Tag: 200-300

On April 6, 2022, Markushyna, Yevheniia; Antonietti, Markus; Savateev, Aleksandr published an article.Computed Properties of 80-07-9 The title of the article was Synthesis of Sulfonyl Chlorides from Aryldiazonium Salts Mediated by a Heterogeneous Potassium Poly(heptazine imide) Photocatalyst. And the article contained the following:

A heterogeneous transition metal-free material, a type of carbon nitride photocatalyst, potassium poly(heptazine imide), was employed to produce sulfonyl chlorides from arenediazonium salts under mild conditions (visible light irradiation, room temperature) with 50-95% yields. The method was suitable for the synthesis of both electron rich and electron deficient compounds and it showed high tolerance toward different functional groups (halides, ester, nitro, cyano groups). Thus, a sustainable photocatalytic alternative to the Meerwein chlorosulfonylation reaction was offered. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Computed Properties of 80-07-9

The Article related to potassium poly heptazine imide preparation surface area, thionyl chloride phenyl diazonium tetrafluoroborate heptazine imide catalyst chlorosulfonylation, phenyl sulfonyl chloride preparation and other aspects.Computed Properties of 80-07-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 20, 2020, Soni, Arvind S.; Vacariu, Condarache M.; Chen, Jeff Y.; Tanner, Martin E. published an article.Quality Control of tert-Butyl trichloroacetimidate The title of the article was Synthesis of a meso-oxa-diaminopimelic acid containing peptidoglycan pentapeptide and coupling to the GlcNAc-anhydro-MurNAc disaccharide. And the article contained the following:

The syntheses of peptidoglycan (PG)-derived peptides containing meso-diaminopimelic acid (meso-Dap) are typically quite lengthy due to the need to prepare orthogonally protected meso-Dap. In this work, the preparation of the PG pentapeptide containing the isosteric analog meso-oxa-Dap is described. The synthesis relies on the ring opening of a peptide embedded aziridine via the attack of a serine residue. The pentapeptide was attached to a GlcNAc-anhydro-MurNAc disaccharide, to produce a putative substrate for the AmpG pore protein. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Quality Control of tert-Butyl trichloroacetimidate

The Article related to meso oxadiaminopimelic acid peptidoglycan pentapeptide synthesis coupling disaccharide, peptide cyclization coupling aziridine peptide ring opening heine reaction, ampg pore protein substrate and other aspects.Quality Control of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 31, 2021, Crump, Doug; Sharin, Tasnia; Chiu, Suzanne; O’Brien, Jason M. published an article.Category: chlorides-buliding-blocks The title of the article was In Vitro Screening of 21 Bisphenol A Replacement Alternatives: Compared with Bisphenol A, the Majority of Alternatives Are More Cytotoxic and Dysregulate More Genes in Avian Hepatocytes. And the article contained the following:

An avian in vitro screening approach was used to determine the effects of 21 bisphenol A (BPA) alternatives. Cytotoxicity and dysregulation of genes associated with estrogen response and other toxicol. relevant pathways evoked by these alternatives were compared with BPA. Most of the BPA alternatives (15/21) were equally or more cytotoxic than BPA in chicken embryonic hepatocytes; variability in cell viability was associated with chem. structure and the log octanol-water partition coefficient (logP) values. A neg. linear relationship (r2 = 0.745; p = 0.49-07; n = 18) was observed between logP and the log median lethal concentration (logLC50) values. The least cytotoxic BPA alternatives elicited the greatest gene dysregulation and, overall, most of the alternatives altered more genes than BPA (measured with a custom polymerase chain reaction array). This overall approach shows promise for use as a screen for hazard-based prioritization of BPA replacement alternatives and to ideally identify those that may be less harmful and/or require addnl. toxicity testing. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Category: chlorides-buliding-blocks

The Article related to gallus hepatocyte bisphenol a alternatives cytotoxicity gene expression, avian toxicity, contaminants of emerging concern, endocrine-disrupting compounds, in vitro toxicology, risk assessment and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 3, 2022, Bolduc, Trevor G.; Lee, Cayo; Chappell, William P.; Sammis, Glenn M. published an article.Safety of tert-Butyl trichloroacetimidate The title of the article was Thionyl fluoride-mediated one-pot substitutions and reductions of carboxylic acids. And the article contained the following:

Thionyl fluoride (SOF2) is an underutilized reagent that is yet to be extensively studied for its synthetic applications. We previously reported that it is a powerful reagent for both the rapid syntheses of acyl fluorides and for one-pot peptide couplings, but the full scope of these nucleophilic acyl substitutions had not been explored. Herein, we report one-pot thionyl fluoride-mediated syntheses of peptides and amides (35 examples, 45-99% yields) that were not explored in our previous study. The scope of thionyl fluoride-mediated nucleophilic acyl substitutions was also expanded to encompass esters (24 examples, 64-99% yields) and thioesters (11 examples, 24-96% yields). In addition, we demonstrate that the scope of thionyl fluoride-mediated one-pot reactions can be extended beyond nucleophilic acyl substitutions to mild reductions of carboxylic acids using NaBH4 (13 examples, 33-80% yields). The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Safety of tert-Butyl trichloroacetimidate

The Article related to peptide amide one pot synthesis thionyl fluoride mediated thioester, carboxylic acid nucleophilic acyl substitution reduction thionyl fluoride mediated, amino acid peptide coupling protection and other aspects.Safety of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Crisan, Manuela; Halip, Liliana; Bourosh, Paulina; Chicu, Sergiu Adrian; Chumakov, Yurii published an article in 2017, the title of the article was Synthesis, structure and toxicity evaluation of ethanolamine nitro/chloronitrobenzoates: a combined experimental and theoretical study.COA of Formula: C7H4ClNO4 And the article contains the following content:

Background: Nitroarom. and chloronitroarom. compounds have been a subject of great interest in industry and recently in medical-pharmaceutic field. 2-Chloro-4-nitro/2-chloro-5-nitrobenzoic acids and 4-nitrobenzoic acid are promising new agents for the treatment of main infectious killing diseases in the world: immunodeficiency diseases and tuberculosis. Results: New ethanolamine nitro/chloronitrobenzoates were synthesized and characterized by X-ray crystallog., UV-vis, FT-IR and elementary anal. techniques. The toxicity of the compounds prepared and correspondent components was evaluated using Hydractinia echinata as test system. A significant lower toxicity was observed for nitroderivative compared with chloronitro-derivatives and individual components. Crystallog. studies, together with the chem. reactivity and stability profiles resulted from d. functional theory and ab initio MO calculations, explain the particular behavior of ethanolamine 4-nitrobenzoate in biol. test. Conclusions: The exptl. and theor. data reveal the potential of these compounds to contribute to the design of new active pharmaceutical ingredients with lower toxicity. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).COA of Formula: C7H4ClNO4

The Article related to ethanolamine nitro chloronitrobenzoate synthesis structure toxicity, chemical reactivity, nitrobenzoic and chloronitrobenzoic acids and derivatives, single crystal x-ray diffraction, toxicity and other aspects.COA of Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nugraha, Adam F.; Kim, Songmi; Wijaya, Farid; Bae, Byungchan; Shin, Dongwon published an article in 2020, the title of the article was Synthetic approaches for poly(phenylene) block copolymers via nickel coupling reaction for fuel cell applications.Reference of 4,4′-Sulfonylbis(chlorobenzene) And the article contains the following content:

Several methods to synthesize poly(phenylene) block copolymers through the nickel coupling reaction were attempted to reduce the use of expensive nickel catalysts in polymerization The model reaction for poly(phenylene) having different types of dichlorobenzene derivative monomers illustrated the potential use of cost-effective catalysts, such as NiBr2 and NiCl2, as alternatives to more expensive catalysts (e.g., bis(1,5-cyclooctadiene)nickel(0) (Ni(COD)2)). By catalyzing the polymerization of multi-block poly(phenylene) with NiBr2 and NiCl2, random copolymers with similar mol. weights could be prepared However, these catalysts did not result in a high-mol.-weight polymer, limiting their wide scale application. Further, the amount of Ni(COD)2 could be reduced in this study by approx. 50% to synthesize poly(phenylene) multi-block copolymers, representing significant cost savings. Gel permeation chromatog. and NMR results showed that the d.p. and ion exchange capacity of the copolymers were almost the same as those achieved through conventional polymerization using 2.5 times as much Ni(COD)2. The flexible quaternized membrane showed higher chloride ion conductivity than com. Fumatech membranes with comparable water uptake and promising chem. stability. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Reference of 4,4′-Sulfonylbis(chlorobenzene)

The Article related to polyphenylene polyethersulfone block copolymer anion exchange membrane fuel cell, nickel coupling reaction, anion-exchange membranes, ion conductivity, multi-block copolymer, poly(phenylene) and other aspects.Reference of 4,4′-Sulfonylbis(chlorobenzene)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Peng, Lei; Li, Kai; Xie, Chuandong; Li, Shan; Xu, Da; Qin, Wenling; Yan, Hailong published an article in 2019, the title of the article was Organocatalytic Asymmetric Annulation of ortho-Alkynylanilines: Synthesis of Axially Chiral Naphthyl-C2-indoles.SDS of cas: 98946-18-0 And the article contains the following content:

A chiral Bronsted base catalyzed asym. annulation of ortho-alkynylanilines was developed to accessed axially chiral naphthyl-C2-indoles via vinylidene ortho-quinone methide intermediates. This strategy provided a unique organocatalytic atroposelective route to axially chiral aryl-C2-indole skeletons with excellent enantioselectivity and functional-group tolerance. This transformation was applicable to decagram-scale preparation (50.0g) with perfect enantioselectivity through simple recrystallization Moreover, the utility of this reaction was demonstrated by a variety of transformations towards chiral naphthyl-C2-indoles for a series of carbon-heteroatom bond formations. Furthermore, the prepared axially chiral naphthyl-C2-indoles were applied as a chiral skeleton for organocatalytic aza-Baylis-Hillman reaction and asym. formal [4+2] tandem cyclization to give the corresponding adducts in high yields with improved enantioselectivity and diastereoselectivity. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).SDS of cas: 98946-18-0

The Article related to anilinoethynyl naphthol cinchon alkaloid catalyst enantioselective heterocyclization, hydroxynaphthyl indole preparation, asymmetric catalysis, atroposelectivity, axially chirality, indoles, organocatalysis and other aspects.SDS of cas: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 27, 2015, Stoll, Dwight R.; O’Neill, Kelly; Harmes, David C. published an article.Application of 99-60-5 The title of the article was Effects of pH mismatch between the two dimensions of reversed-phase × reversed-phase two-dimensional separations on second dimension separation quality for ionogenic compounds-I. Carboxylic acids. And the article contained the following:

Two persistent impediments to wider adoption of two-dimensional liquid chromatog. (2-dimensional-LC) are the perceptions that 2-dimensional methods are generally less sensitive than 1-dimensional ones, and that coupling of certain separation modes in a 2-dimensional system is difficult because of the neg. impact of the effluent of the 1st separation on the 2nd separation The authors address these problems in the specific case where reversed-phase separations were used in both dimensions of a 2-dimensional-LC system, but the pH is varied such that the ionization state of carboxylic acid analytes is different (i.e., neutral or neg. charged, in eluents buffered at pH 2 or 7) in the two columns. The authors 1st demonstrate that the effect of 1st dimension (1D) effluent on the performance of 2nd dimension (2D) separation of ionogenic solutes is much more serious than it is for neutral compounds where the pH of the eluent does not play a role in retention. The authors have systematically varied the properties of the sample solution injected into the 2D column (i.e., the 1D effluent), as well as the 2D eluent, with the goal of establishing guidelines for conditions that yield acceptable 2D performance. The organic solvent content of the 1D effluent and 2D eluent is not as important as the buffer concentrations in these two solutions, and the greater the ratio of buffer concentration in the 1D effluent relative to the 2D eluent, the smaller the volume one can inject into the 2D column before dramatic peak splitting occurs. The authors have then used the information from these simple experiments to guide both 1-dimensional experiments that mimic the 2D separation, and actual 2-dimensional separations, to demonstrate that online adjustment of the properties of the 1D effluent by dilution with a buffered solvent prior to injection into the 2D column is a very effective solution to the pH mismatch problem. When the buffer capacity of the diluent is high enough to effectively titrate the 1D effluent such that its pH approaches that of the 2D eluent, excellent 2D peak shape was obtained for the carboxylic acid analytes, even when the volume of injected sample solution exceeds the 2D column volume The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Application of 99-60-5

The Article related to ph mismatch 2d reversed phase liquid chromatog, carboxylic acid second dimension separation 2d lc, carboxylic acids, detection sensitivity, solvent mismatch, two-dimensional, volume overload, ph effects and other aspects.Application of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 16, 2021, Abad-Galan, Laura; Cieslik, Patrick; Comba, Peter; Gast, Michael; Maury, Olivier; Neupert, Lucca; Roux, Amandine; Wadepohl, Hubert published an article.Category: chlorides-buliding-blocks The title of the article was Excited State Properties of Lanthanide(III) Complexes with a Nonadentate Bispidine Ligand. And the article contained the following:

EuIII, TbIII, GdIII and YbIII complexes of the nonadentate bispidine derivative L2 (bispidine=3,7-diazabicyclo[3.3.1]nonane) were successfully synthesized and their emission properties studied. The X-ray crystallog. reveals full encapsulation by the nonadentate ligand L2 that enforces to all LnIII cations a common highly sym. capped square antiprismatic (CSAPR) coordination geometry (pseudo C4v symmetry). The well-resolved identical emission spectra in solid state and in solution confirm equal structures in both media. As therefore expected, this results in long-lived excited states and high emission quantum yields ([EuIIIL2]+, H2O, 298 K, τ=1.51 ms, φ=0.35; [TbIIIL2]+, H2O, 298 K, τ=1.95 ms, φ=0.68). Together with the very high kinetic and thermodn. stabilities, these complexes are a possible basis for interesting biol. probes. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Category: chlorides-buliding-blocks

The Article related to lanthanide nonadentate bispidine complex preparation luminescence, crystal structure lanthanide nonadentate bispidine complex, lanthanides, luminescence, nonadentate ligand, photophysics, quantum yield and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 25, 2011, Bregman, Howard; Buchanan, John L.; Chakka, Nagasree; Dimauro, Erin F.; Du, Bingfan; Nguyen, Hanh Nho; Zheng, Xiao Mei published a patent.Safety of 3-(4-Chlorophenoxy)azetidine hydrochloride The title of the patent was Preparation of aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain. And the patent contained the following:

The present invention provides compounds I [X = NH, NMe, O, S; S, T and U = CR3, N; A = (hetero)aryl; R1 = H, alkyl, haloalkyl, etc.; R11 = H or alkyl; R2 = H, alkyl, aryl, etc.; R3 = H, halo, alkyl, etc.; R4 = H, alkyl, halo, etc.; R5 = H, alkyl, (hetero)aryl; R6 = (un)substituted (hetero)aryl, heterocyclyl, cycloalkyl, etc.; or NR5R6 = (un)substituted heteroaryl, heterocyclyl, bridged heterocyclyl, spiroheterocyclyl] that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. over three-hundred compounds I were prepared and formulated. thus, reacting 2,4-dichloro-1,3,5-triazine with 3-amino-2-methylbenzamide followed by treating the resulting 3-(4-chloro-1,3,5-triazin-2-ylamino)-2-methylbenzamide with 1-(3,4-dimethylphenyl)piperazine afforded II. compounds I were tested on human Nav1.7 expressed stably in 293 cells (data given). also provided are pharmaceutical compositions containing compounds I and processes for preparing such compounds The experimental process involved the reaction of 3-(4-Chlorophenoxy)azetidine hydrochloride(cas: 490021-97-1).Safety of 3-(4-Chlorophenoxy)azetidine hydrochloride

The Article related to aryl carboxamide amide preparation analgesic sodium channel inhibitor, voltage gated sodium channel blocker aryl carboxamide amide preparation, chronic pain treatment aryl carboxamide amide preparation and other aspects.Safety of 3-(4-Chlorophenoxy)azetidine hydrochloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics