Tag: 200-300

On March 24, 2005, Le Grand, Darren Mark published a patent.COA of Formula: C9H11Cl2NO The title of the patent was Preparation of 1,3-disubstituted azetidine derivatives for use as CCR-3 receptor antagonists in the treatment of inflammatory and allergic diseases. And the patent contained the following:

Compounds of formula I and II [Ar = Ph optionally substituted by one or more substituents selected from halo, C1-C8-alkyl, cyano, nitro; X1 = S, S(O), S(O)2; X2 = C(O), O, CH2, S, S(O), S(O)2; m = 1, 2, 3, 4; R1 = H, C1-C8-alkyl optionally substituted; Q = C(Rb)(Rc) where Rb and Rc are independently C1-C8-alkyl or Rb and Rc together form a C3-C10-cycloalkyl; Y = O, S; R2 = H, C1-C8-alkyl, C3-C10-cycloalkyl; R3 = C1-C8-alkyl substituted by Ph, phenoxy, acyloxy, naphthyl, or R3 is C3-C10-cycloalkyl optionally having a benzo group, a heterocyclic group] were prepared and are useful for treating conditions that are mediated by CCR-3, for example an inflammatory or allergic condition, particularly an inflammatory or obstructive airways disease. E.g., 1-benzhydryl-3-(4-chlorophenylsulfanyl)azetidine was oxidized with MCPBA, and treated with 1-chloroethoxycarbonyl chloride to give 3-(4-chlorobenzenesulfinyl)azetidine. Reaction of the latter with [(S)-1-(tert-butyldiphenylsilanyloxymethyl)-3-iodopropyl]carbamic acid tert-Bu ester gave [(S)-1-(tert-butyldiphenylsilanyloxymethyl)-3-[3-(4-chlorophenylsulfinyl)azetidin-1-yl]propyl]carbamic acid tert-Bu ester. The latter was desilylated, then treated with TFA to give (S)-2-amino-4-[3-(4-chlorobenzenesulfinyl)azetidin-1-yl]butan-1-ol. Reaction of the latter with 3,5-dimethoxyphenyl isocyanate resulted in 1-[(S)-3-[3-(4-chlorobenzenesulfinyl)azetidin-1-yl]-1-hydroxymethylpropyl]-3-(3,5-dimethoxyphenyl)urea. The experimental process involved the reaction of 3-(4-Chlorophenoxy)azetidine hydrochloride(cas: 490021-97-1).COA of Formula: C9H11Cl2NO

The Article related to inflammatory allergic disease treatment azetidine derivative preparation, azetidine derivative preparation ccr3 receptor antagonist, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.COA of Formula: C9H11Cl2NO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 6, 2015, Bogdan, Andrew; Cowart, Marlon D.; Degoey, David A.; Jinkerson, Tammie K.; Koenig, John R.; Kort, Michael E.; Liu, Bo; Matulenko, Mark A.; Nelson, Derek W.; Patel, Meena V.; Peltier, Hillary; Scanio, Marc J.; Wakefield, Brian D. published a patent.Related Products of 490021-97-1 The title of the patent was Preparation of 6-heteroaryloxy- or 6-aryloxyquinoline-2-carboxamides as sodium channel blockers. And the patent contained the following:

The invention is related to the preparation of title compounds I [R1 = (un)substituted Ph, 5-6 membered heteroaryl; R2 = H, alkyl, alkoxyalkyl, etc.; R3 = H, alkenyl, haloalkyl, etc.; or R2NR3 = (un)substituted 4-8 membered monocyclic heterocycle, 6-11 membered bicyclic heterocycle, 10-12 membered tricyclic heterocycle, 7-11 membered spirocyclic heterocycle or 8-11 membered bicyclic heteroaryl comprised of a monocyclic heterocycle fused to a monocyclic heteroaryl], pharmaceutically acceptable salts, esters, amides, and radiolabeled forms that are sodium channel blockers useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. The invention is also related to pharmaceutical compositions containing I, and methods for using such compounds and compositions Thus, II was prepared by a multi-step synthesis starting from quinoline-2,6-diol. II was active in FRET-based membrane potential assays for human sodium channels Nav1.7 and Nav1.8. The experimental process involved the reaction of 3-(4-Chlorophenoxy)azetidine hydrochloride(cas: 490021-97-1).Related Products of 490021-97-1

The Article related to quinolinecarboxamide heteroaryloxy aryloxy preparation sodium channel blocker pain, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Related Products of 490021-97-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anand, Keshav; Wakode, Sharad published an article in 2018, the title of the article was Synthesis, characterization and biological evaluation of benzimidazole derivatives.HPLC of Formula: 99-60-5 And the article contains the following content:

A series of benzimidazole derivatives were synthesized by a single step process by reacting o-phenylenediamine and benzoic acid. The purity and structure confirmation of the synthesized compounds were done by TLC and 1H-NMR. The compounds were evaluated for anti-microbial, anti-fungal and antioxidant activity. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).HPLC of Formula: 99-60-5

The Article related to benzimidazole preparation antibacterial antioxidant antifungal activity, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.HPLC of Formula: 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mu, Shuai; Niu, Duan; Liu, Ying; Zhang, Dashuai; Liu, Dengke; Liu, Changxiao published an article in 2015, the title of the article was An Improved, Scalable and Impurity-Free Process for Lixivaptan.Synthetic Route of 99-60-5 And the article contains the following content:

An optimized synthetic method in high efficiency has been developed for the synthesis of lixivaptan from 2-nitrobenzyl bromide and pyrrole-2-carboxaldehyde. The byproducts among this procedure and an unknown impurity in crude product were investigated. The byproducts were speculated by 1H NMR or MS. The unknown impurity was characterized by 1H NMR, 13C NMR, and HRMS, confirming the structures as N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-N-(5-fluoro-2-methylbenzoyl)-5-fluoro-2-methylbenzamide. Afterwards, the impurity was synthesized to make comparisons. The target product lixivaptan was obtained with 47.6% overall yield and 99.93% purity. This cost-effective and environmentally friendly process is suitable for scale-up production The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Synthetic Route of 99-60-5

The Article related to lixivaptan improved scalable impurity free synthesis, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Synthetic Route of 99-60-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 3, 2021, Zou, Ying; Huang, Zhi-Cheng; Xiang, Min; Li, Chen-Yi; Li, Xia; Tian, Fang; Wang, Li-Xin published an article.SDS of cas: 14602-86-9 The title of the article was Spiro-Scaffold Chiral Organocatalyst of 3,2′-Pyrrolidinyl Spiro-oxindole Amine and its Catalytic Evaluation in the Enantioselective Aldol Condensation between 3-(3-hydroxy-1H-pyrazol-1-yl)-Oxindole and Paraformaldehyde. And the article contained the following:

Spirocyclic chiral organocatalyst based on (R)-spiro[indoline-3,2′-pyrrolidine]-2-one was successfully prepared from racemic 1,2-dihydrospiro[indole-3,2′-pyrrolidine]-2-one using L-menthol as chiral auxiliary in 4 steps in 28%-40% overall yield with at least 99% ee in scale up preparation and its catalytic activity was evaluated in the enantioselective aldol condensation between 3-(3-hydroxy-1H-pyrazol-1-yl)oxindoles I (R1 = H, 5-Me, 5-MeO, 5-Cl, 7-Me; R2 = Me, H2C:CHCH2, n-Bu, Ph, PhCH2, 4-BrC6H4CH2) and paraformaldehyde. The spiro organocatalyst showed superior catalytic activity and selectivity compared with its counterparts, and most substrates offered good to excellent results with up to 96% yield and 96% ee. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).SDS of cas: 14602-86-9

The Article related to oxindole hydroxymethyl hydroxypyrazolyl asym synthesis, hydroxypyrazolyl oxindole enantioselective aldol condensation paraformaldehyde spiro pyrrolidine organocatalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.SDS of cas: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 31, 2022, Clemens, Jennifer; Bell, Emily L.; Londregan, Allyn T. published an article.Product Details of 98946-18-0 The title of the article was Selective N2-Alkylation of 1H-Indazoles and 1H-Azaindazoles. And the article contained the following:

A general and selective procedure for the N2-alkylation of 1H-indazoles and 1H-azaindazoles is presented. Promoted by either trifluoromethanesulfonic acid or copper(II) triflate, diverse 1H-indazoles/azaindazoles are selectively alkylated with varied primary, secondary, and tertiary alkyl 2,2,2-trichloroacetimidates at the N2-nitrogen to afford the corresponding 2-alkyl-2H-indazoles/azaindazoles. Forty-one examples are included along with a discussion of reaction optimization, scope, and mechanism. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Product Details of 98946-18-0

The Article related to alkyl indazole azaindazole preparation regioselective, indazole azaindazole primary secondary tertiary alkyl trichloroacetimidate alkylation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Product Details of 98946-18-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 8, 2022, Li, Xuan; Chen, Mengnan; Xie, Chuan; Zhang, Jing published an article.Application of 80-07-9 The title of the article was Visible light-activated ruthenium-catalyzed direct arylation at ambient temperature. And the article contained the following:

A visible light-activated ruthenium-catalyzed direct arylation of aryl C-H bonds 1-R-2-R1-3-R2-4-R3C6H2 (R = 5-methyl-1H-pyrazol-1-yl, isoquinolin-1-yl, 1H-indazol-1-yl, etc.; R1 = H, OMe, Me, F; R2 = H, Me, Ph, CF3, C(O)Me, C(O)OMe; R1 R2 = -CH=CH-CH=CH-; R3 = H, Me, OMe, CF3, Cl, C(O)OMe; R2 R3 = -CH=CH-CH=CH-) with aryl (pseudo)halides R4X (R4 = Ph, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.; X = I, Cl, Br, OTf), which operates at ambient temperature with broad substrate scopes and excellent compatibility of functionalities was presented. The key to success of this strategy is the efficient generation of active catalytic species via photo-induced ligand dissociation The choices of the bases and solvents also have significant influence on the catalytic efficiency. The experimental process involved the reaction of 4,4′-Sulfonylbis(chlorobenzene)(cas: 80-07-9).Application of 80-07-9

The Article related to biphenylpyrazole preparation chemoselective photochem, phenylpyrazole aryl halide arylation ruthenium catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 80-07-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 22, 2022, Thorat, Vijaykumar H.; Tsai, Yu-Lin; Huang, Yong-Ran; Cheng, Chien-Hong; Hsieh, Jen-Chieh published an article.Recommanded Product: 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride The title of the article was Nickel-Catalyzed Denitrogenative Cyclization of 1,2,3,4-Benzothiatriazin-1,1(2H)-dioxides with Arynes To Synthesize Biaryl Sultams. And the article contained the following:

The nickel-catalyzed denitrogenative cyclization reaction of 1,2,3,4-benzothiatriazine-1,1-dioxides with arynes to generate the polysubstituted biaryl sultams with tolerance of a wide diversity of substituents on every subunit was reported. The mechanistic study indicated that the reaction was initiated by the formation of a diradical species, which reacted with a nickel complex to form a nickelacycle intermediate and carried out the subsequent cyclization through insertion of an aryne. The experimental process involved the reaction of 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride(cas: 82711-97-5).Recommanded Product: 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

The Article related to biaryl fuse sultam preparation, benzothiatriazine aryne nickel catalyst denitrogenative heterocyclization, Heterocyclic Compounds (More Than One Hetero Atom): Thiazines and other aspects.Recommanded Product: 5-Fluoro-2-nitrobenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 6, 2006, Brohm, Dirk; Diedrichs, Nicole; Huebsch, Walter; Schneider, Dirk; Froehlen, Britta-Nicole; Gerdes, Christoph; Gnoth, Mark Jean; Perzborn, Elisabeth; Voehringer, Verena published a patent.Category: chlorides-buliding-blocks The title of the patent was Preparation of azetidinylpyrazolines as anticoagulation agents. And the patent contained the following:

Title compounds I [X = (CH2)m; m = 0-3; Y = (CH2)n; n = 0-3; R1 = tetramic acid, NR5R6, etc.; R2 = Me, cycloalkyl, Ph, etc.; R3 = substituted Ph, thienyl; A = bond, O; R5 = H, Me, Et, etc.; R6 = H, Me, Et, etc.] and their pharmaceutically acceptable salts and formulations were prepared For example, N-acylation of 3-propylazetidine with phenol ester II afforded azetidinylpyrazoline III in 72% yield. In protease activated receptor 1 assays, 6-examples of compounds I exhibited IC50 values ranging from 14-395 nM. The experimental process involved the reaction of 3-(4-Chlorophenoxy)azetidine hydrochloride(cas: 490021-97-1).Category: chlorides-buliding-blocks

The Article related to azetidinylpyrazoline preparation protease activated receptor par1 anticoagulation agent, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 12, 2008, Johnson, Christopher Norbert; Jones, David G.; Liang, Xi; Macpherson, David Timothy; Miller, Aaron B.; Naylor, Antoinette; Stanway, Steven James; Takle, Andrew Kenneth; Trani, Giancarlo published a patent.Related Products of 1056264-66-4 The title of the patent was Indazole derivatives as estrogen receptor beta mediators and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

The invention relates to indazole derivatives of formula I which have pharmacol. activities, to processes for their preparation, to compositions containing them and to uses of these compounds in the treatment of estrogen receptor beta (ER-β) mediated diseases. Compounds of formula I wherein Ra, Rb and Rc are independently halo, C1-4 alkoxy, C1-4 alkyl, C2-4 alkenyl, C1-5 alkanoyl, CF3, CF3O and CN; provided that when one of the substitutes is attached to the C-5 of the indazole bicycle, this substituent Ra is not methoxy; m is 0-3; n is 0-1; p is 0-4; m, n and p together is ≤ 5; and their pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by debenzylation of 1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indazole. All the invention compounds were evaluated for their ER-β receptor binding ability. From the assay, it was determined that II and other tested compounds exhibited the pIC50 value of > 7. The experimental process involved the reaction of 2-Bromo-3-chloro-6-fluorobenzaldehyde(cas: 1056264-66-4).Related Products of 1056264-66-4

The Article related to indazole derivative preparation estrogen receptor mediator receptor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Related Products of 1056264-66-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics