Tag: 100-200

Aromatic nucleophilic substitution. VI. Reactions of polychlorofluorobenzene with nucleophilic agents was written by Kobrina, L. S.;Yakobson, G. G.. And the article was included in Zhurnal Obshchei Khimii in 1965.Application of 4815-64-9 This article mentions the following:

In the title benzene derivatives the greater mobility of F over Cl atoms was utilized for a series of nucleophilic displacements. 2,4,6-Cl₃C₆H₂F mixed with HNO₃ (d. 1.52) at 20掳 and kept 3 hrs. at 60掳 gave the 3-nitro derivative, 77%, b. 216-20% n²⁰_D 1.5680, which chlorinated at 200-20掳 to 73% 2,3,4,6-tetrachlorofluorobenzene m. 25-6掳. m-FC₆H₄Cl (100 g.) in AcOH (88 g.) treated with 176 g. HNO₃ (d. 1.52) and heated 6 hrs. at 50掳 gave 94.5% nitro derivatives which reduced with Fe in aqueous NH₄Cl in 2 hrs. to 88% mixed amines, b₂₈ 102-3掳, which with Ac₂O gave N-acetyl derivatives, m. 96-100掳. These nitrated in concentrated H₂SO₄-AcOH with HNO₃ (d. 1.52) at 20掳 6 hrs. gave 81% nitro derivatives, m. 135-7掳, which hydrolyzed by heating with concentrated H₂SO₄ 3 hrs. to 90% aminonitrofluorochlorobenzenes m. 73-6掳, which diazotized and treated with EtOH and FeSO₄ gave 65.5% 3-fluoro-5-chloronitrobenzene b₂₀ 106-10掳, n²⁰_D 1.5482, which reduced with Fe as above to 80.5% 3-fluoro-5-chloroaniline, b₁₉ 98掳, 1.5622; N-acetyl derivative m. 116-18掳, chlorinated at 110掳 in AcOH 12 hrs. to 89% 2,4,5,6-tetrachloro derivative, m. 204-5掳, which heated with concentrated H₂SO₄ 5 hrs. gave 92% 2,4,5,6-tetrachloro-3-fluoroaniline m. 150掳. Mixing at 20掳 2,3,4,5-tetrachlorofluorobenzene and HNO₃ (d. 1.52) at 20掳 and heating 6 hrs. at 60掳 gave 60% 3,4,5,6-tetrachloro-2-fluoronitrobenzene m. 52-2.5掳, which reduced with Fe as above to the corresponding aniline m. 186.5-87掳. Heating 2,3,5,6-tetrachloro-4-fluoronitrobenzene with Fe in AcOH 1 hr. gave 96% 2,3,5,6-tetrachloro-4-fluoroaniline, m. 157-7.5掳. In 2 hrs. at 100掳 with MeNH₂ 2,3,4,5-tetrachlorofluorobenzene gave 93% 2,3,4,5-tetrachloro-N-methylaniline, m. 117-18掳; similarly was prepared 98% 2,3,4,6-tetrachloro analog m. 42-4掳; 94% 2,3,5,6-tetrachloro analog m. 54-6掳; 2,4,5,6-tetrachloro-3-fluoroaniline similarly gave 85% 2,4,5,6-tetrachloro-di-N-methyl-1,3-phenylenediamine m. 68-8.5掳; in 10 hrs. 2,4,5,6-tetrachloro-3-fluoroaniline and Me₂NH gave 90% 2,4,5,6-tetrachloro-1,3-di-N,N-dimethylphenylenediamine b₁, 140-1掳. Similar reactions with MeONa in MeOH in 2 hrs. gave: 91% pentachloroanisole; 95% 3,4,5,6-tetrachloro-慰-anisidine; 89% 2,3,4,6-tetrachloro-m-anisidine; 93% 2,3,5,6-tetrachloro-p-anisidine, while reaction with NaSH in glycol in the presence of pyridine gave in 0.103 hr.: 97% pentachlorothiophenol; 93% 2,3,5,6-tetrachlorothiophenol m. 103-5掳; 72% 2,3,4,6-tetrachlorothiophenol m. 101-2掳; 2,2,4,5-tetrachlorothiophenol m. 91-3掳, from appropriate fluoro analogs. In the experiment, the researchers used many compounds, for example, 1-Chloro-3-fluoro-5-nitrobenzene (cas: 4815-64-9Application of 4815-64-9).

1-Chloro-3-fluoro-5-nitrobenzene (cas: 4815-64-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 4815-64-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New Generation of Amino Coumarin Methyl Sulfonate-Based Fluorogenic Substrates for Amidase Assays in Droplet-Based Microfluidic Applications was written by Woronoff, Gabrielle;El Harrak, Abdeslam;Mayot, Estelle;Schicke, Olivier;Miller, Oliver J.;Soumillion, Patrice;Griffiths, Andrew D.;Ryckelynck, Michael. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2011.Reference of 6834-42-0 This article mentions the following:

Droplet-based microfluidics is a powerful tool for biol. and chem. as it allows the production and the manipulation of picoliter-size droplets acting as individual reactors. In this format, high-sensitivity assays are typically based on fluorescence, so fluorophore exchange between droplets must be avoided. Fluorogenic substrates based on the coumarin leaving group are widely used to measure a variety of enzymic activities, but their application in droplet-based microfluidic systems is severely impaired by the fast transport of the fluorescent product between compartments. Here the authors report the synthesis of new amidase fluorogenic substrates based on 7-aminocoumarin-4-methanesulfonic acid (ACMS), a highly water-soluble dye, and their suitability for droplet-based microfluidics applications. Both substrate and product had the required spectral characteristics and remained confined in droplets from hours to days. As a model experiment, a phenylacetylated ACMS was synthesized and used as a fluorogenic substrate of Escherichia coli penicillin G acylase. Kinetic parameters (k_cat and K_m) measured in bulk and in droplets on-chip were very similar, demonstrating the suitability of this synthesis strategy to produce a variety of ACMS-based substrates for assaying amidase activities both in microtiter plate and droplet-based microfluidic formats. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed 3-Aryl-5-acyl-1,2,4-thiadiazole Formation from Ketones, Amidines, and Sulfur Powder was written by Wang, Zilong;Xie, Hao;Xiao, Fuhong;Guo, Yanjun;Huang, Huawen;Deng, Guo-Jun. And the article was included in European Journal of Organic Chemistry in 2017.Related Products of 18637-02-0 This article mentions the following:

An efficient strategy for the preparation of 3,5-disubstituted 1,2,4-thiadiazoles from ketones, amidines, and sulfur powder under palladium-catalyzed conditions was developed. In this transformation, aromatic ketones act as both the carbon and acyl sources. The reaction provided efficient access to 3-aryl-5-acyl-1,2,4-thiadiazoles from readily available starting materials. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Related Products of 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gold Catalyzed Decarboxylative Cross-Coupling of Iodoarenes was written by Daley, Ryan A.;Morrenzin, Aaron S.;Neufeldt, Sharon R.;Topczewski, Joseph J.. And the article was included in Journal of the American Chemical Society in 2020.Computed Properties of C7H3ClF2O2 This article mentions the following:

Decarboxylative cross-coupling of (hetero)aryl carboxylates with iodoarenes in the presence of a gold cata-lyst (>25 examples, up to 96% yield) was reported. This reaction was site specific, which overcomes prior limitations associated with gold cat-alyzed oxidative coupling reactions. The reactivity of the (hetero)aryl carboxylate correlated qual. to the field effect pa-rameter (Fortho). Reactions with isolated gold complexes and DFT calculations supported a mechanism proceeding through oxida-tive addition at a gold(I) cation with decarboxylation being viable at either gold(I) or silver(I) species. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7Computed Properties of C7H3ClF2O2).

3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C7H3ClF2O2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

PTP-1B inhibitors: Cyclopenta[d][1,2]-oxazine derivatives was written by Cho, Sung Yun;Baek, Ji Yoen;Han, Sang Sub;Kang, Seung Kyu;Ha, Jae Du;Ahn, Jin Hee;Lee, Jae Don;Kim, Kwang Rok;Cheon, Hyae Gyeong;Rhee, Sang Dal;Yang, Sung Don;Yon, Gyu Hwan;Pak, Chwang Siek;Choi, Joong-Kwon. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Name: 3-Cyanobenzoyl chloride This article mentions the following:

A series of novel cyclopenta[d][1,2]-oxazine derivatives was prepared and evaluated for their inhibitory activity toward protein tyrosine phosphatase 1B (PTP-1B). Compound 6s (I)was found to be an inhibitor of PTP-1B with nanomolar IC₅₀ value and high level of selectivity over other recombinant phosphatases. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Name: 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Name: 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel synthesis of isoquinolin-3-ols was written by Ainscough, Martin A.;Temple, Arthur F.. And the article was included in Journal of the Chemical Society, Chemical Communications in 1976.Name: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Cycloaddition reaction of phenacetyl chlorides with alkyl or aryl thiocyanates in the presence of SnCl4 gave 1-substituted isoquinolin-3-ols. E.g., PhCH2COCl with MeSCN in PhNO2 in the presence of SnCl4 gave 65% 1-methylthioisoquinolin-3-ol (I). In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Name: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and evaluation of sulfonylurea-containing 4-phenoxyquinolines as highly selective c-Met kinase inhibitors was written by Nan, Xiang;Jiang, Yi-Fan;Li, Hui-Jing;Wang, Jun-Hu;Wu, Yan-Chao. And the article was included in Bioorganic & Medicinal Chemistry in 2019.HPLC of Formula: 620-19-9 This article mentions the following:

Deregulation of receptor tyrosine kinase c-Met has been reported in human cancers and is considered as an attractive target for small mol. drug discovery. In this study, a series of 4-phenoxyquinoline derivatives bearing sulfonylurea moiety were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against tested four cell lines in vitro. The pharmacol. data indicated that most of the tested compounds showed moderate to significant potency as compared with foretinib, with the most promising compound 13x (c-Met kinase IC₅₀ = 1.98 nM) demonstrated relatively good selectivity vs. 10 other tyrosine kinases and remarkable cytotoxicities against HT460, MKN-45, HT-29 and MDA-MB-231 with IC₅₀ values of 0.055 渭M, 0.064 渭M, 0.16 渭M and 0.49 渭M, resp. The preliminary structure activity relationships indicated that a sulfonylurea moiety as linker as well as mono-EGWs (such as R₁ = 4-F) on the terminal Ph rings contributed to the antitumor activity. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9HPLC of Formula: 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Characterization of Copper(I)-Cysteine Complex Supported on Magnetic Layered Double Hydroxide as an Efficient and Recyclable Catalyst System for Click Chemistry Using Choline Azide as Reagent and Reaction Medium was written by Pazoki, Farzane;Salamatmanesh, Arefe;Bagheri, Sepideh;Heydari, Akbar. And the article was included in Catalysis Letters in 2020.Formula: C8H9Cl This article mentions the following:

In this study, Fe₃O₄@LDH@cysteine-Cu(I) nanoparticles (LDH is layered double hydroxides) were designed as a novel and recyclable catalytic system and successfully synthesized. These nanoparticles showed high catalytic activity for preparation of the triazoles I (R¹ = H₂C:CH, Ph, 4-MeOC₆H₄, 4-O₂NC₆H₄CO, etc.; R² = HOCH₂, HO₂C, Ph, 1-hydroxycyclohexyl, etc.) through reaction of the alkynes R²C顚咰H with organic halides R¹CH₂X (X = Br, Cl) in the presence of choline azide as reagent and reaction medium. In addition, Fe₃O₄@LDH@cysteine-Cu(I) could be easily recovered and reused for five times without any significant loss in catalytic activity. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Formula: C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel CpAg(I)-Containing Organometallic Coordination Polymers Generated from Fulvene Ligands was written by Dong, Yu-Bin;Jin, Guo-Xia;Zhao, Xia;Tang, Bo;Huang, Ru-Qi;Smith, Mark D.;Stitzer, K. E.;Zur Loye, Hans-Conrad. And the article was included in Organometallics in 2004.Reference of 1711-11-1 This article mentions the following:

Two new fulvene ligands, L1 and L2, have been synthesized by an aroylation reaction of the cyclopentadienyl anion. The coordination chem. of L1 and L2 was investigated. Two novel CpAg(I)-containing polymeric compounds, 1 ([Ag₄(L1)₂(渭-H₂O)₂(SO₃CF₃)₄]路(渭-bis-畏¹-C₆H₆))路H₂O and 2 ([Ag₂(L2)(H₂O)(SO₃CF₃)₂]路0.5(C₆H₆)), have been synthesized. Compounds 1 and 2 have been fully characterized by IR spectroscopy, elemental anal., and single-crystal x-ray diffraction. The solid state structure of 1 features a macro-ring-containing one-dimensional chain motif. The solid state structure of 2 features a one-dimensional double-chain motif. These double chains are further cross-linked to each other via CpAg(SO₃CF₃)₂AgCp (Ag路路路Ag contact of 4.215(15) 脜) linkage into a novel 2-D network with large cavities (effective cross-section of ca. 21 脳 9 脜), in which the benzene guest mols. are located. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Reference of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactivity of benzylic acylammonium chlorides. A novel method for the synthesis of N-phenacylamides was written by Coskun, Necdet;Tirli, Fatma. And the article was included in Synthetic Communications in 1997.Name: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Tertiary amines R¹C₆H₄CH₂NR²CH₂COC₆H₄R³-4 [R¹ = H, 2,3-(MeO)₂, 3,4-(MeO)₂, 2-NO₂, etc., R² = Me, PhCH₂, 3,4-(MeO)₂C₆H₃CH₂, R³ = H, MeO] reacted with acid chlorides R⁴COCl [R⁴ = 3-MeOC₆H₄CH₂, 3,4-(MeO)₂C₆H₄CH₂, PhCH₂, 4-MeOC₆H₄CH₂] to give corresponding benzyl chlorides and N-phenacylamides R⁴CONR²CH₂COC₆H₄R³-4. The effect of the substituents in the benzyl group on the reactivity of the intermediate acylammonium chlorides was investigated. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Name: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics