83-5 This article mentions the following:

Compounds that prevent farnesylation of Cryptoccoccus neoformans Ras protein by inhibiting protein farnesyl transferase with 3-4 nanomolar affinities was developed . Farnesylation directs Ras to the cell membrane and was required for infectivity of this lethal pathogenic fungus. Our high-affinity compounds inhibit fungal growth with 3-6 micromolar min. inhibitory concentrations (MICs), 4- to 8-fold better than Fluconazole, an antifungal commonly used in the clinic. Compounds bound with distinct inhibition mechanisms at two alternative, partially overlapping binding sites, accessed via different inhibitor conformations. Antifungal potency depends critically on the selected inhibition mechanism because this determines the efficacy of an inhibitor at low in vivo levels of enzyme and farnesyl substrate was showed. How chem. modifications of the antifungals encode desired inhibitor conformation and concomitant inhibitory mechanism was elucidated. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Related Products of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, cytotoxic activity, and 2D- and 3D-QSAR studies of 19-carboxyl-modified novel isosteviol derivatives as potential anticancer agents was written by Liu, Cong-Jun;Zhang, Tao;Yu, Shu-Ling;Dai, Xing-Jie;Wu, Ya;Tao, Jing-Chao. And the article was included in Chemical Biology & Drug Design in 2017.HPLC of Formula: 6590-96-1 This article mentions the following:

Two series of novel acylthiosemicarbazide and oxadiazole fused-isosteviol derivatives were synthesized based on the 19-carboxyl modification. The target compounds were evaluated for their cytotoxicities against three cancer cell lines (HCT-116, HGC-27, and JEKO-1) using an MTT assay. Lead compounds from the acylthiosemicarbazides (4) showed IC₅₀ values in the lower micromolar range. For example, compounds (4i, 4l, 4m, 4r, and 4s) exhibited significant inhibitory activities against the three cell lines with IC₅₀ values of 0.95-3.36 μm. Furthermore, 2D-HQSAR and 3D-topomer CoMFA analyses were established, which could be used to develop second generation of isosteviol derivatives as anticancer agents. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1HPLC of Formula: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A pillar[5]arene-based crosslinked polymer material for selective adsorption of organic dyes was written by Zhang, Ge;Lou, Xin-Yue;Li, Meng-Hao;Yang, Ying-Wei. And the article was included in Dyes and Pigments in 2022.Safety of Trimesoylchloride This article mentions the following:

Industrial wastewater containing organic dyes poses severe threats to the global aquatic ecosystem. The exploration of low-cost and environmentally friendly adsorbents has become a major task for the fast and effective elimination of organic dye contaminants. The authors fabricate a new type of polymeric dye adsorbent (P1) by crosslinking bihydrazide-functionalized pillar[5]arene with trimesoyl chloride as linkers. Benefiting from the π-electron rich cavity of pillar[5]arene, P1 demonstrated outstanding potential in the selective adsorption and separation of small cationic dyes. Kinetic exptl. results prove that the adsorption behaviors for methylene blue (MB) and neutral red (NR) are accurately matched with the pseudo-second-order model and Freundlich isotherm model. The integral adsorption rate is determined by both external diffusion and intra-particle diffusion. The pillararene-based polymer adsorbent can be recycled 5 times with almost no loss of adsorption efficiency, holding great potential to function as an available material for wastewater regeneration and purification In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Safety of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics