Tag: 100-200

Palladium-Catalyzed Cascade Deboronation/Regioselective B-P Coupling of closo-Carboranes was written by Yang, Ziyi;Sun, Chaofan;Wei, Xing;Lu, Jian;Lu, Ju-You. And the article was included in ChemCatChem in 2022.Related Products of 75-57-0 The following contents are mentioned in the article:

A cascade deboronation/regioselective B-P coupling of closo-carboranes is disclosed using a combination of palladium catalysts and nitrogen or phosphine-containing directing groups. Unsym. C-substituted closo-carboranes, including C-monosubstituted and unsym. 1,2-disubstituted closo-carboranes, are tolerated. Select closo-carboranes bearing other directing groups, such as benzoxazole, and diphenylphosphine, are compatible substrates for this reaction. Phosphine and arsenic can be utilized as effective coupling partners. Furthermore, a catalytic amount of palladium salt mediates the regioselective B-H activation process. Readily available closo-carboranes as the starting materials for direct one-pot synthesis of functionalized nido-carboranes and the in-situ formation of nido-carborane intermediates without purification are important features in terms of practical applications. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Related Products of 75-57-0).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 75-57-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Facile and expedient synthesis of α,β-unsaturated isoxazol-5(4H)-ones under mild conditions was written by Ghorbani, Fatemeh;Kiyani, Hamzeh;Pourmousavi, Seied Ali. And the article was included in Research on Chemical Intermediates in 2020.Quality Control of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

It was found that nano-SiO₂-H₂SO₄ was catalyzed the three-component cyclocondensation of aryl/heteroaryl aldehydes, hydroxylamine hydrochloride and β-ketoesters toward the synthesis of α,β-unsaturated isoxazol-5(4H)-ones under green conditions. The reaction yielded the corresponding heterocycles at room temperature in relatively shorter reaction times. It merits mentioning that the mild conditions allowed the synthesis of several α,β-unsaturated isoxazol-5(4H)-ones using this method. Some new derivatives of isoxazolones were also synthesized and characterized. It was efficient, clean, simple, safe and ecol. friendly. This straightforward method was cost-effective and required no preparation of reactants. The three-component annulation was performed without using energy sources, for example heat, ultrasound wave, and microwave irradiation This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Quality Control of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, antimicrobial activity, and determination of the lipophilicity of ((cyclohex-3-enylmethylene)hydrazinyl)thiazole derivatives was written by Biernasiuk, Anna;Kawczynska, Magdalena;Berecka-Rycerz, Anna;Rosada, Beata;Gumieniczek, Anna;Malm, Anna;Dzitko, Katarzyna;Laczkowski, Krzysztof Z.. And the article was included in Medicinal Chemistry Research in 2019.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Synthesis and investigation of antimicrobial activity of fifteen novel thiazoles containing cyclohexene moiety are presented. Among the derivatives, compounds 3a-3d, 3f, 3n, and 3o showed very strong activity against the reference Candida spp. strains with MIC = 0.015-3.91μg/mL. The activity of these compounds is similar and even higher than the activity of nystatin used as pos. control. Compounds 3d, 3f, 3n, 3o showed the highest activity with very strong effect towards most of yeasts isolated from clin. materials with MIC = 0.015-7.81μg/mL. The cytotoxicity studies for the most active compounds showed that Candida spp. growth was inhibited at noncytotoxic concentrations for the mammalian L929 fibroblast. In addition, a good correlation was obtained between lipophilicity of compounds determined using reversed phase thin-layer chromatog. and their antifungal activity. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Category: chlorides-buliding-blocks).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL) was written by Mayer, Nicole;Schweiger, Martina;Fuchs, Elisabeth;Migglautsch, Anna K.;Doler, Carina;Grabner, Gernot F.;Romauch, Matthias;Melcher, Michaela-Christina;Zechner, Rudolf;Zimmermann, Robert;Breinbauer, Rolf. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Computed Properties of C6H9ClO3 The following contents are mentioned in the article:

High serum fatty acid (FA) levels are causally linked to the development of insulin resistance, which eventually progresses to type 2 diabetes and non-alc. fatty liver disease (NAFLD) generalized in the term metabolic syndrome. Adipose triglyceride lipase (ATGL) is the initial enzyme in the hydrolysis of intracellular triacylglycerol (TG) stores, liberating fatty acids that are released from adipocytes into the circulation. Hence, ATGL-specific inhibitors have the potential to lower circulating FA concentrations, and counteract the development of insulin resistance and NAFLD. In this article, we report about structure-activity relationship (SAR) studies of small mol. inhibitors of murine ATGL which led to the development of Atglistatin. Atglistatin is a specific inhibitor of murine ATGL, which has proven useful for the validation of ATGL as a potential drug target. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Computed Properties of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Computed Properties of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nickel-catalyzed Sonogashira reactions of non-activated secondary alkyl bromides and iodides was written by Yi, Jun;Lu, Xi;Sun, Yan-Yan;Xiao, Bin;Liu, Lei. And the article was included in Angewandte Chemie, International Edition in 2013.Computed Properties of C6H12BrCl The following contents are mentioned in the article:

A nickel-catalyzed Sonogashira cross-coupling of terminal alkynes with non-activated secondary alkyl iodides and bromides is described. This reaction provides a useful approach to the synthesis of substituted alkynes (in particular, dialkylated asym. alkynes) from readily available substrates. The bis(oxazoline) family of ligands was found to be effective for mediating nickel-catalyzed C(sp)-C(sp3) cross-couplings of both secondary and primary alkyl halides under fairly mild reaction conditions (room temperature to -20°C). This reaction exhibited good compatibility with a variety of synthetically important functional groups and therefore, could be used for the synthesis and modifications of biol. relevant mols. Furthermore, high diastereoselectivities were observed in C(sp)-C(sp3) cross-couplings of terminal alkynes with 1,3- and 1,4-substituted cyclohexyl iodides. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Computed Properties of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Growth, structural, and solid-state properties of a hybrid metal-organic crystal: tetramethylammonium cadmium nitrate was written by Bhuvaneswari, N.;Sivakumar, S.;Venkatachalam, K.;Siva, V.. And the article was included in Journal of Materials Science: Materials in Electronics in 2022.Computed Properties of C4H12ClN The following contents are mentioned in the article:

A new metal-organic single crystals of tetramethylammonium cadmium nitrate (TMACN) have been grown by solution growth method. The grown TMACN crystals have been characterized by single-crystal X-ray diffraction (SCXRD) and powder X-ray diffraction anal. Furthermore, TMACN crystals have been subjected to scanning electron microscope (SEM), Fourier transform infra-red, Fourier transform Raman, UV-Visible, and Vickers microhardness studies. The surface morphol. has been investigated by SEM anal. From UV-Visible anal., the grown crystals have been optically transparent from 200 to 900 nm. The mech. stability has been investigated by Vickers microhardness study. Time-dependent dielec. studies have been measured by LCR meter. The dielec. constant varies with increasing frequency observed using dielec. study. Photoluminescence spectral study give the information about the crystal which emits green emission. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Computed Properties of C4H12ClN).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C4H12ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Analysis of monitoring results of 32 dyes in oxidized hair dyes was written by Wang, Sha-sha;Ren, Lian;Liao, Xue. And the article was included in Huagong Sheji Tongxun in 2021.SDS of cas: 95-88-5 The following contents are mentioned in the article:

Using the determination method of 32 components including p-phenylenediamine in the “Safety Tech. Specifications for Cosmetics” (2015 edition), 24 batches of com. available oxidized hair dyes were tested, and the test results, batch formulations, and label indications were tested. The quality of cosmetics on the market was compared and analyzed to provide tech. support for cosmetics supervision. The results showed that none of the 32 components were detected, 16 batches of samples had inconsistent test results and batch formula, accounting for 67%, and 16 batches of samples had inconsistent test results and labeling, accounting for 67%, 5 batches of samples had inconsistent batch formula and labeling, accounting for 21%, and there were 16 batches of problematic samples, and the failure rate was 67%. It is recommended that the standardized supervision of production enterprises should be strengthened. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5SDS of cas: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

One-step Access to Resorcinsalens-Solvent-Dependent Synthesis, Tautomerism, Self-sorting and Supramolecular Architectures of Chiral Polyimine Analogues of Resorcinarene was written by Szymkowiak, Joanna;Warzajtis, Beata;Rychlewska, Urszula;Kwit, Marcin. And the article was included in Chemistry – A European Journal in 2018.SDS of cas: 95-88-5 The following contents are mentioned in the article:

Substituted 2,4- and 4,6-dihydroxyisophthalaldehydes were condensed with optically pure and racemic trans-1,2-diaminocyclohexane to form resorcinarene-like polyimine macrocycles (resorcinsalens), the structure and stoichiometry of which were controlled by the choice of the reaction medium. Particularly, the cyclocondensation reactions were driven by the solubility, tautomerization, or by social self-sorting. The resorcinsalens crystallized as inclusion compounds, in which the guest mols. were situated either in channels or in voids. In the highly hydrated crystals of one of the [2+2] macrocycles and chloroform-solvated crystals of a [4+4] product the channels were interconnected, as in zeolites, enabling possible migration of loosely bound solvent mols. in three dimensions. The association mode depended on the structural modification of the host mol. and the type of included solvent mol.(s). This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5SDS of cas: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Biosynthesis of α-Substituted β-Ketoesters via the Tandem Knoevenagel Condensation-Reduction Reaction Using a Single Enzyme was written by Liu, Xiaolong;Li, Xiangjie;Wang, Zhelun;Zhou, Jinlong;Fan, Xinjiong;Fu, Yao. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.Computed Properties of C6H9ClO3 The following contents are mentioned in the article:

Saturated α-substituted β ketoesters are important building blocks in synthesis of pharmaceuticals and agrochems. Herein, we report a one-pot biosynthesis of α-substituted β-ketoesters via Knoevenagel condensation and reduction of received unsaturated alkenes in situ, catalyzed by single ene-reductase (NerA). A series of inexpensive and readily available aldehydes and 1,3-diketones were condensed and reduced by NerA in aqueous solution at room temperature We also note that low loadings (3 mg/mL) of NerA are sufficient to facilitate the cascade process, both E and Z isomeric intermediates can be reduced effectively and improved the overall yield up to 95%. Meanwhile, the method can be applied in preparative-scale synthesis of pharmaceutical intermediate. This process conforms to the concepts of green chem. and shows advantages for synthesis of high value saturated α-substituted β ketoesters. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Computed Properties of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-Activity Relationship Analysis of Pd-PEPPSI Complexes in Cross-Couplings: a Close Inspection of the Catalytic Cycle and the Precatalyst Activation Model was written by Nasielski, Joanna;Hadei, Nilofaur;Achonduh, George;Kantchev, Eric Assen B.;O’Brien, Christopher J.;Lough, Alan;Organ, Michael G.. And the article was included in Chemistry – A European Journal in 2010.Related Products of 6294-17-3 The following contents are mentioned in the article:

A series of Pd-N-heterocyclic carbene (Pd-NHC) complexes with various NHC, halide and pyridine ligands (PEPPSI (pyridine, enhanced, precatalyst, preparation, stabilization and initiation) precatalysts) were prepared, and the effects of these ligands on catalyst activation and performance were studied in the Kumada-Tamao-Corriu (KTC), Negishi, and Suzuki-Miyaura cross-coupling reactions. The lowered reactivity of more hindered 2,6-dimethylpyridyl complex 4 in the Negishi and KTC reactions is consistent with slow reductive dimerization of the organometallic reaction partner during precatalyst activation. Comparative rate studies of complexes 1, 4 and 5 in the KTC and Suzuki-Miyaura reactions verify that 4 activated more slowly than the others. A potential on/off mechanism of pyridine coordination to NHC-Pd⁰ is also plausible, in which the more basic pyridine stays bound for longer. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Related Products of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics