Tag: 200-300

On October 5, 2018, Shan, Huanyu; Zhou, Qiaoxia; Yu, Jinglu; Zhang, Shuoqing; Hong, Xin; Lin, Xufeng published an article.Related Products of 14602-86-9 The title of the article was Rhodium-Catalyzed Asymmetric Addition of Organoboronic Acids to Aldimines Using Chiral Spiro Monophosphite-Olefin Ligands: Method Development and Mechanistic Studies. And the article contained the following:

The synthesis of a novel type of chiral spiro monophosphite-olefin (SMPO) ligands based on a hexamethyl-1,1′-spirobiindane scaffold was accomplished starting from Bisphenol C. The optimal ligand could serve as an elegant chiral bidentate ligand in the Rh-catalyzed asym. 1,2-addition of organoboronic acids to various acyclic/cyclic aldimines, leading to chiral amines with high yields and excellent enantioselectivities. Detailed stereochem. models for enantioselective induction were elucidated through DFT calculations and postulated the origins of the higher enantioselectivity of phosphite-olefin ligands. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Related Products of 14602-86-9

The Article related to chiral spiro monophosphite olefin ligand preparation asym addition catalyst, addition boronic acid aldimine chiral spiro monophosphite olefin ligand, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Three Or More Hetero Atoms and other aspects.Related Products of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Periasamy, Mariappan; Edukondalu, Athukuri; Ramesh, Eagala published an article in 2017, the title of the article was Synthesis and Desymmetrization of meso-2,3-Diphenylpiperazine for Application in Asymmetric Transformations.Electric Literature of 14602-86-9 And the article contains the following content:

The meso-2,3-diphenylpiperazine was prepared in 86 % yield with 99:1 dr from the readily accessible 5,6-diphenyl-2,3-dihydropyrazine by NaBH4/MeOH reduction The corresponding diastereomeric amides prepared using (R)-(-)-menthyl chloroformate, after separation, benzylation and hydrolysis gave both isomers of optically active N-benzyl-2,3-diphenylpiperazine samples in up to 94% ee which after further enrichment using the simple achiral oxalic acid afforded samples of both enantiomers in 99% ee. Reaction of the chiral optically active N-benzyl-2,3-diphenylpiperazine with terminal alkynes and aldehydes in the presence of ZnCl2 gave the corresponding propargylamines with very high diastereoselectivities (up to 99:1 dr) from which both enantiomers of chiral allenes were obtained in up to 82-86% ee by reaction with ZnBr2 in toluene at 120°. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Electric Literature of 14602-86-9

The Article related to meso diphenylpiperazine preparation desymmetrization chiral propargylamine allene stereoselective, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Electric Literature of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Schnell, Simon D.; Hoff, Lukas V.; Panchagnula, Advaita; Wurzenberger, Maximilian H. H.; Klapotke, Thomas M.; Sieber, Simon; Linden, Anthony; Gademann, Karl published an article in 2020, the title of the article was 3-Bromotetrazine: labelling of macromolecules via monosubstituted bifunctional s-tetrazines.Application In Synthesis of tert-Butyl trichloroacetimidate And the article contains the following content:

Synthesis and first characterization of the novel chem. probe 3-bromotetrazine and establish its reactivity toward nucleophiles was reported. This led to the synthesis of several novel classes of 3-monosubstituted s-tetrazines, e.g., I. A remarkable functional group selectivity was observed and was utilized to site-selectively functionalize different complex mols. The stability of 3-bromotetrazine under the reaction conditions facilitated the development of a protocol for protein functionalization, which enabled a “minimal”, bifunctional tetrazine unit as a bio-orthogonal handle for inverse electron demand Diels-Alder reactions. Addnl., a novel tetrazine-based chem. probe was developed and its application in the context of thiol-targeted natural product isolation and labeling of mammalian cells was demonstrated. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Application In Synthesis of tert-Butyl trichloroacetimidate

The Article related to chem probe bromotetrazine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Three Or More Hetero Atoms and other aspects.Application In Synthesis of tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2019, Charitos, Georgios; Trafalis, Dimitrios T.; Dalezis, Panayiotis; Potamitis, Constantinos; Sarli, Vasiliki; Zoumpoulakis, Panagiotis; Camoutsis, Charalambos published an article.Name: 2-Chloro-4-nitrobenzoic acid The title of the article was Synthesis and anticancer activity of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives. And the article contained the following:

A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles I [R = Ph, 4-MeOC6H4CH2, PhCH:CH, Ph(CH2)3, 4-pyridinyl, etc.] has been designed, synthesized and evaluated as potential anticancer agents. The strategy of combining two chem. different but pharmacol. compatible mols. (the 1,2,4-triazole and 1,3,4-thiadiazole) in one frame has been emphasized. Several of the newly synthesized 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles I showed substantial cytostatic and cytotoxic antineoplastic activity in vitro, while they have produced relatively low acute toxicities in vivo, giving potentially high therapeutic ratios. In silico screening has revealed several protein targets including apoptotic protease-activating factor 1 (APAF1) and tyrosine-protein kinase HCK which may be involved in the biol. activities of active analogs. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Name: 2-Chloro-4-nitrobenzoic acid

The Article related to triazolothiadiazole benzyl aminosulfonyl preparation cytostatic cytotoxic antineoplastic, triazole amino mercapto condensation aromatic arylalkanoic acid, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Name: 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 4, 2007, Urban, Andreas; Brohm, Dirk; Birkmann, Alexander; Schohe-Loop, Rudolf; Koletzki, Diana; Harrenga, Axel; Stoll, Friederike; Mundt, Stefan; Paulsen, Daniela published a patent.HPLC of Formula: 15258-72-7 The title of the patent was Substituted N-benzyl-N-phenylbenzenesulfonamides as antiviral agents, their preparation, pharmaceutical compositions, and use in therapy. And the patent contained the following:

The invention relates to substituted N-benzyl-N-phenylbenzenesulfonamides of formula I, which are antiviral agents. In compounds I, R1 is OH or NR9R10, where R9 and R10 are independently selected from H, C1-6 alkyl, (un)substituted benzyl, (un)substituted phenethyl, and C3-6 cycloalkyl; R2 is H, halo, cyano, OH, NH2, CF3, CF3O, (un)substituted C1-4 alkyl, (un)substituted C1-4 alkoxy, (un)substituted C1-4 alkylamino, or 5- to 7-membered heterocyclylamino, or R1R2 is -OCH2-; and R3 is H, halo, cyano, OH, NH2, CF3, CF3O, (un)substituted C1-4 alkyl, (un)substituted C1-4 alkoxy, (un)substituted C1-4 alkylamino, or (un)substituted 5- to 7-membered heterocyclylamino. Further, in compounds I, R4 is halo, cyano, Me, Et, or cyclopropyl; R5 is selected from H, (un)substituted C1-4 alkyl, (un)substituted C2-4 alkenyl, (un)substituted C1-4 alkoxy, (un)substituted C1-4 alkylthio, (un)substituted C1-4 alkylamino, and (un)substituted 5- to 10-membered heteroaryl-Y-CH2, where Y is -O-, -S-, or -N(R11)-, and R11 is H, C1-4 alkyl, or C3-6 cycloalkyl; R6 is halo, cyano, nitro, Me, Et, CF3, CF3O, or 2-cyanovinyl; R7 is selected from H, (un)substituted C1-4 alkyl, (un)substituted C2-4 alkenyl, (un)substituted C1-4 alkoxy, (un)substituted C1-4 alkylthio, and C1-4 alkylamino; and R8 is halo, cyano, nitro, Me, Et, CF3, or CF3O; including salts and solvates thereof. The invention also relates to the preparation of I, pharmaceutical compositions comprising a compound I and a pharmaceutically acceptable adjuvant and optionally comprising an addnl. active ingredient, as well as to the use of the compositions for the treatment of viral infections, especially against hepatitis C viruses. Amidation of 3-chlorobenzenesulfonyl chloride with 6-amino-1,3-dihydroisobenzofuran-1-one followed by N-alkylation with 2,6-dichlorobenzyl bromide resulted in the formation of benzenesulfonamide II. The compounds of the invention are antiviral agents, e.g., compound II expressed an EC50 value of 1 μM and a CC50 value for cytotoxicity of more than 100 μM. The experimental process involved the reaction of 1-Chloro-2-(chloromethyl)-3-nitrobenzene(cas: 15258-72-7).HPLC of Formula: 15258-72-7

The Article related to benzenesulfonamide benzyl phenyl preparation antiviral, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.HPLC of Formula: 15258-72-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 1, 2015, Maxson, Tucker; Bertke, Jeffery A.; Gray, Danielle L.; Mitchell, Douglas A. published an article.Quality Control of 2-Chloro-4-nitrobenzoic acid The title of the article was Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitrobenzamido)-2-hydroxypropyl]decahydroisoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitrobenzoyl)pyrrolidin-2-yl]-2-hydroxyethyl}decahydroisoquinoline-3-carboxamide. And the article contained the following:

The crystal structure and absolute configuration of the two new title nelfinavir analogs, C24H35ClN4O5, (I), and C27H39ClN4O5, (II), have been determined Each of these mols. exhibits a number of disordered moieties. There are intramol. N-H·-O hydrogen bonds in both (I) and (II). In (I) it involves the two carboxamide groups, while in (II) it involves the N-tert-Bu carboxamide group and the 2-hydroxyl O atom. The intermol. hydrogen bonding in (I) (O-H-O and N-H-O) leads to two-dimensional sheets that extend parallel to the ac plane. The intermol. hydrogen bonding in (II) (O-H-O) leads to chains that extend parallel to the a axis. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Quality Control of 2-Chloro-4-nitrobenzoic acid

The Article related to nelfinavir analog crystal structure configuration, hiv protease inhibitor, absolute configuration, chiral crystal, crystal structure, nelfinavir, Crystallography and Liquid Crystals: Polytypism, Polymorphism, Crystal Phase Transitions, Ordering, Amorphization and other aspects.Quality Control of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 15, 2021, Lu, Ronghua; Yang, Tilong; Chen, Xin; Fan, Wenzheng; Chen, Pinhong; Lin, Zhenyang; Liu, Guosheng published an article.Name: tert-Butyl trichloroacetimidate The title of the article was Enantioselective Copper-Catalyzed Radical Cyanation of Propargylic C-H Bonds: Easy Access to Chiral Allenyl Nitriles. And the article contained the following:

The first enantioselective copper-catalyzed cyanation of propargylic C-H bonds via radical relay was established using novel BoxOTMS ligands, providing an efficient and straightforward tool for the construction of structurally diverse chiral allenyl nitriles in good yields with excellent enantioselectivities. This reaction features high functional group tolerance and mild conditions. In addition, the chiral allene products can be readily converted to other chiral compounds via axis-to-center chirality transfer. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Name: tert-Butyl trichloroacetimidate

The Article related to trimethylsilyl cyanide aralakyl alkyne copper catalyst enantioselective chemoselective cyanation, aryl allenyl nitrile preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Name: tert-Butyl trichloroacetimidate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 16, 2018, Yang, Shuai; Wang, Feng; Wu, Yanqi; Hua, Wenkai; Zhang, Fengzhi published an article.Synthetic Route of 99-60-5 The title of the article was Synthesis of Functionalized Triphenylenes via a Traceless Directing Group Strategy. And the article contained the following:

A ligand-free Pd-catalyzed cascade reaction between o-chlorobenzoic acids and cyclic diaryliodonium salts is reported. This one-pot procedure involves a carboxylic acid directed O-arylation followed by intramol. decarboxylative annulation affording various valuable triphenylenes, e.g., I, which can be further transformed into diversified building blocks for material chem. It was shown that an aromatic halide can react with diaryliodonium salts under the direction of carboxylic acid functionality. It was also demonstrated that the carboxylic acid could be employed as both a traceless directing group and functional handle for the atom- and step-economical one-pot double cross-coupling annulation reaction with cyclic diaryliodonium salts as the π-extending agents. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Synthetic Route of 99-60-5

The Article related to haloarylcarboxylic acid diaryliodonium arylation intramol decarboxylative annulation, triphenylene preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Synthetic Route of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 17, 2021, Maraswami, Manikantha; Diggins, Thomas; Goh, Jeffrey; Tio, Raymond; Ong, Wan Qing Renee; Hirao, Hajime; Loh, Teck-Peng published an article.Electric Literature of 1021089-12-2 The title of the article was Intramolecular Alkene-Alkene Coupling via Rh(III)-Catalyzed Alkenyl sp2 C-H Functionalization: Divergent Pathways to Indene or α-Naphthol Derivatives. And the article contained the following:

Highly selective synthesis of either indene or 1-naphthol derivatives through intramol. alkene-alkene cross-coupling is reported. The reaction works with different alkene pairs that couple to give the corresponding products in good to satisfactory yields. The indene products of authors reaction also allow further derivatization. The reaction pathway is dependent on alkene functionalities. The experimental process involved the reaction of Methyl 2-(2-bromo-3-chlorophenyl)acetate(cas: 1021089-12-2).Electric Literature of 1021089-12-2

The Article related to indene alpha naphthol preparation density functional theory, alkene intramol coupling rhodium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Benzocyclopropenes, Benzocyclobutenes, and Indenes and other aspects.Electric Literature of 1021089-12-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 31, 2019, Zhou, Qiaoxia; Pan, Rihuang; Shan, Huanyu; Lin, Xufeng published an article.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Synthesis and Optical Resolution of 3,3,3′,3′-Tetramethyl-1,1′-spirobiindane-7,7′-diol. And the article contained the following:

A novel chiral C2-sym. spiro diol, 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-diol (TMSIOL), was conveniently prepared via practical seven-step route from Bisphenol A in 45.1% overall yield. L-Menthyl chloroformate was used as optical resolving agent for the separation of the two enantiomers of TMSIOL. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to tetramethyl spirobiindanediol preparation optical resolution enantioselective, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Benzocyclopropenes, Benzocyclobutenes, and Indenes and other aspects.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics