Tag: 200-300

On September 2, 2020, Berzins, Agris; Kons, Artis; Sarsuns, Kristaps; Belyakov, Sergey; Actins, Andris published an article.Synthetic Route of 99-60-5 The title of the article was On the Rationalization of Formation of Solvates: Experimental and Computational Study of Solid Forms of Several Nitrobenzoic Acid Derivatives. And the article contained the following:

Anal. of crystal structures, mol. properties, interaction strength in solution, and computationally generated nonsolvated form crystal structure landscapes of 5 chloronitrobenzoic acid isomers and 2 addnl. 2-substituted 4-nitrobenzoic acids were used to rationalize the obtained solvate landscape of these compounds Screening of the solid forms was performed for each of the compounds, and crystal structures of the obtained nonsolvated forms and selected solvates were determined Mol. conformation, intermol. interactions, and packing efficiency of nonsolvated forms and solvates were analyzed to understand factors contributing to structure stabilization and determining the formation of the observed crystal structures. Computationally generated crystal structure landscapes of nonsolvated forms were tested for the possibility to predict the propensity to form solvates and identify polymorphic compounds Most of the solvates were obtained with solvents acting as strong H bond acceptors and/or able to form aromatic interactions. Solute-solvent association Gibbs energy representing interaction strength is the most apparent identifiable factor explaining the solvate formation of the studied compounds, and using this tool, the existence of 3 new multicomponent phases was successfully predicted. Solid form screening and crystal structure anal. of 7 nitrobenzoic acid derivatives showed that these compounds form solvates with solvents acting as strong H bond acceptors and/or able to form aromatic interactions. Solute-solvent association Gibbs energy representing interaction strength is the most apparent identifiable factor explaining the solvate formation of the studied compounds The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Synthetic Route of 99-60-5

The Article related to nitro benzoate derivative structure intermol interaction strength stabilization gibbs, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Synthetic Route of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 2, 2020, Oyama, Ryoko; Abe, Manabu published an article.HPLC of Formula: 98946-18-0 The title of the article was Reactivity and Product Analysis of a Pair of Cumyloxyl and tert-Butoxyl Radicals Generated in Photolysis of tert-Butyl Cumyl Peroxide. And the article contained the following:

Alkoxyl radicals play important roles in various fields of chem. Understanding their reactivity is essential to applying their chem. for industrial and biol. purposes. Hydrogen-atom transfer and C-C β-scission reactions have been reported from alkoxyl radicals. The ratios of these two processes were investigated using cumyloxyl (CumO•) and tert-butoxyl radicals (t-BuO•), resp. However, the products generated from the pair of radicals have not been investigated in detail. In this study, CumO• and t-BuO• were simultaneously generated from the photolysis of tert-Bu cumyl peroxide to understand the chem. behavior of the pair of radicals by analyzing the products and their distribution. ESR and/or transient absorption spectroscopy analyses of radicals, including CumO• and t-BuO•, provide more information about the radicals generated during the photolysis of tert-Bu cumyl peroxide. Furthermore, the photoproducts of (3-(tert-butylperoxy)pentane-3-yl)benzene demonstrated that the ether products were formed in in-cage reactions. The triplet-sensitized reaction induced by acetophenone, which is produced from CumO•, clarified that the spin state did not affect the product distribution. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).HPLC of Formula: 98946-18-0

The Article related to cumyloxyl tertbutoxyl radical formation reactivity peroxide photolysis, Physical Organic Chemistry: Degradation Reactions, Including Mass Spectral Fragmentation and other aspects.HPLC of Formula: 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 5, 2020, Qin, Shuai; Zhang, Pu; Qin, Yu-Jun; Guo, Zhi-Xin published an article.Synthetic Route of 80-07-9 The title of the article was Facile synthesis of diarylsulfones from arenes and 3CdSO4·xH2O via mechanochemistry. And the article contained the following:

A variety of substituted diarylsulfones RSO2R1 [R = R1 = 4-PhC6H4, 4-MeC6H4, 2-Br-4-MeOC6H3, 2-thienyl, etc.; R = 4-MeC6H4, 4-ClC6H4, 3,4-Me2C6H3, etc., R1 = 2-MeC6H4, 2-ClC6H4, 2,3-Me2C6H3, etc.] could be synthesized from simple arenes and 3CdSO4·xH2O in the presence of P2O5 under high-speed ball milling. We propose that the aromatic sulfonation is performed by arene and in-situ generated H2SO4 followed by electrophilic substitution with another arene to give the diarylsulfones. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Synthetic Route of 80-07-9

The Article related to diarylsulfone green preparation ball milling, arene cadmium sulfate mechanochem diarylsulfone green preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfoxides and Sulfones and other aspects.Synthetic Route of 80-07-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 11, 2022, Falconnet, Alban; Arndt, Jan-Dirk; Hashmi, A. Stephen K.; Schaub, Thomas published an article.Safety of 4,4′-Sulfonylbis(chlorobenzene) The title of the article was Triflic-Acid-Catalyzed Friedel-Crafts Reaction for the Synthesis of Diaryl Sulfones. And the article contained the following:

The Friedel-Crafts sulfonylation for the synthesis of diaryl sulfones derivatives was achieved by using triflic acid (TfOH) as the acidic catalyst with aryl sulfonyl chlorides and arenes at elevated temperatures Different sulfones could be synthesized with this method in good to excellent yield and with high selectivity. In contrast to the previous methodol. reported for this sulfonylation, the catalyst and the excess of arene could be easily recovered and re-used in further batches. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Safety of 4,4′-Sulfonylbis(chlorobenzene)

The Article related to arenesulfonyl chloride arene triflic acid friedel crafts sulfonylation, diarylsulfone preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfoxides and Sulfones and other aspects.Safety of 4,4′-Sulfonylbis(chlorobenzene)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 16, 2021, Cai, Wei; Zhou, Yiming; He, Yanlin; Chen, Kaihong; Yu, Cui; Huang, You published an article.COA of Formula: C11H19ClO2 The title of the article was Designing and Accurately Developing a [6 + 2] Dipolar Cycloaddition for the Synthesis of Benzodiazocines. And the article contained the following:

Herein, a concept for the design of 1,6-dipoles that bypasses the regioselectivity was described. Through the introduction of an amino group into Morita-Baylis-Hillman (MBH) carbonates, unprecedented [6 + 2] dipolar cycloadditions were accurately developed with Cs2CO3, efficiently delivering a series of benzodiazocines I (R1 = 9-Cl, 10-Me, 8-OMe, etc., R2 = Me, Et, i-Bu, etc.; R3 = OMe, OAllyl, Ph, etc.; R4 = 4-MeC6H4, 2,4-F2C6H3, 1-naphthyl, etc.) in mild conditions. Computational studies bring a deeper understanding of this reaction. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).COA of Formula: C11H19ClO2

The Article related to benzodiazocine preparation, morita baylis hillman carbonate isocyanate dipolar cycloaddition, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.COA of Formula: C11H19ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 15, 2011, Sukchol, Kulthida; Thongyai, Supakanok; Praserthdam, Piyasan published an article.HPLC of Formula: 14602-86-9 The title of the article was Preparation and characterization of novel polyimide with chiral side chain for twist nematic liquid crystal display. And the article contained the following:

The synthesis of novel polyimide (PI) films containing chirals in side chain was investigated for utilizing in twist nematic (TN) liquid crystal display (LCD). The polyimide with amine side groups (PI4 a.m.) was prepared by two steps copolymerization of 4,4′-hexafluoroisopropylidene diphthalic anhydride (6FDA), 4,4′-oxydianiline (ODA), and 3,3′-diaminobezidine (4AM) in N-methyl-2- pyrrolidinone (NMP). In the first step, the oligomer of 6FDA-ODA with mole ratio 4:3 was synthesized. In the second step, the oligomer was reacted with 4AM by gradually dropping the oligomer into 4AM solution with the mole ratio 4:5 to obtain amino groups containing polyimide P14AM. By reacting chiral compounds, mandelic acid, menthyl chloroformate, and menthyl glyoxylate hydrate using condensation reaction with amine groups along polyimide mols., the novel polyimides can be synthesized. Their chem. structures were confirmed by Fourier transform IR spectroscopy and NMR spectroscopy (1H-NMR). The coated glass slides pairs were coated with PI4AM and with each polyimide/chiral. The liquid crystals (LCs) were inserted between two coated glass slides at above the nematic temperature under the polarized light microscope to observe the alignment of LCs. The results showed the alignment of LCs in some certain direction under polyimide/chiral pair, regardless of the type of the chiral mol. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).HPLC of Formula: 14602-86-9

The Article related to polyimide chiral side chain alignment liquid crystal display, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Other and other aspects.HPLC of Formula: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 1, 2017, Lemmerer, Andreas; Motlaung, Xolani published an article.Reference of 2-Chloro-4-nitrobenzoic acid The title of the article was Stoichiometric and polymorphic salts of hexamethylenetetraminium and 2-chloro-4-nitrobenzoate. And the article contained the following:

Four mol. salts made from hexamethylenetetraminium and 2-chloro-4-nitrobenzoate have been synthesized and are reported, namely ammonium hexamethylenetetraminium bis(2-chloro-4-nitrobenzoate), NH4+·C6H13N4+·2C7H3ClNO4-, (I), hexamethylenetetraminium hydrogen bis(2-chloro-4-nitrobenzoate), 0.5C6H13N4+·C7H3.50ClNO4-, (II), hexamethylenetetraminium 2-chloro-4-nitrobenzoate, C6H13N4+·C7H3ClNO4-, (IIIa) and (IIIb). All four mol. salts show N+-H··O- hydrogen bonding. Salt (I) crystallized out with an NH4+ counter-ion which came from decomposition of 50% of the hexamethylenetetraminium cation in solution (II) shows an unusual asym. unit, with both a hexamethylenetetraminium cation and a partially deprotonated 2-chloro-4-nitrobenzoate anion. Salts (IIIa) and (IIIb) are polymorphs of each other. This work shows that hexamethylenetetramine only protonates once, even in the presence of excess acid. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Reference of 2-Chloro-4-nitrobenzoic acid

The Article related to hexamethylenetetraminium chloro nitrobenzoate stoichiometric polymorphic salt, crystal structure, mol­ecular salts, polymorphs, stoichiometric ratio, Crystallography and Liquid Crystals: Crystal Morphology (Habit), Orientation, Crystallinity and other aspects.Reference of 2-Chloro-4-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 19, 2013, Senczyszyn, Jemma; Brice, Heloise; Clayden, Jonathan published an article.Formula: C11H19ClO2 The title of the article was Spirocyclic Dihydropyridines by Electrophile-Induced Dearomatizing Cyclization of N-Alkenyl Pyridinecarboxamides. And the article contained the following:

On treatment with acylating or sulfonylating agents, N-alkenyl pyridinecarboxamides (N-pyridinecarbonyl enamines) undergo a dearomatizing cyclization initiated by pyridine acylation and followed by intramol. trapping of the resulting pyridinium cation (e.g., I → II). The products are spirocyclic dihydropyridines which may be further elaborated to spirocyclic heterocycles with drug-like features. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Formula: C11H19ClO2

The Article related to electrophile induced dearomatizing spirocyclization alkenylpyridinecarboxamide, spirocyclic hydropyridine preparation, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Formula: C11H19ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 23, 2006, Clayton, Joshua; Ma, Fupeng; Van Wagenen, Bradford; Ukkiramapandian, Radhakrishnan; Egle, Ian; Empfield, James; Isaac, Methvin; Slassi, Abdelmalik; Steelman, Gary; Urbanek, Rebecca; Walsh, Sally published a patent.Recommanded Product: Methyl 4-bromo-2-chloro-6-methylbenzoate The title of the patent was Preparation of isoindolones as metabotropic glutamate receptor potentiators. And the patent contained the following:

The title compounds I [R1 = (un)substituted 3-7 membered ring that may contain one or more heteroatoms selected from N, O and S; R2, R3 = H, alkyl, aryl, etc.; R4, R6 = H, OH, halo, etc.; R5 = H, halo, NO2, etc.; R7 = H, halo, NO2, etc.; R8, R9 = H, halo, NO2, etc.; or, where n is greater than 1, two or more R8 and/or R9 on adjacent carbons may be absent to form an alkenyl or alkynyl moiety], useful as metabotropic glutamate receptor modulators, particularly in neurol. and psychiatric disorders, were prepared E.g., a multi-step synthesis of II, was given. Generally, compounds I were active in assays described (e.g., mGluR2 assay) at concentrations (or with EC50 values) less than 10 μM. The pharmaceutical composition comprising the compound I is disclosed. The experimental process involved the reaction of Methyl 4-bromo-2-chloro-6-methylbenzoate(cas: 877149-10-5).Recommanded Product: Methyl 4-bromo-2-chloro-6-methylbenzoate

The Article related to isoindolone preparation metabotropic glutamate receptor potentiator mglur2, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: Methyl 4-bromo-2-chloro-6-methylbenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 28, 2018, Karami, Kazem; Rahimi, Mahzad; Dinari, Mohammad published an article.Category: chlorides-buliding-blocks The title of the article was High catalytic activity of a new Ag phosphorus ylide complex supported on montmorillonite: synthesis, characterization, and application for room temperature nitro reduction. And the article contained the following:

In this work, the phosphorus ylide, [PPh3CHC(O)CH2Cl], was reacted with AgNO3 to give the [Ag{C(H)PPh3C(O)CH2Cl}2]+NO3- as the product. Then, it was supported on the modified montmorillonite nanoclay to prepare a new catalyst for the reduction reaction. The structure and morphol. of the nanoclay catalyst were characterized by FT-IR, X-ray powder diffraction, SEM, energy-dispersive X-ray anal. and transmission electron microscopy techniques; also, the content of silver was obtained by inductively coupled plasma analyzer. This composition was exploited to study its catalytic activity in the reduction in aromatic nitro compounds; it displayed the high catalytic activity. Factors such as catalyst amount, solvent, temperature and reaction time were all systematically investigated to elucidate their effects on the yield of catalytic reduction in nitroarenes. This catalytic system exhibited high activity toward aromatic nitro compounds under mild conditions. The catalyst was reused five times without any significant loss in its catalytic activity. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Category: chlorides-buliding-blocks

The Article related to nitro reduction montmorillonite supported silver phosphorus ylide complex, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics