Tag: 100-200

Reductive dehalogenation and dehalogenative sulfonation of phenols and heteroaromatics with sodium sulfite in an aqueous medium was written by Tomanova, Monika;Jedinak, Lukas;Cankar, Petr. And the article was included in Green Chemistry in 2019.Formula: C6H5ClO2 The following contents are mentioned in the article:

Prototropic tautomerism was used as a tool for the reductive dehalogenation of (hetero)aryl bromides and iodides, or dehalogenative sulfonation of (hetero)aryl chlorides and fluorides, using sodium sulfite as the sole reagent in an aqueous medium. This protocol does not require a metal or phase transfer catalyst and avoids using organic solvent as the reaction medium. This method is especially suitable for substrates that readily tautomerize (such as 2- or 4-halogenated aminophenols and 4-halogenated resorcinols), for which dehalogenation or sulfonation proceeds under mild reaction conditions (</= 60°). As sodium sulfite is an inexpensive, safe, and environmentally less hazardous reagent, this method has at least three potential applications: (i) in the deprotection of halogens as protecting groups, using sodium sulfite as a reducing agent; (ii) in the sulfonation of aromatic halides under mild reaction conditions avoiding hazardous and corrosive reagents/solvents; and (iii) in the transformation of toxic halogenated aromatics into less harmful compounds This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Formula: C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A benzo[b]xanthene-derived fluorescent probe capable of two-photon ratiometric imaging of lysosomal cysteine with high specificity was written by Tamima, Umme;Song, Chang Wook;Santra, Mithun;Reo, Ye Jin;Banna, Hasanul;Islam, Reyazul Md;Ahn, Kyo Han. And the article was included in Sensors and Actuators, B: Chemical in 2020.Quality Control of 4-Chlororesorcinol The following contents are mentioned in the article:

Cysteine, an important biothiol, is associated with diverse biol. processes, demanding efficient in vivo detection probes. Accordingly, various types of fluorescent probes have been reported so far, but still those with practical applicability are in demand. One of the challenges is how to minimize interference from other biomols. We disclose the benzoxanthene-based fluorescent probe that shows excellent substrate selectivity, and, furthermore, good ratiometric and two-photon imaging properties. The probe, which is also photostable and biocompatible, senses cysteine through very fast 1,6-conjugate addition to the benzoxanthene core, a new dipolar dye system that emits in the deep-red wavelength region. The probe enables reliable two-photon ratiometric imaging of the endogenous lysosomal cysteine. The cysteine adduct can be reverted to the probe by hydrogen peroxide most effectively among several reactive oxygen species both in solution as well as in cell. An application of the probe to quantify the cysteine level in human blood plasma is also demonstrated. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Quality Control of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ditopic pyridyl-benzothiazole – Pyridylmethylene-2-thiohydantoin conjugates: Synthesis and study in complexation with CuCl₂ was written by Chorbu, Alexander A.;Barskaya, Elena S.;Moiseeva, Anna A.;Guk, Dmitry A.;Krasnovskaya, Olga O.;Lyssenko, Konstantin A.;Rzheutski, Artem V.;Abramovich, Maksim S.;Polyakova, Margarita N.;Berezina, Anna V.;Zyk, Nikolai V.;Beloglazkina, Elena K.. And the article was included in Polyhedron in 2022.Formula: C6H12BrCl The following contents are mentioned in the article:

New ditopic ligands (L) consisting of 2-(2-pyridyl)benzothiazole and 5-pyridylmethylene-2-thioimidazol-4-one moieties linked with polymethylene chains of various lengths (compounds 4) or triazole-containing linker (compounds 9, 11) were synthesized and their coordination properties in the reactions with CuCl₂ were studied. All the obtained copper complexes had the LCuCl₂ composition Ligands 4 with polymethylene linkers coordinate CuCl₂ initially at the 5-pyridylmethylene-2-thioimidazolone moiety, but then copper chloride migrates to the 2-pyridylbenzothiazole fragment. In contrast, ligands 9, 11 with the triazole-containing linkers coordinate CuCl₂ at 5-pyridylmethylene-2-thio-imidazolone and triazole fragments, and then the structure of the complex in the solution does not change. In DMF, the initially formed Cu²⁺ complexes may be reduced to Cu¹⁺ compounds, based on electrochem. study data. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Formula: C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tuning the effects of N1 substituents on the 2-methylimidazolium functionalized polynorbornene alkaline anion exchange membranes was written by Huang, Shengmei;He, Xiaohui;Guo, Yan;Chen, Defu. And the article was included in Polymer in 2020.Related Products of 6294-17-3 The following contents are mentioned in the article:

The N1-substituted (Me, iso-Pr, Bu, benzyl or dodecyl) 2-methylimidazolium functionalized polynorbornene (rPNB-RMIm-30) AEMs are prepared and the effects of substituents are studied. The N1-Bu or isopropyl-substituted 2-methylimidzolium (rPNB-BuMIm-30 or rPNB-iPrMIm-30) anion exchange membrane (AEM) reveals much better alk. durability than that of Me, benzyl and dodecyl-substituted 2-methylimidazolium-based AEMs, reflected by the almost unaltered FT-IR spectra and TGA curves after being subjected to 1 M NaOH for 720 h at 60°C, with a conductivity degradation of 17% and 14% resp. Furthermore, a highest hydroxide conductivity (51.5 mS cm^-1, 80°C) is achieved of the rPNB-BuMIm-30 AEM, attributing to its well-defined phase-separated structure, as evidenced by results of at. force microscope (AFM) and X-ray scattering (SAXS). Membrane electrode assembly (MEA) with rPNB-BuMIm-30 AEM exhibits a peak power d. of 205 mWcm^-2 at 60°C. This study paves the way of N1-Substituented 2-methylimidazolium-based AEM for fuel cells practical application. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Related Products of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ametryn detection by proton assisted transfer at a single micro-interface between two immiscible electrolyte solutions was written by Lu, Guofeng;Despas, Christelle;Liu, Liang;Herzog, Gregoire. And the article was included in Journal of Electroanalytical Chemistry in 2020.Quality Control of Tetramethylammonium chloride The following contents are mentioned in the article:

Ion transfer at micro-interfaces formed between two immiscible electrolyte solutions (μITIES) is a powerful platform for the detection of charged species. Ametryn was used as a model target analyte to study the detection at μITIES of lipophilic and ionisable herbicides derived from triazine. A two-step detection method is proposed, which is taking advantage of the spontaneous partition of triazine derivatives at open-circuit potential, and of their ability to assist proton transfer across the interface. First, the neutral form of ametryn is accumulated in a small volume of organic phase (V_org = 50μL) at open-circuit potential, which leads to its preconcentration (V_aq >> V_org). In a 2nd step, a.c. voltammetry was run to allow the limit of detection to reach sub-micromolar levels of ametryn in 3 river samples. Phosphate buffer was added to the real samples to provide a constant supply of proton for ametryn detection. The excess of buffer ensured that the anal. response was proportional to the ametryn concentration This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Quality Control of Tetramethylammonium chloride).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of Tetramethylammonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation was written by Winter, Jon J. G.;Anderson, Malcolm;Blades, Kevin;Brassington, Claire;Breeze, Alexander L.;Chresta, Christine;Embrey, Kevin;Fairley, Gary;Faulder, Paul;Finlay, M. Raymond V.;Kettle, Jason G.;Nowak, Thorsten;Overman, Ross;Patel, S. Joe;Perkins, Paula;Spadola, Loredana;Tart, Jonathan;Tucker, Julie A.;Wrigley, Gail. And the article was included in Journal of Medicinal Chemistry in 2015.SDS of cas: 957120-53-5 The following contents are mentioned in the article:

Constitutively active mutant KRas displays a reduced rate of GTP hydrolysis via both intrinsic and GTPase-activating protein-catalyzed mechanisms, resulting in the perpetual activation of Ras pathways. We describe a fragment screening campaign using X-ray crystallog. that led to the discovery of three fragment binding sites on the Ras:SOS complex. The identification of tool compounds binding at each of these sites allowed exploration of two new approaches to Ras pathway inhibition by stabilizing or covalently modifying the Ras:SOS complex to prevent the reloading of Ras with GTP. Initially, we identified ligands that bound reversibly to the Ras:SOS complex in two distinct sites, but these compounds were not sufficiently potent inhibitors to validate our stabilization hypothesis. We conclude by demonstrating that covalent modification of Cys118 on Ras leads to a novel mechanism of inhibition of the SOS-mediated interaction between Ras and Raf and is effective at inhibiting the exchange of labeled GDP in both mutant (G12C and G12V) and wild type Ras. This study involved multiple reactions and reactants, such as (3-Carbamoyl-5-chlorophenyl)boronic acid (cas: 957120-53-5SDS of cas: 957120-53-5).

(3-Carbamoyl-5-chlorophenyl)boronic acid (cas: 957120-53-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 957120-53-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Optogenetic control of kinetochore function was written by Zhang, Huaiying;Aonbangkhen, Chanat;Tarasovetc, Ekaterina V.;Ballister, Edward R.;Chenoweth, David M.;Lampson, Michael A.. And the article was included in Nature Chemical Biology in 2017.SDS of cas: 6294-17-3 The following contents are mentioned in the article:

Kinetochores act as hubs for multiple activities during cell division, including microtubule interactions and spindle checkpoint signaling. Each kinetochore can act autonomously, and activities change rapidly as proteins are recruited to, or removed from, kinetochores. Understanding this dynamic system requires tools that can manipulate kinetochores on biol. relevant temporal and spatial scales. Optogenetic approaches have the potential to provide temporal and spatial control with mol. specificity. Here we report new chem. inducers of protein dimerization that allow us to both recruit proteins to and release them from kinetochores using light. We use these dimerizers to manipulate checkpoint signaling and mol. motor activity. Our findings demonstrate specialized properties of the CENP-E (kinesin-7) motor for directional chromosome transport to the spindle equator and for maintenance of metaphase alignment. This work establishes a foundation for optogenetic control of kinetochore function, which is broadly applicable to exptl. probing of other dynamic cellular processes. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3SDS of cas: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Green synthesis of coumarin derivatives using Bronsted acidic pyridinium based ionic liquid [MBSPy][HSO₄] to control an opportunistic human and a devastating plant pathogenic fungus Macrophomina phaseolina was written by Uroos, Maliha;Javaid, Arshad;Bashir, Amina;Tariq, Javaria;Khan, Iqra Haider;Naz, Sadia;Fatima, Sameeta;Sultan, Misbah. And the article was included in RSC Advances in 2022.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

An eco-friendly simple protocol has been devised for the preparation of coumarin derivatives using doubly Bronsted acidic task specific ionic liquid (TSIL) as a catalyst. Solvent-free conditions were employed for the reaction of different substituted phenols with β-ketoester in TSIL to produce corresponding substituted coumarin derivatives in good to excellent yields at ambient conditions; at room temperature and with reduced reaction times. The ionic liquid catalyst can be recycled and reused up to five times. All the synthesized coumarins were evaluated for their antifungal activities against Macrophomina phaseolina, a plant as well as an opportunistic human pathogenic fungus affecting more than 500 plant species worldwide and with no registered com. fungicide available against it, to date. Amongst all the coumarins tested, compounds 3f and 3i showed excellent antifungal activity comparable to reference fungicide mancozeb. The current methodol. provides an easy and expedient way to access the coumarin core in search of potential fungicides for sustainable agriculture. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gellan gum gel tissue phantoms and gel dosimeters with tunable electrical, mechanical and dosimetric properties was written by Brzozowski, Pawel;Penev, Kalin I.;Mequanint, Kibret. And the article was included in International Journal of Biological Macromolecules in 2021.SDS of cas: 75-57-0 The following contents are mentioned in the article:

Gellan gum gels have been proposed as tissue- and water-mimicking materials (phantoms) applied in medical imaging and radiotherapy dosimetry. Phantoms often require ionic additives to induce desirable elec. conductivity, resistance to biol. spoilage, and radical scavenging properties. However, gellan gum is strongly crosslinked by the typically used sodium salts, forming difficult-to-work with gels with reduced optical clarity. Herein we investigated lithium and tetramethylammonium chloride to induce the required elec. conductivity while maintaining optical clarity; lithium formate and methylparaben were used as a radical scavenger and antimicrobial additive, resp. Using a multifactorial design of experiments, we studied and modeled the elec. and mech. properties and liquid expulsion (syneresis) properties of the gels. Finally, by the addition of a radiation-sensitive tetrazolium salt, dosimeters with favorable properties were produced. The results described herein may be used to prepare tissue phantoms and dosimeters with tuned elec., mech., and dosimetric properties. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0SDS of cas: 75-57-0).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 75-57-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dealuminated Cs-ZK-5 zeolite for propylene/propane separation was written by Min, Jung Gi;Christian Kemp, K.;Kencana, Kevin S.;Mukti, Rino R.;Hong, Suk Bong. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2021.Electric Literature of C4H12ClN The following contents are mentioned in the article:

Developing new, more efficient adsorbents for propylene/propane separation is of urgent need, as the current energy-intensive cryogenic distillation method has to be replaced to achieve green chem. goals. Here, we report that 973 K-steamed cesium ZK-5 zeolite with a framework Si/Al ratio of 16 (Cs-ZK-5-16-973) shows high propylene uptake and propylene/propane selectivity (1.9 mmol g^-1 and 2.4, resp.) at 298 K and atm. pressure, together with fast adsorption kinetics, mainly due to its modified 8-ring window dimensions. More interestingly, no significant loss in uptake or selectivity was observed even after repeated adsorption-desorption cycling under vacuum-swing adsorption mode and dynamic breakthrough experiments, which may be a result of the lack of strong acid sites to induce propylene oligomerization at room temperature This impressive regeneration is comparable with the behavior of the pure-silica small-pore zeolite ITQ-12, but much better than that of Na-A and Ca-A, rendering Cs-ZK-5-16-973 potentially useful for selective propylene/propane separation This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Electric Literature of C4H12ClN).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C4H12ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics