Tag: 200-300

Huang, Yong; Zhang, Lu; Wang, Meng; Li, Chengze; Zheng, Wei; Chen, Hualong; Liang, Ying; Wu, Zehui published an article in 2022, the title of the article was Optimization of Precursor Synthesis Conditions of (2S,4S)4-[18F]FPArg and Its Application in Glioma Imaging.Application In Synthesis of tert-Butyl trichloroacetimidate And the article contains the following content:

Although the tracer (2S,4S)4-[18F]FPArg is expected to provide a powerful imaging method for the diagnosis and treatment of clin. tumors, it has not been realized due to the low yield of chem. synthesis and radiolabeling. A simple synthetic method for the radiolabeled precursor of (2S,4S)4-[18F]FPArg in stable yield was obtained by adjusting the sequence of the synthetic steps. Furthermore, the biodistribution experiments confirmed that (2S,4S)4-[18F]FPArg could be cleared out quickly in wild type mouse. Cell uptake experiments and U87MG tumor mouse microPET-CT imaging experiments showed that the tumor had high uptake of (2S,4S)4-[18F]FPArg and the clearance was slow, but (2S,4S)4-[18F]FPArg was rapidly cleared in normal brain tissue. MicroPET-CT imaging of nude mice bearing orthotopic HS683-Luc showed that (2S,4S)4-[18F]FPArg can penetrate blood-brain barrier and image gliomas with a high contrast. Therefore, (2S,4S)4-[18F]FPArg is expected to be further applied in the diagnosis and efficacy evaluation of clin. glioma. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Application In Synthesis of tert-Butyl trichloroacetimidate

The Article related to carbamimidoyl carboxyaminomethyl carboxyamino fluoroheptanoic acid glioma imaging optimization, (2s,4s)4–[18f]fparg, amino acid, glioma imaging, positron emission tomography, tracer and other aspects.Application In Synthesis of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 22, 2022, Verdhi, Lenin Kumar; Fridman, Natalia; Szpilman, Alex M. published an article.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Copper- and Chiral Nitroxide-Catalyzed Oxidative Kinetic Resolution of Axially Chiral N-Arylpyrroles. And the article contained the following:

A readily prepared C2-sym., α-hydrogen-substituted chiral hydroxylamine served as a precatalyst to generate a chiral nitroxide in situ. This chiral nitroxide catalyst in combination with a copper co-catalyst functions as an oxidant for an unprecedented enantioselective oxidative kinetic resolution (OKR) of racemic axially chiral N-arylpyrrole alcs. using atm. oxygen as an environmentally friendly terminal oxidant. The OKR process provided the axially chiral N-arylpyrroles in er up to 3.5:96.5 and with s factors up to 24. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to racemic arylpyrrole alc copper catalyst oxidative kinetic resolution, arylpyrrole alc enantioselective green preparation, aryl pyrrole aldehyde enantioselective green preparation and other aspects.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 1, 2017, Patel, Krishnakant; Song, Fengling; Andreana, Peter R. published an article.HPLC of Formula: 14602-86-9 The title of the article was Synthesis of substrate analogues as potential inhibitors for Mycobacterium tuberculosis enzyme MshC. And the article contained the following:

Mycothiol cysteine ligase (MshC) is a key enzyme in the mycothiol (MSH) biosynthesis and a promising target for developing new anti-mycobacterial compounds Herein, we report on the synthesis of substrate analogs, as potential inhibitors, for the MshC enzyme. The target mols. were synthesized employing a Schmidt glycosylation strategy using an enantiomerically pure inositol acceptor and 2-deoxy trichloroacetimidate glycosyl donors with glycosylation yields greater than 70% and overall yields >5%. The inositol acceptor was obtained via chiral resolution of (±)-myo-inositol. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).HPLC of Formula: 14602-86-9

The Article related to mycothiol cysteine ligase mshc mycobacterium substrate analog inhibitor tuberculosis, chiral resolution, glucosamine inositol, mshc, mycothiol, substrate analogues, tuberculosis and other aspects.HPLC of Formula: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 10, 2013, Watanabe, Yutaka; Uemura, Tsuyoshi; Yamauchi, Satoe; Tomita, Kousei; Saeki, Takafumi; Ishida, Ryousuke; Hayashi, Minoru published an article.Recommanded Product: 14602-86-9 The title of the article was Regioselective functionalization of unprotected myo-inositol by electrophilic substitution. And the article contained the following:

Unprotected myo-inositol was treated with various electrophiles, such as aroyl chlorides, tosyl chloride and tert-butyldiphenylsilyl chloride in a solution of LiCl/DMA or DMSO to afford regioselectively 1,3-di-O-substituted or racemic 1-O-substituted derivatives, e.g. I, depending on a quantity of reagents and reaction time. reaction with the solvents. α-Unbranched alkanoic acid anhydrides in LiCl/DMA in the presence of triethylamine were suitable for acylation of myo-inositol, in contrast to the fact that acylation using alkanoyl chlorides in aprotic polar solvents generally does not proceed well due to decomposition of the reagents by the. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Recommanded Product: 14602-86-9

The Article related to acylation inositol alkanoyl chloride regioselective electrophilic substitution cyclitol preparation, regioselective electrophilic substitution inositol aroyl chloride alkanoic acid anhydride and other aspects.Recommanded Product: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 7, 2020, Zhao, Ruiyue; Ploessl, Karl; Zha, Zhihao; Choi, Seokrye; Alexoff, David; Zhu, Lin; Kung, Hank F. published an article.Category: chlorides-buliding-blocks The title of the article was Synthesis and Evaluation of 68Ga- and 177Lu-Labeled (R)- vs (S)-DOTAGA Prostate-Specific Membrane Antigen-Targeting Derivatives. And the article contained the following:

Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer cells and therefore is an attractive target for prostate cancer diagnosis and radionuclide therapy. Recently, published results from clin. studies using a new PSMA-targeting PET imaging agent, [68Ga]Ga-PSMA-093 ([68Ga]Ga-HBED-CC-O-carboxymethyl-Tyr-CO-NH-Glu), support the development of this agent for the diagnosis of prostate cancer. In this study, the HBED-CC chelating group in PSMA-093 was replaced by stereoselective (R)- or (S)-DOTAGA. This chelating group serves not only for chelating 68Ga but is also amendable for complexing other radioactive metals for radionuclide therapy. The corresponding optically pure (R)- and (S)-[68Ga/177Lu]-DOTAGA derivatives, (R)-[68Ga/177Lu]-13 and (S)-[68Ga/177Lu]-13, were successfully prepared Comparison of radiolabeling, binding affinity, cell uptake, and biodistribution between the two isomers was performed. Radiolabeling of (R)-[177Lu]Lu-13 and (S)-[177Lu]Lu-13 at 50°C suggested that rates of complex formation were time-dependent and the formation of (S)-[177Lu]Lu-13 was distinctly faster. The rates of complex formation for the corresponding 68Ga agents were comparable between structural isomers. The natGa and natLu equivalent showed high binding PSMA affinity (IC50 = 24-111 nM), comparable to that of the parent agent, [natGa]Ga-PSMA-093 (IC50 = 34.0 nM). Results of cell uptake and biodistribution studies in PSMA-expressing PC3-PIP tumor-bearing mice appeared to show no difference between the labeled (R)- and (S)-isomers. This is the first time that a pair of [68Ga/177Lu]-(R)- and (S)-DOTAGA isomers of PSMA agents were evaluated. Results of biol. studies between the isomers showed no noticeable difference; however, the distinctions on the rate of Lu complex formation should be considered in the development of new 177Lu-DOTAGA-based radionuclide therapy agents in the future. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Category: chlorides-buliding-blocks

The Article related to gallium lutetium dotag chelating agent optical isomer radionuclide therapy, dotaga, psma, biodistribution, cell uptake, chelating agents, gallium, lutetium, optical isomers, prostate cancer and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 9, 2013, Garner, A. Christopher; Hodgkinson, Roy C.; Wallis, John D. published an article.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Menthyloxycarbonyl phosphonium chlorides: new derivatives for determining the enantiomeric excess of chiral tertiary phosphines. And the article contained the following:

The direct alkoxycarbonylation of tertiary phosphines with alkyl chloroformates was examined and the products characterized by NMR and x-ray crystallog. anal. The derivation of representative chiral tertiary phosphines with enantiopure menthyl chloroformate allows the determination of the enantiomeric excess of scalemic mixtures by 31P NMR spectroscopic anal. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to menthyloxycarbonyl phosphonium chloride derivative tertiary phosphine enantiomeric excess determination, menthyl chloroformate derivation tertiary phosphine enantiomer determination p31 nmr and other aspects.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 1, 2017, Koshizawa, Tomoaki; Morimoto, Toshiharu; Watanabe, Gen; Watanabe, Toshiaki; Yamasaki, Nao; Sawada, Yoshikazu; Fukuda, Tomoaki; Okuda, Ayumu; Shibuya, Kimiyuki; Ohgiya, Tadaaki published an article.Application of 98946-18-0 The title of the article was Optimization of a novel series of potent and orally bioavailable GPR119 agonists. And the article contained the following:

We describe the discovery and optimization of a novel series of furo[3,2-d]pyrimidines as G protein-coupled receptor 119 agonists. Agonistic activity of 4 (EC50 = 129 nM) was improved by replacing the intramol. hydrogen bond between the fluorine atom and the aniline hydrogen in the head moiety with a covalent C-C bond to enhance conformational restriction, which consequently gave a lead compound 12 (EC50 = 53 nM). Optimized compound 26, which was identified by the further optimization of 12, exhibited potent activity (EC50 = 42 nM) with improved clearance in liver microsomes and induced a 33% reduction in blood glucose area under the curve at a dose of 10 mg/kg in an oral glucose tolerance test in C57BL/6N mice. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Application of 98946-18-0

The Article related to furo pyrimidine derivative preparation oral gpr119 agonist diabetes, furo[3,2-d]pyrimidine, gpr119 agonists, intramolecular hydrogen bond, restricted conformation, type 2 diabetes mellitus and other aspects.Application of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 1, 2019, Modha, Sachin G.; Poethig, Alexander; Dreuw, Andreas; Bach, Thorsten published an article.Formula: C11H19ClO2 The title of the article was [6π] Photocyclization to cis-Hexahydrocarbazol-4-ones: Substrate Modification, Mechanism, and Scope. And the article contained the following:

Upon irradiation at λ = 366 nm, tertiary N-alkoxycarbonyl-N-aryl-β-enaminones, e.g., I, furnished exclusively the trans-hexahydrocarbazol-4-ones, e.g., II, by a conrotatory [6π] photocyclization but epimerized on silica to cis-hexahydrocarbazol-4-ones, e.g., III (14 examples, 44-98% yield). The acceptor substitution on the nitrogen atom enhanced the stability of the cyclized products compared to N-alkyl-N-aryl-β-enaminones reported previously. The mechanism of the [6π] photocyclization was investigated by quenching experiments, deuterium-labeling experiments, and DFT calculations, suggesting a triplet pathway for the conrotatory ring closure followed by a suprafacial [1,4] hydrogen migration. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Formula: C11H19ClO2

The Article related to cis hexahydrocarbazolone preparation intramol diastereoselective photocyclization alkoxycarbonylarylenaminone, hexahydrocarbazolone cis trans epimerization mechanistic study dft homo lumo and other aspects.Formula: C11H19ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hossian, Asik; Jana, Ranjan published an article in 2016, the title of the article was Carboxyl radical-assisted 1,5-aryl migration through Smiles rearrangement.Quality Control of 2-Chloro-4-nitrobenzoic acid And the article contains the following content:

We report herein, a silver(I)-catalyzed Smiles rearrangement of 2-aryloxy- or 2-(arylthio)benzoic acids to provide aryl-2-hydroxybenzoate or aryl-2-mercaptobenzoate dimer, resp., through 1,5-aryl migration from oxygen or sulfur to carboxylate oxygen. Mechanistically, the aryl ether moiety undergoes an intramol. ipso attack by the carboxyl radical followed by a C-O or C-S bond cleavage. Aryl-2-mercaptobenzoates undergo oxidative dimerization through a thiol moiety in situ. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Quality Control of 2-Chloro-4-nitrobenzoic acid

The Article related to carboxy radical aryl migration smiles rearrangement, aryloxybenzoic arylthiobenzoic acid silver catalyst smiles rearrangement, arylhydroxybenzoate arylmercaptobenzoate dimer preparation and other aspects.Quality Control of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 15, 2020, Ma, Yichang; Zeng, Jianxian; Zeng, Yajie; Zhou, Hu; Liu, Guoqing; Liu, Yuan; Zeng, Lingwei; Jian, Jian; Yuan, Zhengqiu published an article.Formula: C12H8Cl2O2S The title of the article was Preparation and performance of poly(4-vinylpyridine)-b-polysulfone-b-poly(4-vinylpyridine) triblock copolymer/polysulfone blend membrane for separation of palladium (II) from electroplating wastewaters. And the article contained the following:

In order to sep. palladium (II) from electroplating wastewaters, poly(4-vinylpyridine)-b-polysulfone-b-poly(4-vinylpyridine) (P4VP-PSF-P4VP) / polysulfone blend membranes were fabricated by combining non-solvent induced phase separation, surface segregation and self-assembly of block copolymer. Amphiphilic P4VP-PSF-P4VP was used as the membrane base material, which was synthesized by introducing the functional monomer of 4-vinylpyridine (4-VP), and polysulfone as the additive. Effects of blend ratio and 4-VP content on membrane performance, such as structure, hydrophilicity, pure water flux and adsorption capacity towards Pd (II), were investigated. The membranes exhibited dense surface structure and low roughness due to surface segregation and self-assembly of P4VP-PSF-P4VP. The presence of 4-VP increased hydrophilicity and water flux of membrane, and it also provided good adsorption capacity towards Pd (II) (up to 103.1 ± 5.15 mg/g). Further, the membrane was used to sep. Pd (II) from simulated wastewaters during filtration. It showed good rejection ability and high selectivity towards Pd (II) in co-existence of Cu (II) and Ni (II), and selectivity coefficients of Pd/Cu and Pd/Ni are 41.9 ± 1.88 and 97.8 ± 4.32, resp. In filtration process of actual electroplating wastewater, the membrane also exhibited excellent rejection performance (Pd (II) rejection reached up to 96.8 ± 2.71%). Perhaps it is suitable for future practice applications. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Formula: C12H8Cl2O2S

The Article related to electroplating wastewater palladium adsorption filtration membrane polysulfone triblock copolymer, adsorption membrane, amphiphilic copolymer, electroplating wastewater, palladium (ii) and other aspects.Formula: C12H8Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics