Tag: 100-200

Synthesis and evaluation of a series of 6-chloro-4-methylumbelliferyl glycosides as fluorogenic reagents for screening metagenomic libraries for glycosidase activity was written by Chen, Hong-Ming;Armstrong, Zachary;Hallam, Steven J.;Withers, Stephen G.. And the article was included in Carbohydrate Research in 2016.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Screening of large enzyme libraries such as those derived from metagenomic sources requires sensitive substrates. Fluorogenic glycosides typically offer the best sensitivity but typically must be used in a stopped format to generate good signal. Use of fluorescent phenols of pKa < 7, such as halogenated coumarins, allows direct screening at neutral pH. The synthesis and characterization of a set of nine different glycosides of 6-chloro-4-methylumbelliferone are described. The use of these substrates in a pooled format for screening of expressed metagenomic libraries yielded a “hit rate” of 1 in 60. Hits were then readily deconvoluted with the individual substrates in a single plate to identify specific activities within each clone. The use of such a collection of substrates greatly accelerates the screening process. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Category: chlorides-buliding-blocks).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tandem intramolecular cyclisation/1,3-aryl shift in N-(4,4-diethoxybutyl)-1-arylmethanimines (Kazan reaction): synthesis of 3-benzylidene-1-pyrrolines was written by Smolobochkin, A. V.;Gazizov, A. S.;Melyashova, A. S.;Voronina, J. K.;Strelnik, A. G.;Vatsadze, S. Z.;Burilov, A. R.;Pudovik, M. A.;Fedorova, O. A.;Sinyashin, O. G.. And the article was included in RSC Advances in 2017.Electric Literature of C6H5ClO2 The following contents are mentioned in the article:

In this article, a novel tandem reaction, which transformed N-(4,4-diethoxybutyl)imines into 3-arylidene-1-pyrrolines, was described. The substrate scope of the starting acetals included arenes with electron-donating and withdrawing groups. The X-ray study of products confirmed the E-stereochem. of the double bonds formed. The best yields (99%) were found in boiling xylene in the presence of TsOH (or 2-nitroresocinol) during 40 (50) hours. The study of substituents effect on the course of the reaction revealed that cascade process took place, combining acid-catalyzed intramol. cyclization of N-(4,4-diethoxybutyl)imines and unusual 1,3-sigmatropic shift of the aryl fragment. Cyclic imines that were formed in high/excellent yields were of interest both from the viewpoint of their biol. activity and synthetic usefulness. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Electric Literature of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

One pot, multicomponent protocol for the synthesis of novel imidazo[1,2-a]pyrimidine-based pyran analogs: a potential biological scaffold was written by Gungor, Tugba. And the article was included in Monatshefte fuer Chemie in 2020.Application In Synthesis of 4-Chlororesorcinol The following contents are mentioned in the article:

An efficient procedure between imidazo[1,2-a]pyrimidine-2-carbaldehyde, malononitrile, enolizable C-H activated acidic compounds, ROH (R = 3-hydroxyphenyl, 4-chloro-3-hydroxyphenyl, naphthalen-1-yl, etc.) dimedone and sodium carbonate is described for the synthesis of potential biol. active, novel imidazo[1,2-a]pyrimidine-based pyran analogs I (R¹ = 7-OH, 6-Cl-7-OH, 7,8-CH=CHCH=CH) and II through one pot, multicomponent reactions at room temperature This method provided mild reaction conditions, simple purification without column chromatog., and moderate to good yields for the construction of imidazo[1,2-a]pyrimidine-based pyran derivatives I and II. The structures of target compounds were established with different spectroscopic analyses. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Application In Synthesis of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The structure-based optimization of δ-sultone-fused pyrazoles as selective BuChE inhibitors was written by Zhang, Ziwen;Min, Jingli;Chen, Mengdie;Jiang, Xia;Xu, Yingying;Qin, Huali;Tang, Wenjian. And the article was included in European Journal of Medicinal Chemistry in 2020.Synthetic Route of C6H9ClO3 The following contents are mentioned in the article:

Structure-based optimization was conducted to improve the potency and selectivity of BuChE inhibitors with δ-sulfonolactone-fused pyrazole scaffold. By mimicking the hydrophobic interactions of donepezil at PAS, the introduction of a tertiary benzylamine at 5-position can significantly increase BuChE inhibitory activity. Compounds C4 and C6 were identified as high selective nanomolar BuChE inhibitors (IC₅₀ = 8.3 and 7.7 nM, resp.), which exhibited mild antioxidant capacity, nontoxicity, lipophilicity and neuroprotective activity. Kinetic studies showed that BuChE inhibition of compound C6 was mixed-type against BuChE (K_i = 24 nM) and >2000-fold selectivity for BuChE over AChE. The proposed binding mode of new inhibitors was consistent with the results of structure-activity relationship anal. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Synthetic Route of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Synthetic Route of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions was written by Mukherjee, Herschel;Blain, J. Craig;Vandivier, Lee E.;Chin, Donovan N.;Friedman, Jessica E.;Liu, Fei;Maillet, Ashley;Fang, Chao;Kaplan, Jenifer B.;Li, Jinxing;Chenoweth, David M.;Christensen, Allan Beck;Petersen, Lars Kolster;Hansen, Nils Jakob Vest;Barrera, Luis;Kubica, Neil;Kumaravel, Gnanasambandam;Petter, Jennifer C.. And the article was included in ACS Chemical Biology in 2020.Related Products of 638-07-3 The following contents are mentioned in the article:

RNA is emerging as a valuable target for the development of novel therapeutic agents. The rational design of RNA-targeting small mols., however, has been hampered by the relative lack of methods for the anal. of small mol.-RNA interactions. Here, the authors present the authors’ efforts to develop such a platform using photoaffinity labeling. This technique, termed Photoaffinity Evaluation of RNA Ligation-Sequencing (PEARL-seq), enables the rapid identification of small mol. binding locations within their RNA targets and can provide information on ligand selectivity across multiple different RNAs. These data, when supplemented with small mol. SAR data and RNA probing data enable the construction of a computational model of the RNA-ligand structure, thereby enabling the rational design of novel RNA-targeted ligands. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Related Products of 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Intermolecular Photocatalyzed Heck-like Coupling of Unactivated Alkyl Bromides by a Dinuclear Gold Complex was written by Xie, Jin;Li, Jian;Weingand, Vanessa;Rudolph, Matthias;Hashmi, A. Stephen K.. And the article was included in Chemistry – A European Journal in 2016.Product Details of 6294-17-3 The following contents are mentioned in the article:

A practical protocol for a photocatalyzed alkyl-Heck-like reaction of unactivated alkyl bromides and different alkenes promoted by dinuclear gold photoredox catalysis in the presence of an inorganic base is reported. Primary, secondary, and tertiary unactivated alkyl bromides with β-hydrogen can be applied. Esters, aldehydes, ketones, nitriles, alcs., heterocycles, alkynes, alkenes, ethers, and halogen moieties are all well tolerated. In addition to 1,1-diarylalkenes, silylenol ethers and enamides can also be applied, which further increases the synthetic potential of the reaction. The mild reaction conditions, broad substrate scope, and an excellent functional-group tolerance deliver an ideal tool for synthetic chemists that can even be used for challenging late-stage modifications of complex natural products. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Product Details of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nickel-catalyzed reductive thiolation and selenylation of unactivated alkyl bromides was written by Fang, Yi;Rogge, Torben;Ackermann, Lutz;Wang, Shun-Yi;Ji, Shun-Jun. And the article was included in Nature Communications in 2018.Reference of 6294-17-3 The following contents are mentioned in the article:

Herein, a user-friendly, nickel-catalyzed reductive thiolation of unactivated primary and secondary alkyl bromides with thiosulfonates as reliable thiolation reagents, which are easily prepared and bench-stable is presented. Furthermore, a series of selenides is also prepared in a similar fashion with selenosulfonates as selenolation reagents. This catalytic method offers a facile synthesis of a wide range of unsym. alkyl-aryl or alkyl-alkyl sulfides and selenides I (R = -CH₂Ph, -OPh, -CH₂CH₂CN, etc.; X = S, Se; R¹ = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, etc.) under mild conditions with an excellent tolerance of functional groups. Likewise, the use of sensitive and stoichiometric organometallic reagents can be avoided. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Reference of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Heterogeneously Catalyzed Pechmann Condensation Employing the HFe(SO₄)₂.4H₂O-Chitosan Nano-Composite: Ultrasound-Accelerated Green Synthesis of Coumarins was written by Zarei, Forough;Soleimani-Amiri, Somayeh;Azizi, Zahra. And the article was included in Polycyclic Aromatic Compounds in 2022.Product Details of 638-07-3 The following contents are mentioned in the article:

A heterogeneous magnetic HFe(SO₄)₂.4H₂O-chitosan nano-composite (HFe(SO₄)₂.4H₂O-Ch NCs) was designed and synthesized through a facile and economical two-steps procedure. The synthesized was identified by XRD, EDX, FT-IR, VSM, SEM, TEM, and TGA techniques. The resulting HFe(SO₄)₂.4H₂O-Ch NCs was applied as an efficient nano-catalyst in the green synthesis of coumarin derivatives through Pechmann condensation under solvent-free conditions at 100 °C, and also with ultrasonic-assisted at 70 °C. High yields of the products, short reaction times, and mild reaction conditions were perceived in both methods. The ability of detachment, recycling, and reuse of the nano-catalyst was investigated under reaction conditions. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Product Details of 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Self-assembly of reverse micelle nanoreactors by zwitterionic polyoxometalate-based surfactants for high selective production of β-hydroxyl peroxides was written by Hu, Guicong;Chang, Wen;An, Sai;Qi, Bo;Song, Yu-Fei. And the article was included in Chinese Chemical Letters in 2022.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

A zwitterionic polyoxymetalate (POM) based surfactant was synthesized by covalently grafting two cationic long alkyl tails onto the lacunary site of [PW₁₁O₃₉]^7-. With decreased electrostatic repulsions and increased hydrophobic effect, the POM-based reverse micelles with an average diameter of 5 nm were obtained. Interestingly, when these reverse micelles were applied for catalyzing the oxidation of styrene, an unprecedented β-hydroxyl peroxide compound, 2-hydroxyl-2-phenylethan-1-tert-butylperoxide, was produced with high selectivity of 95.2%. In comparison, the cetyltrimethylammonium electrostatically encapsulated POMs mainly generated the epoxides or 1,2-diols. A free radical mechanism were proposed for the oxidation reaction catalyzed by the zwitterionic POM surfactants. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Category: chlorides-buliding-blocks).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of several 4H-chromene derivatives of expected antitumor activity was written by Fouda, Ahmed M.. And the article was included in Medicinal Chemistry Research in 2016.COA of Formula: C6H5ClO2 The following contents are mentioned in the article:

Multi-component reactions for the preparation of 4H-chromene derivatives under microwave irradiation from different aromatic aldehydes with a mixture of malononitrile and phenol derivatives were established. The cytotoxic activity of the target compounds was evaluated against four cancer cell lines MCF-7, HCT-116, HepG-2 and A549 in comparison with vinblastine and colchicine as reference drugs. Generally, several compounds showed good cell growth inhibitory activity as compared to standard drugs. The structure-activity relationship studies reported that the substitution at 4- and 6-positions in 4H-chromene nucleus with the specific halogen atom increases the ability of the mol. against the different cell lines. The structures of the synthesized compounds were established on the basis of spectral data, IR, ¹H NMR, ¹³C NMR and MS data. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5COA of Formula: C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics