Tag: 100-200

Preparation of chiral ligands connected with quaternary ammonium group for recyclable catalytic asymmetric transfer hydrogenation in ionic liquid was written by Uchimoto, Hitomi;Tsuji, Tomoko;Kawasaki, Ikuo;Arimitsu, Kenji;Yasui, Hiroyuki;Yamashita, Masayuki;Ohta, Shunsaku;Nishide, Kiyoharu. And the article was included in Chemical & Pharmaceutical Bulletin in 2015.HPLC of Formula: 6294-17-3 The following contents are mentioned in the article:

Reuse of chiral ruthenium catalyst in catalytic asym. transfer hydrogenation (CATH) has attracted attention from economic and environmental viewpoints, and reactions using ionic liquids (ILs) as solvent are recognized as one of the most useful methods for reuse of the catalyst. Authors have synthesized (1S,2S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine (TsDPEN) derivatives with various ionic moieties, and investigated the effect of their structure with respect to catalytic ability and recyclability in CATH with ILs. Ligand 3a having an imidazolium group showed the best results, and significant differences were observed depending on the structure of the ionic moiety or the length of the alkyl chain connecting the ligand site and the ionic moiety. Among various prochiral ketones used as substrates at various cycles, 3a showed a relatively good result. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3HPLC of Formula: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.HPLC of Formula: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mechanistic insights into photochemical nickel-catalyzed cross-couplings enabled by energy transfer was written by Kancherla, Rajesh;Muralirajan, Krishnamoorthy;Maity, Bholanath;Karuthedath, Safakath;Kumar, Gadde Sathish;Laquai, Frederic;Cavallo, Luigi;Rueping, Magnus. And the article was included in Nature Communications in 2022.Safety of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Various methods that use a photocatalyst for electron transfer between an organic substrate and a transition metal catalyst have been established. While triplet sensitization of organic substrates via energy transfer from photocatalysts has been demonstrated, the sensitization of transition metal catalysts is still in its infancy. Here, authors describe the selective alkylation of C(sp³)-H bonds via triplet sensitization of nickel catalytic intermediates with a thorough elucidation of its reaction mechanism. Exergonic Dexter energy transfer from an iridium photosensitizer promotes the nickel catalyst to the triplet state, thus enabling C-H functionalization via the release of bromine radical. Computational studies and transient absorption experiments support that the reaction proceeds via the formation of triplet states of the organometallic nickel catalyst by energy transfer. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Safety of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Steglich′s Base Catalyzed Three-Component Synthesis of Isoxazol-5-Ones was written by Faramarzi, Zeinab;Kiyani, Hamzeh. And the article was included in Polycyclic Aromatic Compounds.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

4-(Dimethylamino)pyridine (DMAP) was used as an efficient Bronsted organo-base catalyst for the one-pot, three-component cyclization of various aldehydes, β-keto esters and hydroxylamine hydrochloride. In this organocatalyzed reaction, 3,4-disubstituted isoxazole-5(4H)-ones were efficiently formed in high yields and relatively shorter reaction times. Using 8 mol% of DMAP, a mixture of water-ethanol solvent system and 80 °C gave the best results. The three-component heterocyclization using arylaldehydes containing electron releasing groups was well performed and heterocyclic products were obtained in good to high isolated yields. Aldehydes with electron withdrawing groups did not lead to the formation of products. This method has many advantages such as broad substituent scope, mild and eco-friendly conditions, step and atom economy, com. available and inexpensive organo-basic catalyst. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Safety of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Minimizing aromatics entrainment in dephenolization of coal-based liquids by deep eutectic solvents was written by Yi, Lan;Feng, Jie;Rajendran, Antony;Li, Wen-Ying. And the article was included in Chemical Engineering Science: X in 2020.Formula: C4H12ClN The following contents are mentioned in the article:

Reducing the aromatics entrainment during coal-based liquids dephenolization has been investigated by deep eutectic solvents (DESs) as designed. Results showed that aromatics with a chain alkyl group were more easily entrained and phenolic compounds promoted the transfer of aromatics from oil to DESs. Among the DESs investigated, ChCl-glycerol was the best for separation of phenolic compounds from coal-based liquids, having a lower aromatics entrainment. Although adding H₂O to ChCl-glycerol reduced the aromatics entrainment, simultaneously suppressed the phenol removal efficiency. A narrow boiling range of phenol oil fraction was benefit for phenols extraction with lower aromatics entrainment. The O-H…π and C-H…π among aromatics and phenolic compounds and/or DESs contributed for the aromatics entrainment, and compounds with specific structures were bound to be entrained. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Formula: C4H12ClN).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C4H12ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Insights into the Chloride versus Bromide Effect on the Formation of Urea-Quaternary Ammonium Eutectic Solvents was written by Martins, Monia A. R.;Abranches, Dinis O.;Silva, Liliana P.;Pinho, Simao P.;Coutinho, Joao A. P.. And the article was included in Industrial & Engineering Chemistry Research in 2022.Application of 75-57-0 The following contents are mentioned in the article:

The intermol. interactions of urea and quaternary ammonium salts relevant to their thermodn. nonideality were here investigated by measuring the solid-liquid equilibrium of their binary mixtures The exptl. data revealed that the anion transfer between the quaternary ammonium salt and urea increases with increasing alkyl chain lengths, leading to neg. deviations from ideality in the urea-rich side for [N_4,4,4,4]-based systems. However, the use of bromides instead of chlorides dampens the nonideality of urea because of larger size and lower electronegativity of the anion. The behavior of urea when mixed with ChCl or ChBr was found to be remarkably different, indicating that its nonideality in the ChCl/urea eutectic solvent is governed by urea-chloride rather than hydroxyethyl-urea interactions. The conclusions presented highlight the contribution of charge delocalization in the formation of deep eutectic solvents of type III. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Application of 75-57-0).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 75-57-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of method determining tetramethylammonium hydroxide and tetramethylammonium salts in industrial wastewater by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was written by Koga, Toyokazu;Kashiwabara, Manabu;Hirakawa, Shusaku;Ishibashi, Yuko;Miyawaki, Takashi. And the article was included in Mizu Kankyo Gakkaishi in 2022.Product Details of 75-57-0 The following contents are mentioned in the article:

In this study, author developed a method of determining tetramethylammonium hydroxide and tetramethylammonium salts, present in industrial wastewater as tetramethylammonium ions (TMA), by liquid chromatog.-tandem mass spectrometry (LC-MS/MS). Tetramethylammonium hydroxide was used as a standard solution The lower limit of quantification for TMA anal. by solid-phase extraction (SPE) using a weak cation exchange resin (Oasis WCX) was 0.00034 mg L^-1, and the recovery of surrogate standards ranged from 50 to 120%. Author investigated 30 industrial wastewater samples from Fukuoka Prefecture by the developed TMA anal. method. TMA was detected in two samples, H and X, with concentrations of 0.0014 and 2.5 mg L^-1, resp. In sample X, the immobilization of Daphnia magna was observed even at 50% dilution, and the 48 h-EC₅₀ was 62%. The toxicity removal test indicated reduced toxicity for sample X after SPE-WCX. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Product Details of 75-57-0).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 75-57-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel Quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione Derivatives Against Chloroquine-resistant Plasmodium falciparum was written by Rogerio, Kamilla Rodrigues;Graebin, Cedric Stephan;Pinto Domingues, Luiza Helena;Oliveira, Luana Santos;Fernandes da Silva, Vitoria de Souza;Daniel-Ribeiro, Claudio Tadeu;Carvalho, Leonardo J. M.;Boechat, Nubia. And the article was included in Current Topics in Medicinal Chemistry in 2020.Reference of 638-07-3 The following contents are mentioned in the article:

In this work DHPMs were combined with the quinoline nucleus to obtain new quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione compounds I (R = H, 4-OMe, 4-Cl, etc.; n = 1, 2) with improved antiplasmodial activity as well as decreased cytotoxicity. Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected by a linker group to quinoline ring moieties with different substituents were synthesized and assayed against chloroquine-resistant Plasmodium falciparum, along with the reference drug chloroquine. The derivative without substituents on the aromatic ring I (R = H; n = 1) and the compound I (R = 4-Cl; n = 1) provided the best results, with IC₅₀ = 1.15μM and 1.5μM, resp. Compared to the parent drugs, these compounds presented marked decreases in cytotoxicity, with MDL₅₀ values over 1,000μM and selectivity indexes of >869.5 and >666.6, resp. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Reference of 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei was written by Zhang, Zhongsheng;Barros-Alvarez, Ximena;Gillespie, J. Robert;Ranade, Ranae M.;Huang, Wenlin;Shibata, Sayaka;Molasky, Nora M. R.;Faghih, Omeed;Mushtaq, Aisha;Choy, Robert K. M.;de Hostos, Eugenio;Hol, Wim G. J.;Verlinde, Christophe L. M. J.;Buckner, Frederick S.;Fan, Erkang. And the article was included in RSC Medicinal Chemistry in 2020.COA of Formula: C6H9ClO3 The following contents are mentioned in the article:

Based on crystal structures of Trypanosoma brucei methionyl-tRNA synthetase (TbMetRS) bound to inhibitors, we designed, synthesized, and evaluated two series of novel TbMetRS inhibitors targeting this parasite enzyme. One series has a 1,3-dihydro-imidazol-2-one containing linker, the other has a rigid fused aromatic ring in the linker. For both series of compounds, potent inhibition of parasite growth was achieved with EC₅₀ < 10 nM and most compounds exhibited low general toxicity to mammalian cells with CC₅₀s > 20 000 nM. Selectivity over human mitochondrial methionyl tRNA synthetase was also evaluated, using a cell-based mitochondrial protein synthesis assay, and selectivity in a range of 20-200-fold was achieved. The inhibitors exhibited poor permeability across the blood brain barrier, necessitating future efforts to optimize the compounds for use in late stage human African trypanosomiasis. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3COA of Formula: C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tandem Reaction of 4-Halo-1,3-Dicarbonyl Compounds with Alkynes towards 4-Vinyl-3(2H)-Furanones and 3(2H)-Furanone fused 2-Pyridones was written by Omanakuttan, Vishnu K.;Santhini, P. V.;Shaludheen, S.;Varughese, Sunil;Hopf, Henning;John, Jubi. And the article was included in Asian Journal of Organic Chemistry in 2022.Related Products of 638-07-3 The following contents are mentioned in the article:

A facile synthetic route of 4-vinyl-3(2H)-furanones I [R¹ = OMe, OEt, OtBu, Ph; R² = H, C(O)Ph, CO₂Me, CO₂tBu; R³ = H, Me; R⁴ = H, Me, Br; R⁵ = OMe, OEt, Ph] via tandem Michael addition and intramol. cyclization from the reaction of 4-halo-1,3-dicarbonyl compounds and alkynes was reported. The formation of a side-product (regioisomer) by a stepwise [2+2] cycloaddition between enolate (of the 4-halo-1,3-dicarbonyl compound) and activated alkyne followed by a sequential 4π-ring opening and an intramol. cyclization was also noted. Another interesting observation was the formation of 3(2H)-furanone fused 2-pyridone II [R⁶ = Me, Et; R⁷ = Ph, Bn, 4-MeC₆H₄, etc.] from the reaction of 4-bromo-3-oxo-N-alkyl(aryl)butanamides and activated alkynes with satisfactory to good yields. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Related Products of 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cooperative veratryle and nitroindoline cages for two-photon uncaging in the NIR was written by Cueto Diaz, Eduardo;Picard, Sebastien;Klausen, Maxime;Hugues, Vincent;Pagano, Paolo;Genin, Emilie;Blanchard-Desce, Mireille. And the article was included in Chemistry – A European Journal in 2016.Recommanded Product: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Tandem uncaging systems in which a two-photon absorbing module and a cage moiety, linked via a phosphorous clip, that act together by Foerster resonance energy transfer (FRET) have been developed. A library of these compounds, using different linkers and cages (7-nitroindolinyl or nitroveratryl) has been synthesized. The investigation of their uncaging and two-photon absorption properties demonstrates the scope and versatility of the engineering strategy towards efficient two-photon cages and reveals surprising cooperative and topol. effects. The interactions between the 2PA module and the caging moiety are found to promote cooperative effects on the 2PA response while addnl. processes that enhance the uncaging efficiency are operative in well-oriented nitroindoline-derived dyads. These synergic effects combine to lead to record two-photon uncaging cross-section values (i.e., up to 20 GM) for uncaging of carboxylic acids. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics