Tag: 200-300

On February 28, 2018, Ghorbani, Mahdi; Shams, Alireza; Seyedin, Orkideh; Afshar Lahoori, Nahid published an article.HPLC of Formula: 99-60-5 The title of the article was Magnetic ethylene diamine-functionalized graphene oxide as novel sorbent for removal of lead and cadmium ions from wastewater samples. And the article contained the following:

In this paper, magnetic ethylene diamine-functionalized graphene oxide (MDFGO) as a novel sorbent was synthesized and applied for removal of Pb(II) and Cd(II) from real wastewater samples. The morphol. and mol. structure of MDFGO were studied by different anal. methods. The effective parameters in adsorption efficiency of Pb(II) and Cd(II) were studied and optimized using exptl. design. Under the optimal condition, the effective parameters including pH, sorbent dosage, shaking rate, and adsorption time were 6.2, 33.0 mg, 500 rpm, and 11 min, resp. Mechanism of adsorption kinetic was investigated using the Lagergren pseudo-first-order, pseudo-second-order, and intraparticle diffusion models. It was found that adsorption of lead and cadmium ions in the MDFGO sorbent followed from pseudo-first-order and pseudo-second-order models, resp. Thermodn. parameters (ΔG°, ΔH°, and ΔS°) for the lead and cadmium ions uptake onto the MDFGO sorbent were calculated and indicated that the adsorption processes were spontaneous and endothermic in nature for both cations. In order to investigate the isotherm model for adsorption of Pb(II) and Cd(II), the exptl. data were studied using the Langmuir, Freundlich, and Harkins-Jura isotherm models. The results fitted well with Freundlich model for both metal ions. The new sorbent (MDFGO) was applied to remove Pb(II) and Cd(II) from battery wastewater and electroplating wastewater. The removal percentage of Pb(II) and Cd(II) were 99.6±0.5 and 99.4±0.6, resp., and demonstrated that the new sorbent was very suitable for removal of lead and cadmium ion from the real wastewater samples. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).HPLC of Formula: 99-60-5

The Article related to ethylene diamine graphene oxide adsorption lead cadmium wastewater treatment, adsorption, batteries wastewater samples, electroplating wastewater samples, magnetic ethylene diamine-functionalized graphene oxide, removal of lead and cadmium ions and other aspects.HPLC of Formula: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bendre, Shreya; Zhang, Zhengxing; Kuo, Hsiou-Ting; Rousseau, Julie; Zhang, Chengcheng; Merkens, Helen; Roxin, Aron; Benard, Francois; Lin, Kuo-Shyan published an article in 2020, the title of the article was Evaluation of Met-Val-Lys as a renal brush border enzyme-cleavable linker to reduce kidney uptake of 68Ga-labeled DOTA-conjugated peptides and peptidomimetics.Related Products of 98946-18-0 And the article contains the following content:

High kidney uptake is a common feature of peptide-based radiopharmaceuticals, leading to reduced detection sensitivity for lesions adjacent to kidneys and lower maximum tolerated therapeutic dose. In this study, we evaluated if the Met-Val-Lys (MVK) linker could be used to lower kidney uptake of 68Ga-labeled DOTA-conjugated peptides and peptidomimetics. A model compound, [68Ga]Ga-DOTA-AmBz-MVK(Ac)-OH (AmBz: aminomethylbenzoyl), and its derivative, [68Ga]Ga-DOTA-AmBz-MVK(HTK01166)-OH, coupled with the PSMA (prostate-specific membrane antigen)-targeting motif of the previously reported HTK01166 were synthesized and evaluated to determine if they could be recognized and cleaved by the renal brush border enzymes. Addnl., positron emission tomog. (PET) imaging, ex vivo biodistribution and in vivo stability studies were conducted in mice to evaluate their pharmacokinetics. [68Ga]Ga-DOTA-AmBz-MVK(Ac)-OH was effectively cleaved specifically by neutral endopeptidase (NEP) of renal brush border enzymes at the Met-Val amide bond, and the radio-metabolite [68Ga]Ga-DOTA-AmBz-Met-OH was rapidly excreted via the renal pathway with minimal kidney retention. [68Ga]Ga-DOTA-AmBz-MVK(HTK01166)-OH retained its PSMA-targeting capability and was also cleaved by NEP, although less effectively when compared to [68Ga]Ga-DOTA-AmBz-MVK(Ac)-OH. The kidney uptake of [68Ga]Ga-DOTA-AmBz-MVK(HTK01166)-OH was 30% less compared to that of [68Ga]Ga-HTK01166. Our data demonstrated that derivatives of [68Ga]Ga-DOTA-AmBz-MVK-OH can be cleaved specifically by NEP, and therefore, MVK can be a promising cleavable linker for use to reduce kidney uptake of radiolabeled DOTA-conjugated peptides and peptidomimetics. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Related Products of 98946-18-0

The Article related to renal brush border enzyme cleavable linker kidney uptake, cancer imaging and therapy, cleavable linkers, kidney uptake, neutral endopeptidase (nep), prostate-specific membrane antigen (psma), radiopharmaceuticals, renal brush border enzymes and other aspects.Related Products of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 15, 2016, Cha, Eunju; Kim, Sohee; Lee, Kang Mi; Kim, Ho Jun; Kim, Ki Hun; Kwon, Oh-Seung; Park, Ki Duk; Lee, Jaeick published an article.SDS of cas: 14602-86-9 The title of the article was Relationship between chromatographic resolution and amide structure of chiral 2-hydroxy acids as O-(-)-menthoxycarbonylated diastereomeric derivatives for enantiomeric separation on achiral gas chromatography. And the article contained the following:

The relation between chromatog. resolution and amide structure of chiral 2-hydroxy acids as O-(-)-menthoxycarbonylated diastereomeric derivatives on achiral gas chromatog. was studied to elucidate the best diastereomeric conformation for enantiomeric separation of chiral 2-hydroxy acids. Thirteen chiral 2-hydroxy acids were converted into nine different diastereomeric O-(-)-menthoxycarbonylated amide derivatives using the primary, secondary and cyclic amines to achieve complete enantiomeric separation through an achiral column. Each enantiomeric pair of 2-hydroxy acids as O-(-)-menthoxycarbonylated tert-butylamide derivatives was resolved on both the DB-5 and DB-17 columns with resolution factors ranging from 1.7 to 4.8 and 1.7 to 3.4, resp. The structure of the amide moiety is shown to significantly affect chromatog. resolution O-(-)-menthoxycarbonylated tert-butylamide derivatives are the best diastereomeric conformations for enantiomeric separation of 2-hydroxy acids. When comparing with the authors’ previous O-trifluoroacetylated(-)-menthyl ester derivatization method, the present results suggested that size differences between groups attached to the chiral center and conformational rigidity can have stronger effects on resolution than the distance between chiral centers. The elution of R- and S-stereoisomers was affected by the class of amine; i.e., primary, secondary, or cyclic, regardless of the substituents on the amine group, the structure of the 2-hydroxy acid, and the polarity of the column. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).SDS of cas: 14602-86-9

The Article related to hydroxycarboxylic acid enantiomer resolution derivation achiral gc, amide structure chiral hydroxy acid menthoxycarbonylated diastereomeric derivative gc, (−)-menthoxycarbonylated tert-butylamides, 2-hydroxy acids, enantiomeric separation and other aspects.SDS of cas: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 4, 2020, Maeda, Chihiro; Nagahata, Keiji; Shirakawa, Takuma; Ema, Tadashi published an article.Related Products of 14602-86-9 The title of the article was Azahelicene-Fused BODIPY Analogues Showing Circularly Polarized Luminescence. And the article contained the following:

Helical carbazole-based BODIPY analogs I (X = O, S; Y = F or YY = 1,1′-binaphthalene-2,2′-diolato; R = H, RR = benzo) were readily synthesized via aza[7]helicenes. The structures of azahelicene-incorporated BF2 dyes were elucidated by x-ray diffraction anal. DFT calculations revealed that the π-conjugated system expanded from the helicene moiety to the BODIPY framework. The azahelicene-fused boron complexes showed the Cotton effects and the circularly polarized luminescence (CPL) in the visible region. Furthermore, an axially chiral binaphthyl group was attached to the helically chiral dyes, which enhanced the chiroptical properties. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Related Products of 14602-86-9

The Article related to bodipy azahelicene boron preparation benzothiazole benzoxazole derivative resolution, cd fluorescence cotton effect azahelicene benzothiazole benzoxazole bodipy, crystal structure bodipy azahelicene boron benzothiazole benzoxazole complex and other aspects.Related Products of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 3, 2016, Yu, Haiqing; Li, Yanxia; Ge, Yang; Song, Zhendong; Wang, Changyuan; Huang, Shanshan; Jin, Yue; Han, Xu; Zhen, Yuhong; Liu, Kexin; Zhou, Youwen; Ma, Xiaodong published an article.Computed Properties of 99-60-5 The title of the article was Novel 4-anilinoquinazoline derivatives featuring an 1-adamantyl moiety as potent EGFR inhibitors with enhanced activity against NSCLC cell lines. And the article contained the following:

With the aim of overcoming gefitinib resistance, a series of novel quinazoline derivatives bearing an adamantyl group on the aniline ring were synthesized as potent epidermal growth factor receptor (EGFR) inhibitors. Most of these analogs are comparable to gefitinib in their ability to inhibit non-small cell lung cancer (NSCLC) cell lines, and several also exhibited significantly enhanced anti-tumor potency. Specifically, compound I, with an IC50 value of 2.06 μM against A431 cells with the wild-type EGFR and of 0.009 μM against the gefitinib-sensitive cells, displayed approx. 5-fold higher potency than the lead compound to inhibit the cells harboring the EGFRT790M mutant. In addition, the mol. simulation and Western blot anal. results also indicated that these compounds effectively interfered with the EGFRT790M activity, and may serve as a new alternative structure to develop more effective antitumor agents. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Computed Properties of 99-60-5

The Article related to adamantyl anilinoquinazoline preparation epidermal growth factor receptor inhibitor, egfr inhibitor adamantyl anilinoquinazoline preparation, quinazoline adamantyl preparation egfr inhibitor, adamantyl, egfr, nsclc, quinazoline, t790m and other aspects.Computed Properties of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 25, 2019, Sun, Shuai-Shuai; Chen, Junyou; Zhao, Rui; Bierer, Donald; Wang, Jun; Fang, Ge-Min; Li, Yi-Ming published an article.Product Details of 98946-18-0 The title of the article was Efficient synthesis of a side-chain extended diaminodiacid for solid-phase synthesis of peptide disulfide bond mimics. And the article contained the following:

Solid-phase incorporation of diaminodiacids is one of the most effective approaches for synthesis of peptide disulfide bond mimics. One of a limitation of current diaminodiacid toolbox is that only four-atom linkage mimics are available that may not fully meet the activity optimization requirement. In this work, we developed a new diaminodiacid that contains a five-atom thioether (C-C-S-C-C) bridge for the first time. With this diaminodiacid in hand, we successfully obtained oxytocin containing new disulfide bond mimic by solid phase peptide synthesis. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Product Details of 98946-18-0

The Article related to diamino diacid synthesis solid phase incorporation peptide disulfide bond, oxytocin mimic cyclic peptide solid phase synthesis oxidative cyclization, homoserine protection sulfonation substitution hydrolysis bromination thioalkylation and other aspects.Product Details of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 15, 2012, Isherwood, Matthew L.; Guzzo, Peter R.; Henderson, Alan J.; Hsia, Ming Min; Kaur, Jagjit; Nacro, Kassoum; Narreddula, Venkateswara R.; Panduga, Shailaja; Pathak, Rashmi; Shimpukade, Bharat; Tan, Valentina; Xiang, Kai; Qiang, Zhu; Ghosh, Animesh published an article.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was An efficient synthesis of (7S,10R)-2-bromo-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole: application in the preparation and structural confirmation of a potent 5-HT6 antagonist. And the article contained the following:

(7S,10R)-5-Methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole I is a potent 5-HT6 antagonist (h5-HT6Ki = 1.5 nM) which is derived from an epiminocyclohept[b]indole scaffold. In order to synthesize I on a multi-gram scale to support advanced biol. testing, an efficient chiral resolution of the intermediate tert-Bu 2-bromo-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-11-carboxylate II was developed. After derivatizing II with (1R)-(-)-menthyl chloroformate it was found that a single diastereomer III could be isolated by selective precipitation from n-hexane. The absolute stereochem. of III was determined by X-ray crystallog. and the structure was confirmed as (7S,10R)-tert-Bu 2-bromo-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-11-carboxylate. Removal of the chiral auxiliary under basic conditions afforded intermediate II in >99% enantiomeric purity and with 80% yield based on recovery from the racemic compound II. Intermediate enantiomer II was used successfully to synthesize 5-HT6 antagonist I on a multi-gram scale. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to methyltrifluoromethylphenylsulfonylhexahydroepiminocycloheptaindole preparation chem resolution, substitution hydrolysis, butylbromohexahydroepiminocycloheptaindolecarboxylate menthyl chloroformate separation hydrolysis methylation and other aspects.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 23, 2012, Buhr, Wilm; Burckhardt, Susanna; Duerrenberger, Franz; Funk, Felix; Geisser, Peter Otto; Corden, Vincent Anthony; Courtney, Stephen Martin; Davenport, Tara; Slack, Mark; Ridgill, Mark Peter; Yarnold, Christopher John; Dawson, Graham; Boyce, Susan; Ellenbroek, Albertus Antonius published a patent.Electric Literature of 82711-97-5 The title of the patent was Novel sulfonaminoquinoline derivatives as hepcidin antagonists and their preparation and use in the treatment of iron metabolic disorders. And the patent contained the following:

The invention is related to the preparation of title compounds I [R1-6 = independently H, halo, CN, (un)substituted aroxy, heterocyclyl, etc.; R7 = H, (un)substituted alk(en/yn)yl, aryl, etc.; R8 = H, NH2 and derivatives, OH and derivatives, etc.; or R6 and R8 together form a residue II or III; X = C, N; R9-12 = independently H, NO2, CO2H and derivatives, etc.; R13 = H, (un)substituted aryl, acyl, alkyl, etc.; R14, R15 = H, halo, (un)substituted alkoxycarbonyl, aminosulfonyl, etc.] and their pharmaceutically acceptable salts as hepcidin antagonists, pharmaceutical compositions containing them, and to their use as medicaments, in particular for treating iron metabolism disorders, for example, iron deficiency diseases and anemias, in particular anemias combined with chronic inflammation diseases and anemia of inflammation. Thus, reaction of 7-methyl-8-nitroquinoline with 1,1-dimethoxy-N,N-dimethylmethanamine, oxidation of dimethyl[(E)-2-(8-nitroquinolin-7-yl)ethenyl]amine, reductive amination of 8-nitroquinoline-7-carboxaldehyde with aniline, Pd/C hydrogenation of N-[(8-nitroquinolin-7-yl)methyl]phenylamine and cyclization of [7-[(phenylamino)methyl]quinolin-8-yl]amine with 1-[(1H-imidazol-1-yl)sulfonyl]-3-methyl-1H-imidazol-3-ium trifluoromethanesulfonate gave IV. Selected I were evaluated for their hepcidin antagonistic activity. From the assay, it was determined that compound IV exhibited an IC50 value of 0.46 μM towards ferroportin. The experimental process involved the reaction of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride(cas: 82711-97-5).Electric Literature of 82711-97-5

The Article related to sulfonaminoquinoline preparation hepcidin antagonist treatment iron metabolic disorder, dioxothiatriazaphenanthrene dioxothiadiazachrysene dioxoazacyclopentanaphthalene dioxothiatriazachrysene preparation anemia hepcidin antagonist and other aspects.Electric Literature of 82711-97-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Bowen; Li, Tiejun; Aliyu, Muinat A.; Li, Zhen Hua; Tang, Wenjun published an article in 2019, the title of the article was Enantioselective Palladium-Catalyzed Cross-Coupling of α-Bromo Carboxamides and Aryl Boronic Acids.Electric Literature of 98946-18-0 And the article contains the following content:

We herein report an enantioselective palladium-catalyzed cross-coupling between α-bromo carboxamides and aryl boronic acids, generating a series of chiral α-aryl carboxamides in good yields and excellent enantioselectivities. The development of a chiral P,P=O ligand was critical in overcoming the second transmetalation issue and allows the first asym. palladium-catalyzed coupling of α-bromo carbonyl compounds The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Electric Literature of 98946-18-0

The Article related to enantioselective alpha aryl carboxamide preparation palladium catalyst, cross coupling alpha bromo carboxamide arylboronic acid phosphorus ligand, asymmetric catalysis, cross-coupling, palladium, phosphorus ligands, transmetalation and other aspects.Electric Literature of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 1, 2016, Tiwari, Vinay Shankar; Murugula, Raghavendra; Yadav, Shyam Raj; Haq, Wahajul published an article.Recommanded Product: 98946-18-0 The title of the article was Synthesis of 4-hydroxy-2-methylproline derivatives via pyrrolidine ring assembly: Chromatographic resolution and diastereoselective synthesis approaches. And the article contained the following:

4-Hydroxy-2-methylproline diastereomers are successfully prepared without the use of an external chiral auxiliary. Dihydroxylation of the key intermediate (I) (Z = benzyloxycarbonyl) resulted in lactone (II) as a mixture of diastereomers in good yield. Mesylation, hydrogenation and concomitant intramol. cyclization of II led to the formation of both (2R,4R)- and (2R,4S)-4-hydroxy-2-methylprolines as a mixture of diastereomers. Appropriate protection followed by chromatog. separation resulted in isolation of both cis- and trans-diastereomers in enantiomerically pure form and in equal quantity. In subsequent experiments, the synthesis of the more challenging diastereomers (2R,4R)- and (2S,4S)-4-hydroxy-2-methylproline was achieved by diastereoselective iodolactonization of (R)- or (S)-allylalanine obtained after hydrolysis of intermediate I, followed by pyrrolidine ring closer under mild alk. conditions. After selective protection and deprotection, Fmoc-(2R,4R)-α-Me-Hyp(tBu)-OH (III) (Fmoc = 9-fluorenylmethoxycarbonyl), a building block suitable for solid phase peptide synthesis was obtained. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: 98946-18-0

The Article related to hydroxymethylproline enantioselective and diastereoselective synthesis solvent effect, allylalanine ring opening diastereoselective iodo lactonization reaction mechanism hydrolysis, pyrrolidine ring assembly chromatog resolution and other aspects.Recommanded Product: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics