Tag: 200-300

On November 22, 2018, Boss, Christoph; Corminboeuf, Olivier; Fretz, Heinz; Lyothier, Isabelle; Pozzi, Davide; Richard-Bildstein, Sylvia; Siendt, Herve; Sifferlen, Thierry published a patent.Category: chlorides-buliding-blocks The title of the patent was Preparation of benzofuran and benzothiophene derivatives as PGE2 receptor modulators. And the patent contained the following:

The title compounds I [R1 = (independently) alkyl, alkoxy, halo, etc.; n = 1-3; R2 =H, alkyl, halo, or cyano; X = S or O; R3 = H, Me or CF3; R41 and R42 = (independently) H, Me; or R41 and R42, together with the carbon atom to which they are attached, represent a cycloprop-1,1-diyl group; R51 and R52 = (independently) H, Me; or R51 and R52, together with the carbon atom to which they are attached, represent a cycloprop-1,1-diyl group; Ar1 = (un)substituted Ph, or 5-6 membered heteroaryl, 8-10 membered bicyclic heteroaryl, etc.] or pharmaceutically acceptable salts thereof, useful in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor, were prepared E.g., a multi-step synthesis of {6-[4-Ethoxy-5-(1H-tetrazol-5-yl)-thiophen-2-yl]-pyrimidin-4-yl}-[2-(5-fluoro-2,7-dimethylbenzo[b]thiophen-3-yl)ethyl]amine, starting from Me 3-ethoxythiophene-2-carboxylate, was described. Exemplified compounds I were evaluated for EP2 and EP4 antagonistic activities (data given). The invention further relates to novel benzofurane and benzothiophene derivatives I and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds I, and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4. The experimental process involved the reaction of Methyl 4-bromo-2-chloro-6-methylbenzoate(cas: 877149-10-5).Category: chlorides-buliding-blocks

The Article related to benzofuran benzothiophene pyrimidinylamino preparation prostaglandin ep2 ep4 receptor antitumor, immune response modulator cancer benzofuran benzothiophene pyrimidinylamino preparation and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jamatia, Ramen; Gupta, Ajay; Pal, Amarta Kumar published an article in 2016, the title of the article was Superparamagnetic Copper Ferrite Nanoparticles Catalyzed One Step Regioselective Synthesis of Dibenzodiazepinones via Ligand and Base Free Ullmann Type Coupling Reaction.Product Details of 99-60-5 And the article contains the following content:

CuFe2O4 superparamagnetic nanoparticles were used as an efficient heterogeneous catalyst for the one-step synthesis of dibenzodiazepinones via Ullmann type coupling reaction. The catalyst was highly stable, efficient and easily synthesized from readily available starting materials. The prepared CuFe2O4 NPs were characterized using various characterization techniques such as TEM, SEM, EDX, XRD, VSM, XPS and FT-IR anal. The thermal stability of the catalyst was also examined by TGA anal. The present methodol. eliminated the multistep procedure for the synthesis of the said compounds The catalyst efficiently catalyzed the reaction under milder condition furnishing high yield of the product within a short reaction time with higher regioselectivity. Furthermore, the CuFe2O4 super paramagnetic nanoparticles were easily separated by an external magnet and reused for four consecutive runs. The present protocol was devoid of any base or ligands and showed excellent result for reproducibility and gram scale reaction which addressing the issues of sustainability and environment friendliness. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Product Details of 99-60-5

The Article related to copper ferrite nanoparticle catalyst preparation, dibenzodiazepinone preparation green chem, chlorobenzoic acid phenylenediamine copper ferrite catalyst regioselective ullmann coupling and other aspects.Product Details of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 6, 2019, Moreira, Ryan; Diamandas, Matthew; Taylor, Scott D. published an article.Safety of tert-Butyl trichloroacetimidate The title of the article was Synthesis of Fmoc-protected amino alcohols via the Sharpless asymmetric aminohydroxylation reaction using FmocNHCl as the nitrogen source. And the article contained the following:

The aminohydroxylation of various alkenes using FmocNHCl (9-fluorenylmethyl chlorocarbamate) as a nitrogen source is reported. In general, in the absence of a ligand, the reaction provided racemic Fmoc-protected amino alcs. with excellent regioselectivity but in low to moderate yields. However, in some instances, the yield of an amino alc. product and the regioselectivity could be altered by the addition of a catalytic amount of triethylamine (TEA). The Sharpless asym. variant of this reaction (Sharpless asym. aminohydroxylation (SAAH)), using (DHQD)2PHAL (DHQD) or (DHQ)2PHAL (DHQ) as chiral ligands, proceeded more readily and in higher yield compared to the same reaction in the absence of a chiral ligand. The enantiomeric ratios (er) of all but two examples exceeded 90:10 with many examples giving er values of 95:5 or higher, making FmocNHCl a highly practical reagent for preparing chiral amino alcs. The SAAH reaction using FmocNHCl was used for the preparation of D-threo-β-hydroxyasparagine and D-threo-β-methoxyaspartate, suitably protected for Fmoc solid phase peptide synthesis. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Safety of tert-Butyl trichloroacetimidate

The Article related to amino alc fmoc protected enantioselective regioselective synthesis hydroxyasparagine methoxyaspartate, sharpless asym aminohydroxylation fluorenylmethyl chlorocarbamate nitrogen source and other aspects.Safety of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mohanty, Aruna Kumar; Song, Young Eun; Kim, Jung Rae; Kim, Nowon; Paik, Hyun-jong published an article in 2021, the title of the article was Phenolphthalein anilide based poly(ether sulfone) block copolymers containing quaternary ammonium and imidazolium cations: anion exchange membrane materials for microbial fuel cell.Synthetic Route of 80-07-9 And the article contains the following content:

A class of phenolphthalein anilide (PA)-based poly(ether sulfone) multiblock copolymers containing pendant quaternary ammonium (QA) and imidazolium (IM) groups were synthesized and evaluated as anion exchange membrane (AEM) materials. The AEMs were flexible and mech. strong with good thermal stability. The ionomeric multiblock copolymer AEMs exhibited well-defined hydrophobic/hydrophilic phase-separated morphol. in small-angle X-ray scattering and at. force microscopy. The distinct nanophase separated membrane morphol. in the AEMs resulted in higher conductivity (IECw = 1.3-1.5 mequivalent/g, σ(OH-) = 30-38 mS/cm at 20°C), lower water uptake and swelling. Finally, the membranes were compared in terms of microbial fuel cell performances with the com. cation and anion exchange membranes. The membranes showed a maximum power d. of ∼310 mW/m2 (at 0.82 A/m2); 1.7 and 2.8 times higher than the Nafion 117 and FAB-PK-130 membranes, resp. These results demonstrated that the synthesized AEMs were superior to Nafion 117 and FAB-PK-130 membranes. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Synthetic Route of 80-07-9

The Article related to phenolphthalein anilide polyether sulfone copolymer membrane microbial fuel cell, anion exchange membrane, cardo group, hydroxide conductivity, imidazolium, microbial fuel cell, quaternary ammonium and other aspects.Synthetic Route of 80-07-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 1, 2019, Huang, Yong; Liu, Song; Wu, Renbo; Zhang, Lifang; Zhang, Yan; Hong, Haiyan; Zhang, Aili; Xiao, Hao; Liu, Yajing; Wu, Zehui; Zhu, Lin; Kung, Hank F. published an article.Recommanded Product: tert-Butyl trichloroacetimidate The title of the article was Synthesis and preliminary evaluation of a novel glutamine derivative: (2S,4S)4-[18F]FEBGln. And the article contained the following:

We report the preparation of a novel glutamine derivative, (2S,4S)-2,5-diamino-4-(4-(2-fluoroethoxy)benzyl)-5-oxopentanoic acid, (2S, 4S)4-[18F]FEBGln ([18F]4), through efficient organic and radiosyntheses. In vitro assays of [18F]4 using MCF-7 cells showed that it entered cells via multiple amino acid transporter systems including system L and ASC2 transporters but not through the system A transporter. [18F]4 showed promising properties for tumor imaging and may serve as a lead compound for further optimizing and targeting the system L transporter associated with enhanced glutamine metabolism in cancer cells. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: tert-Butyl trichloroacetimidate

The Article related to glutamine derivative tumor imaging agent diamino fluoroethoxybenzyl oxopentanoic acid, amino acid transporter system uptake chirality, amino acid, glutamine, radiosynthesis, synthesis, transporter and other aspects.Recommanded Product: tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thakal, Samridhi; Singh, Amit; Singh, Vikramjeet published an article in 2022, the title of the article was In vitro and in silico evaluation of N-(alkyl/aryl)-2-chloro-4-nitro-5- [(4-nitrophenyl)sulfamoyl]benzamide derivatives for antidiabetic potential using docking and molecular dynamic simulations.Application In Synthesis of 2-Chloro-4-nitrobenzoic acid And the article contains the following content:

Synthesis of N-(alkyl/aryl)-2-chloro-4-nitro-5-[(4-nitrophenyl)sulfamoyl]benzamide derivativesI(R = n-Pr, Ph, furan-2-ylmethyl, etc.) was synthesized and evaluated for its in vitro antidiabetic potential against α-glucosidase and α-amylase enzymes and also for its antimicrobial potential. Compounds I (R = 2-methyl-4-nitrophenyl, 2-methyl-5-nitrophenyl, (III)) were found to be the most potent α-glucosidase and α-amylase inhibitors with IC50 values of 10.13 and 1.52μM, resp. The docking results depicted reasonable dock score -10.2 to -8.0 kcal/mol (α-glucosidase), -11.1 to -8.3 kcal/mol (α-amylase) and binding interactions of synthesized mols. with resp. targets with enzymes. During mol. dynamic simulations, anal. of RMSD of ligand protein complex suggested stability of the most active compound at binding site of target proteins. Compound I (R = 2-chloro-4-nitrophenyl) showed antibacterial potential against Gram pos. and Gram neg. bacteria and compound (III) showed excellent antifungal potential against Candida albicans and Aspergillus niger. The computational studies were also executed to predict the drug-likeness and ADMET properties of the title compounds The I showed significant antidiabetic and antimicrobial potential which is equally supported by the mol. dynamic and docking studies. This study will prove useful in revealing the mol. structure and receptor target site details which can be further utilized for the development of newer active antidiabetic and antimicrobial agents. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Application In Synthesis of 2-Chloro-4-nitrobenzoic acid

The Article related to chloronitro nitrophenylsulfamoyl benzamide preparation docking antidiabetic antifungal antibacterial activity, antimicrobial activity, in silico admet, molecular modeling, α-glucosidase, α-amylase and other aspects.Application In Synthesis of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 3, 2021, Pascoe, Cameron A.; Engelhardt, Daniel B.; Rosana, Albert Remus R.; van Belkum, Marco J.; Vederas, John C. published an article.HPLC of Formula: 98946-18-0 The title of the article was Methylene analogs of neopetrosiamide as potential antimetastatic agents: solid-supported syntheses using diamino diacids for pre-stapling of peptides with multiple disulfides. And the article contained the following:

Neopetrosiamide, a 28-residue peptide from Neopetrosia sp., contains three disulfide bonds and hinders mammalian tumor cell invasion. Proper connectivity of disulfide bonds is crucial for activity. Synthetic replacement of single disulfide bridges with methylene bridges gives active analogs. Pre-stapling of one ring enhances the correct formation of the remaining disulfides by reducing isomeric possibilities and possibly initiating the correct 3D fold. Cloning and expression of neopetrosiamide in E. coli affords access to the natural linear peptide. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).HPLC of Formula: 98946-18-0

The Article related to cyclic peptide neopetrosiamide methylene analog synthesis antimetastatic antitumor agent, diamino acid solid phase peptide synthesis coupling oxidative cyclization, natural product neopetrosiamide and other aspects.HPLC of Formula: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Miralles, Pablo; Yusa, Vicent; Sanchis, Yovana; Coscolla, Clara published an article in 2021, the title of the article was Determination of 60 Migrant Substances in Plastic Food Contact Materials by Vortex-Assisted Liquid-Liquid Extraction and GC-Q-Orbitrap HRMS.SDS of cas: 80-07-9 And the article contains the following content:

A GC-HRMS anal. method for the determination of 60 migrant substances, including aldehydes, ketones, phthalates and other plasticizers, phenol derivatives, acrylates, and methacrylates, in plastic food contact materials (FCM) has been developed and validated. The proposed method includes migration tests, according to Commission Regulation (EU) 10/2011, using four food simulants (A, B, C, and D1), followed by vortex-assisted liquid-liquid extraction (VA-LLE) and GC-Q-Orbitrap HRMS anal. in selected ion monitoring (SIM) mode, with a resolving power of 30,000 FWHM and a mass accuracy ≤5 ppm. The method was validated, showing satisfactory linearity (R2 ≥ 0.98 from 40 to 400μg L-1), limits of quantification (40μg L-1), precision (RSD, 0.6-12.6%), and relative recovery (81-120%). The proposed method was applied to the anal. of field samples, including an epoxy-coated tin food can, a drinking bottle made of Tritan copolyester, a disposable glass made of polycarbonate, and a baby feeding bottle made of polypropylene, showing that they were in compliance with the current European regulation regarding the studied substances. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).SDS of cas: 80-07-9

The Article related to aldehyde ketone phthalate benzyl methacrylate gc q orbitrap hrms, food contact materials, food simulants, gas chromatography, high-resolution mass spectrometry, migration test, target analysis and other aspects.SDS of cas: 80-07-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 31, 2021, Khokra, Sukhbir Lal; Kaur, Simranjeet; Banwala, Sahil; Wadhwa, Karan; Husain, Asif published an article.Product Details of 99-60-5 The title of the article was Synthesis, Molecular Docking, and Biological Evaluation of Some Novel 2- (5-Substituted 1,3,4-oxadiazole-2-yl)-1,3-benzothiazole Derivatives as Anticonvulsant Agents. And the article contained the following:

Benzothiazole is an organosulfur heterocyclic compound that has a considerable place in drug discovery due to significant pharmacol. actions. The main objective of the present study was to synthesize some novel 2-(5-substituted 1,3,4-oxadiazole-2-yl)-1,3-benzothiazole derivatives and evaluate them for their anticonvulsant activity using in silico and in vivo methods. A set of sixteen 2-(5-substituted 1, 3, 4-oxadiazole-2-yl)-1, 3-benzothiazole derivatives were prepared using multi-step reactions starting from o-amino-thiophenol and characterized by suitable spectral techniques. The synthesized compounds were evaluated for anticonvulsant activity using in silico and in vivo methods. In silico mol. docking study was performed using Molegro Virtual Docker software to analyze binding modes of compounds with the internal ligand of PDB ID: 1OHY and 1OHV; and in vivo pharmacol. activities were tested for both generalized tonic-clonic seizures and generalized absence (petit mal) seizures using Maximal Elec. Shock and PTZ-induced seizure models, resp. Some new 2-(5-substituted-1,3,4-oxadiazole-2-yl)-1,3- benzothiazole (5a-5p) were successfully synthesized by finally refluxing 1, 3-benzothiazole-2-carboxyhydrazide with different aromatic acids in phosphoryl chloride. Docking results showed that compounds 5c, 5j, and 5m were found to have the highest number of H-bond interactions; i.e. 4, 4, and 7 resp. with target proteins 1OHY and 6, 3, and 4 resp. with target protein 1OHV, whereas phenytoin showed only two H-bonding with both proteins. In the Maximal electroshock seizure method, the synthesized compounds 5h, 5k and 5o demonstrated potent anticonvulsant activity against the tonic seizure with a significant decrease in tonic hind leg extension period with a mean duration of 7.9, 7.4, and 7.0 s resp., as compared to the other synthesized compounds In contrast, in the PTZ-induced seizure model, compounds 5c, 5h, and 5m showed protection against clonic convulsion with significant elevation in the onset time of clonic convulsion at 311.2, 308.0, and 333.11 s, resp. Thus, from the results, it can be concluded that compound 5h, a benzothiazole derivative endowed with an oxadiazole ring, can be developed as a potential anticonvulsant agent. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Product Details of 99-60-5

The Article related to oxadiazole benzothiazole derivative anticonvulsant agent mol docking, benzothiazole-based oxadiazoles derivatives, anticonvulsant agents, molecular docking, phenytoin, spectroscopy., synthesis and other aspects.Product Details of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 15, 2018, Kaur, Avneet; Pathak, Dharam P.; Sharma, Vidushi; Wakode, Sharad published an article.Related Products of 99-60-5 The title of the article was Synthesis, biological evaluation and docking study of a new series of di-substituted benzoxazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents. And the article contained the following:

A new series of substituted-N-(3,4-dimethoxyphenyl)-benzoxazole derivatives 13a-13p was synthesized and evaluated in vitro for their COX (I and II) inhibitory activity, in vivo anti-inflammatory and ulcerogenic potential. Compounds 13d, 13h, 13k, 13l and 13n exhibited significant COX-2 inhibitory activity and selectivity towards COX-2 over COX-1. These selected compounds were screened for their in vivo anti-inflammatory activity by carrageenan induced rat paw edema method. Among these compounds, 13d (2-chloro-N-(2-(3,4-dimethoxyphenyl)benzoxazol-5-yl)benzamide) was the most promising analogs of the series with percent inhibition of 84.09 and IC50 value of 0.04 μM and 1.02 μM (COX-2 and COX-1) resp. Furthermore, ulcerogenic study was performed and tested compounds (13d, 13h, 13k, 13l) demonstrated a significant gastric tolerance than ibuprofen. Mol. docking study was also performed with resolved crystal structure of COX-2 to understand the binding mechanisms of newly synthesized inhibitors in the active site of COX-2 enzyme and the results were found to be concordant with the biol. evaluation studies of the compounds These newly synthesized inhibitors also showed acceptable pharmacokinetic profile in the in silico ADME/T analyses. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Related Products of 99-60-5

The Article related to benzoxazole derivative preparation cyclooxygenase cox2 inhibitor antiinflammatory ulcer, anti-inflammatory activity, benzoxazole derivatives, selective cox-2 inhibitors, ulcerogenic liability and other aspects.Related Products of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics