Tag: 100-200

Semi-Industrial Fluorination of β-Keto Esters with SF₄ : Safety vs Efficacy was written by Trofymchuk, Serhii A.;Kliukovskyi, Denys V.;Semenov, Sergey V.;Khairulin, Andrii R.;Shevchenko, Valerii O.;Bugera, Maksym Y.;Tarasenko, Karen V.;Volochnyuk, Dmitriy M.;Ryabukhin, Sergey V.. And the article was included in Synlett in 2020.Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

The possibility of deoxofluorination of β-keto esters using SF₄ was investigated. The scope and limitation of the reaction were determined The efficient method for the synthesis of β,β-difluorocarboxylic acids was elaborated based on the reaction. The set of mentioned acids, being the perspective building blocks for medicinal chem., were synthesized on multigram scale. The safety of SF₄ use was discussed. The described method does not improve upon the safety of using SF₄, but practical recommendations for working with the reagent were proposed. Despite the hazards of using toxic SF₄, a significant increase of efficacy in the synthesis of medicinal-chem.-relevant building blocks, based on the reaction, in comparison with earlier described approaches was shown. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anion-Dependent Outstanding Luminescence Enhancement of Eu(D-facam)₃ Upon Coexistence With the Tetramethylammonium Cation was written by Li, Ziying;Minami, Haruki;Nakamura, Kazuki;Kobayashi, Norihisa. And the article was included in ChemPhysChem in 2021.Application of 75-57-0 The following contents are mentioned in the article:

The effect of Me₄N⁺ salts with different counteranions on the photophys. properties of a chiral Eu(III) complex (Eu(D-facam)₃) were studied. Anion-dependent luminescence of the Eu(III) complex was observed, and particularly in the presence of acetate ions, an outstanding luminescence enhancement (>300 times) and induced circularly polarized luminescence (g_lum = -0.63) were obtained. The energy transfer process was then evaluated using key photophys. parameters, and the sensitization efficiency of the Eu(III) complex significantly increased in the presence of Me₄NOAc (TMAOAc). The interactions between Eu(D-facam)₃ and TMAOAc were confirmed by luminescence anal., CD spectroscopy, FTIR spectroscopy and mass spectral measurements. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Application of 75-57-0).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application of 75-57-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Comparative studies of novel oxadiazole derivative having chiral center and their anti-microbial activities was written by Mistry, Bhavnaben D.;Desai, Kishor R.;Intwala, Sanket M.. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2014.Related Products of 141109-14-0 The following contents are mentioned in the article:

A series of oxadiazole derivatives I [X = H, Y = NH₂ or X = NH₂, Y = H, and R = H, 3-CH₃, 2-OH, 2,4-(Cl)₂, 2-NO₂, etc.] were synthesized by the reaction of (-)(2R)-2-amino-2-(2-chlorophenyl)acetohydrazide and (+)(2S)-2-amino-2-(2-chloro phenyl)acetohydrazide with con. H₂SO₄, L(+)-tartaric acid, D(-)-tartaric acid, hydrazine hydrate, POCl₃ and various aromatic acid resp. and screened for their antibacterial and antifungal activities against different microorganisms by micro dilution method. The synthesized compounds I indicate that some of them show better antibacterial and antifungal activity than compared to their reference drug. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Related Products of 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, and evaluation of novel 3,4-isoxazolediamide derivatives for the combination treatment of azole-resistant candidiasis was written by Liu, Lei;Sun, Yixiang;Gao, Zixuan;Yin, Wenbo;Jiang, Hong;Wu, Tianxiao;Sun, Yin;Qin, Qiaohua;Zhao, Dongmei;Cheng, Maosheng. And the article was included in Archiv der Pharmazie (Weinheim, Germany).Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

Herein, the structural optimization and structure-activity relationship studies of 3,4-isoxazolediamide analogs I [R¹ = 4-FC₆H₄, 3-isoxazole, benzo(b)thien-2-yl, etc.] and II [R² = NHMe, NH(i-Pr), NMe₂, etc.] were reported. As a new class of fungal Hsp90 inhibitor, compound I [R¹ = 5-(morpholinomethyl)isoxazol-3-yl] was found to have good synergistic effects with fluconazole and to avoid potential mammalian toxicity. It also showed remarkable metabolic stability in vitro. Collectively, compound I [R¹ = 5-(morpholinomethyl)isoxazol-3-yl] could be a promising lead compound for drug discovery targeting fungal Hsp90 and deserves further investigation. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient nicotinamide adenine dinucleotide phosphate [NADP(H)] recycling in closed-loop continuous flow biocatalysis was written by Baumer, Benedikt;Classen, Thomas;Pohl, Martina;Pietruszka, Joerg. And the article was included in Advanced Synthesis & Catalysis in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Biocatalytic redox reactions regularly depend on expensive cofactors that require recycling. For continuous conversions in flow chem., this is often an obstacle since the cofactor is washed away. Here, we present a quasi-stationary recycling system for NADP utilizing an immobilized alc. dehydrogenase. Four model substrates were reduced with high enantioselectivity as a proof of concept. The two-phase system enables continuous production as well as quick substrate changes. This setup may serve as a general cofactor regeneration module for continuous biocatalytic devices employing (co-)substrates being miscible in organic solvent. The system resulted in space-time yields up to 117 g L^-1 h^-1 and total turnover numbers for NADP higher than 12,000 mol/mol are possible. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Enamides by Ruthenium-Catalyzed Reaction of Alkyl Azides with Acid Anhydrides in Ionic Liquid was written by Pak, Han Kyu;Han, Junghoon;Jeon, Mina;Kim, Yongjin;Kwon, Yearang;Park, Jin Yong;Rhee, Young Ho;Park, Jaiwook. And the article was included in ChemCatChem in 2015.Related Products of 6294-17-3 The following contents are mentioned in the article:

Enamides were synthesized by a ruthenium-catalyzed one-pot, one-step procedure from alkyl azides and acid anhydrides. The substrate scope includes not only secondary azides, but also primary aliphatic ones to give a wide range of enamides containing various functional groups. This one-step procedure was based on the newly discovered activity of Severin’s diruthenium complex ([CpR̂uCl₂]₂: Cp=̂η⁵-1-methoxy-2,4-di-tert-butyl-3-neopentylcyclopentadienyl) for the transformation of alkyl azides into the corresponding N-H imine intermediates in ionic liquids The formation of ruthenium tetrazene complexes was observed in the stoichiometric reaction of Severin’s complex with alkyl azides, which acted as the catalyst for the formation of N-H imine intermediates. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Related Products of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nickel-Catalyzed Reductive Thiolation of Unactivated Alkyl Bromides and Arenesulfonyl Cyanides was written by Wang, Fei;Rao, Weidong;Wang, Shun-Yi. And the article was included in Journal of Organic Chemistry in 2021.Quality Control of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

The cross-electrophile coupling between unactivated alkyl bromides RBr [R = 2-phenylethyl, but-3-en-1-yl, 1-[(tert-butoxy)(oxo)methane]piperidin-4-yl, etc.] with arenesulfonyl cyanides R¹S(O)₂CN (R¹ = 4-CH₃C₆H₄, C₆H₅, 4-CH₃OC₆H₄, 4-ClC₆H₄) catalyzed by Ni(acac)₂ under reductive conditions to form unsym. sulfides is developed. This approach for sulfide synthesis is practical, relies on available, unfunctionalized materials such as alkyl (pseudo)halides, and is scalable. This catalytic strategy provides a complementary method for the preparation of unsym. alkyl-aryl sulfides under mild conditions with good functional group tolerance. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Quality Control of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An unexpected synthesis and application of ethyl 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate was written by Li, Yang;Dong, Shiyu;Tang, Bingyue;Zou, Hongtao;Jiang, Wenting. And the article was included in Research on Chemical Intermediates in 2020.SDS of cas: 638-07-3 The following contents are mentioned in the article:

An unexpected and direct synthesis of Et 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate from the chlorotrimethylsilane-promoted Friedlander reaction between 1-(2-amino-5-iodophenyl)ethanone and Et 4-chloro-3-oxobutanoate has been disclosed. As a versatile and attractive building block, a synthetic application of the Et 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate in the successive Williamson ether synthesis with various phenols 2-R-3-R¹-4-R²-C₆H₂OH (R = H, Me, Cl, t-Bu, etc.; R¹ = H, Br; R² = H, Me, Cl, Br, t-Bu) and in situ ester hydrolysis reaction has been achieved and the corresponding 2,4-bis(aroxymethyl)quinoline-3-carboxylic acids I were obtained in good yields of 71-86%. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3SDS of cas: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Base-Promoted Reactions of Organostibines with Alkynes and Organic Halides to Give Chalcogenated (Z)-Olefins and Ethers was written by Le, Liyuan;Li, Shuangshuang;Zhang, Dejiang;Yin, Shuang-Feng;Kambe, Nobuaki;Qiu, Renhua. And the article was included in Organic Letters in 2022.Quality Control of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Herein, with air-stable chalcogenated stibines (Sb-ER) as organometallic chalcogenating reagents, base-promoted (Z)-hydrochalcogenation of alkynes with DMSO/DMSO-d₆ as hydrogen/deuterium sources, giving chalcogenated (Z)-olefins in good yields and with excellent regioselectivity was developed. These reagents, easily synthesized from halostibines with in situ generated [Zn(ER)₂] at room temperature within a few minutes, was also used in the base-promoted C(sp³)-S(Se) cross-coupling with C(sp³)-X and copper-catalyzed C(sp²)-S(Se) cross-coupling with C(sp²)-X (X = F, CI, Br, I) under mild conditions. This protocol was also be simply extended to organobismuth complexes (Bi-ER) with good functional tolerance. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Quality Control of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Quality Control of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Aromatic polyphosphonates as high refractive index polymers was written by Macdonald, Emily K.;Lacey, Joseph C.;Ogura, Ichiro;Shaver, Michael P.. And the article was included in European Polymer Journal in 2017.Electric Literature of C6H5ClO2 The following contents are mentioned in the article:

Highly refractive and transparent polyphosphonates with varying aromatic backbones have been synthesized by polycondensation of phosphonic dichlorides and diols, significantly expanding the reported scope of these intrinsic high refractive index polymers. The polyphosphonates display excellent thermal properties, with thermal stability up to 450°C and tuneable glass transition temperatures ranging from 41 to 214°C by terminating the polymer with different alcs. The polymers synthesized also possess excellent optical properties, with low UV cut off points and high refractive indexes up to 1.66, the highest reported for this type of polymer. We also report Abbe numbers for this class of polymers for the first time; all are high (>22), making these polymers excellent potential candidates for a range of optical applications. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Electric Literature of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics