Tag: 200-300

Hurst, Timothy E.; Taylor, Richard J. K. published an article in 2017, the title of the article was A Cu-Catalysed Radical Cross-Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles.Electric Literature of 14602-86-9 And the article contains the following content:

The synthesis of acridanes and related compounds through a Cu-catalyzed radical cross-dehydrogenative coupling of simple 2-[2-(arylamino)aryl]malonates is reported. This method can be further streamlined to a one-pot protocol involving the in situ formation of the 2-[2-(arylamino)aryl]malonate by α-arylation of di-Et malonate with 2-bromodiarylamines under Pd catalysis, followed by Cu-catalyzed cyclization. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Electric Literature of 14602-86-9

The Article related to acridane derivative preparation, arylaminophenylmalonate preparation dehydrogenative coupling copper catalyst, acridanes, copper, cross‐coupling, dehydrogenation, homogeneous catalysis, nitrogen heterocycles, one‐pot reaction and other aspects.Electric Literature of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 15, 2013, Romero-Estudillo, Ivan; Boto, Alicia published an article.Synthetic Route of 14602-86-9 The title of the article was Creating diversity by site-selective peptide modification: A customizable unit affords amino acids with high optical purity. And the article contained the following:

The development of peptide libraries by site-selective modification of a few parent peptides would save valuable time and materials in discovery processes, but still is a difficult synthetic challenge. Herein natural hydroxyproline is introduced as a “convertible” unit for the production of a variety of optically pure amino acids, including expensive N-alkyl amino acids, and to achieve the mild, efficient, and site-selective modification of peptides. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Synthetic Route of 14602-86-9

The Article related to hydroxyproline amino acid regioselective synthesis tandem radical scission oxidation, oxo homoalanine reductive amination lactamization horner wadsworth emmons reaction, peptide synthesis hydroxyproline reduction alkylation and other aspects.Synthetic Route of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fandrick, Keith R.; Li, Wenjie; Zhang, Yongda; Tang, Wenjun; Gao, Joe; Rodriguez, Sonia; Patel, Nitinchandra D.; Reeves, Diana C.; Wu, Jiang-Ping; Sanyal, Sanjit; Gonnella, Nina; Qu, Bo; Haddad, Nizar; Lorenz, Jon C.; Sidhu, Kanwar; Wang, June; Ma, Shengli; Grinberg, Nelu; Lee, Heewon; Tsantrizos, Youla; Poupart, Marc-Andre; Busacca, Carl A.; Yee, Nathan K.; Lu, Bruce Z.; Senanayake, Chris H. published an article in 2015, the title of the article was Concise and practical asymmetric synthesis of a challenging atropisomeric HIV integrase inhibitor.Recommanded Product: 98946-18-0 And the article contains the following content:

A practical and efficient synthesis of a complex chiral atropisomeric HIV integrase inhibitor, I, has been accomplished. The combination of a copper-catalyzed acylation along with the implementation of the biaryl monophosphorus (BI-DIME) ligands for a ligand-controlled Suzuki cross-coupling and an unprecedented bis(trifluoromethane)sulfonamide-catalyzed tert-butylation rendered the synthesis of this complex mol. robust, safe, and economical. Furthermore, the overall synthesis was conducted in a diastereoselective fashion with respect to the imbedded atropisomer. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: 98946-18-0

The Article related to bisquinoline integrase inhibitor diastereoselective preparation thermal equilibration, boronic acid aryl chloride suzuki cross coupling, suzuki couplings, acylation, asymmetric synthesis, phosphine ligands, tert-butylation and other aspects.Recommanded Product: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bihdan, Oleksii A.; Parchenko, Volodymyr V. published an article in 2018, the title of the article was Some aspects of synthesis 3-(2-fluorophenyl)-6-R1-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole and 3-(2-,3-fluorophenyl)-6-R3-7h[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines.Safety of 2-Chloro-4-nitrobenzoic acid And the article contains the following content:

The synthesis of new 3-(2-fluorophenyl)-6-R1-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles I (R1 = Ph, 2-bromo-5-methoxyphenyl, furan-2-yl, etc.) and 3-(2-fluorophenyl, 3-fluorophenyl)-6-R3-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines II (R2 = 2-F, 3-F; R3 = Me, Ph, 4-fluorophenyl, 4-methoxyphenyl) and the passage of cyclization reaction have been described. By using the compound 5-(2-fluorophenyl)-4-amino-1,2,4-triazol-3-thiol, the reaction of its cyclization in the presence of corresponding aryl, heterocarboxylic acids in POCl3 medium has been investigated. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Safety of 2-Chloro-4-nitrobenzoic acid

The Article related to triazolothiadiazole fluorophenyl preparation, carboxylic acid aminotriazole thiol fluorophenyl heterocyclization, triazolothiadiazine fluorophenyl preparation, bromoketone aminotriazole thiol fluorophenyl heterocyclization and other aspects.Safety of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2018, Kaur, Avneet; Pathak, Dharam P.; Sharma, Vidushi; Narasimhan, Balasubramanian; Sharma, Prateek; Mathur, Rajani; Wakode, Sharad published an article.SDS of cas: 99-60-5 The title of the article was Synthesis, biological evaluation and docking study of N-(2-(3,4,5-trimethoxybenzyl)benzoxazole-5-yl) benzamide derivatives as selective COX-2 inhibitor and anti-inflammatory agents. And the article contained the following:

A series of N-(2-(3,4,5-trimethoxybenzyl)-benzoxazole-5-yl)benzamide derivatives (3a-3n) was synthesized and evaluated for its in vitro inhibitory activity against COX-1 and COX-2. The compounds with considerable in vitro activity (IC50 < 1 μM), were evaluated in vivo for their anti-inflammatory and ulcerogenic potential. Out of the fourteen newly synthesized compounds; 3b (N-(2-(3,4,5-trimethoxybenzyl)benzoxazol-5-yl)-4-chlorobenzamide), 3d (N-(2-(3,4,5-trimethoxybenzyl)benzoxazol-5-yl)-2-chlorobenzamide), 3e, 3h, 3l and 3m were found to be most potent COX-2 inhibitors in in vitro enzymic assay with IC50 in the range of 0.14-0.69 μM. In vivo anti-inflammatory activity of these six compounds (3b, 3d, 3e, 3h, 3l and 3m) was assessed by carrageenan induced rat paw edema method. The compound 3b (79.54%), 3l (75.00%), 3m (72.72%) and 3d (68.18%) exhibited significant anti-inflammatory activity than standard drug ibuprofen (65.90%). Ulcerogenic activity with histopathol. studies was performed, and the screened compounds demonstrated significant gastric tolerance than ibuprofen. Mol. Docking study was also performed with resolved crystal structure of COX-2 to understand the interacting mechanisms of newly synthesized inhibitors with the active site of COX-2 enzyme and the results were found to be in line with the biol. evaluation studies of the compounds The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).SDS of cas: 99-60-5

The Article related to trimethoxybenzylbenzoxazoleyl benzamide derivative preparation cox2 inhibitor antiinflammatory docking, anti-inflammatory activity, cox-1, cox-2, histopathology, n-(3,4,5-trimethoxybenzyl)benzoxazole, ulcerogenic activity and other aspects.SDS of cas: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

David, Nadege; Pasceri, Raffaele; Kitson, Russell R. A.; Pradal, Alexandre; Moody, Christopher J. published an article in 2016, the title of the article was Formal total synthesis of diazonamide A by indole oxidative rearrangement.COA of Formula: C6H10Cl3NO And the article contains the following content:

A short formal total synthesis of the marine natural product diazonamide A is described. The route is based on indole oxidative rearrangement, and a number of options were investigated involving migration of tyrosine or oxazole fragments upon oxidation of open chain or macrocyclic precursors. The final route proceeds from 7-bromoindole by sequential palladium-catalyzed couplings of an oxazole fragment at C-2, followed by a tyrosine fragment at C-3. With the key 2,3-disubstituted indole readily in hand, formation of a macrocyclic lactam set the stage for the crucial oxidative rearrangement to a 3,3-disubstituted oxindole. Notwithstanding the concomitant formation of the unwanted indoxyl isomer, the synthesis successfully delivered, after deprotection, the key oxindole intermediate, thereby completing a formal total synthesis of diazonamide A. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).COA of Formula: C6H10Cl3NO

The Article related to natural product diazonamide a synthon total synthesis macrocyclic peptidomimetic, peptide coupling iodination oxazole tyrosine indole oxidative rearrangement macrocyclization, natural products, oxindoles, total synthesis and other aspects.COA of Formula: C6H10Cl3NO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kim, Sang Hee; Lee, Kyu Ha; Chu, Ji Young; Kim, Ae Rhan; Yoo, Dong Jin published an article in 2020, the title of the article was Enhanced hydroxide conductivity and dimensional stability with blended membranes containing hyperbranched PAES/linear PPO as anion exchange membranes.Related Products of 80-07-9 And the article contains the following content:

A series of novel blended anion exchange membranes (AEMs) were prepared with hyperbranched brominated poly(arylene ether sulfone) (Br-HB-PAES) and linear chloromethylated poly(phenylene oxide) (CM-PPO). The as-prepared blended membranes were fabricated with different weight ratios of Br-HB-PAES to CM-PPO, and the quaternization reaction for introducing the ionic functional group was performed by triethylamine. The Q-PAES/PPO-XY (quaternized-PAES/PPO-XY) blended membranes promoted the ion channel formation as the strong hydrogen bonds interconnecting the two polymers were maintained, and showed an improved hydroxide conductivity with excellent thermal behavior. In particular, the Q-PAES/PPO-55 membrane showed a very high hydroxide ion conductivity (90.9 mS cm-1) compared to the pristine Q-HB-PAES membrane (32.8 mS cm-1), a result supported by the morphol. of the membrane as determined by the AFM anal. In addition, the rigid hyperbranched structure showed a suppressed swelling ratio of 17.9-24.9% despite an excessive water uptake of 33.2-50.3% at 90°C, and demonstrated a remarkable alk. stability under 2.0 M KOH conditions over 1000 h. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Related Products of 80-07-9

The Article related to chloromethylated polyphenylene oxide polyarylene ether sulfone blend dimensional stability, alkaline fuel cell, anion conductivity, anion exchange membrane, blended membranes, dimensional stability, hyperbranched polymer and other aspects.Related Products of 80-07-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 4, 2020, Kayser, Silke; Hansen, Jacob C.; Staudt, Markus; Moroz, Aleksandra; Larsen, Younes; Temperini, Piero; Yi, Feng; Syrenne, Jed T.; Krogsgaard-Larsen, Niels; Iliadis, Stylianos; Nielsen, Birgitte; Hansen, Kasper B.; Pickering, Darryl S.; Bunch, Lennart published an article.HPLC of Formula: 98946-18-0 The title of the article was Stereoselective Synthesis of New (2S,3R)-3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid Analogues Utilizing a C(sp3)-H Activation Strategy and Structure-Activity Relationship Studies at the Ionotropic Glutamate Receptors. And the article contained the following:

Competitive antagonists for ionotropic glutamate receptors (iGluRs) are highly valuable tool compounds for studying health and disease states in the central nervous system. However, only few subtype selective tool compounds are available and the discovery of antagonists with novel iGluR subtype selectivity profiles remains a profound challenge. In this paper, we report an elaborate structure-activity relationship (SAR) study of the parental scaffold 2,3-trans-3-carboxy-3-phenyl-proline by the synthesis of 40 new analogs. Three synthetic strategies were employed with two new strategies of which one being a highly efficient and fully enantioselective strategy based on C(sp3)-H activation methodol. The SAR study led to the conclusion that selectivity for the NMDA receptors was a general trend when adding substituents in the 5′-position. Selective NMDA receptor antagonists were obtained with high potency (IC50 values as low as 200 nM) and 3-34-fold preference for GluN1/GluN2A over GluN1/GluN2B-D NMDA receptors. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).HPLC of Formula: 98946-18-0

The Article related to stereoselective preparation carboxyphenyl pyrrolidine carboxylate analog ionotropic glutamate receptor, c(sp3)−h activation, electrophysiology, ionotropic glutamate receptors, nmda receptor antagonist, proline analogues and other aspects.HPLC of Formula: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 5, 2020, Scheepers, Matthew C.; Lemmerer, Andreas published an article.Name: 2-Chloro-4-nitrobenzoic acid The title of the article was Synthesis and Characterization of a Series of Sulfamethazine Multicomponent Crystals with Various Benzoic Acids. And the article contained the following:

Nine multi-component crystals consisting of sulfamethazine (sz) with HOBz and its derivatives were synthesized and characterized. Eight of the 9 multi-component crystals are co-crystals, while 1 is a mol. salt. The co-formers used to form multi-component crystals with sz include: 2-chloro-4-nitrobenzoic acid (2c4n), 2-chloro-5-nitrobenzoic acid (2c5n), salicylic acid (2hba), 3-hydroxybenzoic acid (3hba), 4-hydroxybenzoic acid (4hba), 4-bromobenzoic acid (4Brba), HOBz (ba), cinnamic acid (ca) and toluic acid (ta). These multi-component crystals were characterized by single-crystal x-ray diffraction (SC-XRD), Powder X-ray diffraction (PXRD) and Differential Scanning Calorimetry (DSC). SC-XRD showed that 8 of the co-formers that interacted with sz formed the amidine-carboxyl synthon; with the only exception to this were sz+4hba which formed the imidine-carboxyl synthon formed instead. PXRD confirmed that the single crystals were representative of the bulk material. DSC showed most of the multi-component crystals to have only a melting phase transition, which differed from the m.ps. of the co-formers. The only exceptions were sz+4brba and sz+ca, where an addnl. endothermic peak was observed, which corresponds to an amorphous phase transition before melting. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Name: 2-Chloro-4-nitrobenzoic acid

The Article related to sulfamethazine benzoic acid derivative multicomponent synthesis hydrogen bond, crystal structure sulfamethazine benzoic acid derivative multicomponent, mol structure sulfamethazine benzoic acid derivative multicomponent and other aspects.Name: 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gong, Ya-Ping; Tang, Long-Qian; Liu, Tong-Shen; Liu, Zhao-Peng published an article in 2019, the title of the article was Synthesis and evaluation of novel 2H-benzo[e]-[1,2,4]thiadiazine 1,1-dioxide derivatives as PI3Kδ inhibitors.Reference of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride And the article contains the following content:

The carbonyl group in the quinazolinone core with a sulfonyl group, designed a series of novel 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives I [R1 = H, F; R2 = Ph, 3-methoxyphenyl, 6-methoxypyridin-3-yl, 1H-indol-5-yl, etc.] as PI3Kδ inhibitors was replaced. After the reduction of nitro group in N-(2,6-dimethylphenyl)-2-nitrobenzenesulfonamide and N-(2,6-dimethylphenyl)-2-nitro-5-fluorobenzenesulfonamide, the resulting 2-aminobenzenesulfonamides were reacted with tri-Me orthoacetate to give the 3-methyl-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives After bromination of the 3-Me group, the nucleophilic substitution with the 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine provided the resp. iodide derivatives, which were further reacted with a series of arylboronic acids via Suzuki coupling to furnish the 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives I. In agreement with the quinazolinone derivatives, the introduction of a 5-indolyl or 3,4-dimethoxyphenyl at the affinity pocket generated the most potent analogs I [R1 = H; R2 = 1H-indol-5yl, 3,4-dimethoxyphenyl] with the IC50 values of 217 to 266 nM, resp. In comparison with the quinazolinone lead compounds I these 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives exhibited much decreased PI3Kδ inhibitory potency, but maintained the high selectivity over other PI3K isoforms. Unlike the quinazolinone lead compound I that was a dual PI3Kδ/γ inhibitor, the benzothiadiazine 1,1-dioxide I [R1 = H; R2 = 3,4-dimethoxyphenyl] was more than 21-fold selective over PI3Kγ. Moreover, the introducing of a fluorine atom at the 7-position of the 2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide core, I in general, was not favored for the PI3Kδ inhibitory activity. In agreement with their high PI3Kδ selectivity, I [R1 = H; R2 = 1H-indol-5yl, 3,4-dimethoxyphenyl] significantly inhibited the SU-DHL-6 cell proliferation. The experimental process involved the reaction of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride(cas: 82711-97-5).Reference of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

The Article related to pyrazolopyrimidinylmethyl dimethylphenyl benzothiadiazine dioxide preparation phosphatidylinositol kinase antitumor sar, 2h-benzo[e][1,2,4]thiadiazine 1,1-dioxide, pi3ks, pi3kδ inhibitors, anticancer, anticancer agents and other aspects.Reference of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics