Tag: 200-300

Wang, Lei; Zhong, Jialing; Lin, Xufeng published an article in 2019, the title of the article was Atroposelective Phosphoric Acid Catalyzed Three-Component Cascade Reaction: Enantioselective Synthesis of Axially Chiral N-Arylindoles.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

An efficient organocatalytic atroposelective three-component cascade reaction of 2,3-diketoesters, aromatic amines, and 1,3-cyclohexanediones has been developed for the highly enantioselective synthesis of axially chiral N-arylindoles. The success of this method derives from the use of a newly developed second-generation chiral spirocyclic phosphoric acid as the catalyst. In addition, this protocol was extended to the synthesis of an axially chiral monophosphorus ligand. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to atroposelective phosphoric acid catalyst three component cascade reaction, enantioselective synthesis axially chiral arylindole, atroposelectivity, indoles, multicomponent reaction, organocatalysis, synthetic methods and other aspects.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 1, 2019, Gotoh, Kazuma; Ishida, Hiroyuki published an article.COA of Formula: C7H4ClNO4 The title of the article was Crystal structures of the two isomeric hydrogen-bonded cocrystals 2-chloro-4-nitrobenzoic acid-5-nitroquinoline (1/1) and 5-chloro-2-nitrobenzoic acid-5-nitroquinoline (1/1). And the article contained the following:

The structures of two isomeric compounds of 5-nitroquinoline with chloro- and nitro-substituted benzoic acid, namely, 2-chloro-4-nitrobenzoic acid-5-nitroquinoline (1/1), (I), and 5-chloro-2-nitrobenzoic acid-5-nitroquinoline (1/1), (II), both C7H4ClNO4·C9H6N2O2, have been determined at 190 K. In each compound, the acid and base mols. are held together by an O-H···N hydrogen bond. In the crystal of (I), the hydrogen-bonded acid-base units are linked by a C-H···O hydrogen bond, forming a tape structure along [1 [inline formula omitted] 0]. The tapes are stacked into a layer parallel to the ab plane via N-O···π interactions between the nitro group of the base mol. and the quinoline ring system. The layers are further linked by other C-H···O hydrogen bonds, forming a three-dimensional network. In the crystal of (II), the hydrogen-bonded acid-base units are linked into a wide ribbon structure running along [1 [inline formula omitted] 0] via C-H···O hydrogen bonds. The ribbons are further linked via another C-H···O hydrogen bond, forming a layer parallel to (110). Weak π-π interactions [centroid-centroid distances of 3.7080 (10) and 3.7543 (9) Å] are observed between the quinoline ring systems of adjacent layers. Hirshfeld surfaces for the 5-nitroquinoline mols. of the two compounds mapped over shape index and dnorm were generated to visualize the weak intermol. interactions. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).COA of Formula: C7H4ClNO4

The Article related to chloro nitrobenzoic acid nitroquinoline isomeric hydrogen bond crystal structure, 2-chloro-4-nitro­benzoic acid, 5-chloro-2-nitro­benzoic acid, 5-nitro­quinoline, hirshfeld surface, crystal structure, hydrogen bond and other aspects.COA of Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Coppock, Matthew B.; Warner, Candice R.; Dorsey, Brandi; Orlicki, Joshua A.; Sarkes, Deborah A.; Lai, Bert T.; Pitram, Suresh M.; Rohde, Rosemary D.; Malette, Jacquie; Wilson, Jere A.; Kearney, Paul; Fang, Kenneth C.; Law, Scott M.; Candelario, Sherri L.; Farrow, Blake; Finch, Amethist S.; Agnew, Heather D.; Heath, James R.; Stratis-Cullum, Dimitra N. published an article in 2017, the title of the article was Protein Catalyzed Capture Agents with Tailored Performance for In Vitro and In Vivo Applications.Reference of tert-Butyl trichloroacetimidate And the article contains the following content:

We report on peptide-based ligands matured through the Protein Catalyzed Capture (PCC) agent method to tailor mol. binders for in vitro sensing/diagnostics and in vivo pharmacokinetics parameters. A Vascular Endothelial Growth Factor (VEGF) binding peptide and a peptide against the Protective Antigen (PA) protein of Bacillus anthracis discovered through phage and bacterial display panning technologies, resp., were modified with click handles and subjected to iterative in situ click chem. screens using synthetic peptide libraries. Each azide-alkyne cycloaddition iteration, promoted by the resp. target proteins, yielded improvements in metrics for the application of interest. The anti-VEGF PCC was explored as a stable in vivo imaging probe. It exhibited excellent stability against proteases and a mean elimination in vivo half-life (T1/2) of 36 min. I.p. injection of the reagent results in slow clearance from the peritoneal cavity and kidney retention at extended times, while i.v. injection translates to rapid renal clearance. The ligand competed with the com. antibody for binding to VEGF in vivo. The anti-PA ligand was developed for detection assays that perform in demanding phys. environments. The matured anti-PA PCC exhibited no solution aggregation, no fragmentation when heated to 100 oC, and a > 81% binding activity for PA after heating at 90°C for 1 h. We discuss the potential of the PCC agent screening process for the discovery and enrichment of next generation antibody alternatives. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Reference of tert-Butyl trichloroacetimidate

The Article related to vegf binding peptide pet imaging agent pharmacokinetics, biological stability, peptide, protective antigen, protein catalyzed capture agent, synthetic antibody, thermal stability, vascular endothelial growth factor and other aspects.Reference of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 8, 2016, Esvan, Yannick J.; Zeinyeh, Wael; Boibessot, Thibaut; Nauton, Lionel; Thery, Vincent; Knapp, Stefan; Chaikuad, Apirat; Loaec, Nadege; Meijer, Laurent; Anizon, Fabrice; Giraud, Francis; Moreau, Pascale published an article.Recommanded Product: 99-60-5 The title of the article was Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure. And the article contained the following:

The design and synthesis of new pyrido[3,4-g]quinazoline derivatives is described as well as their protein kinase inhibitory potencies toward five CMGC family members (CDK5, CK1, GSK3, CLK1 and DYRK1A). The interest for this original tricyclic heteroaromatic scaffold as modulators of CLK1/DYRK1A activity was validated by nanomolar potencies (compounds 10-nitropyrido[3,4-g]quinazolin-2-amine and Pyrido[3,4-g]quinazoline-2,10-diamine). CLK1 co-crystal structures with two inhibitors revealed the binding mode of these compounds within the ATP-binding pocket. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 99-60-5

The Article related to pyridoquinazoline derivative preparation cmgc protein kinase inhibitor, clk1 pyridoquinazolineamine cocrystal structure, clk1 binding mode, cmgc family, kinase inhibitors, pyrido[3,4-g]quinazoline, ser/thr kinases and other aspects.Recommanded Product: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 30, 2009, Kureshy, Rukhsana I.; Prathap, K. Jeya; Agrawal, Santosh; Kumar, Manish; Khan, Noor-ul H.; Abdi, Sayed H. R.; Bajaj, Hari C. published an article.HPLC of Formula: 1072792-33-6 The title of the article was Highly Efficient Recyclable CoIII-salen Complexes in the Catalyzed Asymmetric Aminolytic Kinetic Resolution of Aryloxy/Terminal Epoxides for the Simultaneous Production of N-Protected 1,2-Amino Alcohols and the Corresponding Epoxides in High Optical Purity. And the article contained the following:

Chiral CoIII-salen complexes bearing different substituents at the 3,3′- and 5,5′-positions of the salen unit, namely H, t-Bu, morpholinomethyl, and piperidinomethyl, have been synthesized. These complexes were used as catalysts in an environmentally benign protocol for the highly enantioselective aminolytic kinetic resolution (AKR) of racemic aryloxy/terminal epoxides with various carbamates as the nucleophile in the presence of different ionic liquids at room temperature Excellent yields (>99% with respect to the nucleophile) of N-protected 1,2-amino alcs. with high regio- and enantioselectivities (ee >99 %) were achieved with the simultaneous formation of the corresponding epoxides with high chiral purity (ee up to >99%) and in quant. yields with t-Bu-substituted Co(III)-salen complex in the ionic liquid [bmim]PF6 as the reaction medium in around 5 h. The catalyst is recyclable in this ionic-liquid-mediated AKR process (up to six cycles with no loss of performance), and the process is five times faster than the homogeneous process performed with conventional organic solvents.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009). The experimental process involved the reaction of tert-Butyl (R)-(3-chloro-2-hydroxypropyl)carbamate(cas: 1072792-33-6).HPLC of Formula: 1072792-33-6

The Article related to aryloxy epoxide terminal asym kinetic resolution aminolysis cobalt salen, epoxide chiral asym synthesis, alc amino protected asym synthesis, cobalt salen complex catalyst asym aminolytic kinetic resolution epoxide and other aspects.HPLC of Formula: 1072792-33-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Race, Nicholas J.; Faulkner, Adele; Fumagalli, Gabriele; Yamauchi, Takayuki; Scott, James S.; Ryden-Landergren, Marie; Sparkes, Hazel A.; Bower, John F. published an article in 2017, the title of the article was Enantioselective Narasaka-Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters.Recommanded Product: 14602-86-9 And the article contains the following content:

The first examples of highly enantioselective Narasaka-Heck cyclizations were described. A SPINOL-derived P,N-ligand system enabled Pd-catalyzed 5-exo cyclization of a range of oxime esters with sterically diverse trisubstituted alkenes to generate dihydropyrroles containing tetrasubstituted nitrogen-bearing stereocenters in 56 to 86% yield and 90 : 10 to 95 : 5 e.r. These processes were rare examples of reactions that proceeded via enantioselective migratory insertion of alkenes into Pd-N bonds, and the first where trisubstituted alkenes were used to generate tetrasubstituted stereocenters with high enantioselectivity. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Recommanded Product: 14602-86-9

The Article related to benzyl diphenylphosphanyl octahydrobinaphthalenyl oxazole palladium catalyst preparation, perfluorobenzoyl oxime alkenyl preparation narasaka heck cyclization, alkenyl dihydropyrrole enantioselective preparation and other aspects.Recommanded Product: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 8, 2016, Masuda, Yuichi; Maruyama, Chitose; Kawabata, Kyuichi; Hamano, Yoshimitsu; Doi, Takayuki published an article.Application of 98946-18-0 The title of the article was Synthesis of (2S,3R,4R)-3,4-dihydroxyarginine and its inhibitory activity against nitric oxide synthase. And the article contained the following:

A synthesis of (2S,3R,4R)-3,4-dihydroxyarginine, a metabolic intermediate of streptothricin, was accomplished. The (3R,4R)-dihydroxy groups were constructed by asym. syn-dihydroxylation of (E)-alkene, which was obtained by cross-metathesis of allylamine and L-vinylglycine derivatives The synthesis of (2S,3S,4S)-3,4-dihydroxyarginine was also achieved in the same manner. The (2S,3R,4R)-3,4-dihydroxyarginine exhibited inhibitory activity against inducible nitric oxide synthase, unlike (2S,3S,4S)-3,4-dihydroxyarginine. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Application of 98946-18-0

The Article related to arginine dihydroxy enantioselective diastereoselective synthesis metabolic intermediate streptothricin, nitric oxide synthase inhibitor dihydroxyarginine, allylamine vinylglycine cross metathesis alkene asym syn dihydroxylation and other aspects.Application of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 15, 2019, De Luca, Stefania; Digilio, Giuseppe; Verdoliva, Valentina; Tovillas, Pablo; Jimenez-Oses, Gonzalo; Peregrina, Jesus M. published an article.Category: chlorides-buliding-blocks The title of the article was Lanthionine peptides by S-alkylation with substituted cyclic sulfamidates promoted by activated molecular sieves: Effects of the sulfamidate structure on the yield. And the article contained the following:

A green and efficient method for preparing lanthionine peptides by a highly chemoselective and stereochem. controlled procedure is presented. It involves an S-alkylation reaction, promoted by activated mol. sieves, on chiral cyclic sulfamidates, both N-protected and unprotected. Of note, the reaction yield was high also for cyclic sulfamidates bearing a free amine group, while other strategies failed to achieve a ring-opening nucleophilic reaction with N-unprotected substrates. To prove the feasibility of the procedure, the synthesis of a thioether ring B mimetic of the natural lantibiotic haloduracin β was performed. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Category: chlorides-buliding-blocks

The Article related to lanthionine peptide enantioselective synthesis green chem, solid phase peptide synthesis, chiral cyclic sulfamidate s alkylation thioetherification cyclization, thioether ring b preparation natural lantibiotic beta haloduracin and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 1, 2018, Zhou, Qian; You, Chaoqun; Zheng, Cong; Gu, Yawen; Gu, Hongchao; Zhang, Rui; Wu, Hongshuai; Sun, Baiwang published an article.Quality Control of 2-Chloro-4-nitrobenzoic acid The title of the article was 3-Nitroacridine derivatives arrest cell cycle at G0/G1 phase and induce apoptosis in human breast cancer cells may act as DNA-target anticancer agents. And the article contained the following:

DNA is considered to be one of the most promising targets for anticancer agents. Acridine analogs have anticancer activity based on DNA binding and topoisomerases inhibition. However, due to the side effects, resistance and low bioavailability, a few have entered into clin. usage and the mechanisms of action are not fully understood. Novel acridine derivatives are needed for effective cancer therapy. A series of novel 3-nitroacridine-based derivatives were synthesized, their DNA binding and anticancer activities were evaluated. The chem. modifications at position 9 of the 3-nitroacridine were crucial for DNA affinity, thus optimizing anticancer activity. UV-Vis and CD (CD) spectroscopy indicated interaction of compounds with DNA, and the binding modes were intercalation and groove binding. MTT assay and clonogenic assay showed that compounds 1, 2 and 3 had obvious cell growth inhibition effect. They induced cell apoptosis in human breast cancer cells in a dose-dependent manner, and exhibited anticancer effect via DNA damage as well as cell cycle arrest at G0/G1 phage. Using confocal fluorescent microscope, the apoptotic features were observed The results suggested that compounds 1-3 with high DNA binding affinity and good inhibitory effect of cancer cell proliferation can be developed as prime candidates for further chem. optimization. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Quality Control of 2-Chloro-4-nitrobenzoic acid

The Article related to breast cancer dna target anticancer agent 3 nitroacridine derivative, apoptosis cell cycle arrest g1 g0 phase, acridine derivatives, anticancer activity, apoptosis, dna binding, structure-activity relationship (sar), synthesis and other aspects.Quality Control of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 30, 2016, Al-Ghorbani, Mohammed; Pavankumar, G. S.; Naveen, P.; Thirusangu, Prabhu; Prabhakar, B. T.; Khanum, Shaukath Ara published an article.COA of Formula: C7H4ClNO4 The title of the article was Synthesis and an angiolytic role of novel piperazine-benzothiazole analogues on neovascularization, a chief tumoral parameter in neoplastic development. And the article contained the following:

A novel series of benzoic acid N’-[2-(4-benzothiazol-2-yl-piperazin-1-yl)-acetyl]-hydrazides (6a-j) were synthesized and characterized by IR, 1H, 13C NMR, elemental and mass spectral analyses. The in-vitro cytotoxicity and cell viability assay of the synthesized compounds 6a-j were evaluated against Dalton’s lymphoma ascites (DLA) cells. The authors’ results showed that compound 3-bromobenzoic acid N’-[2-(4-benzothiazol-2-yl-piperazin-1- yl)-acetyl]-hydrazide (6c) with a bromo group on Ph ring has showed promising antiproliferative efficacy. Further investigation of compound (6c) on in-vivo treatment model depicts the increased tumor suppression through inhibition of angiogenesis. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).COA of Formula: C7H4ClNO4

The Article related to piperazine benzothiazole analog preparation antitumor neovascularization structure activity, antiproliferative angiogenesis piperazine benzothiazole analog, angiogenesis, antiproliferative, dla cells, piperazine–benzothiazole and other aspects.COA of Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics