Tag: 200-300

On February 21, 2011, Voss, Felix; Herdtweck, Eberhardt; Bach, Thorsten published an article.Product Details of 14602-86-9 The title of the article was Hydrogen bond induced enantioselectivity in Mn(salen)-catalyzed sulfoxidation reactions. And the article contained the following:

A chiral Mn(salen) complex exhibiting two lactam binding sites at two rigid 1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-2-one skeletons is capable of enantioselective sulfoxidation due to spatially remote substrate hydrogen bonding. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Product Details of 14602-86-9

The Article related to hydrogen bond induced enantioselectivity sulfoxidation manganese salen catalyst, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Product Details of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 29, 2017, Bahamonde, Ana; Murphy, John J.; Savarese, Marika; Bremond, Eric; Cavalli, Andrea; Melchiorre, Paolo published an article.Computed Properties of 14602-86-9 The title of the article was Studies on the Enantioselective Iminium Ion Trapping of Radicals Triggered by an Electron-Relay Mechanism. And the article contained the following:

A combination of electrochem., spectroscopic, computational, and kinetic studies was used to elucidate the key mechanistic aspects of the previously reported enantioselective iminium ion trapping of photochem. generated carbon-centered radicals. The process, which provides a direct way to forge quaternary stereocenters with high fidelity, relies on the interplay of two distinct catalytic cycles: the aminocatalytic electron-relay system, which triggers the stereoselective radical trap upon iminium ion formation, and the photoredox cycle, which generates radicals under mild conditions. Critical to reaction development was the use of a chiral amine catalyst, bearing a redox-active carbazole unit, which could rapidly reduce the highly reactive and unstable intermediate generated upon radical interception. The carbazole unit, however, is also involved in another step of the electron-relay mechanism: the transiently generated carbazole radical cation acts as an oxidant to return the photocatalyst into the original state. By kinetic and spectroscopic studies, the authors have identified the last redox event as being the turnover-limiting step of the overall process. This mechanistic framework is corroborated by the linear correlation between the reaction rate and the reduction potential of the carbazole unit tethered to the aminocatalyst. The redox properties of the carbazole unit can thus be rationally tuned to improve catalytic activity. This knowledge may open a path for the mechanistically driven design of the next generation of electron-relay catalysts. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Computed Properties of 14602-86-9

The Article related to enantioselective iminium trapping radical triggered electron relay safety, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Computed Properties of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 14, 2016, Murphy, John J.; Bastida, David; Paria, Suva; Fagnoni, Maurizio; Melchiorre, Paolo published an article.Product Details of 14602-86-9 The title of the article was Asymmetric catalytic formation of quaternary carbons by iminium ion trapping of radicals. And the article contained the following:

An important goal of modern organic chem. is to develop new catalytic strategies for enantioselective carbon-carbon bond formation that can be used to generate quaternary stereogenic centers. Whereas considerable advances have been achieved by exploiting polar reactivity, radical transformations have been far less successful. This is despite the fact that open-shell intermediates are intrinsically primed for connecting structurally congested carbons, as their reactivity is only marginally affected by steric factors. Here we show how the combination of photoredox and asym. organic catalysis enables enantioselective radical conjugate additions to β,β-disubstituted cyclic enones to obtain quaternary carbon stereocenters with high fidelity. Critical to our success was the design of a chiral organic catalyst, containing a redox-active carbazole moiety, that drives the formation of iminium ions and the stereoselective trapping of photochem. generated carbon-centered radicals by means of an electron-relay mechanism. We demonstrate the generality of this organocatalytic radical-trapping strategy with two sets of open-shell intermediates, formed through unrelated light-triggered pathways from readily available substrates and photoredox catalysts-this method represents the application of iminium ion activation (a successful catalytic strategy for enantioselective polar chem.) within the realm of radical reactivity. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Product Details of 14602-86-9

The Article related to asym catalysis formation quaternary carbon iminium ion trapping radical, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Product Details of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 19, 2010, Narasimhan, Sri Kamesh; Kerwood, Deborah J.; Wu, Lei; Li, Jun; Han, Yongbin; Zhu, Shifa; Shah, Akshay; Lombardi, Rosina; Freedman, Teresa B.; Luk, Yan-Yeung published an article.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Induced folding by chiral nonplanar aromatics. [Erratum to document cited in CA151:336592]. And the article contained the following:

In view of their relevant contributions to this work, Yongbin Han, Shifa Zhu, and Akshay Shah have been added as coauthors for this article. The correct version of the Author list is given. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to erratum folding chiral nonplanar aromatic, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Slonov, Azamat; Musov, Ismel; Zhansitov, Azamat; Rzhevskaya, Elena; Khakulova, Diana; Khashirova, Svetlana published an article in 2020, the title of the article was The effect of modification on the properties of polyetherimide and its carbon-filled composite.Category: chlorides-buliding-blocks And the article contains the following content:

The effect of oligophenylene sulfone (OPSU) and polycarbonate (PC) on the rheol., mech. and thermal properties of polyetherimide (PEI) and a carbon-filled composite based on it was studied. It is shown that the introduction of OPSU and PC leads to a decrease in the melt viscosity of PEI and a carbon-filled composite based on it with the preservation of their mech. properties and heat resistance at a sufficiently high level. It was found that composites with OPSU have higher mech. and thermal properties compared with composites with PC. Samples from modified carbon-filled PEI were printed by the fused deposit modeling (FDM) method. Three-dimensionally printed samples from carbon-filled PEI modified by OPSU showed significantly higher mech. properties than composites with PC. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Category: chlorides-buliding-blocks

The Article related to polyetherimide carbon composite modification mech property, 3d printing, carbon fibers, mechanical properties, modification, polycarbonate, polyetherimide, polyphenylene sulfone and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Brodrecht, Martin; Herr, Kevin; Bothe, Sarah; de Oliveira, Marcos Jr.; Gutmann, Torsten; Buntkowsky, Gerd published an article in 2019, the title of the article was Efficient building blocks for solid-phase peptide synthesis of spin labeled peptides for electron paramagnetic resonance and dynamic nuclear polarization applications.Formula: C6H10Cl3NO And the article contains the following content:

Specific spin labeling allows the site-selective investigation of biomols. by EPR and DNP enhanced NMR spectroscopy. A novel spin labeling strategy for com. available Fmoc-amino (Fmoc = 9-fluorenylmethoxycarbonyl) acids is developed. In this approach, the PROXYL spin label is covalently attached to the hydroxyl side chain of three amino acids hydroxyproline (Hyp), serine (Ser) and tyrosine (Tyr) by a simple three-step synthesis route. The obtained PROXYL containing building-blocks are N-terminally protected by the Fmoc-protection group, which makes them applicable for the use in solid-phase peptide synthesis (SPPS). This approach allows the insertion of the spin label at any desired position during SPPS, which makes it more versatile than the widely used post synthetic spin labeling strategies. For the final building-blocks, the radical activity is proven by EPR. DNP enhanced solid-state NMR experiments employing these building-blocks in a TCE solution show enhancement factors of up to 26 for 1H and 13C (1H→13C cross-polarization). To proof the viability of the presented building-blocks for insertion of the spin label during SPPS the penta-peptide Acetyl-Gly-Ser(PROXYL)-Gly-Gly-Gly was synthesized employing the spin labeled Ser building-block. This peptide could successfully be isolated and the spin label activity proved by EPR and DNP NMR measurements, showing enhancement factors of 12.1±0.1 for 1H and 13.9±0.5 for 13C (direct polarization). The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Formula: C6H10Cl3NO

The Article related to amino acid fmoc protected spin label proxyl esr dnp, solid phase peptide synthesis spin label esr dnp nmr, epr, amino acids, hyperpolarization, solid-state nmr, spin labeling and other aspects.Formula: C6H10Cl3NO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 30, 2020, Wang, Guangcheng; Liu, Wenjing; Tang, Juan; Ma, Xue; Gong, Zipeng; Huang, Yong; Li, Yongjun; Peng, Zhiyun published an article.Recommanded Product: 99-60-5 The title of the article was Design, synthesis and anticancer evaluation of benzophenone derivatives bearing naphthalene moiety as novel tubulin polymerization inhibitors. And the article contained the following:

A series of (phenyl)(4-methoxynaphthalen-1-yl)methanones I [Ar = Ph, 4-FC6H4, naphthalen-2-yl, etc.] was designed, synthesized via reaction of 1-methoxynaphthalene with aromatic carboxylic acids and evaluated for their antiproliferative activity against human breast cancer cell line (MCF-7). Most of the tested derivatives I showed good to moderate cytotoxicity against MCF-7 cell line, among which compound I [Ar = 3-OH-4-MeOC6H3] (IC50 = 1.47 ± 0.14μM) was found to be the most active compound, which was more active than the standard drug cisplatin (IC50 = 15.24 ± 1.27μM). In vitro tubulin polymerization inhibition assay, EBI competition assay, cell cycle anal. and cell apoptosis assay identified that compound I [Ar = 3-OH-4-MeOC6H3] was a new tubulin polymerization inhibitor by targeting the colchicine binding site. Mol. docking study showed that compound I [Ar = 3-OH-4-MeOC6H3] possessed high binding affinities with the colchicine binding site of tubulin through hydrogen bond, cation-π, and hydrophobic interaction. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 99-60-5

The Article related to phenyl methoxynaphthalenyl methanone preparation sar tubulin polymerization antitumor human, anticancer activity, benzophenone, naphthalene, tubulin polymerization inhibitors and other aspects.Recommanded Product: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Engl, Oliver D.; Saadi, Jakub; Cosimi, Elena; Wennemers, Helma published an article in 2017, the title of the article was Synthesis of Monothiomalonates – Versatile Thioester Enolate Equivalents for C-C Bond Formations.Recommanded Product: tert-Butyl trichloroacetimidate And the article contains the following content:

A method for the preparation of monothiomalonates, used as thioester enolate equivalent for stereoselective C-C bond formation, is disclosed; the method allows the thioester and ester groups and the carbon substituents to be varied. Reaction of Meldrum’s acid and 2-substituted Meldrum’s acids with arylthiols or (4-methoxyphenylthio)trimethylsilane mediated by Et3N and TMSCl in MeCN yielded malonic acid monothioesters which were isolated in most cases by extraction O-alkylation of the resulting malonic acid monothioesters with alkyl triflates or alkyl acetimidates yielded the desired monothiomalonates in 34-92% overall yields. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: tert-Butyl trichloroacetimidate

The Article related to monothiomalonate preparation, ring opening meldrum acid aryl thiol chlorotrimethylsilane ethylamine, alkylation malonic acid monothioester alkyl trichloroacetimidate triflate and other aspects.Recommanded Product: tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 16, 2018, Hawkins, Paige M. E.; Giltrap, Andrew M.; Nagalingam, Gayathri; Britton, Warwick J.; Payne, Richard J. published an article.Computed Properties of 98946-18-0 The title of the article was Total synthesis of Ecumicin. And the article contained the following:

The first total synthesis of the potent anti-mycobacterial cyclic depsipeptide natural product ecumicin is described. Synthesis was achieved via a solid-phase strategy, incorporating the synthetic non-proteinogenic amino acids N-methyl-4-methoxy-L-tryptophan and threo-β-hydroxy-L-phenylalanine into the growing linear peptide chain. The synthesis employed key on-resin esterification and dimethylation steps as well as a final macrolactamization between the unusual N-methyl-4-methoxy-L-tryptophan unit and a bulky N-methyl-L-valine residue. The synthetic natural product possessed potent antimycobacterial activity against the virulent H37Rv strain of Mycobacterium tuberculosis (MIC90 = 312 nM). The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Computed Properties of 98946-18-0

The Article related to natural product cyclic depsipeptide antimycobacterial agent tuberculostatic drug, solid phase peptide synthesis esterification dimethylation macrolactamization steric effect and other aspects.Computed Properties of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 3, 2021, Joshi, Bhaskar D.; Chisholm, John D. published an article.SDS of cas: 98946-18-0 The title of the article was Formation of pyrroloindolines via the alkylation of tryptamines with trichloroacetimidates. And the article contained the following:

Pyrroloindolines and related systems are present in a large number of complex natural products. These core structures have generated considerable synthetic interest, as many of the compounds possess challenging, elaborate structures and interesting biol. properties. Recently, we have focused on using trichloroacetimidates for the synthesis of these fascinating mols., e.g., I. Trichloroacetimidates can be used as an electrophilic source of an alkyl group to form the pyrroloindoline directly from tryptamine derivatives In this manner trichloroacetimidates provide a flexible solution to forming highly functionalized pyrroloindoline core structures, needing only a catalytic amount of a Lewis acid to effect the requisite transformations. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).SDS of cas: 98946-18-0

The Article related to pyrroloindoline preparation electrophilic alkylation cyclization tryptamine trichloroacetimidate, alkylation, heterocycle, pyrroloindoline, trichloroacetimidate, tryptamine and other aspects.SDS of cas: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics